NAV

Methfuroxam

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Methfuroxam
DrugBank Accession Number
DB16231
Background

Methfuroxam is under investigation in clinical trial NCT01213407 (Dendritic Cell Cancer Vaccine for High-grade Glioma).

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 229.279
Monoisotopic: 229.110278727
Chemical Formula
C14H15NO2
Synonyms
  • Furavax
  • Trivax
External IDs
  • H-719
  • UBI-2238
  • UBI-H 719
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
4K9VG91RQZ
CAS number
28730-17-8
InChI Key
ZWJNEYVWPYIKMB-UHFFFAOYSA-N
InChI
InChI=1S/C14H15NO2/c1-9-10(2)17-11(3)13(9)14(16)15-12-7-5-4-6-8-12/h4-8H,1-3H3,(H,15,16)
IUPAC Name
2,4,5-trimethyl-N-phenylfuran-3-carboxamide
SMILES
CC1=C(C)C(C(=O)NC2=CC=CC=C2)=C(C)O1

References

General References
Not Available
ChemSpider
31609
ChEBI
142825
ChEMBL
CHEMBL1395509
ZINC
ZINC000000155059

Clinical Trials

Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
PhaseStatusPurposeConditionsCount
2CompletedTreatmentGlioblastoma Multiforme (GBM)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0641 mg/mLALOGPS
logP2.83ALOGPS
logP3.12Chemaxon
logS-3.6ALOGPS
pKa (Strongest Acidic)14.91Chemaxon
pKa (Strongest Basic)-2.7Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count1Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area42.24 Å2Chemaxon
Rotatable Bond Count2Chemaxon
Refractivity69.45 m3·mol-1Chemaxon
Polarizability25.72 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-0790000000-a23fb0ed7eb68200ef74
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a4i-5900000000-57b921b886ae46b0c9d3
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-052f-9810000000-0fecb4f2e22fc01ffb76
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-000g-9820000000-8fe6cbd7d2da5f2e1b48
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-05mn-9300000000-23fc9d88d1eda3ac2581
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-00kf-9100000000-4d19336a207608334bc5
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-152.9087206
predicted
DarkChem Lite v0.1.0
[M-H]-160.6748644
predicted
DarkChem Lite v0.1.0
[M-H]-153.74834
predicted
DeepCCS 1.0 (2019)
[M+H]+155.8375239
predicted
DarkChem Lite v0.1.0
[M+H]+161.4565644
predicted
DarkChem Lite v0.1.0
[M+H]+156.10634
predicted
DeepCCS 1.0 (2019)
[M+Na]+160.6208644
predicted
DarkChem Lite v0.1.0
[M+Na]+162.19948
predicted
DeepCCS 1.0 (2019)

Drug created at December 15, 2020 18:16 / Updated at December 20, 2020 03:39