Identification
- Summary
Magnesium is a medication used for many purposes including constipation, indigestion, magnesium deficiency, and pre-eclampsia.
- Brand Names
- Vitafol-one
- Generic Name
- Magnesium
- DrugBank Accession Number
- DB14513
- Background
Magnesium is classified as an alkaline earth metal and has 2 hydration shells.1 The element can be found in abundance in the hydrosphere and in mineral salts such as dolomite and magnesium carbonate.1
Common dietary sources of magnesium include nuts (cashews, peanuts, almonds), beans, bananas, apples, carrots, broccoli, and leafy greens.8,11 Magnesium is an important enzyme cofactor and is essential to several metabolic processes.3 Further, the mineral helps regulate blood pressure and is necessary for RNA, DNA and protein synthesis among several other functions.3
Despite the importance of magnesium and its availability via several food sources, an estimated 56 to 68% of adults who live in developed, western countries do not meet the recommended daily intake (RDI) of magnesium.5 Several factors and common behaviours reduce the availability of magnesium in the diet such as food processing and cooking vegetables (which are normally a rich source of magnesium).5
- Type
- Small Molecule
- Groups
- Approved, Experimental, Investigational
- Structure
Structure for Magnesium (DB14513)
- Weight
- Average: 26.321
Monoisotopic: 26.00069176 - Chemical Formula
- H2Mg
- Synonyms
- Magnesio
- Magnésium
- Magnesium metallicum
- Magnesium powder
- Mg
Pharmacology
- Indication
Healthy levels of magnesium can be achieved through a well balanced diet, but if food sources are insufficient, magnesium supplements can be used to prevent and treat magnesium deficiencies.11
In medicine, various magnesium salts may be used in laxative and antacid products.1 For example, magnesium citrate is available over-the-counter and may be used to manage occasional constipation.9 Magnesium sulfate may be used on its own or with total parenteral nutrition to treat hypomagnesemia.10 Magnesium sulfate is also indicated to prevent seizures in pregnant women with pre-eclampsia, and to manage seizures associated with eclampsia.4,10
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Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination to treat Calcium deficiency Combination Product in combination with: Calcium (DB01373) ••• ••• Used in combination to prevent Magnesium deficiency Combination Product in combination with: Zinc (DB01593) •••••••••••• Used in combination to treat Magnesium deficiency Combination Product in combination with: Zinc (DB01593) •••••••••••• Used in combination to treat Magnesium deficiency Combination Product in combination with: Calcium (DB01373) ••• ••• Treatment of Magnesium deficiency ••• ••• - Contraindications & Blackbox Warnings
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Magnesium is important for many biochemical processes and is therefore quite common in humans.5 The majority of magnesium is stored in the bones (>50%), while the remainder is stored in muscle, soft tissue, red blood cells and serum.1 This is functionally important since the bones behave as a magnesium exchange reservoir and help maintain healthy levels of magnesium.1
Magnesium plays an important role in the regulation of several bodily processes including blood pressure, insulin metabolism, muscular contraction, vasomotor tone, cardiac excitability, nerve transmission and neuromuscular conduction.3 Disruptions in homeostatic levels of magnesium (often times hypomagnesemia) can impact the nervous system, muscles, or can lead to cardiac abnormalities.3
- Mechanism of action
Magnesium is a cofactor for at least 300 enzymes and is important for several functions in the body with some key processes identified below.3 Enzymes that rely on magnesium to operate help produce energy through oxidative phosphorylation, glycolysis and ATP metabolism.5 They are also involved in nerve function, muscle contraction, blood glucose control, hormone receptor binding, protein synthesis, cardiac excitability, blood pressure control, gating of calcium channels and transmembrane ion flux.5
