NAV

ZK-93423

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
ZK-93423
DrugBank Accession Number
DB17063
Background

ZK-93423 is a beta-carboline with muscle relaxant activity with agonistic properties at the benzodiazepine receptor.1

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 390.439
Monoisotopic: 390.157957196
Chemical Formula
C23H22N2O4
Synonyms
  • 9H-Pyrido[3,4-b]indole-3-carboxylicacid, 4-(methoxymethyl)-6-(phenylmethoxy)-, ethyl ester
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
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Not Available

Interactions

Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
B6PWX5B47Q
CAS number
83910-44-5
InChI Key
ALBKMJDFBZVHAK-UHFFFAOYSA-N
InChI
InChI=1S/C23H22N2O4/c1-3-28-23(26)22-18(14-27-2)21-17-11-16(29-13-15-7-5-4-6-8-15)9-10-19(17)25-20(21)12-24-22/h4-12,25H,3,13-14H2,1-2H3
IUPAC Name
ethyl 6-(benzyloxy)-4-(methoxymethyl)-9H-pyrido[3,4-b]indole-3-carboxylate
SMILES
CCOC(=O)C1=NC=C2NC3=C(C=C(OCC4=CC=CC=C4)C=C3)C2=C1COC

References

General References
  1. Klockgether T, Pardowitz I, Schwarz M, Sontag KH, Turski L: Evaluation of the muscle relaxant properties of a novel beta-carboline, ZK 93423 in rats and cats. Br J Pharmacol. 1985 Oct;86(2):357-66. doi: 10.1111/j.1476-5381.1985.tb08904.x. [Article]
ChemSpider
108771
BindingDB
85039
ChEBI
92593
ChEMBL
CHEMBL1518572
ZINC
ZINC000005857871
Wikipedia
ZK-93423

Clinical Trials

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PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00246 mg/mLALOGPS
logP4.27ALOGPS
logP3.86Chemaxon
logS-5.2ALOGPS
pKa (Strongest Acidic)11.72Chemaxon
pKa (Strongest Basic)2.09Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count4Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area73.44 Å2Chemaxon
Rotatable Bond Count8Chemaxon
Refractivity110.36 m3·mol-1Chemaxon
Polarizability42.72 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at October 11, 2022 19:26 / Updated at December 01, 2022 11:34