Identification
- Brand Names
- Irospan 24/6 Kit, Mega-C, Moviprep, Plenvu, Tandem Plus
- Generic Name
- Sodium ascorbate
- DrugBank Accession Number
- DB14482
- Background
Not Available
- Type
- Small Molecule
- Groups
- Approved, Nutraceutical
- Structure
Structure for Sodium ascorbate (DB14482)
- Weight
- Average: 198.106
Monoisotopic: 198.01403223 - Chemical Formula
- C6H7NaO6
- Synonyms
- Ascorbato sódico
- Ascorbic acid sodium salt
- L-Ascorbic acid sodium salt
- L-Ascorbic acid, monosodium salt
- Monosodium L-ascorbate
- Sodium ascorbate
- sodium L-ascorbate
- Vitamin C sodium
- Vitamin C, sodium salt
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination for symptomatic treatment of Common cold Combination Product in combination with: Acetaminophen (DB00316) •••••••••••• ••••••• ••••••• •••••••••••• Used in combination for symptomatic treatment of Coughing Combination Product in combination with: Menglytate (DB15983) ••• ••• ••••••• •••••• •••••••••••••• Used in combination for symptomatic treatment of Fever Combination Product in combination with: Acetaminophen (DB00316) •••••••••••• ••••••• ••••••• •••••••••••• Used in combination for symptomatic treatment of Fever Combination Product in combination with: Acetaminophen (DB00316) ••• ••• ••••••• ••••••• •••••••••••• Used in combination for symptomatic treatment of Flu caused by influenza Combination Product in combination with: Acetaminophen (DB00316) •••••••••••• ••••••• ••••••• •••••••••••• - Associated Therapies
- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcetazolamide The risk or severity of dehydration can be increased when Acetazolamide is combined with Sodium ascorbate. Aclidinium The therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Aclidinium. Alfentanil The therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Alfentanil. Alloin The risk or severity of adverse effects can be increased when Sodium ascorbate is combined with Alloin. Amantadine The therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Amantadine. - Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Active Moieties
Name Kind UNII CAS InChI Key Ascorbic acid unknown PQ6CK8PD0R 50-81-7 CIWBSHSKHKDKBQ-JLAZNSOCSA-N Sodium cation ionic LYR4M0NH37 17341-25-2 FKNQFGJONOIPTF-UHFFFAOYSA-N - Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Mega-C-sodium Inj 250mg/ml Solution 250 mg / mL Intravenous Kripps Pharmacy Ltd. 1981-12-31 Not applicable Canada 
Vitamin C Liquid 250 mg / mL Intramuscular; Intravenous Sandoz Canada Incorporated 1989-12-31 Not applicable Canada - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image C Wafer 500 Chewable 500mg Wafer 500 mg / waf Oral Nu Life Nutrition Ltd. 1986-12-31 2000-05-23 Canada Natural Fruit Chew C 250mg Tangy Orange Flavour Tablet 250 mg Oral Natural Factors Nutritional Products Ltd. 2001-01-01 2009-09-28 Canada Sodium Ascor Crystal 888.8mg/gm USP Powder 888.8 mg / g Oral Vita Health Products Inc 1996-10-11 2002-07-31 Canada Tgi Tab 50mg Tablet 50 mg / tab Oral Seroyal International Inc. 1980-12-31 1996-09-10 Canada Vitamin C 60mg Tablet 60 mg Oral Wn Pharmaceuticals Ltd. 1999-04-09 2008-07-17 Canada - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Animal Shaped Chew Vit C Tab 250mg Sodium ascorbate (159 mg) + Ascorbic acid (110 mg) Tablet Oral Hall Laboratories, Ltd. 1982-12-31 2003-09-11 Canada Appedrine Sodium ascorbate (10 mg) + Benzocaine (3 mg) + Ferrous fumarate (3.33 mg) + Nicotinamide (3.33 mg) + Riboflavin (.4 mg) + Thiamine hydrochloride (.33 mg) + Vitamin A acetate (1333 unit) + Vitamin D (133 unit) Tablet Oral Chattem, Inc. 1975-12-31 2004-07-08 Canada Ascorbex 500 Tab Sodium ascorbate (337.5 mg) + Ascorbic acid (200 mg) Tablet Oral SantÉ Naturelle (Ag) LtÉe 1988-12-31 2004-08-05 Canada Bugs Bunny and Friends Multiple Vitamins Sodium ascorbate (50 mg) + Cyanocobalamin (3 mcg) + Folic acid (0.1 