Menthol

Identification

Brand Names

Activon Arthritis, Bengay, Calazime Skin Protectant, Calmodrox, Calmoseptine Ointment, Capzasin Quick Relief, Chloraseptic Sore Throat, Chloraseptic Sore Throat + Cough, Delsym Cough Plus Soothing Action, Delsym Cough Relief Plus Soothing Action, Dendracin Neurodendraxcin, Fast Freeze, Flexall Ultra Plus, Gold Bond Maximum Relief, Icy Hot Arthritis, Ivy-dry Cream, Lidopro, Lidothol, Listerine Antiseptic, Max-freeze, Medi-derm, Medi-derm With Lidocaine, Medicaine Sting and Bite, Medrox, Men-phor, Mentholatum, Orasep Reformulated Dec 2013, Ortho-nesic, Rematex, Salonpas Gel-patch, Salonpas Pain Relieving Patch, Sarna Sensitive, Sucrets, Tiger Balm, Vaporex, Vicks Vaporub, Xoten-C

Generic Name

Menthol

DrugBank Accession Number

DB14123

Background

Not Available

Type

Small Molecule

Groups

Approved

Structure

3D

Download

MOLSDF3D-SDFPDBSMILESInChI

Similar Structures

Structure for Menthol (DB14123)

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Weight

Average: 156.269
Monoisotopic: 156.151415264

Chemical Formula

C₁₀H₂₀O

Synonyms

• (+-)-Menthol
• (1R,2S,5R)-Menthol
• DL-menthol
• Hexahydrothymol
• Menthol natural
• Menthol racemic
• Menthol racemique
• p-Menthan-3-ol
• Racementhol
• Racementholum
• Racementol

External IDs

• 89-78-1
• FEMA NO. 2665

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Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action

Target	Actions	Organism
UTransient receptor potential cation channel subfamily M member 8	agonist	Humans

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

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Not Available

Interactions

Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Not Available

Food Interactions

No interactions found.

Products

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Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
0 Degrees Pain Relieving	Gel	5 g/100mL	Topical	Rlabs, Llc	2016-04-01	2016-08-11
2 in 1 Relief Value Pack	Kit; Patch	0.05 g/1g	Topical	RB Health (US) LLC	2020-09-30	2024-12-31
4Jointz	Cream	1.5 g/100g	Topical	Arp(usa) Pty Ltd	2017-01-31	Not applicable
4RLF Topical Analgesic	Cream	0.1 g/1mL	Topical	Rinati Skin, LLC	2021-08-23	Not applicable
A.C.C Fresh and Cooling Scalp Mist	Liquid	0.3 g/100mL	Topical	Nature4 Co., Ltd.	2019-10-01	Not applicable

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
1st Medxpatch With Lidocaine 4%	Menthol (5 g/1) + Capsaicin (0.025 g/1) + Lidocaine (4 g/1) + Methyl salicylate (20 g/1)	Patch	Topical	1ST MEDX LLC	2018-03-15	Not applicable
1st RELIEF TOPICAL	Menthol (10 mg/1mL) + Lidocaine (40 mg/1mL)	Spray	Topical	1st Class Pharmaceuticals, Inc.	2014-12-02	Not applicable
24 Alopecia Reliefshampoo	Menthol (0.3 g/100mL) + Panthenol (0.2 g/100mL) + Salicylic acid (0.25 g/100mL)	Shampoo	Topical	DERMA CENTRIC INC	2020-08-08	Not applicable
24/7 Life Medicated Chest Rub	Menthol (2.6 g/100g) + Eucalyptus oil (1.2 g/100g) + Synthetic camphor (4.8 g/100g)	Ointment	Topical	Lil' Drug Store Products, Inc.	2022-11-11	Not applicable
2x Med Liq	Menthol (0.1 mg/100mL) + Benzocaine (20 mg/100mL)	Liquid	Oral	Lornamead	2021-09-01	Not applicable

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
1st Medxpatch With Lidocaine 4%-rx	Menthol (5 g/1) + Capsaicin (0.0375 g/1) + Lidocaine (4 g/1) + Methyl salicylate (20 g/1)	Patch	Topical	1ST MEDX LLC	2018-03-15	Not applicable
1st Medxpatch With Lidocaine 4%-rx	Menthol (5 1/1) + Capsaicin (0.0375 1/1) + Lidocaine (4 1/1) + Methyl salicylate (20 1/1)	Patch	Topical	Direct Rx	2020-10-14	Not applicable
24 Alopecia Reliefshampoo	Menthol (0.3 g/100mL) + Panthenol (0.2 g/100mL) + Salicylic acid (0.25 g/100mL)	Shampoo	Topical	DERMA CENTRIC INC	2020-08-08	Not applicable
4125 First Aid Kit	Menthol (0.33 g/100g) + Ammonia (0.045 g/0.3mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Benzethonium chloride (0.2 g/100g) + Benzethonium chloride (0.2 g/100g) + Benzocaine (10 g/100g) + Benzocaine (10 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Neomycin sulfate (3.5 mg/1g) + Polymyxin B sulfate (5000 [iU]/1g) + Water (98.6 mL/100mL)	Inhalant; Kit; Liquid; Ointment; Spray; Swab	Ophthalmic; Respiratory (inhalation); Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable
4204 First Aid Kit	Menthol (7 mg/1) + Acetaminophen (325 mg/1) + Benzalkonium chloride (0.13 g/100mL) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (24.64 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL)	Kit; Liquid; Lozenge; Ointment; Spray; Swab; Tablet	Ophthalmic; Oral; Topical	Honeywell Safety Products USA, Inc	2018-10-18	Not applicable

