Identification
- Generic Name
- Calcium phosphate dihydrate
- DrugBank Accession Number
- DB14481
- Background
Not Available
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Calcium phosphate dihydrate (DB14481)
- Weight
- Average: 172.086
Monoisotopic: 171.9449658 - Chemical Formula
- CaH5O6P
- Synonyms
- Calcium monohydrogen phosphate dihydrate
- Calcium phosphate dibasic, hydrous
- Calcium phosphate dihydrate, dibasic
- Calcium phosphate, dibasic, dihydrate
- Calcium phosphate, dibasic, hydrous
- D.C.P.
- Dibasic calcium phosphate dihydrate
- Dibasic calcium phosphate hydrate
- Dicalcium phosphate dihydrate
Pharmacology
- Indication
For use as an over the counter calcium and phosphate supplement, antacid, or a source of calcium and phosphate in toothpaste Label 3.
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Therapies
- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Calcium phosphate reacts with acid in the stomach to raise the pH 3. In toothpaste it provides a source of calcium and phosphate ions to support remineralization of the teeth 1. As a supplement it provides a source of calcium and phospate, both of which are important ions in bone homeostasis.
- Mechanism of action
The phosphate ions in calcium phosphate likely react with hydrochloric acid in the stomach to neutralize the pH. In toothpaste and in systemic circulation, calcium phosphate provides a source of calcium and phosphate ions to support remineralization of the teeth and bone homeostasis respectively. The increase in plasma calcium reduces calcium flux from osteocyte activity by reducing the secretion of parathyroid hormone (PTH) 2. Calcium does this by stimulating a G-protein coupled calcium receptor on the surface of parathyroid cells. The reduction in calcium flux increases the amount of calcium deposited in bone resulting in an increase in bone mineral density. The reduction in PTH secretion also reduces the amount of vitamin D metabolized to its active form, calcidiol. Since calcidiol increases the expression of calcium dependent ATPases and transient receptor potential cation channel subfamily V member 6 (TRPV6) both of which are involved in calcium uptake from the gut, a reduction in calcidiol results in less calcium absorption. Additionally, TRPV5, the channel responsible for calcium reabsorption in the kidney, is downregulated when PTH secretion is reduced thus increasing calcium excretion via the kidneys. Another hormone, calitonin, is likely involved in the reduction of bone resorption during periods of high plasma calcium.
Target Actions Organism AExtracellular calcium-sensing receptor Not Available Humans NCalreticulin Not Available Humans UCalcium and integrin-binding protein 1 Not Available Humans UProgrammed cell death protein 6 Not Available Humans USorcin Not Available Humans UCalcineurin B homologous protein 1 Not Available Humans NSPARC Not Available Humans NCalnexin Not Available Humans NFibrillin-2 Not Available Humans NProtein S100-B Not Available Humans NCalsequestrin-2 Not Available Humans NRegucalcin Not Available Humans NPeflin Not Available Humans UProtein S100-A6 Not Available Humans NTranslationally-controlled tumor protein Not Available Humans UCalcium and integrin-binding family member 2 Not Available Humans NProtein S100-A13 Not Available Humans NCalsequestrin-1 Not Available Humans UNucleobindin-1 Not Available Humans UNucleobindin-2 Not Available Humans UCalmodulin Not Available Humans UFibrillin-3 Not Available Humans UGrancalcin Not Available Humans UCalcium-dependent secretion activator 1 Not Available Humans UCalmodulin-2 Not Available Humans UCalmodulin-3 Not Available Humans UProtein S100-A16 Not Available Humans UCalretinin Not Available Humans UCalcyphosin Not Available Humans UCalcium-dependent secretion activator 2 Not Available Humans UCalreticulin-3 Not Available Humans UNeurexin-1 Not Available Humans UNeuronal calcium sensor 1 Not Available