Peripheral Nervous System Agents
- Name
- Peripheral Nervous System Agents
- Accession Number
- DBCAT000043
- Description
Drugs that act principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system. (From Smith and Reynard, Textbook of Pharmacology, 1991, p75)
- Drugs
Drug Drug Description Botulinum toxin type A A purified form of botulinum toxin type A used to block acetylcholine release in the treatment of chronic sialorrhea, muscle spasticity, and dystonia, as well as in cosmetic applications. Amphetamine A CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Cevimeline A muscarinic agonist with parasympathomimetic activities that is used for the symptomatic treatment of dry mouth in patients with Sjögren's Syndrome. Lorazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures. Phentermine A sympathomimetic anorectic agent used as a short-term adjunct therapy that is included in a regimen of weight reduction in cases of exogenous obesity. Tramadol A centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults. Betaxolol A cardioselective beta blocking agent commonly used to treat hypertension and elevated intraocular pressure (when administered ophthalmically). Succinylcholine A depolarizing skeletal muscle relaxant used adjunctly to anesthesia and for skeletal muscle relaxation during intubation, mechanical ventilation, and surgical procedures. Pregabalin An anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants. Benzatropine An anticholinergic drug used to treat Parkinson's disease (PD) and extrapyramidal symptoms, except tardive dyskinesia. Lidocaine A local anesthetic used in a wide variety of superficial and invasive procedures. Morphine An opioid agonist used for the relief of moderate to severe acute and chronic pain. Bupivacaine A local anesthetic used in a wide variety of superficial and invasive procedures. Dihydroergotamine An ergot alkaloid used in the acute treatment of migraine headache and cluster headache. Hydromorphone An opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated. Indomethacin A nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. Ipratropium An anticholinergic drug used in the control of symptoms related to bronchospasm in chronic obstructive pulmonary disease (COPD). Olanzapine An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders. Atenolol A synthetic beta-1 selective blocker used in the management of hypertension and chronic angina, and to reduce mortality in known or suspected myocardial infarction in hemodynamically stable patients. Doxylamine An antihistamine used to treat insomnia and allergy symptoms and is used with pyridoxine in the treatment of nausea and vomiting in pregnancy. Phenylephrine An alpha-1 adrenergic agonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics. Carbamoylcholine A direct acting miotic agent administered ophthalmically to decrease intraocular pressure after cataract surgery, and to induce miosis during surgery. Methocarbamol A CNS depressant indicated with rest, physical therapy and other treatments to control the discomfort associated with various acute musculoskeletal conditions. Hyoscyamine An anticholinergic indicated to treat functional gastrointestinal disorders, biliary and renal colic, and acute rhinitis. Prochlorperazine A phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. Duloxetine A serotonin norepinephrine reuptake inhibitor used to treat generalized anxiety disorder, neuropathic pain, osteoarthritis, and stress incontinence. Celecoxib An NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis. Sotalol A methane sulfonanilide beta adrenergic antagonist used to treat life-threatening ventricular arrhythmias and to maintain sinus rhythm in atrial fibrillation or flutter. Oxycodone An opioid used in the management of moderate to severe pain. Haloperidol An antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium. Carbamazepine An anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia. Clonidine An alpha-2 adrenergic agonist used to treat hypertension and severe cancer pain, among other conditions, and to treat withdrawal symptoms from various substances. It is also used to aid in the diagnosis of pheochromocytoma and to prevent migraines. Diclofenac An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. Fluticasone propionate A glucocorticoid used to treat asthma, inflammatory pruritic dermatoses, and nonallergic rhinitis. Labetalol An alpha and beta adrenergic antagonist used to treat hypertension, angina, and sympathetic overactivity syndrome. Chloroquine An antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis. Bisoprolol A beta-1 adrenergic blocking agent used to prevent myocardial infarction and heart failure and to treat mild to moderate hypertension. Adenosine A medication used in myocardial perfusion scintigraphy and to treat supraventricular tachycardia. Epinephrine A hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma. Galantamine A cholinesterase inhibitor used to manage mild to moderate dementia associated with Alzheimer's Disease. Sufentanil An opioid used to induce and maintain anesthesia, to act as an analgesic in labor and delivery, and to treat severe, acute pain. Apomorphine A morphine derivative D2 dopamine agonist used to treat hypomobile "off" episodes of advanced Parkinson's disease. Procaine A local anesthetic used for anesthesia, peripheral nerve block, and spinal nerve block. Meclizine A histamine H1 antagonist used to treat nausea, vomiting, and dizziness associated with motion