L-Acetylleucine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
L-Acetylleucine
DrugBank Accession Number
DB16956
Background

Not Available

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 173.212
Monoisotopic: 173.105193347
Chemical Formula
C8H15NO3
Synonyms
  • (s)-2-acetamido-4-methylpentanoic acid
  • Acetyl-l-leucine
  • Acetylleucine, (s)-
  • Acetylleucine, l-
  • L-leucine, n-acetyl-
  • Leucine, n-acetyl-, l-
  • N-acetyl leucine
  • N-acetyl-l-(-)-leucine
  • N-acetyl-l-leucine
  • N-Acetyl-Leucine
  • N-acetylleucine
External IDs
  • NSC-206316

Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Brand nameGranule, for solution1000 mg/1OralIntraBio Inc2024-01-18Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Brand nameL-Acetylleucine (1000 mg/1)Granule, for solutionOralIntraBio Inc2024-01-18Not applicableUS flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
E915HL7K2O
CAS number
1188-21-2
InChI Key
WXNXCEHXYPACJF-ZETCQYMHSA-N
InChI
InChI=1S/C8H15NO3/c1-5(2)4-7(8(11)12)9-6(3)10/h5,7H,4H2,1-3H3,(H,9,10)(H,11,12)/t7-/m0/s1
IUPAC Name
(2S)-2-acetamido-4-methylpentanoic acid
SMILES
CC(C)C[C@H](NC(C)=O)C(O)=O

References

General References
Not Available
Human Metabolome Database
HMDB0011756
KEGG Compound
C02710
ChemSpider
64075
RxNav
2375522
ChEBI
17786
ChEMBL
CHEMBL56021
ZINC
ZINC000000135384
PDBe Ligand
LAY
PDB Entries
5afg / 5nfu

Clinical Trials

Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
PhaseStatusPurposeConditionsCount
4Active Not RecruitingTreatmentVasovagal Syncope1
4CompletedNot AvailableHealthy Subjects (HS)1
4CompletedNot AvailableMigraine1
4CompletedNot AvailablePill Capsule Endoscopy Completion Rates1
4CompletedBasic ScienceBlood Pressures1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Granule, for solutionOral1000 mg/1
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility10.9 mg/mLALOGPS
logP0.78ALOGPS
logP0.49Chemaxon
logS-1.2ALOGPS
pKa (Strongest Acidic)4.2Chemaxon
pKa (Strongest Basic)-1.8Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area66.4 Å2Chemaxon
Rotatable Bond Count4Chemaxon
Refractivity43.61 m3·mol-1Chemaxon
Polarizability18.07 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at September 14, 2022 22:04 / Updated at December 01, 2022 11:33