Humans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAluminum hydroxide Aluminum hydroxide can cause a decrease in the absorption of Calcium phosphate dihydrate resulting in a reduced serum concentration and potentially a decrease in efficacy. Calcium acetate Calcium acetate can cause a decrease in the absorption of Calcium phosphate dihydrate resulting in a reduced serum concentration and potentially a decrease in efficacy. Calcium carbonate Calcium carbonate can cause a decrease in the absorption of Calcium phosphate dihydrate resulting in a reduced serum concentration and potentially a decrease in efficacy. Calcium chloride Calcium chloride can cause a decrease in the absorption of Calcium phosphate dihydrate resulting in a reduced serum concentration and potentially a decrease in efficacy. Calcium glucoheptonate Calcium glucoheptonate can cause a decrease in the absorption of Calcium phosphate dihydrate resulting in a reduced serum concentration and potentially a decrease in efficacy. - Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Active Moieties
Name Kind UNII CAS InChI Key Calcium Phosphate unknown 97Z1WI3NDX 10103-46-5 QORWJWZARLRLPR-UHFFFAOYSA-H Phosphate ion ionic NK08V8K8HR 14265-44-2 NBIIXXVUZAFLBC-UHFFFAOYSA-K - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Biorepair Sensitive Teeth Paste 18.6 g/100g Oral Coswell Spa 2017-06-02 Not applicable US 
Biorepair Total Protection Paste 15.11 g/100g Oral Coswell Spa 2017-06-04 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Biovita Calcium phosphate dihydrate (20 mg/1g) + Ascorbic acid (5 mg/1g) + Bacillus subtilis (3 mg/1g) + Nicotinamide (0.1 mg/1g) + Riboflavin (0.2 mg/1g) + Thiamine mononitrate (0.3 mg/1g) Granule Oral Ildong Pharmaceutical Co., Ltd. 2015-06-03 2019-09-13 US Biovita Calcium phosphate dihydrate (20 mg/1g) + Ascorbic acid (5 mg/1g) + Bacillus subtilis (3 mg/1g) + Nicotinamide (0.1 mg/1g) + Riboflavin (0.2 mg/1g) + Thiamine mononitrate (0.3 mg/1g) Granule Oral OASIS TRADING 2018-12-25 Not applicable US Finefra Aid Tooth Calcium phosphate dihydrate (0.04 g/100g) + Alcloxa (0.04 g/100g) + Calcium carbonate (0.10 g/100g) + alpha-Tocopherol acetate (0.04 g/100g) Paste, dentifrice Topical Jewoo Medical Co,.Ltd 2020-05-01 Not applicable US Hae Yan Tooth Calcium phosphate dihydrate (0.09 g/100g) + Alcloxa (0.09 g/100g) + Aminocaproic acid (0.09 g/100g) + Calcium carbonate (37 g/100g) Paste Oral WOORILIFE&HEALTH 2020-05-25 Not applicable US Hea YanToothpaste Calcium phosphate dihydrate (0.09 g/100g) + Alcloxa (0.09 g/100g) + Aminocaproic acid (0.09 g/100g) + Calcium carbonate (37 g/100g) Paste, dentifrice Dental WOORI LIFE & HEALTH 2023-04-24 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Biorepair Sensitive Teeth Calcium phosphate dihydrate (18.6 g/100g) Paste Oral Coswell Spa 2017-06-02 Not applicable US Biorepair Total Protection Calcium phosphate dihydrate (15.11 g/100g) Paste Oral Coswell Spa 2017-06-04 Not applicable US Biovita Calcium phosphate dihydrate (20 mg/1g) + Ascorbic acid (5 mg/1g) + Bacillus subtilis (3 mg/1g) + Nicotinamide (0.1 mg/1g) + Riboflavin (0.2 mg/1g) + Thiamine mononitrate (0.3 mg/1g) Granule Oral Ildong Pharmaceutical Co., Ltd. 2015-06-03 2019-09-13 US Biovita Calcium phosphate dihydrate (20 mg/1g) + Ascorbic acid (5 mg/1g) + Bacillus subtilis (3 mg/1g) + Nicotinamide (0.1 mg/1g) + Riboflavin (0.2 mg/1g) + Thiamine mononitrate (0.3 mg/1g) Granule Oral OASIS TRADING 2018-12-25 Not applicable US Finefra Aid Tooth Calcium phosphate dihydrate (0.04 g/100g) + Alcloxa (0.04 g/100g) + Calcium carbonate (0.10 g/100g) + alpha-Tocopherol acetate (0.04 g/100g) Paste, dentifrice Topical Jewoo Medical Co,.Ltd 2020-05-01 Not applicable US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as alkaline earth metal phosphates. These are inorganic compounds in which the largest oxoanion is phosphate, and in which the heaviest atom not in an oxoanion is an alkaline earth metal.