The mitochondrial intracellular space is rich in magnesium, since it is required to produce the active form of ATP (adenosine triphosphate) from ADP (adenosine diphosphate) and inorganic phosphate, and behaves as a counter ion for the energy rich molecule.1,5 Additionally, magnesium is essential for ATP metabolism.3
- Absorption
Approximately 24-76% of ingested magnesium is absorbed in the gastrointestinal tract, primarily via passive paracellular absorption in the small intestine.3
- Volume of distribution
According to a pharmacokinetic review, the volume of distribution of magnesium sulphate when used to manage patients with pre-eclampsia and eclampsia ranged from 13.65 to 49.00 L.4
- Protein binding
20% of the magnesium found in human serum is protein bound.7 Approximately 60-70% of this fraction is bound to albumin while the remainder is bound to globulin proteins.7 Magnesium has the ability to bind to 3751 human proteins.6
- Metabolism
Magnesium does not appear to be metabolized.7
- Route of elimination
- Half-life
Magnesiums biologic half-life is reported to be approximately 1000 hours or 42 days.5
- Clearance
Not Available
- Adverse Effects
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The recommended dietary allowance of magnesium ranges from 30 mg for infants to 420 mg for males between the age of 31 and 50.11 According to the institute of Medicine (IOM), the majority of adults can tolerate 350 mg of magnesium per day without experiencing adverse effects.5 Symptoms of magnesium toxicity include diarrhea and other gastrointestinal effects, thirst, muscle weakness, drowsiness, severe back and pelvic pain, hypotension, dizziness, confusion, difficulty breathing, lethargy, and deterioration of kidney function.3,5 Other more severe symptoms associated with magnesium overdose include loss of consciousness, respiratory arrest, cardiac arrhythmias and cardiac arrest.5
Regular use of laxatives containing magnesium may lead to severe and even fatal hypermagnesemia.2
Discontinuation of magnesium products including supplements, laxatives, and antacids is usually sufficient to manage mild cases of magnesium overdose; however, patients should also be screened for renal impairment.5
In severe cases of magnesium overdose, patients may require supportive care and interventions including intravenous fluids and furosemide, IV calcium chloride or calcium gluconate, renal dialysis and artificial respiratory support.5
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbatacept The serum concentration of Magnesium can be decreased when it is combined with Abatacept. Acetazolamide The serum concentration of Magnesium can be decreased when it is combined with Acetazolamide. Acetyl sulfisoxazole The serum concentration of Magnesium can be decreased when it is combined with Acetyl sulfisoxazole. Aclidinium The therapeutic efficacy of Magnesium can be decreased when used in combination with Aclidinium. Adalimumab The serum concentration of Magnesium can be decreased when it is combined with Adalimumab. - Food Interactions
- Take with or without food. Taking magnesium supplements with food may reduce the risk of diarrhea.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Active Moieties
Name Kind UNII CAS InChI Key Magnesium oxide unknown 3A3U0GI71G 1309-48-4 AXZKOIWUVFPNLO-UHFFFAOYSA-N Magnesium cation ionic T6V3LHY838 22537-22-0 JLVVSXFLKOJNIY-UHFFFAOYSA-N - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Acti Mag 250 Caplet Tablet 250 mg Oral Acti Form Ltd. 1991-12-31 2005-03-21 Canada 
Bye Zero Powder 4.95 g/500g Topical Korea Life Science 2020-10-06 Not applicable US 
Bye Zero Liquid 4.95 g/500mL Topical Korea Life Science 2020-10-06 Not applicable US Chelated Magnesium 150mg - Tab Tablet 150 mg / tab Oral Health Wise Nutrition Inc. 1997-08-15 2000-07-29 Canada Chelated Magnesium Supplement - Tab 100mg Tablet 100 mg Oral Albion 1996-09-06 2007-10-19 Canada - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 24 Multivitamins + Minerals Magnesium (65 mg) + Ascorbic acid (150 mg) + Beta carotene (10000 unit) + Biotin (25 mcg) + Calcium (130 mg) + Cholecalciferol (400 unit) + Choline bitartrate (25 mg) + Chromium (20 mcg) + Copper (1 mg) + Cyanocobalamin (25 mcg) + Ferrous fumarate (15 mg) + Folic acid (.8 mg) + Inositol (25 mg) + Manganese (2 mg) + Molybdenum (20 mcg) + Niacin (25 mg) + Calcium pantothenate (25 