mg) + Nicotinamide (15 mg) + Pyridoxine hydrochloride (1 mg) + Riboflavin (1.5 mg) + Thiamine mononitrate (1.5 mg) + Vitamin A acetate (5000 unit) + Vitamin D (400 unit) Tablet Oral Bayer Inc Consumer Care 1996-12-31 2004-04-15 Canada Bugs Bunny Chew Multi Vit Plus Iron Sodium ascorbate (50 mg / tab) + Cyanocobalamin (3 mcg / tab) + Ferrous fumarate (12 mg / tab) + Folic acid (.1 mg / tab) + Nicotinamide (15 mg / tab) + Pyridoxine hydrochloride (1 mg / tab) + Riboflavin (1.5 mg / tab) + Thiamine mononitrate (1.5 mg / tab) + Vitamin A acetate (5000 unit / tab) + Vitamin D (400 unit / tab) Tablet Oral Miles Inc. Pharmaceutical Division 1983-12-31 1996-09-09 Canada - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Centratex Sodium ascorbate (200 mg/1) + Cupric sulfate (0.8 mg/1) + Cyanocobalamin (15 ug/1) + Folic acid (1 mg/1) + Iron (106 mg/1) + Magnesium sulfate (6.9 mg/1) + Manganese sulfate (1.3 mg/1) + Nicotinamide (30 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (5 mg/1) + Riboflavin (6 mg/1) + Thiamine mononitrate (10 mg/1) + Zinc sulfate, unspecified form (18.2 mg/1) Capsule Oral Centurion Labs, LLC 2009-06-14 Not applicable US 
Davimet Sodium ascorbate (36 mg/1) + Ascorbic acid (24 mg/1) + Cholecalciferol (10 ug/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (10 mg/1) + Folic acid (1667 ug/1) + Niacin (13.5 mg/1) + Pyridoxine hydrochloride (1.05 mg/1) + Riboflavin (1.2 mg/1) + Thiamine mononitrate (1.05 mg/1) + Vitamin A (750 ug/1) Tablet, chewable Oral PureTek Corporation 2022-09-19 Not applicable US Davimet-M Sodium ascorbate (36 mg/1) + Ascorbic acid (24 mg/1) + Cholecalciferol (10 ug/1) + DL-alpha tocopheryl acetate (10 mg/1) + Levomefolate calcium (1000 ug/1) + Mecobalamin (4.5 ug/1) + Niacin (13.5 mg/1) + Pyridoxine hydrochloride (1.05 mg/1) + Riboflavin (1.2 mg/1) + Thiamine mononitrate (1.05 mg/1) + Vitamin A (750 ug/1) Tablet, chewable Oral PureTek Corporation 2023-11-30 Not applicable US Dexatran Sodium ascorbate (200 mg/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (15 ug/1) + Ferrous fumarate (18 mg/1) + Folic acid (1 mg/1) + Magnesium sulfate heptahydrate (6.9 mg/1) + Manganese sulfate (1.3 mg/1) + Nicotinamide (30 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (5 mg/1) + Riboflavin (6 mg/1) + Thiamine mononitrate (10 mg/1) + Zinc sulfate, unspecified form (18.2 mg/1) Capsule Cutaneous; Oral PureTek Corporation 2023-02-15 Not applicable US Irospan 24/6 Sodium ascorbate (100 mg/1) + Sodium ascorbate (100 mg/1) + Biotin (300 ug/1) + Biotin (300 ug/1) + Calcium carbonate (100 mg/1) + Cyanocobalamin (10 ug/1) + Cyanocobalamin (10 ug/1) + Ferrous bisglycinate (65 mg/1) + Folic acid (1 mg/1) + Folic acid (1 mg/1) + Calcium formate (155 mg/1) + Iron Dextran (65 mg/1) + Niacin (25 mg/1) + Niacin (25 mg/1) + Calcium pantothenate (300 ug/1) + Calcium pantothenate (7 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Riboflavin sodium (5 mg/1) + Riboflavin (5 mg/1) + Succinic acid (150 mg/1) + Thiamine hydrochloride (5 mg/1) + Thiamine hydrochloride (5 mg/1) Kit; Tablet; Tablet, film coated Oral WOMENS CHOICE PHARMACEUTICALS LLC 2011-04-15 Not applicable US
Categories
- Drug Categories
- Acids, Acyclic
- Antioxidants
- Biological Factors
- Carbohydrates
- Compounds used in a research, industrial, or household setting
- Diet, Food, and Nutrition
- Food
- Hydroxy Acids
- Laxatives
- Micronutrients
- Physiological Phenomena
- Protective Agents
- Sugar Acids
- Urinary Acidifying Agents
- Vitamin C and analogues
- Vitamins
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as butenolides. These are dihydrofurans with a carbonyl group at the C2 carbon atom.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Dihydrofurans
- Sub Class
- Furanones
- Direct Parent
- Butenolides
- Alternative Parents