- Kingdom
- Inorganic compounds
- Super Class
- Mixed metal/non-metal compounds
- Class
- Alkaline earth metal oxoanionic compounds
- Sub Class
- Alkaline earth metal phosphates
- Direct Parent
- Alkaline earth metal phosphates
- Alternative Parents
- Inorganic oxides / Inorganic calcium salts
- Substituents
- Alkaline earth metal phosphate / Inorganic calcium salt / Inorganic oxide / Inorganic salt
- Molecular Framework
- Not Available
- External Descriptors
- hydrate, calcium salt (CHEBI:4496)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- O7TSZ97GEP
- CAS number
- 7789-77-7
- InChI Key
- XAAHAAMILDNBPS-UHFFFAOYSA-L
- InChI
- InChI=1S/Ca.H3O4P.2H2O/c;1-5(2,3)4;;/h;(H3,1,2,3,4);2*1H2/q+2;;;/p-2
- IUPAC Name
- calcium dihydrate hydrogen phosphate
- SMILES
- O.O.[Ca++].OP([O-])([O-])=O
References
- General References
- Reynolds EC: Calcium phosphate-based remineralization systems: scientific evidence? Aust Dent J. 2008 Sep;53(3):268-73. doi: 10.1111/j.1834-7819.2008.00061.x. [Article]
- Barrett KE, Barman SM, Boitano S, Brooks HL (2012). Ganong's Review of Medical Physiology (24th ed.). McGraw Hill. [ISBN:978-0-07-17803-2]
- HSDB: Calcium Phosphate [Link]
- External Links
Clinical Trials
- Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Capsule Oral Paste Oral 18.6 g/100g Paste Oral 15.11 g/100g Granule Oral Paste, dentifrice Topical Paste Oral Paste Dental Gel, dentifrice Oral Paste, dentifrice Dental Paste, dentifrice Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 38.9 mg/mL ALOGPS logP -0.55 ALOGPS logP -1 Chemaxon logS -0.69 ALOGPS pKa (Strongest Acidic) 1.8 Chemaxon Physiological Charge -2 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 83.42 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 12.41 m3·mol-1 Chemaxon Polarizability 5.24 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (â„«2) Source type Source [M-H]- 105.5041532 predictedDarkChem Lite v0.1.0 [M-H]- 104.25548 predictedDeepCCS 1.0 (2019) [M+H]+ 107.78008 predictedDeepCCS 1.0 (2019) [M+Na]+ 116.38976 predictedDeepCCS 1.0 (2019)
Targets
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Use our structured and evidence-based datasets to unlock newinsights and accelerate drug research.
Use our structured and evidence-based datasets to unlock new insights and accelerate drug research.
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- General Function
- Phosphatidylinositol phospholipase c activity
- Specific Function
- Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.
- Gene Name
- CASR
- Uniprot ID
- P41180
- Uniprot Name
- Extracellular calcium-sensing receptor
- Molecular Weight
- 120672.385 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- General Function
- Zinc ion binding
- Specific Function
- Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently wit...
- Gene Name
- CALR
- Uniprot ID
- P27797
- Uniprot Name
- Calreticulin
- Molecular Weight
- 48141.2 Da
References
- UniProt: Calreticulin [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.