mg) + Potassium (15 mg) + Potassium Iodide (.1 mg) + Pyridoxine hydrochloride (25 mg) + Racemethionine (25 mg) + Riboflavin (25 mg) + Selenium (20 mcg) + Thiamine hydrochloride (25 mg) + Vanadium (20 mcg) + Vitamin A palmitate (5000 unit) + Vitamin E (50 unit) + Zinc (10 mg) Tablet Oral Stanley Pharmaceuticals, A Division Of Vita Health Products Inc. 1997-04-30 2002-07-31 Canada 50 Plus Multiple Vitamins & Minerals Magnesium (100 mg) + Ascorbic acid (90 mg) + Biotin (45 mcg) + Calcium (200 mg) + Cholecalciferol (400 unit) + Chromium (10 mcg) + Copper (2 mg) + Cyanocobalamin (25 mcg) + Folic acid (0.4 mg) + Manganese (5 mg) + Molybdenum (25 mcg) + Nicotinamide (40 mg) + Pantothenic acid (10 mg) + Potassium Iodide (0.15 mg) + Pyridoxine hydrochloride (3 mg) + Riboflavin (3.2 mg) + Selenium (25 mcg) + Thiamine mononitrate (2.25 mg) + Vanadium (10 mcg) + Vitamin A palmitate (6000 unit) + Zinc (15 mg) Tablet Oral Gfr Pharma Ltd. 2002-10-20 2004-06-15 Canada Acetabolan III Vitamin and Mineral Supplement Magnesium (112.5 mg) + Ascorbic acid (250.0 mg) + Pyridoxine hydrochloride (2.63 mg) + Zinc (7.5 mg) Capsule Oral Iovate Health Sciences International Inc. 2003-12-05 2007-07-18 Canada Acetabolan-II Vitamin and Mineral Supplement Magnesium (90 mg) + Ascorbic acid (200 mg) + Pyridoxine hydrochloride (2.1 mg) + Zinc (6 mg) Capsule Oral Iovate Health Sciences International Inc. 2000-11-20 2005-06-21 Canada Acti-cal/mag 2:1 + Zinc and D Caplet Magnesium (175.0 mg) + Calcium (350.0 mg) + Cholecalciferol (100 unit) + Zinc (6.0 mg) Tablet Oral Acti Form Ltd. 1991-12-31 2005-03-21 Canada - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Bye Zero Magnesium (4.95 g/500mL) Liquid Topical Korea Life Science 2020-10-06 Not applicable US Bye Zero Magnesium (4.95 g/500g) Powder Topical Korea Life Science 2020-10-06 Not applicable US C-Nate DHA Magnesium (30 mg/1) + Ascorbic acid (100 mg/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (1 mg/1) + Cyanocobalamin (15 ug/1) + Ferrous fumarate (28 mg/1) + Folic acid (1 mg/1) + Omega-3 fatty acids (200 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3 mg/1) + Thiamine mononitrate (3 mg/1) + Vitamin E (30 [iU]/1) + Zinc oxide (20 mg/1) Capsule, gelatin coated Oral Centurion Labs, LLC 2013-01-01 Not applicable US Calcium Folic Acid Plus D Chewable Magnesium (50 mg/1) + Boron (250 ug/1) + Calcium carbonate (1342 mg/1) + Cholecalciferol (300 [iU]/1) + Cyanocobalamin (125 ug/1) + Folic acid (1 mg/1) + Pyridoxine (10 mg/1) Wafer Oral Acella Pharmaceuticals, LLC 2009-03-20 2022-08-02 US Cavan-EC SOD DHA Magnesium (25 mg/1) + Ascorbic acid (130 mg/1) + Beta carotene (3000 [iU]/1) + Calcium (230 mg/1) + Cholecalciferol (410 [iU]/1) + Copper (2 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (440 mg/1) + Pyridoxine hydrochloride (28 mg/1) + Riboflavin (4 mg/1) + Sodium feredetate (30 mg/1) + Thiamine mononitrate (1.8 mg/1) + Vitamin E (30 mg/1) + Zinc (26 mg/1) Kit Oral Seton Pharmaceuticals 2010-01-10 2014-07-15 US
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- I38ZP9992A
- CAS number
- 7439-95-4
- InChI Key
- RSHAOIXHUHAZPM-UHFFFAOYSA-N
- InChI
- InChI=1S/Mg.2H
- IUPAC Name
- magnesium dihydride
- SMILES
- [MgH2]
References
- General References
- Jahnen-Dechent W, Ketteler M: Magnesium basics. Clin Kidney J. 2012 Feb;5(Suppl 1):i3-i14. doi: 10.1093/ndtplus/sfr163. [Article]
- Bokhari SR, Siriki R, Teran FJ, Batuman V: Fatal Hypermagnesemia Due to Laxative Use. Am J Med Sci. 2018 Apr;355(4):390-395. doi: 10.1016/j.amjms.2017.08.013. Epub 2017 Sep 12. [Article]
- Grober U, Schmidt J, Kisters K: Magnesium in Prevention and Therapy. Nutrients. 2015 Sep 23;7(9):8199-226. doi: 10.3390/nu7095388. [Article]
- Okusanya BO, Oladapo OT, Long Q, Lumbiganon P, Carroli G, Qureshi Z, Duley L, Souza JP, Gulmezoglu AM: Clinical pharmacokinetic properties of magnesium sulphate in women with pre-eclampsia and eclampsia. BJOG. 2016 Feb;123(3):356-66. doi: 10.1111/1471-0528.13753. Epub 2015 Nov 24. [Article]
- Schwalfenberg GK, Genuis SJ: The Importance of Magnesium in Clinical Healthcare. Scientifica (Cairo). 2017;2017:4179326. doi: 10.1155/2017/4179326. Epub 2017 Sep 28. [Article]
