Ditiocarb zinc

Identification

Generic Name

Ditiocarb zinc

DrugBank Accession Number

DB14193

Background

Ditiocarb zinc, also known as Diethyldithiocarbamic acid zinc salt, is a known chelator for copper and zinc. It also a dermatological sensitizer and allergen. Sensitivity to ditiocarb zinc may be identified with a clinical patch test.

Type

Small Molecule

Groups

Approved

Structure

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MOLSDFPDBSMILESInChI

Similar Structures

Structure for Ditiocarb zinc (DB14193)

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Weight

Average: 361.948
Monoisotopic: 359.980077988

Chemical Formula

C₁₀H₂₀N₂S₄Zn

Synonyms

• Bis(diethyldithiocarbamato)zinc
• DEDTC
• Diethyldithiocarbamic acid zinc salt
• Ethazate
• Ethyl cymate
• Ethyl zimate
• Ethyl Ziram
• Ethylzimate
• Zinc Diethyldithiocarbamate
• Zinc N,N-diethyldithiocarbamate
• Zinc, bis(diethylcarbamodithioato-S,S')-

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Pharmacology

Indication

Ditiocarb Zinc is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years of age and older.

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Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">

Not Available

Interactions

Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drug	Interaction
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Roxadustat	Ditiocarb zinc can cause a decrease in the absorption of Roxadustat resulting in a reduced serum concentration and potentially a decrease in efficacy.

Food Interactions

Not Available

Products

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Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
T.R.U.E. Test Thin-Layer Rapid Use Patch Test	Ditiocarb zinc (68 ug/48h) + 2,2'-Dibenzothiazyl disulfide (20 ug/48h) + 2-mercaptobenzothiazole (61 ug/48h) + 4-(Isopropylamino)diphenylamine (10 ug/48h) + Bacitracin (486 ug/48h) + Balsam of Peru (648 ug/48h) + Benzocaine (378 ug/48h) + Benzylparaben (162 ug/48h) + Bisphenol A diglycidyl ether (32 ug/48h) + Bromothalonil (4 ug/48h) + Bronopol (203 ug/48h) + Budesonide (0.8 ug/48h) + Butylparaben (162 ug/48h) + Chlorquinaldol (77 ug/48h) + Cinchocaine hydrochloride (66 ug/48h) + Cinnamaldehyde (41 ug/48h) + Cinnamyl alcohol (63 ug/48h) + Clioquinol (77 ug/48h) + Cobalt chloride hexahydrate (4 ug/48h) + Diazolidinylurea (446 ug/48h) + Potassium dichromate (15.7 ug/48h) + Dipentamethylenethiuram disulfide (5.5 ug/48h) + Diphenylguanidine (68 ug/48h) + Disperse Blue 106 (41 ug/48h) + Disulfiram (5.5 ug/48h) + Ethyl hydroxybenzoate (162 ug/48h) + Ethylenediamine (18 ug/48h) + Eugenol (41 ug/48h) + Evernia prunastri (81 ug/48h) + Formaldehyde (146 ug/48h) + Geraniol (81 ug/48h) + Hydrocortisone butyrate (16 ug/48h) + Hydroxycitronellal (63 ug/48h) + Imidurea (486 ug/48h) + Isoeugenol (17 ug/48h) + Lanolin alcohols (810 ug/48h) + Methylchloroisothiazolinone (3 ug/48h) + Methylparaben (162 ug/48h) + Morpholinylmercaptobenzothiazole (20 ug/48h) + N,N'-diphenyl-1,4-phenylenediamine (25 ug/48h) + N-Cyclohexyl-N'-phenyl-1,4-phenylenediamine (25 ug/48h) + Neomycin sulfate (486 ug/48h) + Nickel sulfate hexahydrate (36 ug/48h) + Parthenolide (2 ug/48h) + Propylparaben (162 ug/48h) + Quaternium-15 (81 ug/48h) + Rosin (972 ug/48h) + Sodium aurotiosulfate (23 ug/48h) + Tetracaine hydrochloride (66 ug/48h) + Tetramethylthiuram monosulfide (5.5 ug/48h) + Thimerosal (6 ug/48h) + Thiohexam (20 ug/48h) + Thiram (5.5 ug/48h) + Tixocortol pivalate (2 ug/48h) + Zinc dibutyldithiocarbamate (68 ug/48h) + alpha-Amyl cinnamaldehyde (17 ug/48h) + p-Phenylenediamine (65 ug/48h) + p-tert-Butylphenol-formaldehyde resin (low molecular weight) (36 ug/48h)	Kit	Cutaneous	SmartPractice Denmark ApS	2012-03-01	Not applicable