- Specific Function
- Calcium ion binding
- Gene Name
- CIB1
- Uniprot ID
- Q99828
- Uniprot Name
- Calcium and integrin-binding protein 1
- Molecular Weight
- 21703.07 Da
References
- UniProt: Calcium and integrin-binding protein 1 [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Protein dimerization activity
- Specific Function
- Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)-regulated signals along the death pathway (By similarity). Calcium-dependent a...
- Gene Name
- PDCD6
- Uniprot ID
- O75340
- Uniprot Name
- Programmed cell death protein 6
- Molecular Weight
- 21868.32 Da
References
- Uniprot: Programmed cell death protein 6 [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.
- Specific Function
- Calcium channel regulator activity
- Gene Name
- SRI
- Uniprot ID
- P30626
- Uniprot Name
- Sorcin
- Molecular Weight
- 21676.245 Da
References
- UniProt: Sorcin [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.
- Specific Function
- Calcium ion binding
- Gene Name
- CHP1
- Uniprot ID
- Q99653
- Uniprot Name
- Calcineurin B homologous protein 1
- Molecular Weight
- 22455.96 Da
References
- UniProt: Calcineurin B homologous protein 1 [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- General Function
- Extracellular matrix binding
- Specific Function
- Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membran...
- Gene Name
- SPARC
- Uniprot ID
- P09486
- Uniprot Name
- SPARC
- Molecular Weight
- 34631.88 Da
References
- UniProt: SPARC [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- General Function
- Poly(a) rna binding
- Specific Function
- Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembl...
- Gene Name
- CANX
- Uniprot ID
- P27824
- Uniprot Name
- Calnexin
- Molecular Weight
- 67567.695 Da
References
- UniProt: Calnexin [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- General Function
- Fibrillin-2: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.
- Specific Function
- Calcium ion binding
- Gene Name
- FBN2
- Uniprot ID
- P35556
- Uniprot Name
- Fibrillin-2
- Molecular Weight
- 314772.155 Da
References
- UniProt: Fibrillin-2 [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- General Function
- Zinc ion binding
- Specific Function
- Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the b...
- Gene Name
- S100B
- Uniprot ID
- P04271
- Uniprot Name
- Protein S100-B
- Molecular Weight
- 10712.985 Da
References
- UniProt: Protein S100-B [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- General Function
- Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
- Specific Function
- Calcium ion binding
- Gene Name
- CASQ2
- Uniprot ID
- O14958
- Uniprot Name
- Calsequestrin-2
- Molecular Weight
- 46435.28 Da
References
- UniProt: Calsequestrin-2 [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- General Function
- Zinc ion binding
- Specific Function
- Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calci...
- Gene Name
- RGN
- Uniprot ID
- Q15493
- Uniprot Name
- Regucalcin
- Molecular Weight
- 33252.53 Da
References
- UniProt: Regucalcin [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- General Function
- Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (PubMed:27716508). Its role in the heterodimer formed with PDCD6 is however unclear: some evidences show that PEF1 and PDCD6 work together and promote association between PDCD6 and SEC31 in presence of calcium (PubMed:27716508). Other reports show that PEF1 dissociates from PDCD6 in presence of calcium, and may act as a negative regulator of PDCD6 (PubMed:11278427). Also acts as a negative regulator of ER-Golgi transport; possibly by inhibiting interaction between PDCD6 and SEC31 (By similarity).
- Specific Function
- Binding, bridging
- Gene Name
- PEF1
- Uniprot ID
- Q9UBV8
- Uniprot Name
- Peflin
- Molecular Weight
- 30380.755 Da
References
- UniProt: Peflin [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a rol...
- Gene Name
- S100A6
- Uniprot ID
- P06703
- Uniprot Name
- Protein S100-A6
- Molecular Weight
- 10179.635 Da
References
- UniProt: Protein S100-A6 [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- General Function
- Involved in calcium binding and microtubule stabilization.
