Magnesium ascorbate

Identification

Brand Names

EnBrace HR, EnLyte

Generic Name

Magnesium ascorbate

DrugBank Accession Number

DB14484

Background

Not Available

Type

Small Molecule

Groups

Approved, Nutraceutical

Structure

Similar Structures

Weight: Average: 374.537
Monoisotopic: 374.03356759
Chemical Formula: C₁₂H₁₄MgO₁₂

Synonyms

Ascorbic acid, magnesium salt
L(+)-ascorbic acid magnesium salt
Vitamin C magnesium salt

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Pharmacology

Indication: Not Available
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Pharmacodynamics: Not Available
Mechanism of action: Not Available
Absorption: Not Available
Volume of distribution: Not Available
Protein binding: Not Available
Metabolism: Not Available
Route of elimination: Not Available
Half-life: Not Available
Clearance: Not Available
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Toxicity: Not Available
Pathways: Not Available
Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">: Not Available

Interactions

Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Drug	Interaction
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Amphetamine	The serum concentration of Amphetamine can be decreased when it is combined with Magnesium ascorbate.
Benzphetamine	The serum concentration of Benzphetamine can be decreased when it is combined with Magnesium ascorbate.
Chlorpropamide	Magnesium ascorbate may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
Dextroamphetamine	The serum concentration of Dextroamphetamine can be decreased when it is combined with Magnesium ascorbate.
Diethylpropion	The serum concentration of Diethylpropion can be decreased when it is combined with Magnesium ascorbate.

Food Interactions

Take with or without food. Taking magnesium supplements with food may reduce the risk of diarrhea.

Products

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Active Moieties

Name	Kind	UNII	CAS	InChI Key
Ascorbic acid	unknown	PQ6CK8PD0R	50-81-7	CIWBSHSKHKDKBQ-JLAZNSOCSA-N

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
Energy 80 Prolonged Release Tab	Magnesium ascorbate (410 mg / tab) + Calcium ascorbate (130 mg / tab) + Cyanocobalamin (100 mcg / tab) + Folic acid (25 mcg / tab) + Pantothenic acid (25 mg / tab) + Pyridoxine hydrochloride (25 mg / tab)	Tablet, extended release	Oral	Sportscience Labs Inc.	1981-12-31	2002-06-20
PramLyte	Magnesium ascorbate (24 mg/1) + 1,2-docosahexanoyl-sn-glycero-3-phosphoserine calcium (6.4 mg/1) + 1,2-icosapentoyl-sn-glycero-3-phosphoserine calcium (800 ug/1) + Betaine (500 ug/1) + Citric acid monohydrate (1.83 mg/1) + Cobamamide (50 ug/1) + Cocarboxylase (25 ug/1) + Escitalopram oxalate (10 mg/1) + Ferrous cysteine glycinate (13.6 mg/1) + Flavin adenine dinucleotide (25 ug/1) + Folic acid (1 mg/1) + Leucovorin (2.5 mg/1) + Levomefolate magnesium (7 mg/1) + NADH (25 ug/1) + Phosphatidyl serine (12 mg/1) + Pyridoxal phosphate (25 ug/1) + Sodium citrate (3.67 mg/1) + Zinc ascorbate (1 mg/1)	Kit	Oral	Allegis Pharmaceuticals, LLC	2015-09-11	2016-01-04

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
EnBrace HR	Magnesium ascorbate (24 mg/1) + 1,2-docosahexanoyl-sn-glycero-3-phosphoserine calcium (6.4 mg/1) + 1,2-icosapentoyl-sn-glycero-3-phosphoserine calcium (800 ug/1) + Betaine (500 ug/1) + Cobamamide (50 ug/1) + Cocarboxylase (25 ug/1) + Ferrous cysteine glycinate (13.6 mg/1) + Flavin adenine dinucleotide (25 ug/1) + Folic acid (1 mg/1) + Magnesium L-threonate (1 mg/1) + Leucovorin (2.5 mg/1) + Levomefolate magnesium (5.23 mg/1) + NADH (25 ug/1) + Phosphatidyl serine (12 mg/1) + Pyridoxal phosphate (25 ug/1) + Zinc ascorbate (1 mg/1)	Capsule, delayed release pellets	Oral	Jaymac Pharma	2011-08-12	Not applicable

Chemical Identifiers

UNII: 0N1G678593
CAS number: 15431-40-0
InChI Key: AIOKQVJVNPDJKA-ZZMNMWMASA-L
InChI: InChI=1S/2C6H8O6.Mg/c2*7-1-2(8)5-3(9)4(10)6(11)12-5;/h2*2,5,7-10H,1H2;/q;;+2/p-2/t2*2-,5+;/m00./s1
IUPAC Name: magnesium(2+) bis((2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate)
SMILES: [Mg++].[H][C@@]1(OC(=O)C(O)=C1[O-])[C@@H](O)CO.[H][C@@]1(OC(=O)C(O)=C1[O-])[C@@H](O)CO

References

General References

Not Available

External Links

ChemSpider: 17339241
Wikipedia: Mineral_ascorbates

Clinical Trials

Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">

Phase	Status	Purpose	Conditions	Count
4	Withdrawn	Treatment	Menstrual Related Mood Disorder / Premenstrual Dysphoric Disorder (PMDD) / Premenstrual Syndrome (PMS) / Premenstrual tension with edema	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Tablet, extended release	Oral
Capsule, liquid filled	Oral
Capsule, delayed release pellets	Oral
Tablet	Oral
Capsule	Oral
Kit	Oral

Prices

Not Available

Patents

Not Available

Properties

State

Not Available

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
Water Solubility	9.07 mg/mL	ALOGPS
logP	-1.7	ALOGPS
logP	-1.9	Chemaxon
logS	-1.6	ALOGPS
pKa (Strongest Acidic)	4.36	Chemaxon
pKa (Strongest Basic)	-3	Chemaxon
Physiological Charge	-1	Chemaxon
Hydrogen Acceptor Count	5	Chemaxon
Hydrogen Donor Count	3	Chemaxon
Polar Surface Area	110.05 Å²	Chemaxon
Rotatable Bond Count	4	Chemaxon
Refractivity	47.58 m³·mol^-1	Chemaxon
Polarizability	14.53 Å³	Chemaxon
Number of Rings	2	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	No	Chemaxon
Veber's Rule	No	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Not Available

Chromatographic Properties

Collision Cross Sections (CCS)

Adduct	CCS Value (Å²)	Source type	Source
[M-H]-	138.6376793	predicted	DarkChem Lite v0.1.0
[M+H]+	140.2096793	predicted	DarkChem Lite v0.1.0
[M+Na]+	138.8811793	predicted	DarkChem Lite v0.1.0

Drug created at July 06, 2018 22:23 / Updated at June 12, 2020 16:53

Magnesium ascorbate

Identification

Structure for Magnesium ascorbate (DB14484)

Pharmacology

Interactions

Products

Categories

Chemical Identifiers

References

Clinical Trials

Pharmacoeconomics

Properties

Spectra

Collision Cross Sections (CCS)