Categories

Drug Categories

• Alcohols
• Antipruritics
• Cyclohexane Monoterpenes
• Cyclohexanes
• Cyclohexanols
• Cycloparaffins
• Dermatologicals
• Fatty Alcohols
• Hexanols
• Lipids
• Monoterpenes
• Terpenes

Classification

Not classified

Affected organisms

Not Available

Chemical Identifiers

UNII

L7T10EIP3A

CAS number

1490-04-6

InChI Key

NOOLISFMXDJSKH-UHFFFAOYSA-N

InChI

InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3

IUPAC Name

5-methyl-2-(propan-2-yl)cyclohexan-1-ol

SMILES

CC(C)C1CCC(C)CC1O

References

General References

Not Available

External Links

Human Metabolome Database

HMDB0035765

ChemSpider

1216

BindingDB

248162

RxNav

1430390

ChEBI

25187

ChEMBL

CHEMBL256087

Wikipedia

Menthol

Clinical Trials

Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">

Phase	Status	Purpose	Conditions	Count
4	Active Not Recruiting	Treatment	Chronic Lower Back Pain (CLBP)	1
4	Completed	Prevention	Healthy Subjects (HS)	1
4	Completed	Prevention	Menstrual Cycle Abnormal	1
4	Completed	Treatment	Cervical Ripening / Induction of Labour	1
4	Completed	Treatment	Chronic Lower Back Pain (CLBP)	2