- Specific Function
- Calcium ion binding
- Gene Name
- TPT1
- Uniprot ID
- P13693
- Uniprot Name
- Translationally-controlled tumor protein
- Molecular Weight
- 19595.205 Da
References
- UniProt: Translationally-controlled tumor protein [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Calcium-binding protein critical for proper photoreceptor cell maintenance and function. Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release (PubMed:23023331, PubMed:26173970, PubMed:26426422). May be involved in the mechanotransduction process (By similarity).
- Specific Function
- Calcium ion binding
- Gene Name
- CIB2
- Uniprot ID
- O75838
- Uniprot Name
- Calcium and integrin-binding family member 2
- Molecular Weight
- 21643.38 Da
References
- UniProt: Calcium and integrin-binding family member 2 [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- General Function
- Zinc ion binding
- Specific Function
- Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion doe...
- Gene Name
- S100A13
- Uniprot ID
- Q99584
- Uniprot Name
- Protein S100-A13
- Molecular Weight
- 11471.095 Da
References
- UniProt: Protein S100-A13 [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- General Function
- Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction.
- Specific Function
- Calcium ion binding
- Gene Name
- CASQ1
- Uniprot ID
- P31415
- Uniprot Name
- Calsequestrin-1
- Molecular Weight
- 45159.635 Da
References
- UniProt: Calsequestrin-1 [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Major calcium-binding protein of the Golgi. May have a role in calcium homeostasis (By similarity).
- Specific Function
- Calcium ion binding
- Gene Name
- NUCB1
- Uniprot ID
- Q02818
- Uniprot Name
- Nucleobindin-1
- Molecular Weight
- 53878.96 Da
References
- UniProt: Nucleobindin-1 [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Titin binding
- Specific Function
- Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number...
- Gene Name
- CALM1
- Uniprot ID
- P0DP23
- Uniprot Name
- Calmodulin
- Molecular Weight
- 16837.47 Da
References
- UniProt: Calmodulin-1 [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Fibrillin-3: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-containing microfibrils provide long-term force bearing structural support.
- Specific Function
- Calcium ion binding
- Gene Name
- FBN3
- Uniprot ID
- Q75N90
- Uniprot Name
- Fibrillin-3
- Molecular Weight
- 300352.86 Da
References
- UniProt: Fibrillin-3 [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions.
- Specific Function
- Calcium ion binding
- Gene Name
- GCA
- Uniprot ID
- P28676
- Uniprot Name
- Grancalcin
- Molecular Weight
- 24009.85 Da
References
- UniProt: Grancalcin [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity).
- Specific Function
- Lipid binding
- Gene Name
- CADPS
- Uniprot ID
- Q9ULU8
- Uniprot Name
- Calcium-dependent secretion activator 1
- Molecular Weight
- 152785.36 Da
References
- UniProt: Calcium-dependent secretion activator 1 [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).
- Specific Function
- Calcium channel inhibitor activity
- Gene Name
- CALM2
- Uniprot ID
- P0DP24
- Uniprot Name
- Calmodulin-2
- Molecular Weight
- 16837.47 Da
References
- UniProt: Calmodulin-2 [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
- Specific Function
- Calcium ion binding
- Gene Name
- CALM3
- Uniprot ID
- P0DP25
- Uniprot Name
- Calmodulin-3
- Molecular Weight
- 16837.47 Da
References
- UniProt: Calmodulin-3 [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Calcium-binding protein. May play a role in cellular signaling events (Potential).
- Specific Function
- Calcium ion binding
- Gene Name
- CAPS
- Uniprot ID
- Q13938
- Uniprot Name
- Calcyphosin
- Molecular Weight
- 20967.15 Da
References
- UniProt: Calcyphosin [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity).