- Piovesan D, Profiti G, Martelli PL, Casadio R: The human "magnesome": detecting magnesium binding sites on human proteins. BMC Bioinformatics. 2012;13 Suppl 14:S10. doi: 10.1186/1471-2105-13-S14-S10. Epub 2012 Sep 7. [Article]
- Swaminathan R: Magnesium metabolism and its disorders. Clin Biochem Rev. 2003 May;24(2):47-66. [Article]
- Allen MJ, Sharma S: Magnesium . [Article]
- Citroma Magnesium Citrate DailyMed label [Link]
- Magnesium Sulfate Injection, USP 50% [Link]
- NIH document, Magnesium [Link]
- External Links
- ChemSpider
- 16787263
- 6574
- ChEMBL
- CHEMBL2146125
- Wikipedia
- Magnesium
Clinical Trials
- Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count 4 Completed Prevention Acute Kidney Injury (AKI) 1 4 Completed Prevention Cerebral Ischemia / Intracranial Hemorrhages / Periventricular Leukomalacia / Premature Births 1 4 Completed Treatment Alcohol-Induced Disorders 1 4 Completed Treatment Migraine 1 4 Recruiting Other Magnesium Deficiency / New-onset Atrial Fibrillation (NOAF) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet Oral 250 mg Tablet, film coated Oral Tablet, effervescent Oral 10 mmol/1 Tablet, effervescent Oral 15 mmol/1 Lozenge Oral Powder, for solution Oral Powder, for suspension Oral Granule, effervescent Oral Powder Topical 4.95 g/500g Wafer Oral Tablet Oral 150 mg / tab Tablet Oral 125 mg Tablet Oral 50 mg / tab Granule, for solution Oral Tablet Capsule Capsule, gelatin coated; kit; tablet Oral Powder Parenteral 243 MG Powder; powder, for solution; powder, for suspension Oral 300 MG Powder Oral 10 mmol Tablet, film coated Oral 2.5 mmol Granule Oral 5 mmol Tablet, chewable Oral Tablet, delayed release Oral Tablet Oral Tablet, effervescent Oral Capsule Oral Injection, solution Parenteral 58.62 mg/10mL Injection, solution Parenteral 29.31 mg/5mL Granule Oral 500 mg Tablet Oral 32.8 mg Tablet Oral 48.61 mg Powder, for solution Oral 10 mmol Tablet, film coated Oral 60.76 mg Powder, for solution Oral 5 mmol Powder Parenteral 121.525 mg/5g Tablet, effervescent Oral 7.5 mmol Tablet, effervescent Oral 182.29 mg Powder Parenteral 243.05 mg/4g Injection, solution Parenteral 72.92 mg/10mL Tablet, film coated Oral 364.625 mg/5g Capsule Oral 100 mg Tablet Oral 100 mg Granule, for solution Oral 121.5 mg/5g Tablet, effervescent Oral 243 MG Capsule Oral 72.5 mg / cap Capsule Oral 125 mg Capsule Oral 150 mg Granule Oral 400 mg Lozenge Oral 98.6 mg Tablet, effervescent Oral 121.525 mg Injection, solution Parenteral 76.78 mg/10mL Tablet, delayed release Oral 40 mg Suspension Oral 243.04 mg/10g Capsule Oral 243 MG Solution Intramuscular; Intravenous 150 mg/ml Solution Intramuscular; Intravenous Tablet Oral 100 mg / tab Capsule Oral 245 MG Tablet, soluble Oral 365 mg Capsule Oral 20 mg / cap Tablet, chewable Oral 121.5 mg Liquid Topical 4.95 g/500mL Kit Oral Liquid Oral Plaster Topical 3 g/100g Injection, emulsion Intravenous Emulsion Intravenous Solution Intraperitoneal Liquid Oral 10.24 mg / mL Tablet Oral 188 mg / tab Tablet Oral 375 mg / tab Capsule, coated Oral Capsule Oral Tablet Oral Capsule, gelatin coated Oral Tablet, coated Oral Tablet, extended release Oral Powder, for solution Oral Solution Intravenous Capsule, liquid filled; kit Oral Capsule, liquid filled Oral Capsule; kit; tablet, coated Oral Powder Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
Property Value Source melting point (°C) 651 °C https://pubchem.ncbi.nlm.nih.gov/compound/Magnesium#section=Melting-Point boiling point (°C) 1100 °C https://pubchem.ncbi.nlm.nih.gov/compound/Magnesium#section=Odor water solubility insoluble in cold water https://pubchem.ncbi.nlm.nih.gov/compound/Magnesium#section=Solubility - Predicted Properties
Property Value Source logP -1.4 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 0 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 1.6 m3·mol-1 Chemaxon Polarizability 3.27 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Carriers
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Toxic substance binding
- Specific Function
- Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
- Gene Name
- ALB
- Uniprot ID
- P02768
- Uniprot Name
- Serum albumin
- Molecular Weight
- 69365.94 Da
References
- Swaminathan R: Magnesium metabolism and its disorders. Clin Biochem Rev. 2003 May;24(2):47-66. [Article]
Transporters
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors.