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Kit; patch	Topical	0.05 g/1g
Gel	Oral
Kit; liquid; lozenge; ointment; spray; swab; tablet	Ophthalmic; Oral; Topical
Kit	Ophthalmic; Oral; Respiratory (inhalation); Topical
Inhalant; kit; liquid; ointment; spray; swab; tablet	Ophthalmic; Oral; Respiratory (inhalation); Topical
Inhalant; kit; liquid; ointment; spray; swab	Ophthalmic; Respiratory (inhalation); Topical
Kit; liquid; ointment; spray; swab	Ophthalmic; Topical
Cream; gel; kit; liquid; ointment; spray; swab	Ophthalmic; Topical
Cream	Topical	0.1 g/1mL
Cream	Oral
Liquid	Topical	0.3 g/100mL
Gel	Topical	5 mg/100mL
Mouthwash	Buccal; Dental
Gel	Topical	100 mg/1g
Patch	Topical	5000 mg/1h
Liquid	Topical	1.27 g/100mL
Patch	Topical	6500 mg/1h
Patch	Topical	6500 mg/8h
Patch	Topical	5000 mg/8h
Patch	Transdermal	5000 mg/8h
Liquid	Topical	40 mg/1mL
Liquid	Topical	0.0127 g/1mL
Liquid	Topical	4 g/100mL
Patch	Transdermal	6500 mg/8h
Cream	Topical	28 g/90mL
Gel	Topical	12 mg/1mL
Cream	Topical	70 mg/1mL
Gel	Topical	80 mg/1mL
Liquid	Topical	80 g/1000g
Spray	Topical	80 g/1000g
Stick	Topical	0.05138 g/1g
Solution	Topical	35 mg/1mL
Cream	Topical	35 mg/1mL
Lozenge	Oral	7.6 1/1
Lozenge	Oral	8.6 1/1
Tape	Topical
Aerosol, spray	Percutaneous; Topical; Transdermal
Aerosol, spray	Cutaneous; Topical; Transdermal
Liquid	Topical	1.05 g/84g
Cream	Topical	0.2 g/4g
Gel	Topical	3 mg/100mL
Patch	Topical	30 mg/1
Patch	Topical	2.5 mg/100mg
Ointment	Topical	0.31 g/100g
Gel	Topical	70 mg/1L
Spray	Topical	70 mg/1L
Spray	Topical	700 mL/1L
Ointment	Enteral
Spray	Topical	5 mL/100mL
Lotion	Topical	0.15 g/100g
Mouthwash	Oral
Rinse	Periodontal
Spray	Topical	10 g/100mL
Gel	Topical	3.2 g/100mL
Gel	Topical	3 g/100mL
Liquid	Topical	3 g/100mL
Gel	Topical	3.969 g/113.4g
Gel	Topical	5 g/113.4g
Gel	Topical	3.969 g/90g
Cream	Topical	3.7 g/100g
Lotion	Topical	1 g/100g
Cream	Topical	12.5 mg/1g
Cream	Topical	1.4125 g/113g
Lozenge	Oral	2.8 mg/1
Patch	Topical	5 mg/100mg
Gel	Topical	1.25 g/100g
Powder	Topical	0.15 g/100g
Stick	Topical	1.34 g/57g
Gel, dentifrice	Topical	10 mg/1g
Cream	Topical	10 g/100g
Mouthwash	Buccal
Solution	Topical	100 mg/1mL
Patch	Topical	470 mg/1
Patch	Topical; Transdermal
Cream	Topical	4 g/100g
Spray	Topical	9 g/100mL
Stick	Topical	2.6 mg/1g
Cream	Topical	25 mg/1mL
Lotion	Topical	5 g/95g
Patch	Topical	4.62 g/100g
Liniment	Topical	3.7 g/100mL
Gel	Topical	3 g/120mL
Gel	Topical	2.4 mg/120mL
Gel	Topical	3 mg/120mL
Gel	Topical	1.5 g/60mL
Gel	Topical	50 mg/1g
Patch	Topical	50 mg/1
Gel	Topical	4.5 g/100g
Gel	Topical	5.085 g/113g
Spray	Topical	11.8 g/118mL
Lozenge	Oral	9.1 mg/1
Cream; kit; solution / drops	Topical
Gel; kit; solution / drops	Topical
Lozenge	Oral	5.97 mg/1
Liquid	Topical	4.2 mL/60mL
Patch	Topical	0.5 mg/1
Gel	Topical	1 g/10mL
Gel	Topical	8.9 g/89mL
Lotion	Topical	5.11 g/113g
Gel	Topical	30 mg/1g
Gel	Topical	2.1 g/60mL
Gel	Topical	4.0 g/100mL
Gel	Topical	0.03 g/1g
Patch	Topical	56 mg/1g
Cream; kit	Topical	100 mg/1g
Patch	Topical	0.3 g/6g
Gel	Topical	35 mg/1mL
Gel	Topical	105 mg/1mL
Stick	Topical	100 mg/1g
Stick	Topical	105 mg/1g
Liquid	Topical	105 mg/1mL
Aerosol, spray	Topical	105 mg/1mL
Spray	Topical	105 mg/1mL
Spray	Topical	590 mg/1mL
Patch	Topical	0.156 g/1
Patch	Topical	0.348 g/1
Salve	Topical	1 g/100g
Salve	Topical	1.1 g/100g
Soap	Topical	1 g/100mL
Kit; ointment; stick	Topical
Gel	Topical	2.0 g/100g
Gel	Topical	.02 g/1g
Powder	Topical	1.5 mg/1g
Powder	Topical	10 mg/1g
Liquid	Topical	70 mg/1mL
Cream	Topical	100 mg/1mL
Cream	Topical	170 g/90mL
Gel	Topical	0.025 g/1g
Cream	Topical	55 mg/1mL
Ointment	Respiratory (inhalation)
Ointment	Topical
Liquid	Topical	5 mg/1mL
Cream	Topical	0.5 g/100g
Cream	Topical	40 mg/1g
Salve	Topical	7.9 g/71.9g
Patch	Topical	0.05 mg/1
Lotion	Topical	5 mg/1000mL
Oil	Topical	0.08 kg/1kg
Oil	Topical	8 g/100mL
Cream	Topical	125 mg/1mL
Ointment	Topical	1.25 g/100mL
Cream	Topical	1.25 g/100mL
Cream	Topical	1.5 g/100g
Liquid	Topical	0.25 g/100mL
Liquid	Transdermal
Shampoo	Topical	0.3 g/100mL
Oil	Topical	1.5 g/50g
Lozenge	Oral	4.5 mg/1
Lozenge	Oral	1.3 mg/1
Lozenge	Oral	1.4 mg/1
Salve	Topical	27.6 mg/1g
Lozenge	Oral
