NAV

Amidephrine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Amidephrine is a sympathomimetic indicated in the treatment of acute, chronic, vasomotor, and allergic rhinitis.

Generic Name
Amidephrine
DrugBank Accession Number
DB16623
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
3D
Similar Structures
Weight
Average: 244.31
Monoisotopic: 244.088163557
Chemical Formula
C10H16N2O3S
Synonyms
  • Amidefrine
  • Amidephrine
External IDs
  • MJ-1996
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Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Treatment ofAllergic rhinitis (ar)••• ••••••••••• • •••••
Treatment ofChronic rhinitis••• ••••••••••• • •••••
Treatment ofVasomotor rhinitis••• ••••••••••• • •••••
Treatment ofAcute rhinitis••• •••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
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Not Available

Interactions

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This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
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AcebutololThe therapeutic efficacy of Amidephrine can be decreased when used in combination with Acebutolol.
AlfuzosinThe therapeutic efficacy of Amidephrine can be decreased when used in combination with Alfuzosin.
AmitriptylineThe therapeutic efficacy of Amidephrine can be decreased when used in combination with Amitriptyline.
AmitriptylinoxideThe risk or severity of hypertension can be increased when Amitriptylinoxide is combined with Amidephrine.
AmoxapineThe therapeutic efficacy of Amidephrine can be decreased when used in combination with Amoxapine.
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Amidephrine mesylateS3IG39T94B1421-68-7INSXAGGBFMXUIH-UHFFFAOYSA-N

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
7E2P22546V
CAS number
37571-84-9
InChI Key
ZHOWHMXTJFZXRB-UHFFFAOYSA-N
InChI
InChI=1S/C10H16N2O3S/c1-11-7-10(13)8-4-3-5-9(6-8)12-16(2,14)15/h3-6,10-13H,7H2,1-2H3
IUPAC Name
N-{3-[1-hydroxy-2-(methylamino)ethyl]phenyl}methanesulfonamide
SMILES
CNCC(O)C1=CC(NS(C)(=O)=O)=CC=C1

References

General References
  1. BASG: Fentrinol - Nasentropfen (Amidephrine) Nasal Drops [Link]
ChemSpider
14288
ChEBI
134994
ChEMBL
CHEMBL146408
Wikipedia
Amidephrine

Clinical Trials

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PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Solution / drops; suspension / dropsNasal1 mg/ml
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-1.2Chemaxon
pKa (Strongest Acidic)9.91Chemaxon
pKa (Strongest Basic)9.25Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count4Chemaxon
Hydrogen Donor Count3Chemaxon
Polar Surface Area78.43 Å2Chemaxon
Rotatable Bond Count4Chemaxon
Refractivity61.95 m3·mol-1Chemaxon
Polarizability25.2 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-002b-0390000000-287ec1c30364929091e3
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-0090000000-d1df19f0c3467b81be75
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0002-0910000000-bb6e409d2fa98166b523
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-002f-5590000000-397dfedd8b7b365b7e24
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0apj-1900000000-3e41ecfaf84783930c71
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-9200000000-773d8772762aadb847f0
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-150.48601
predicted
DeepCCS 1.0 (2019)
[M+H]+152.84401
predicted
DeepCCS 1.0 (2019)
[M+Na]+158.93715
predicted
DeepCCS 1.0 (2019)

Drug created at February 24, 2021 21:33 / Updated at April 30, 2021 13:08