This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Brand Names
- Choletec
- Generic Name
- Mebrofenin
- DrugBank Accession Number
- DB15779
- Background
Not Available
- Type
- Small Molecule
- Groups
- Approved, Experimental
- Structure
Structure for Mebrofenin (DB15779)
- Weight
- Average: 387.23
Monoisotopic: 386.047735 - Chemical Formula
- C15H19BrN2O5
- Synonyms
- Mebrofenin
- Mebrofenine
- Mebrofenino
- Mebrofeninum
- External IDs
- SQ 26962
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Diagnostic agent Bile duct disorders •••••••••••• •••••••••• ••••••• •••••••••••• ••• •••••••• - Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Choletec Injection, powder, lyophilized, for solution 45 mg/1 Intravenous Bracco Diagnostics Inc 1987-01-21 Not applicable US 
Mebrofenin Injection, powder, lyophilized, for solution 10 mg/1 Intravenous AnazaoHealth Corporation 2012-06-19 Not applicable US - Generic Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Kit for the Preparation of Technetium Tc 99m Mebrofenin Injection, powder, lyophilized, for solution 45 mg/10mL Intravenous Sun Pharmaceutical Industries, Inc. 2008-01-29 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Mebrofenin Mebrofenin (10 mg/1) Injection, powder, lyophilized, for solution Intravenous AnazaoHealth Corporation 2012-06-19 Not applicable US
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 7PV0B6ED98
- CAS number
- 78266-06-5
- InChI Key
- MHPZZZZLAQGTHT-UHFFFAOYSA-N
- InChI
- InChI=1S/C15H19BrN2O5/c1-8-4-9(2)15(10(3)14(8)16)17-11(19)5-18(6-12(20)21)7-13(22)23/h4H,5-7H2,1-3H3,(H,17,19)(H,20,21)(H,22,23)
- IUPAC Name
- 2-({[(3-bromo-2,4,6-trimethylphenyl)carbamoyl]methyl}(carboxymethyl)amino)acetic acid
- SMILES
- CC1=CC(C)=C(Br)C(C)=C1NC(=O)CN(CC(O)=O)CC(O)=O
References
- General References
- Not Available
- External Links
- ChemSpider
- 48922
- 1311500
- ChEBI
- 135608
- ChEMBL
- CHEMBL1605443
- ZINC
- ZINC000000537957
- Wikipedia
- Technetium_(99mTc)_mebrofenin
Clinical Trials
- Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count 1 Completed Basic Science Non Alcoholic Steatohepatitis (NASH) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Injection, powder, lyophilized, for solution Intravenous 45 mg/1 Injection, powder, lyophilized, for solution Intravenous 45 mg/10mL Injection, powder, lyophilized, for solution Intravenous 10 mg/1 Injection, powder, lyophilized, for solution Intravenous 20 mg - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0568 mg/mL ALOGPS logP -0.39 ALOGPS logP -0.42 Chemaxon logS -3.8 ALOGPS pKa (Strongest Acidic) 2.81 Chemaxon pKa (Strongest Basic) 2.14 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 106.94 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 89.27 m3·mol-1 Chemaxon Polarizability 35.27 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-00kr-0319000000-47285fb2023f199ea9a6 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-01ti-7094000000-80a859782faaf2f7938c Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-004i-9210000000-d4e9134a924613dfeb25 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-0j4i-0292000000-d0ab414d0d9378c069fc Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-000l-9060000000-0277d06beaad7828c0d3 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-01rj-3890000000-514496989806c097e400 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 175.92549 predictedDeepCCS 1.0 (2019) [M+H]+ 178.2835 predictedDeepCCS 1.0 (2019) [M+Na]+ 184.71635 predictedDeepCCS 1.0 (2019)
Drug created at August 21, 2020 16:56 / Updated at February 21, 2021 18:55