Gel	Topical	2 g/100g
Gel	Topical
Gel	Topical	1 mg/100mL
Gel	Topical	0.1 mg/1mL
Cream	Topical	20 mg/1g
Liquid	Nasal
Cream	Topical	0.075 g/1g
Spray	Topical	16 g/100mL
Patch	Topical	240 mg/1
Patch	Topical	500 mg/1
Patch	Topical	550 mg/1
Patch	Topical	875 mg/1
Patch	Topical	400 mg/1
Liquid	Topical	16 g/100mL
Patch	Topical	5 g/100g
Lipstick	Topical
Aerosol, spray	Topical	6 mL/60mL
Gel	Topical	0.46 L/3.8L
Ointment	Topical	13 mL/90mL
Swab	Topical	.96 mL/8mL
Gel	Topical	10 g/100mL
Gel	Topical	4 g/100g
Patch	Topical	5 g/1
Patch	Topical	1.14 g/100g
Patch	Topical	100 mg/5mg
Granule, for solution	Oral	490 mg/5g
Kit; oil; tincture	Oral; Topical
Lotion	Topical	1.928 g/96g
Spray	Topical	16 g/100g
Gel	Topical	16 g/100g
Cream	Topical	10 g/100mL
Spray	Topical	160 mg/1mL
Lozenge	Oral	16.0 mg/1
Lozenge	Oral	13.2 mg/1
Lozenge	Oral	15.3 mg/1
Gel	Topical	1.2 g/100mL
Granule, for solution	Topical	11.7 mg/1mL
Patch	Topical	0.75 g/1
Gel	Topical	2.5 g/100mL
Patch	Topical	5 mg/1
Patch	Topical	336 mg/1
Patch	Topical	5 mg/1g
Lozenge	Oral	7.2 mg/7.2mg
Granule	Topical	0.18 g/1001
Tablet, chewable, extended release	Sublingual	0.18 mg/100mg
Tablet	Oral	5.8 mg/5.8mg
Tablet	Oral	7.5 mg/7.5mg
Tape	Cutaneous; Extracorporeal	0.05 g/1g
Lotion	Respiratory (inhalation)
Patch	Topical	0.05 g/1g
Gel	Topical	36 mg/1mL
Liquid	Topical	160 mg/1mL
Lozenge	Oral	20 mg/1
Gel, dentifrice	Dental
Lozenge	Oral	4 mg/1
Lotion	Topical	1 mg/1mL
Cream	Topical	0.025 g/1g
Spray	Topical	60 mg/1mL
Solution	Topical	60 mg/1mL
Liquid	Topical	16 g/100g
Patch, extended release	Transmucosal	2.5 mg/194.851
Patch, extended release	Transmucosal	2.5 mg/194.85mg
Tablet, extended release	Oral; Topical	2.5 mg/150mg
Tablet, extended release	Oral; Topical	2.5 mg/1
Cream	Topical	1.0 g/200mL
Cream	Topical	0.4 g/200mL
Cream	Topical	0.2 g/200mL
Kit	Topical
Kit; lozenge	Topical
Lozenge	Topical	5.8 mg/1
Powder	Topical	0.15 g/1g
Cream	Topical	1.8 g/100g
Lotion	Topical	1.5 mg/1g
Cream; gel; kit; solution	Topical
Gel; kit; solution	Topical
Kit; liquid; solution	Topical
Liquid	Topical	50 mg/1mL
Liquid	Topical	20 mg/1mL
Oil	Topical	3.5 g/100mL
Gel	Topical	24 g/120g
Liquid	Topical	30 mg/1mL
Aerosol, spray	Topical	3 g/100mL
Spray	Topical
Patch	Topical	0.5 g/1g
Gel	Topical	0.06 g/1g
Gel	Topical	3.89 g/100g
Gel	Topical	4.58 g/100g
Cream	Topical	40 mg/1mL
Spray	Topical	3.7 mg/1g
Solution	Topical
Cream	Topical	2.625 g/75g
Gel	Topical	80 mg/1g
Cream	Topical	100 mg/1g
Cream	Topical	3 mg/100mL
Patch	Cutaneous
Lozenge	Oral	8.3 mg/1
Lozenge	Oral	8.5 mg/1
Salve	Topical
Cream	Topical	50 mg/1mL
Liquid	Topical	35 mg/1mL
Disc	Topical
Patch	Topical	4 g/1
Spray	Topical	1000 mg/100mL
Spray	Topical	1700 mg/100mL
Spray	Topical	865.4 mg/50mL
Stick	Topical	0.0425 g/4.25g
Cream	Topical	60 mg/1mL
Liquid	Topical	2.5 g/100mL
Spray	Topical	1.25 g/100mL
Patch	Topical	0.056 g/1g
Cream	Topical	2.8 g/56g
Cream	Topical	27.5 mg/1mL
Cream	Topical	2.4 g/120g
Stick	Topical	0.035 g/7g
Gel	Dental
Spray	Topical	4 g/100mL
Cream	Topical	12.13 mg/1mL
Ointment	Topical	9.6 mL/60mL
Lotion	Topical	0.1 g/100mL
Gel	Topical	100 mg/1mL
Plaster	Topical; Transdermal
Spray	Topical	80 mg/1mL
Gel	Topical	2 g/100mL
Gel	Topical	4 g/100mL
Stick	Topical	20 mg/1g
Patch	Topical	750 mg/1
Gel	Topical	35 mg/1g
Spray	Topical	100 mg/1g
Gel	Topical	33 mg/1mL
Lotion	Topical	12.5 mg/1mL
Sponge	Topical
Swab	Topical
Solution	Oral
Spray	Topical	2.25 g/100mL
Gel	Topical	0.07 g/1g
Gel	Topical	0.16 g/1g
Kit	Oral; Topical
Cream	Topical	16 g/1
Spray	Topical	16 g/1
Granule, for solution	Oral	270 mg/6g
Cream	Topical	1.25 mg/1mL
Crystal	Topical
Lotion	Topical	13.5 mg/1mL
Cream	Topical	0.1 g/100mL
Oil	Topical	24 mg/1mL
Suspension / drops	Oral	2.7 mg/1
Gel	Topical	4.2 mg/100mL
Gel	Topical	5 mg/1g
Spray	Oropharyngeal
Liquid	Topical	3.7 mg/1g
Lozenge	Oral	9 mg/1
Lozenge	Oral	8.4 mg/1
Patch	Topical	50 mg/1mL
Spray	Oral; Topical
Ointment	Topical	1 g/100g
Lotion	Topical	0.005 g/1g
Powder	Topical	0.008 g/1g
Powder	Topical	0.8 g/100g
Spray	Topical	1 g/100g
Lotion	Topical	0.0015 g/1g
Powder	Topical	0.0015 g/1g
Cream	Topical	16 g/100g
Cream	Topical	6.25 g/100g
Cream	Topical	62.5 mg/1mL