Categories

ATC Codes

C05AX04 — Zinc preparations

• C05AX — Other agents for treatment of hemorrhoids and anal fissures for topical use
• C05A — AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
• C05 — VASOPROTECTIVES
• C — CARDIOVASCULAR SYSTEM

Drug Categories

• Acids, Acyclic
• Adjuvants, Immunologic
• Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use
• Allergens
• Anti-Infective Agents
• Antigens
• Biological Factors
• Carbamates
• Cell-mediated Immunity
• Chelating Agents
• Compounds used in a research, industrial, or household setting
• Immunologic Factors
• Increased Histamine Release
• Metal cations
• Metal divalent cations
• Sequestering Agents
• Standardized Chemical Allergen
• Sulfur Compounds
• Thiocarbamates
• Vasoprotectives
• Zinc Compounds

Chemical TaxonomyProvided by Classyfire

Description

This compound belongs to the class of organic compounds known as organosulfur compounds. These are organic compounds containing a carbon-sulfur bond.

Kingdom

Organic compounds

Super Class

Organosulfur compounds

Class

Not Available

Sub Class

Not Available

Direct Parent

Organosulfur compounds

Alternative Parents

Organopnictogen compounds / Organonitrogen compounds / Organic salts / Hydrocarbon derivatives

Substituents

Aliphatic acyclic compound / Hydrocarbon derivative / Organic nitrogen compound / Organic salt / Organonitrogen compound / Organopnictogen compound / Organosulfur compound

Molecular Framework

Not Available

External Descriptors

Not Available

Affected organisms

Not Available

Chemical Identifiers

UNII

ICW4708Z8G

CAS number

14324-55-1

InChI Key

RKQOSDAEEGPRER-UHFFFAOYSA-L

InChI

InChI=1S/2C5H11NS2.Zn/c2*1-3-6(4-2)5(7)8;/h2*3-4H2,1-2H3,(H,7,8);/q;;+2/p-2

IUPAC Name

zinc(2+) bis((diethylcarbamothioyl)sulfanide)

SMILES

[Zn++].CCN(CC)C([S-])=S.CCN(CC)C([S-])=S

References

General References

Not Available

External Links

ChemSpider

24810

RxNav

1427192

ChEBI

144351

ChEMBL

CHEMBL3182813

Clinical Trials

Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">

Phase	Status	Purpose	Conditions	Count

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Kit	Cutaneous

Prices

Not Available

Patents

Not Available

Properties

State

Not Available

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
Water Solubility	0.0346 mg/mL	ALOGPS
logP	3.92	ALOGPS
logP	2.01	Chemaxon
logS	-4	ALOGPS
pKa (Strongest Acidic)	2	Chemaxon
Physiological Charge	-1	Chemaxon
Hydrogen Acceptor Count	0	Chemaxon
Hydrogen Donor Count	0	Chemaxon
Polar Surface Area	3.24 Å2	Chemaxon
Rotatable Bond Count	4	Chemaxon
Refractivity	45.76 m3·mol-1	Chemaxon
Polarizability	16.01 Å3	Chemaxon
Number of Rings	0	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	Yes	Chemaxon
Veber's Rule	Yes	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum	Spectrum Type	Splash Key
Mass Spectrum (Electron Ionization)	MS	splash10-03di-7649000000-566995d6056295a66348

Chromatographic Properties

Collision Cross Sections (CCS)

Not Available

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Drug created at July 03, 2018 21:28 / Updated at June 12, 2020 16:53