NAV

Sonlicromanol

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Sonlicromanol
DrugBank Accession Number
DB16333
Background

Sonlicromanol is under investigation in clinical trial NCT04165239 (The KHENERGYZE Study).

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 332.444
Monoisotopic: 332.20999277
Chemical Formula
C19H28N2O3
Synonyms
  • (S)-6-Hydroxy-2,5,7,8-Tetramethyl-N-((R)-Piperidin-3-Yl)Chroman-2-Carboxamide
  • KH-176
  • KH176
  • Sonlicromanol
External IDs
  • KH-176
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Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Sonlicromanol Hydrochloride858M8246UL2162149-24-6Not applicable

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
JCU3O35RDS
CAS number
1541170-75-5
InChI Key
LZYWLEPSQNXESC-KUHUBIRLSA-N
InChI
InChI=1S/C19H28N2O3/c1-11-12(2)17-15(13(3)16(11)22)7-8-19(4,24-17)18(23)21-14-6-5-9-20-10-14/h14,20,22H,5-10H2,1-4H3,(H,21,23)/t14-,19+/m1/s1
IUPAC Name
(2S)-6-hydroxy-2,5,7,8-tetramethyl-N-[(3R)-piperidin-3-yl]-3,4-dihydro-2H-1-benzopyran-2-carboxamide
SMILES
CC1=C(O)C(C)=C2CC[C@](C)(OC2=C1C)C(=O)N[C@@H]1CCCNC1

References

General References
Not Available
ChemSpider
58828127
ChEMBL
CHEMBL4802153
Wikipedia
Sonlicromanol

Clinical Trials

Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
PhaseStatusPurposeConditionsCount
2Active Not RecruitingTreatmentChronic Progressive External Ophthalmoplegia (CPEO) / Maternally Inherited Diabetes and Deafness (MIDD) / Mitochondrial Disorders / Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation / Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke Like Episodes (MELAS)1
2CompletedTreatmentMIDD / Mitochondrial Disorders / Mitochondrial Encephalomyopathies / Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke Like Episodes (MELAS) / Mitochondrial Myopathies2
2RecruitingTreatmentMitochondrial Disorders / Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation / Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke Like Episodes (MELAS) / Subacute Necrotizing Encephalomyelopathy1
1CompletedTreatmentLeigh's Disease / LHON / Mitochondrial Disorders / Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation / Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke Like Episodes (MELAS)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.224 mg/mLALOGPS
logP1.75ALOGPS
logP2.97Chemaxon
logS-3.2ALOGPS
pKa (Strongest Acidic)10.68Chemaxon
pKa (Strongest Basic)9.49Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count4Chemaxon
Hydrogen Donor Count3Chemaxon
Polar Surface Area70.59 Å2Chemaxon
Rotatable Bond Count2Chemaxon
Refractivity94.73 m3·mol-1Chemaxon
Polarizability38.14 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-0019000000-d536042ad91972a0aa06
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-001i-2019000000-f7f99e2ef74cc6beafb2
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-00lr-3349000000-70a58dd57cef9f96ab2a
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-05mo-8894000000-224141303c55c08a1c7f
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-000f-8932000000-8f24b0c24bcbe75a24cd
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-01qi-7981000000-76e37ac44dd83a491dce
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at December 15, 2020 20:02 / Updated at September 28, 2023 05:47