Gel	Topical	5.44 mg/100mg
Lotion	Cutaneous
Oil	Topical	20 mg/500mg
Cream	Topical	5 g/100mL
Liquid	Topical	5 g/100mL
Lozenge	Oral	7 mg/1
Plaster	Transdermal	35 mg/1
Lozenge	Oral	5.7 mg/1
Lozenge	Oral	6.8 mg/1
Lozenge	Oral	1.8 mg/1
Lozenge	Oral	8.8 mg/1
Lozenge	Oral	8.2 mg/1
Lozenge	Oral	6.4 mg/1
Lozenge	Oral	4.3 mg/1
Lozenge	Oral	2.5 mg/1
Lozenge	Oral	2.7 mg/1
Lozenge	Oral	4.6 mg/1
Lozenge	Oral	3.2 mg/1
Lozenge	Oral	9.4 mg/1
Lozenge	Oral	3.7 mg/1
Lozenge	Oral	6.6 mg/1
Lozenge	Oral	6.7 mg/1
Lozenge	Oral	2.9 mg/1
Lozenge	Oral	15 mg/1
Lozenge	Oral	3.1 mg/1
Lozenge	Oral	18 mg/1
Syrup	Oral	0.1 g/100mL
Gel	Topical	2.0 g/100mL
Poultice	Transdermal	280 mg/12g
Gel	Topical	3.5 mg/100mL
Spray	Topical	10.4 g/100g
Lotion	Topical	4 g/100g
Gel	Topical	3402 mg/85.05g
Lotion	Topical	9068 mg/226.7g
Gel	Topical	2832 mg/70.8g
Spray	Topical	8925 mg/85g
Salve	Topical	1.4 g/111.45g
Patch	Topical	10 g/100g
Cream	Topical	7.4 g/100g
Cream	Topical
Mouthwash	Dental	0.2 g/100mL
Mouthwash	Dental	200 mg/100mL
Gel	Topical	5 g/100g
Solution	Topical	5 g/100g
Cream	Topical	2 mg/100mL
Gel	Topical	8 mg/100mL
Gel	Topical	8 g/8g
Stick	Topical	.1 g/1g
Lozenge	Oral	4.8 mg/1
Spray	Topical	0.06 g/1g
Lozenge	Oral	5.5 mg/1
Lozenge	Oral	1.6 mg/1
Lozenge	Oral	6 mg/1
Lozenge	Oral	5.5 mg/2.51
Cream	Topical	70 mg/1g
Lozenge	Oral	9.99 mg/1
Lozenge	Oral	3 mg/1
Lozenge	Oral	3.18 mg/1
Lozenge	Oral	7.5 1/1
Pastille	Oral	7.5 mg/1
Pastille	Oral	7.6 mg/1
Lozenge	Oral	3.9 mg/1
Lozenge	Oral	8.6 mg/2.5g
Cream	Topical	12.5 mg/1mL
Gel	Topical	2.27 g/227g
Patch	Topical	285 mg/5700mg
Liquid	Topical	16 mg/100mL
Gel	Topical	0.3 g/100mL
Gel	Topical	34.79 mg/1mL
Cream	Topical	2 mg/1g
Gel	Topical	2.84 mg/227mg
Gel	Topical	.02 g/100g
Cream	Topical	30 mg/1g
Gel	Topical	0.15 g/1g
Gel	Topical	16.95 g/113g
Cloth	Topical	50 mg/1g
Gel	Topical	55 mg/1mL
Spray	Topical	89 mg/1mL
Patch	Topical	205.50 mg/1
Patch	Topical	428.50 mg/1
Patch	Topical	205.5 mg/1
Patch	Topical	50.25 mg/1
Patch	Topical	866.25 mg/1
Patch	Topical	787.5 mg/1
Patch	Topical	210 mg/1
Patch	Topical	29.3 mg/1
Liquid	Topical	140.8 mg/1mL
Patch	Topical	750.00 mg/1
Spray	Topical	0.16 g/1mL
Oil	Topical	16 g/100mL
Gel; kit; tablet, delayed release	Oral; Topical
Spray	Topical	1 g/100mL
Liquid	Topical	12.5 mg/1g
Gel	Topical	5 mg/5mL
Cream	Topical	0.525 g/105g
Cream	Topical	2.5 g/500g
Liquid	Topical	0.1 g/100mL
Cream	Topical	2.2 g/100g
Soap	Topical	4 mg/1mL
Lozenge	Oral	5 mg/100mg
Cream	Topical	1.8 g/100mL
Cream	Topical	50 mg/1g
Ointment	Topical	16 g/100mL
Lotion	Topical	8.5 g/100mL
Liquid	Topical	1.4 g/28g
Liquid	Topical	10 g/100mL
Shampoo	Topical	1 mg/1mL
Gel	Topical	6 g/120g
Kit; liquid; ointment	Buccal; Topical
Lotion	Topical	4.49 g/100mL
Stick	Topical
Cream	Topical	30 mg/1mL
Gel	Topical	10 g/100g
Gel	Topical	10 mg/1g
Lotion	Topical	8.5 mg/88mL
Lozenge	Oral	9.3 mg/1
Powder	Topical	1 g/100g
Rinse	Oral
Cream	Dental
Cream	Topical	3 g/100mL
Plaster	Transdermal	3.0 g/100g
Oil	Topical	0.8 mg/50mL
Gel	Topical	12.5 mg/1mL
Gel	Topical	20 mg/1g
Gel	Topical	0.04 g/1g
Spray	Topical	0.005 g/1g
Lozenge	Oral	7.5 mg/1
Lozenge	Oral	5.4 mg/1
Pastille	Oral	1.1 mg/1
Kit; liquid; ointment	Topical
Kit	Oral
Patch	Topical	200 mg/1
Lozenge	Oral	5 mg/1
Aerosol, spray	Topical
Gel; kit; patch	Topical
Powder	Topical	2 g/100g
Lozenge	Oral	5.75 mg/1
Gel	Topical	0.24 mg/1mL
Lozenge	Oral	1.0 mg/1
Lotion	Topical	11.2 g/224g
Cream	Topical	22.7 g/454g
Liquid	Topical	4.2 g/84g
Cream	Topical	5.6 g/112g
Lotion	Topical	3 g/100g
Mouthwash	Dental; Oral
Gel	Topical	50 mg/1mL
Powder	Topical	0.1 g/1g
Lipstick	Topical	5 mg/1g
Shampoo	Topical
Lozenge	Oral	8.6 mg/1
Gel	Topical	.07 g/1g
Powder	Topical	2.26 g/283g
Powder	Topical	0.42 g/283g
Jelly	Topical
Stick	Topical	0.9 g/100g
Patch	Topical	428.5 mg/1
Patch	Topical
Cream	Topical	5 1/85g
Lozenge	Oral	5.8 mg/1
Cloth	Topical	0.05 g/1mL
Cream	Topical	2.36 g/59.1g
Spray	Topical	105 mg/1g
Cream	Topical	5 g/100g
Oil	Topical	6 mg/50mL
Patch	Topical	15 mg/1g
Cream	Topical	26 mg/1mL
Liquid	Nasal	2 g/100g
Lozenge	Oral	0.7 g/1g
Lozenge	Oral	0.86 g/1g
Oil	Topical	0.5 mg/50mL
Powder	Topical	2.8 g/283g
Powder	Topical	2.83 g/283g
