This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Frangula purshiana bark
- DrugBank Accession Number
- DB15478
- Background
Not Available
- Type
- Biotech
- Groups
- Approved, Experimental
- Synonyms
- Aromatic cascara fluidextract
- Aromatic cascara sagrada fluid extract
- Bearberry bark
- Carscara bitterless extract
- Cascara bitterless bark extract
- Cascara buckthorn bark
- Cascara fluidextract, aromatic
- Cascara sagrada
- Cascara sagrada bark
- Cascara sagrada extract
- Cascara sagrada fluidextract
- Chittambark
- Chittem bark
- Frangula purshiana bark
- Frangula purshiana bark extract
- Pursh's buckthorn bark
- Rhamni purshianae cortex
- Rhamnus purshiana
- Rhamnus purshiana bark
- Rhamnus purshiana bark dry extract
- Rhamnus purshiana bark extract
- Rhamnus purshiana stem bark
- Sacred bark
- External IDs
- B2340
- Fema no. 2253
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination to treat Constipation Combination Product in combination with: Boldo leaf extract (DB15815) ••• ••• ••••• - Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcetazolamide The risk or severity of dehydration can be increased when Acetazolamide is combined with Frangula purshiana bark. Aclidinium The therapeutic efficacy of Frangula purshiana bark can be decreased when used in combination with Aclidinium. Alfentanil The therapeutic efficacy of Frangula purshiana bark can be decreased when used in combination with Alfentanil. Amantadine The therapeutic efficacy of Frangula purshiana bark can be decreased when used in combination with Amantadine. Amiloride The risk or severity of dehydration can be increased when Amiloride is combined with Frangula purshiana bark. - Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Aromatic Cascara Sagrada Compound Liquid 1 g / mL Oral D.C. Labs Limited 1951-12-31 2003-07-11 Canada 
Biofant - 41mg/5ml Liquid 41 mg / 5 mL Oral Les Laboratoires Vachon Inc. 1995-12-31 1997-08-08 Canada Cascara Aromatic Liquid 5 g / 10 mL Oral Ingram And Bell Inc. 1953-12-31 1999-08-05 Canada Cascara Aromatic Liq 250mg Liquid 250 mg / mL Oral Dawson Traders Ltd. 1977-12-31 2006-03-22 Canada Cascara Aromatique Elixir Liquid 33.3 g / 100 mL Oral Lab Valmo EnregistrÉ, Division Of Technilab Inc. 1983-12-31 1999-09-17 Canada - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Aid-lax Tab Frangula purshiana bark (30 mg / tab) + Alloin (12 mg / tab) + Phenolphthalein (100 mg / tab) + Sodium taurocholate (60 mg / tab) Tablet Oral Nobel Pharm Enr. 1989-12-31 1997-07-31 Canada Alsiline Frangula purshiana bark (30 mg / tab) + Alloin (12 mg / tab) + Phenolphthalein (100 mg / tab) + Sodium taurocholate (60 mg / tab) Tablet Oral Alsi Cie Ltee 1978-12-31 1997-08-08 Canada AMARO MEDICINALE GIULIANI Frangula purshiana bark (121 mg/100g) + Boldo leaf extract (100 mg/100g) + Gentian violet cation (111 mg/100g) + Rhubarb (356 mg/100g) Solution Oral Giuliani Spa 2014-07-08 Not applicable Italy 
AMARO MEDICINALE GIULIANI Frangula purshiana bark (121 mg/100g) + Boldo leaf extract (100 mg/100g) + Gentian violet cation (111 mg/100g) + Rhubarb (356 mg/100g) Solution Oral Giuliani Spa 2014-07-08 Not applicable Italy AMARO MEDICINALE GIULIANI Frangula purshiana bark (121 mg/100g) + Boldo leaf extract (100 mg/100g) + Gentian violet cation (111 mg/100g) + Rhubarb (356 mg/100g) Solution Oral Giuliani Spa 2014-07-08 Not applicable Italy
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 4VBP01X99F
- CAS number
- 8015-89-2
References
- General References
- Not Available
- External Links
Clinical Trials
- Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution Oral Powder, for solution Oral Powder, for suspension Oral Liquid Oral 41 mg / 5 mL Powder Not applicable 1 kg/1kg Liquid Oral 5 g / 10 mL Liquid Oral 250 mg / mL Liquid Oral 33.3 g / 100 mL Liquid Oral Capsule Oral 400 mg / cap Capsule Oral 450 mg / cap Capsule Oral 100 mg / cap Capsule Oral 500 mg / cap Capsule Oral 400 mg / tab Capsule, coated Oral 400 mg Tablet Oral 487.5 mg Tablet Oral 324 mg / tab Tablet Oral 325 mg Tablet, coated Oral Syrup Oral Capsule Oral 80.5 mg / cap Liquid Oral 325 mg / 30 mL Kit Oral Tablet Oral Liquid Oral 1 g / mL Tablet Oral 200 mg / tab Tablet Oral 160 mg / tab Liquid Oral Capsule Oral Tablet Oral 330 mg / tab Liquid Oral 1.1664 g / 30 mL - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
Drug created at August 30, 2019 15:40 / Updated at October 02, 2020 07:51