NAV

Sulfaguanidine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Sulfaguanidine
DrugBank Accession Number
DB13726
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
3D
Similar Structures
Weight
Average: 214.24
Monoisotopic: 214.052446752
Chemical Formula
C7H10N4O2S
Synonyms
  • Sulfaguanidina
  • Sulfaguanidine
  • Sulfaguanidinum
Poor quality drug data slowing you down?
Unlock 38% more drug discovery time and eliminate decision-making doubts with this one-stop guide to quality drug data.
Download eBook
Poor quality drug data slowing you down?
Download eBook

Pharmacology

Indication

Not Available

Reduce drug development failure rates
Build, train, & validate machine-learning models
with evidence-based and structured datasets.
See how
Build, train, & validate predictive machine-learning models with structured datasets.
See how
Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Treatment ofDiarrhea••••••••••••••••••
Treatment ofDiarrhea caused by bacterial infections••••••••••••••••••
Contraindications & Blackbox Warnings
Prevent Adverse Drug Events Today
Tap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.
Learn more
Avoid life-threatening adverse drug events with our Clinical API
Learn more
Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Improve decision support & research outcomes
With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!
See the data
Improve decision support & research outcomes with our structured adverse effects data.
See a data sample
Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
Integrate drug-drug
interactions in your software
AcarboseThe therapeutic efficacy of Acarbose can be increased when used in combination with Sulfaguanidine.
AcetohexamideThe therapeutic efficacy of Acetohexamide can be increased when used in combination with Sulfaguanidine.
AlbiglutideThe therapeutic efficacy of Albiglutide can be increased when used in combination with Sulfaguanidine.
AlogliptinThe therapeutic efficacy of Alogliptin can be increased when used in combination with Sulfaguanidine.
BenzylpenicillinSulfaguanidine may decrease the excretion rate of Benzylpenicillin which could result in a higher serum level.
Food Interactions
Not Available

Categories

ATC Codes
A07AB03 — Sulfaguanidine
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Benzenesulfonamides
Direct Parent
Benzenesulfonamides
Alternative Parents
Benzenesulfonyl compounds / Aniline and substituted anilines / Sulfonyls / Organosulfonic acids and derivatives / Guanidines / Primary amines / Organopnictogen compounds / Organic oxides / Hydrocarbon derivatives
Substituents
Amine / Aniline or substituted anilines / Aromatic homomonocyclic compound / Benzenesulfonamide / Benzenesulfonyl group / Guanidine / Hydrocarbon derivative / Organic nitrogen compound / Organic oxide / Organic oxygen compound
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
15XQ8043FN
CAS number
57-67-0
InChI Key
BRBKOPJOKNSWSG-UHFFFAOYSA-N
InChI
InChI=1S/C7H10N4O2S/c8-5-1-3-6(4-2-5)14(12,13)11-7(9)10/h1-4H,8H2,(H4,9,10,11)
IUPAC Name
N-(4-aminobenzenesulfonyl)guanidine
SMILES
NC(=N)NS(=O)(=O)C1=CC=C(N)C=C1

References

General References
  1. FDA Thailand Product Information: Sulfayel (sulfaguanidine) oral tablets [Link]
ChemSpider
5133
BindingDB
50027795
RxNav
10174
ChEBI
94621
ChEMBL
CHEMBL338802
ZINC
ZINC000003873927
PDBe Ligand
QA9
Wikipedia
Sulfaguanidine
PDB Entries
8bch

Clinical Trials

Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.805 mg/mLALOGPS
logP-0.55ALOGPS
logP-0.52Chemaxon
logS-2.4ALOGPS
pKa (Strongest Acidic)10.53Chemaxon
pKa (Strongest Basic)7.72Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count5Chemaxon
Hydrogen Donor Count4Chemaxon
Polar Surface Area122.06 Å2Chemaxon
Rotatable Bond Count1Chemaxon
Refractivity63.75 m3·mol-1Chemaxon
Polarizability20.38 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0a4i-1900000000-95dc6d24a8e97c5bb432
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0a4i-0920000000-79d1980f6039651dc7c6
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0a4i-2900000000-bd832b9e527866126002
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-00di-0900000000-a0b67c07c5f8949ded2b
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-014l-9000000000-ba86e443abe8c7a820dc
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-00di-0900000000-c0ce0c1be4e0043842d0
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-9500000000-c1fc8ded31350acd6741
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-153.4175159
predicted
DarkChem Lite v0.1.0
[M-H]-147.46526
predicted
DeepCCS 1.0 (2019)
[M+H]+153.4212159
predicted
DarkChem Lite v0.1.0
[M+H]+149.86082
predicted
DeepCCS 1.0 (2019)
[M+Na]+152.6300159
predicted
DarkChem Lite v0.1.0
[M+Na]+155.91295
predicted
DeepCCS 1.0 (2019)

Drug created at June 23, 2017 20:47 / Updated at February 21, 2021 18:54