Spray	Topical	2 g/100mL
Spray	Topical	2 g/100g
Patch	Topical	440 mg/1
Patch	Topical	600 mg/1
Patch	Topical	910 mg/1
Lozenge	Oral	5.4 1/1
Pastille	Oral	0.005 g/4g
Pastille	Oral	5.4 mg/1
Pastille	Oral	5.8 mg/1
Ointment	Topical	50 mg/1g
Lozenge	Oral	8.0 mg/1
Patch	Topical	19 g/1001
Pastille	Oral	20 mg/1
Ointment	Topical	27 mg/1g
Gel	Topical	30 mg/1mL
Lotion	Topical
Lotion	Topical	1.3 g/100g
Tablet, chewable, extended release	Oral	2.7 mg/2850mg
Tablet, chewable, extended release	Oral	5.8 mg/2850mg
Tablet, chewable, extended release	Oral	7.6 mg/2850mg
Salve	Topical	0.5 g/100g
Liniment	Percutaneous; Transdermal	1 g/3500mL
Salve	Topical	1 g/1500g
Gel; kit; tablet	Oral; Topical
Cream	Topical	4 g/100mL
Cream	Topical	15 mg/1mL
Gel	Topical	0.02 g/1g
Aerosol, foam	Topical	100 mg/1g
Gel	Topical	160 mg/1g
Solution	Topical	40 mg/1mL
Gel	Topical	160 mg/1mL
Gel	Topical	40 mg/1g
Cream	Topical	0.028 g/28g
Cream	Topical	0.106 g/106g
Cream	Topical	0.224 g/224g
Liquid	Topical	1.8 mL/90mL
Cream	Topical	3 g/100g
Cream	Topical	1.5 g/100mL
Patch	Topical	2 g/1001
Spray	Oral
Cream	Topical	2.5 g/100g
Gel	Topical	3.5 g/100mL
Gel	Topical	2.5 g/100g
Gel	Topical	25 mg/1g
Cream	Topical	1.05 g/42g
Gel	Topical	6 g/100mL
Spray	Topical	15.75 g/100mL
Spray	Topical	100 mg/1mL
Cream	Topical	5 uL/1mL
Tape	Topical	10 g/100g
Pill	Vaginal	0.5 g/100g
Lotion	Topical	60 mg/1mL
Ointment	Rectal	275 mg/48.2g
Mouthwash	Oral	0.3 mg/1mL
Spray	Topical	1.7 g/100mL
Lozenge	Oral	2.1 mg/1
Lozenge	Oral	3 1/1
Pastille	Oral	0.18 mg/1
Pastille	Oral	4.8 mg/1
Lozenge	Oral	1.5 mg/1
Lozenge	Oral	2.0 mg/1
Lozenge	Oral	3.5 mg/1
Lozenge	Oral	1.2 mg/1
Gel	Topical	3 g/100g
Lozenge	Oral	2 mg/3g
Oil	Topical	8 g/100g
Cream	Topical	10 mg/1g
Lotion	Topical	5 mg/1g
Spray	Topical	0.16 g/1g
Spray	Topical	5 g/100mL
Lozenge	Oral	8 mg/1
Aerosol, spray	Topical	1 mg/100mg
Aerosol, spray	Topical	5 mg/100mg
Cream	Topical	10 mg/100mg
Liquid	Topical	10 mg/100mg
Spray	Topical	0.1 mg/100mg
Aerosol, foam	Topical	5 mg/100mg
Liniment	Topical
Liquid	Topical	0.2 g/10mL
Tablet, soluble	Oral
Powder	Oral
Spray	Topical	0.5 g/100mL
Capsule; kit; liquid	Oral; Topical
Ointment	Topical	1.25 g/100g
Oil	Transdermal	100 mg/50mL
Gel	Topical	0.33 mg/660mL
Gel	Topical	0.63 g/632.19g
Lozenge	Oral	10 mg/1
Pastille	Oral	10 mg/1
Gel	Topical	85 mg/1mL
Strip	Dental
Film, soluble	Oral
Paste	Topical
Liquid	Oral	20 mg/1mL
Paste	Oral	8.4 mg/0.525g
Lozenge	Oral	1.9 mg/1
Cream	Topical	1.3 g/100g
Cream	Topical	8 g/100g
Gel	Topical	7 g/100mL
Liquid	Topical	6 g/100mL
Cream	Topical	14 g/280g
Granule	Topical	1.6 mg/1g
Granule; kit; liquid; oil	Topical
Liquid	Topical	2.23 mg/1mL
Oil	Topical	12.18 mg/1mL
Oil	Topical	17.62 mg/1mL
Spray	Topical	10 g/100g
Cream	Topical	2 g/100mL
Ointment	Topical	2.5 g/100mL
Ointment	Topical	3.5 g/100mL
Patch	Topical	105 mg/1
Solution	Topical	2 g/100g
Cream	Topical	6 g/100mL
Aerosol, spray	Topical	6 g/100mL
Gel	Topical	15 mg/1mL
Gel	Topical	17.5 mg/1mL
Gel	Topical	0.04 g/1mL
Liquid	Topical	0.16 g/1mL
Gel	Topical	11 g/100mL
Liquid	Topical	10 g/100g
Spray	Topical	10.5 g/100g
Patch	Topical	160 mg/1mL
Stick	Topical	10 g/100g
Tincture	Topical
Gel	Topical	2.4 g/120g
Spray	Topical	7 g/100mL
Gel	Topical	4.54 g/1g
Gel	Topical	10 g/100L
Patch	Topical	0.2 1/1
Patch	Topical	.05 mg/1g
Patch	Topical	50 mg/1g
Patch	Topical	6 g/1
Patch	Topical	30 mg/1mL
Patch	Topical	70 mg/1g
Gel	Topical	4.6 g/100g
Cream	Topical	35 mg/1g
Cream	Topical	4.25 g/85g
Lotion	Topical	160 mg/1mL
Patch	Topical	775 mg/1
Patch	Topical	5 g/1001
Patch	Topical	1.22 g/1
Patch	Topical	350 mg/1
Lotion	Topical	7.5 g/100g
Liquid	Oral
Gel	Topical	1.0 g/100g
Gel	Topical	31 mg/1mL
Spray	Topical	104 mg/1mL
Powder	Topical
Powder	Topical	20 mg/2g
Gel	Topical	1 g/100g
Lotion / shampoo	Topical
Cream	Topical	20 mg/1mL
Shampoo	Topical	0.1 g/100mL
Paste	Dental
Ointment	Topical	13 g/100g
Oil	Topical	15 g/100mL
Kit; oil	Topical
Gel	Topical	120 mg/1g
Gel	Topical	120 mg/1mL
Liquid	Topical	140 mg/1mL
Gel	Topical	40 mg/1mL
Gel	Topical	2 mL/100mL
Cream	Topical	80 mg/1mL
Gel	Topical	4.54 g/227g
Spray	Topical	10.5 g/10.5mL
Cream	Cutaneous; Topical
Ointment	Cutaneous; Topical