- Vinylogous acids / Enoate esters / Secondary alcohols / Lactones / 1,2-diols / Oxacyclic compounds / Monocarboxylic acids and derivatives / Primary alcohols / Organic zwitterions / Organic sodium salts show 3 more
- Substituents
- 1,2-diol / 2-furanone / Alcohol / Aliphatic heteromonocyclic compound / Alpha,beta-unsaturated carboxylic ester / Carbonyl group / Carboxylic acid derivative / Carboxylic acid ester / Enoate ester / Hydrocarbon derivative show 13 more
- Molecular Framework
- Aliphatic heteromonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- S033EH8359
- CAS number
- 134-03-2
- InChI Key
- PPASLZSBLFJQEF-RXSVEWSESA-M
- InChI
- InChI=1S/C6H8O6.Na/c7-1-2(8)5-3(9)4(10)6(11)12-5;/h2,5,7-10H,1H2;/q;+1/p-1/t2-,5+;/m0./s1
- IUPAC Name
- sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate
- SMILES
- [Na+].[H][C@@]1(OC(=O)C(O)=C1[O-])[C@@H](O)CO
References
- General References
- Not Available
- External Links
- KEGG Drug
- D05853
- ChemSpider
- 16736174
- ChEBI
- 113451
- ChEMBL
- CHEMBL591665
- PharmGKB
- PA166163262
- Wikipedia
- Sodium_ascorbate
Clinical Trials
- Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count 4 Completed Not Available Colonoscopy 1 4 Completed Basic Science Functional Constipation (FC) / Irritable Bowel Syndrome Characterized by Constipation 1 4 Completed Diagnostic Colon Adenomas / Colon Lesions / Colon Polyps 1 4 Completed Screening Colorectal Cancer 1 4 Completed Supportive Care Colorectal Cancer 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution Intravenous 10 g Tablet Transmucosal Wafer Oral 500 mg / waf Tablet Oral Tablet, orally disintegrating Transmucosal Capsule Cutaneous; Oral Capsule, delayed release Oral Kit; tablet; tablet, film coated Oral Capsule, liquid filled Oral 560 mg Solution Intravenous 250 mg / mL Kit Oral Kit; solution Oral Powder, for solution Oral Solution Oral Tablet, chewable Oral Tablet, film coated Tablet Oral 250 mg Capsule, gelatin coated; kit; tablet Oral Tablet, film coated Oral Kit Intravenous Capsule, liquid filled Oral Kit; powder, for solution Oral Liquid Oral Solution Oral 72.5 mg Powder Oral Capsule, gelatin coated Oral Tablet, effervescent Oral Powder Oral 888.8 mg / g Injection, solution Intravenous Injection, powder, for solution Intravenous Injection, powder, lyophilized, for solution Intravenous Powder, for solution Intravenous Capsule Oral Tablet Oral 50 mg / tab Tablet, coated Oral Liquid Intramuscular; Intravenous 250 mg / mL Tablet Oral 60 mg Tablet, chewable Buccal Lozenge Oral - Prices
- Not Available
- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region US7169381 No 2007-01-30 2024-09-01 US US7658914 No 2010-02-09 2024-09-01 US US9326969 No 2016-05-03 2033-09-10 US US9592252 No 2017-03-14 2032-08-11 US US9707297 No 2017-07-18 2033-09-10 US US8999313 No 2015-04-07 2033-09-10 US US10016504 No 2018-07-10 2033-09-10 US US10646512 No 2020-05-12 2032-03-25 US US10792306 No 2020-10-06 2032-03-09 US US10780112 No 2020-09-22 2032-03-09 US US10918723 No 2021-02-16 2033-09-10 US US11529368 No 2012-03-09 2032-03-09 US
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 625.0 mg/mL ALOGPS logP -1.4 ALOGPS logP -1.9 Chemaxon logS 0.5 ALOGPS pKa (Strongest Acidic) 4.36 Chemaxon pKa (Strongest Basic) -3 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 110.05 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 47.58 m3·mol-1 Chemaxon Polarizability 14.51 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 136.8172793 predictedDarkChem Lite v0.1.0 [M-H]- 136.0677793 predictedDarkChem Lite v0.1.0 [M-H]- 136.15067 predictedDeepCCS 1.0 (2019) [M+H]+ 136.7731793 predictedDarkChem Lite v0.1.0 [M+H]+ 136.5461793 predictedDarkChem Lite v0.1.0 [M+H]+ 138.3495 predictedDeepCCS 1.0 (2019) [M+Na]+ 136.2521793 predictedDarkChem Lite v0.1.0 [M+Na]+ 136.7061793 predictedDarkChem Lite v0.1.0 [M+Na]+ 144.26205 predictedDeepCCS 1.0 (2019)
Drug created at July 06, 2018 22:02 / Updated at February 20, 2024 23:55