- Specific Function
- Identical protein binding
- Gene Name
- CLDN16
- Uniprot ID
- Q9Y5I7
- Uniprot Name
- Claudin-16
- Molecular Weight
- 33836.11 Da
References
- Seo JW, Park TJ: Magnesium metabolism. Electrolyte Blood Press. 2008 Dec;6(2):86-95. doi: 10.5049/EBP.2008.6.2.86. Epub 2008 Dec 31. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Protein serine/threonine kinase activity
- Specific Function
- Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the g...
- Gene Name
- TRPM6
- Uniprot ID
- Q9BX84
- Uniprot Name
- Transient receptor potential cation channel subfamily M member 6
- Molecular Weight
- 231705.935 Da
References
- Seo JW, Park TJ: Magnesium metabolism. Electrolyte Blood Press. 2008 Dec;6(2):86-95. doi: 10.5049/EBP.2008.6.2.86. Epub 2008 Dec 31. [Article]
- Touyz RM: Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension. Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1103-18. doi: 10.1152/ajpheart.00903.2007. Epub 2008 Jan 11. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Protein serine/threonine kinase activity
- Specific Function
- Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxi...
- Gene Name
- TRPM7
- Uniprot ID
- Q96QT4
- Uniprot Name
- Transient receptor potential cation channel subfamily M member 7
- Molecular Weight
- 212695.37 Da
References
- Touyz RM: Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension. Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1103-18. doi: 10.1152/ajpheart.00903.2007. Epub 2008 Jan 11. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Acts as a magnesium transporter that is responsive to magnesium balance.
- Specific Function
- Divalent inorganic cation transmembrane transporter activity
- Gene Name
- SLC41A1
- Uniprot ID
- Q8IVJ1
- Uniprot Name
- Solute carrier family 41 member 1
- Molecular Weight
- 54900.26 Da
References
- Schaffers OJM, Hoenderop JGJ, Bindels RJM, de Baaij JHF: The rise and fall of novel renal magnesium transporters. Am J Physiol Renal Physiol. 2018 Jun 1;314(6):F1027-F1033. doi: 10.1152/ajprenal.00634.2017. Epub 2018 Feb 7. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Cation transmembrane transporter activity
- Specific Function
- Not Available
- Gene Name
- SLC41A3
- Uniprot ID
- Q96GZ6
- Uniprot Name
- Solute carrier family 41 member 3
- Molecular Weight
- 54766.1 Da
References
- Schaffers OJM, Hoenderop JGJ, Bindels RJM, de Baaij JHF: The rise and fall of novel renal magnesium transporters. Am J Physiol Renal Physiol. 2018 Jun 1;314(6):F1027-F1033. doi: 10.1152/ajprenal.00634.2017. Epub 2018 Feb 7. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665).
- Specific Function
- Magnesium ion transmembrane transporter activity
- Gene Name
- MRS2
- Uniprot ID
- Q9HD23
- Uniprot Name
- Magnesium transporter MRS2 homolog, mitochondrial
- Molecular Weight
- 50317.01 Da
References
- Schaffers OJM, Hoenderop JGJ, Bindels RJM, de Baaij JHF: The rise and fall of novel renal magnesium transporters. Am J Physiol Renal Physiol. 2018 Jun 1;314(6):F1027-F1033. doi: 10.1152/ajprenal.00634.2017. Epub 2018 Feb 7. [Article]
Drug created at July 12, 2018 16:17 / Updated at February 20, 2024 23:55