Gel	Cutaneous; Topical
Kit; patch	Topical
Cream	Topical	4 g/60mL
Spray	Topical	8 g/100mL
Gel	Topical	8 g/100mL
Gel	Topical	10.5 g/10.5mL
Ointment	Topical	16 g/16mg
Lozenge	Oral	2 mg/1
Lotion	Topical	3 g/100mL
Cream	Topical	75 mg/1mL
Patch	Percutaneous; Topical; Transdermal
Liquid	Topical	80 mg/1mL
Patch	Topical	0.875 g/100g
Cream	Topical	1.25 g/100g
Gel	Topical	3.5 mg/1L
Liquid	Topical	34.86 g/1L
Liquid	Topical	34.79 g/1L
Gel	Topical	0.03 g/1mL
Cream	Topical	118.29 mL/100mL
Lotion	Topical	1.5 g/100mL
Lotion	Topical	0.5 g/100mL
Lotion	Topical	1.25 g/100mL
Ointment	Topical	12.7 mg/1g
Lozenge	Oral	6.1 mg/1001
Liquid	Topical	12.5 mg/1mL
Cream	Topical	3.0 g/100g
Liquid	Topical	1.2 mg/15mL
Ointment	Topical	0.2 g/100g
Ointment	Topical	937.5 mg/1g
Liquid	Topical	2.75 g/100mL
Gel	Topical	27.5 mg/1g
Oil	Topical	7 mg/50mL
Patch	Topical	50 g/1
Gel	Topical	40 mg/1
Cream	Topical	0.006 g/0.1g
Cream	Topical	6 mg/100mL
Gel	Topical	6.0 g/100g
Gel	Topical	33.2 g/355mL
Gel	Topical	8.3 g/88.5mL
Kit	Topical	24.03 mg/1mL
Kit; oil	Topical	24.03 mg/1mL
Spray	Topical	4 g/4mL
Liquid	Respiratory (inhalation)	3.2 g/100mL
Patch	Topical	1000 mg/1
Patch	Topical	900 mg/1
Gel	Percutaneous; Topical; Transdermal
Aerosol, foam	Percutaneous; Topical; Transdermal
Ointment	Percutaneous; Topical; Transdermal
Poultice	Percutaneous; Topical; Transdermal	175 mg/1
Gel	Topical	150 mg/1g
Cream	Topical	4.0 g/100mL
Liquid	Topical
Gel	Topical	140 mg/1mL
Paste, dentifrice	Topical	0.2 g/100g
Pastille	Oral	0.69 mg/1
Plaster	Topical
Gel	Topical	12.5 mg/1g
Gel	Topical	12.6 mg/1g
Gel	Topical	2.6 mg/100g
Liquid	Topical	1 g/100mL
Kit	Topical	10 mg/1g
Stick	Topical	10 mg/1g
Patch	Topical	0.85 g/17g
Patch	Topical	0.85 g/1
Cream	Oral	6 g/100mL
Spray	Topical	5 mg/1mL
Kit; liquid	Dental	10 mg/20mL
Lozenge	Oral	6.5 mg/1
Cream	Topical	15 mg/1g
Gel	Topical	2.25 g/100g
Mouthwash	Dental
Liquid	Topical	0.84 g/28g
Solution / drops	Topical
Gel	Topical	2 mg/100mL
Cream	Topical	17.5 mg/1mL
Tablet	Oral	5.8 mg/1
Liquid	Topical	89 mg/1mL
Liquid	Topical	100 mg/1mL
Gel	Topical	6 g/100g
Gel	Topical	0.08 g/1g
Oil	Topical	1 g/93mL
Lozenge	Oral	5.8 1/1
Lozenge	Oral	6.9 mg/1
Lozenge	Oral	2.6 mg/1
Lozenge	Oral	4.1 mg/1
Lozenge	Oral	7.6 mg/1
Lozenge	Oral	5.52 mg/1
Lozenge	Oral	1.1 mg/1
Lozenge	Oral	2.2 mg/1
Cream	Topical	5.9 g/118mL
Stick	Topical	10 g/100mL
Ointment	Topical	1 mg/1g
Cream	Topical	14 mg/1mL
Liniment	Transdermal	3.5 mg/100mL
Oil	Topical	24.56 mg/1mL
Oil	Topical	1.3 mg/50mg
Ointment	Topical	8 g/100g
Patch	Topical	4 g/100g
Stick	Topical	0.6 g/100g
Cream	Topical	2 g/100g
Lozenge	Oral	5.3 mg/1
Cream	Topical	130 mg/1g
Gel	Topical	60 mg/1mL
Gel	Topical	.04 g/1g
Liquid	Topical	2 g/100mL
Gel	Topical	3.9 g/100mL
Spray	Topical	6 g/100mL
Pastille	Oral	2.5 mg/1
Lozenge	Oral	6 mg/4.2g
Patch	Transdermal	3 g/1
Patch	Transdermal
Plaster	Transdermal
Cream	Topical	0.1 g/100g
Liquid	Topical	0.002 g/4mL
Liquid	Topical	0.06 g/120mL
Ointment	Topical	24 mg/1g
Poultice	Transdermal
Dressing	Oral
Cream	Topical	1.4 g/100g
Lotion	Topical	0.5 g/100g
Patch	Topical	150 mg/1
Patch	Topical	300 mg/1
Patch	Topical	375 mg/1
Gel	Topical	5.0 g/100mL
Spray	Topical	10.5 g/100mL
Liquid	Topical	5 g/100g
Gel	Topical	8.5 g/100mL
Lotion	Topical	1.35 mg/100mL
Gel	Topical	4.56 g/114g
Lotion	Topical	8 g/100g
Liniment	Percutaneous
Gel	Topical	5 g/100mL
Gel	Topical	1.25 g/100mL
Cream	Topical	45 mg/1mL
Liquid	Topical	25 g/100g
Cream; kit; solution	Topical
Lozenge	Oral	1.7 mg/1
Lozenge	Oral	3.3 mg/1
Gel	Topical	2.69 g/60mL
Lotion	Topical	2 g/50mL
Aerosol, spray	Topical	0.01 g/1g
Liquid	Topical	0.9 g/100mL
Gel	Topical	0.1 g/100g
Aerosol, spray	Topical	16 g/100g
Granule, for solution	Topical	12.5 mg/1mL
Spray	Oral	2 g/100mL
Patch	Topical	5 1/1
Oil	Transdermal
Oil	Topical
Lotion	Topical	1 g/100mL
Cream	Topical	0.03 g/1g
Lozenge	Oral	5.8 mg/1mg
Gel	Topical	3 g/227g
Liniment	Percutaneous; Transdermal	3 g/100mL
Liniment	Percutaneous; Transdermal
Patch	Topical	10 mg/1000mg
Gel	Topical	20 g/1L
Gel	Topical	37 mg/1g
Gel	Topical	37 mg/1mL
Spray	Topical	37 mg/1g
Gel	Topical	70 mg/1g
Spray	Topical	160 mg/1g
Cream; kit	Topical
Spray	Topical	90 mg/1mL

