NAV

6-diazo-5-oxo-L-norleucine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
6-diazo-5-oxo-L-norleucine
DrugBank Accession Number
DB17537
Background

6-diazo-5-oxo-L-norleucine is a broad-acting glutamine antagonist.

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 171.156
Monoisotopic: 171.064391162
Chemical Formula
C6H9N3O3
Synonyms
Not Available
External IDs
  • DON
  • NSC-7365
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
03J0H273KZ
CAS number
157-03-9
InChI Key
YCWQAMGASJSUIP-YFKPBYRVSA-N
InChI
InChI=1S/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H,11,12)/t5-/m0/s1
IUPAC Name
(2S)-2-amino-6-diazo-5-oxohexanoic acid
SMILES
N[C@@H](CCC(=O)C=[N+]=[N-])C(O)=O

References

General References
Not Available
ChemSpider
16735775
ChEBI
183231
ChEMBL
CHEMBL97485
ZINC
ZINC000003953825
Wikipedia
6-Diazo-5-oxo-L-norleucine

Clinical Trials

Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
PhaseStatusPurposeConditionsCount
1, 2RecruitingTreatmentMalaria, Cerebral1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility17.2 mg/mLALOGPS
logP-1.7ALOGPS
logP-4.2Chemaxon
logS-1ALOGPS
pKa (Strongest Acidic)1.87Chemaxon
pKa (Strongest Basic)9.36Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count5Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area97.46 Å2Chemaxon
Rotatable Bond Count5Chemaxon
Refractivity38.4 m3·mol-1Chemaxon
Polarizability15.81 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at February 15, 2023 17:53 / Updated at February 16, 2023 16:06