- Specific Function
- Lipid binding
- Gene Name
- CADPS2
- Uniprot ID
- Q86UW7
- Uniprot Name
- Calcium-dependent secretion activator 2
- Molecular Weight
- 147733.365 Da
References
- UniProt: Calcium-dependent secretion activator 2 [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much lower than that of CALR.
- Specific Function
- Calcium ion binding
- Gene Name
- CALR3
- Uniprot ID
- Q96L12
- Uniprot Name
- Calreticulin-3
- Molecular Weight
- 44995.345 Da
References
- UniProt: Calreticulin-3 [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Receptor activity
- Specific Function
- Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-term...
- Gene Name
- NRXN1
- Uniprot ID
- Q9ULB1
- Uniprot Name
- Neurexin-1
- Molecular Weight
- 161881.53 Da
References
- UniProt: Neurexin-1 [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Voltage-gated calcium channel activity
- Specific Function
- Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (...
- Gene Name
- NCS1
- Uniprot ID
- P62166
- Uniprot Name
- Neuronal calcium sensor 1
- Molecular Weight
- 21878.565 Da
References
- UniProt: Neuronal calcium sensor 1 [Link]
Carriers
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- General Function
- Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
- Specific Function
- Calcium ion binding
- Gene Name
- CALB1
- Uniprot ID
- P05937
- Uniprot Name
- Calbindin
- Molecular Weight
- 30024.82 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- General Function
- Vitamin d binding
- Specific Function
- Not Available
- Gene Name
- S100G
- Uniprot ID
- P29377
- Uniprot Name
- Protein S100-G
- Molecular Weight
- 9016.14 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- General Function
- Toxic substance binding
- Specific Function
- Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
- Gene Name
- ALB
- Uniprot ID
- P02768
- Uniprot Name
- Serum albumin
- Molecular Weight
- 69365.94 Da
References
- Barrett KE, Barman SM, Boitano S, Brooks HL (2012). Ganong's Review of Medical Physiology (24th ed.). McGraw Hill. [ISBN:978-0-07-17803-2]
Transporters
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- General Function
- Not Available
- Specific Function
- Not Available
- Gene Name
- SLC20A1
- Uniprot ID
- Q8WUM9
- Uniprot Name
- Sodium-dependent phosphate transporter 1
- Molecular Weight
- 73699.01 Da
References
- Biber J, Hernando N, Forster I: Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. doi: 10.1146/annurev-physiol-030212-183748. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- General Function
- Virus receptor activity
- Specific Function
- Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular m...
- Gene Name
- SLC20A2
- Uniprot ID
- Q08357
- Uniprot Name
- Sodium-dependent phosphate transporter 2
- Molecular Weight
- 70391.755 Da
References
- Biber J, Hernando N, Forster I: Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. doi: 10.1146/annurev-physiol-030212-183748. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- General Function
- Sodium:phosphate symporter activity
- Specific Function
- Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx.
- Gene Name
- SLC34A1
- Uniprot ID
- Q06495
- Uniprot Name
- Sodium-dependent phosphate transport protein 2A
- Molecular Weight
- 68936.53 Da
References
- Biber J, Hernando N, Forster I: Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. doi: 10.1146/annurev-physiol-030212-183748. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- General Function
- Sodium:phosphate symporter activity
- Specific Function
- May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the s...
- Gene Name
- SLC34A2
- Uniprot ID
- O95436
- Uniprot Name
- Sodium-dependent phosphate transport protein 2B
- Molecular Weight
- 75758.535 Da
References
- Biber J, Hernando N, Forster I: Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. doi: 10.1146/annurev-physiol-030212-183748. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- General Function
- Sodium:phosphate symporter activity
- Specific Function
- May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx.
- Gene Name
- SLC34A3
- Uniprot ID
- Q8N130
- Uniprot Name
- Sodium-dependent phosphate transport protein 2C
- Molecular Weight
- 63548.94 Da
References
- Kirchheiner J, Meineke I, Muller G, Roots I, Brockmoller J: Contributions of CYP2D6, CYP2C9 and CYP2C19 to the biotransformation of E- and Z-doxepin in healthy volunteers. Pharmacogenetics. 2002 Oct;12(7):571-80. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- General Function
- Calmodulin binding
- Specific Function
- Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably ...