Prices

Not Available

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)	Region
US8809615	No	2014-08-19	2030-01-03
US9233184	No	2016-01-12	2027-08-01

Properties

State

Not Available

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
Water Solubility	0.558 mg/mL	ALOGPS
logP	2.68	ALOGPS
logP	2.66	Chemaxon
logS	-2.4	ALOGPS
pKa (Strongest Acidic)	19.55	Chemaxon
pKa (Strongest Basic)	-0.81	Chemaxon
Physiological Charge	0	Chemaxon
Hydrogen Acceptor Count	1	Chemaxon
Hydrogen Donor Count	1	Chemaxon
Polar Surface Area	20.23 Å2	Chemaxon
Rotatable Bond Count	1	Chemaxon
Refractivity	47.45 m3·mol-1	Chemaxon
Polarizability	19.68 Å3	Chemaxon
Number of Rings	1	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	No	Chemaxon
Veber's Rule	Yes	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum	Spectrum Type	Splash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)	Predicted LC-MS/MS	splash10-0002-9400000000-1725adcedf912eaa92fe
Predicted MS/MS Spectrum - 10V, Negative (Annotated)	Predicted LC-MS/MS	splash10-0a4i-0900000000-b6377df362903ebb5f82
Predicted MS/MS Spectrum - 20V, Positive (Annotated)	Predicted LC-MS/MS	splash10-0541-9200000000-1080fe48e386942d59a2
Predicted MS/MS Spectrum - 20V, Negative (Annotated)	Predicted LC-MS/MS	splash10-0a4i-0900000000-47694ad7d401825e6e66
Predicted MS/MS Spectrum - 40V, Negative (Annotated)	Predicted LC-MS/MS	splash10-00di-1900000000-d727078dd6b1afa92c3d
Predicted MS/MS Spectrum - 40V, Positive (Annotated)	Predicted LC-MS/MS	splash10-0036-9000000000-7c3553f8ea4ed276a44e
Predicted 1H NMR Spectrum	1D NMR	Not Applicable
Predicted 13C NMR Spectrum	1D NMR	Not Applicable

Chromatographic Properties

Collision Cross Sections (CCS)

Adduct	CCS Value (Å2)	Source type	Source
[M-H]-	138.5290104	predicted	DarkChem Lite v0.1.0
[M-H]-	140.38904	predicted	DeepCCS 1.0 (2019)
[M+H]+	139.1843104	predicted	DarkChem Lite v0.1.0
[M+H]+	143.4861	predicted	DeepCCS 1.0 (2019)
[M+Na]+	138.6367104	predicted	DarkChem Lite v0.1.0
[M+Na]+	152.52184	predicted	DeepCCS 1.0 (2019)

Targets

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Details1. Transient receptor potential cation channel subfamily M member 8

Kind

Protein

Organism

Humans

Pharmacological action

Unknown

Actions

Agonist

General Function

Calcium channel activity

Specific Function

Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalypto...

Gene Name

TRPM8

Uniprot ID

Q7Z2W7

Uniprot Name

Transient receptor potential cation channel subfamily M member 8

Molecular Weight

127684.035 Da

References

1. Liu J, Liu L, Zhao M, Ding N, Ge N, Daugherty SL, Beckel JM, Wang S, Zhang X: Activation of TRPM8 channel inhibits contraction of the isolated human ureter. Neurourol Urodyn. 2021 Aug;40(6):1450-1459. doi: 10.1002/nau.24689. Epub 2021 May 20. [Article]

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Drug created at June 24, 2018 13:18 / Updated at November 27, 2021 01:19