- Gene Name
- TRPV6
- Uniprot ID
- Q9H1D0
- Uniprot Name
- Transient receptor potential cation channel subfamily V member 6
- Molecular Weight
- 87284.86 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- General Function
- Ion channel binding
- Specific Function
- Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellul...
- Gene Name
- SLC8A1
- Uniprot ID
- P32418
- Uniprot Name
- Sodium/calcium exchanger 1
- Molecular Weight
- 108546.06 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- General Function
- Calcium channel activity
- Specific Function
- Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current ...
- Gene Name
- TRPV5
- Uniprot ID
- Q9NQA5
- Uniprot Name
- Transient receptor potential cation channel subfamily V member 5
- Molecular Weight
- 82549.89 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Voltage-gated calcium channel activity
- Specific Function
- Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tu...
- Gene Name
- RYR1
- Uniprot ID
- P21817
- Uniprot Name
- Ryanodine receptor 1
- Molecular Weight
- 565170.715 Da
References
- UniProt: Ryanodine receptor 1 [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Suramin binding
- Specific Function
- Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activa...
- Gene Name
- RYR2
- Uniprot ID
- Q92736
- Uniprot Name
- Ryanodine receptor 2
- Molecular Weight
- 564562.71 Da
References
- UniProt: Ryanodine receptor 2 [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.
- Specific Function
- Alpha-actinin binding
- Gene Name
- PKD2L1
- Uniprot ID
- Q9P0L9
- Uniprot Name
- Polycystic kidney disease 2-like 1 protein
- Molecular Weight
- 91981.23 Da
References
- UniProt: Polycystic kidney disease 2-like 1 protein [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Ryanodine-sensitive calcium-release channel activity
- Specific Function
- Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) relea...
- Gene Name
- RYR3
- Uniprot ID
- Q15413
- Uniprot Name
- Ryanodine receptor 3
- Molecular Weight
- 552037.115 Da
References
- UniProt: Ryanodine receptor 3 [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.
- Specific Function
- Calcium channel activity
- Gene Name
- PKD1L3
- Uniprot ID
- Q7Z443
- Uniprot Name
- Polycystic kidney disease protein 1-like 3
- Molecular Weight
- 195891.885 Da
References
- UniProt: Polycystic kidney disease protein 1-like 3 [Link]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.
- Specific Function
- Calcium activated cation channel activity
- Gene Name
- CATSPER1
- Uniprot ID
- Q8NEC5
- Uniprot Name
- Cation channel sperm-associated protein 1
- Molecular Weight
- 90090.225 Da
References
- UniProt: Cation channel sperm-associated protein 1 [Link]
- Kind
- Protein group
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Voltage-gated calcium channel activity
- Specific Function
- Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hor...
Components:
References
- Catterall WA: Structure and regulation of voltage-gated Ca2+ channels. Annu Rev Cell Dev Biol. 2000;16:521-55. [Article]
- Kind
- Protein group
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Voltage-gated calcium channel activity
- Specific Function
- Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hor...
Components:
References
- Catterall WA: Structure and regulation of voltage-gated Ca2+ channels. Annu Rev Cell Dev Biol. 2000;16:521-55. [Article]
- Kind
- Protein group
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Scaffold protein binding
- Specific Function
- Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hor...
Components:
References
- Catterall WA: Structure and regulation of voltage-gated Ca2+ channels. Annu Rev Cell Dev Biol. 2000;16:521-55. [Article]
- Kind
- Protein group
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega-conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.
- Specific Function
- Calcium channel activity
Components:
References
- Catterall WA: Structure and regulation of voltage-gated Ca2+ channels. Annu Rev Cell Dev Biol. 2000;16:521-55. [Article]
Drug created at July 06, 2018 21:47 / Updated at July 01, 2020 02:41