sickness. Scopolamine A belladonna alkaloid with anticholinergic effects indicated for the treatment of nausea and vomiting associated with motion sickness and postoperative nausea and vomiting (PONV). Olopatadine A histamine H1 antagonist used to treat allergic conjunctivitis and rhinitis. Mefenamic acid An NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. Naproxen An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain. Dicyclomine An antimuscarinic agent used to treat IBS. Proparacaine A topical anesthetic used for ophthalmic practice. Tropicamide A muscarinic receptor antagonist used to induce mydriasis and cycloplegia for diagnostic procedures. Biperiden A muscarinic receptor antagonist used to treat parkinsonism and control extrapyramidal side effects of neuroleptic drugs. Fentanyl An opioid analgesic used in anesthesia, for breakthrough cancer pain, or round the clock pain management. Meloxicam An NSAID used to treat osteoarthritis in adults, rheumatoid arthritis in adults, and juvenile rheumatoid arthritis in pediatrics. Diazepam A long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. Pseudoephedrine An alpha and beta adrenergic agonist used to treat nasal and sinus congestion, as well as allergic rhinitis. Suprofen An NSAID used to prevent pupil constriction in ocular surgery. Terbutaline A beta-2 adrenergic agonist used as a bronchodilator and to prevent premature labor. Ondansetron A serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively. Oxymetazoline An alpha-1A adrenoceptor agonist used to treat nasal congestion, allergic reactions of the eye, and facial erythema associated with rosacea. Salmeterol A long-acting beta-2 adrenergic receptor agonist used to treat asthma and COPD. Acetylsalicylic acid A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. Hydrocodone An opioid agonist used as an analgesic and antitussive agent. Methylprednisolone A corticosteroid used to treat inflammation or immune reactions across a variety of organ systems, endocrine conditions, and neoplastic diseases. Bromfenac An NSAID used to treat postoperative pain and inflammation of the eye. Methyldopa A centrally-acting alpha-2 adrenergic agonist used to manage hypertension alone or in combination with hydrochlorothiazide, and to treat hypertensive crises. Cyclopentolate An anticholinergic used to cause mydriasis and cycloplegia for diagnostic testing. Dimenhydrinate A medication used to prevent and treat nausea, vomiting, vertigo, and motion sickness. Gabapentin An anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures. Bethanechol A muscarinic agonist used to treat postoperative and postpartum nonobstructive functional urinary retention and neurogenic atony of the bladder with retention. Ibuprofen An NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation. Echothiophate An acetylcholinesterase inhibitor used in ophthalmic preparations to increase the drainage of intraocular fluid; most commonly used for the treatment of glaucoma. Oxybutynin An antimuscarinic agent that reduces detrusor muscle activity, relaxing the bladder and preventing the urge to void. Isoprenaline A catecholamine non-selective beta-adrenergic agonist typically used to treat bradycardia and heart block. Pilocarpine A muscarinic agonist used to treat dry mouth and various ophthalmic conditions, such as presbyopia, increased intraocular pressure, and angle-closure glaucoma. Benzocaine A topical local anesthetic used for the temporary relief of pain and itching associated with minor burns, sunburn, scrapes and insect bites or minor skin irritations. Guanethidine An antihypertensive agent used in the management of moderate and severe hypertension, either alone or as an adjunct, and for the management of renal hypertension. Orphenadrine A muscarinic antagonist used as an adjunct for the symptomatic relief of musculoskeletal pain and discomfort. Cyclizine An antihistamine and antiemetic drug used for the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness, and vertigo. Naloxone An opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection. Nadolol A non-selective beta-adrenergic antagonist used for the management of arrhythmias, angina pectoris, and hypertension. Budesonide A corticosteroid used to treat Crohn's disease, asthma, COPD, hay fever and allergies, and ulcerative colitis. Metoclopramide An antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying. Dexamethasone A glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders. Ephedrine An alpha and beta-adrenergic agonist indicated to treat hypotension under anesthesia, allergic conditions, bronchial asthma, and nasal congestion. Tiotropium A long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). Ziconotide An N-type calcium channel antagonist used to manage patients with severe chronic pain who cannot tolerate, or who have not responded adequately to other treatments such as intrathecal morphine and systemic analgesics. Methacholine A parasympathomimetic bronchoconstrictor used to diagnose bronchial hyperreactivity in subjects who do not have clinically apparent asthma. Drotaverine A phosphodiesterase-4 inhibitor used to alleviate gastrointestinal and genitourinary smooth muscle spasms. Tetryzoline An alpha-adrenergic agonist used in the temporary symptomatic relief of discomfort and redness of the eyes due to minor irritations, as well as alleviate nasal congestion. Nepafenac An ophthalmic NSAID used for the symptomatic treatment of pain and inflammation associated with cataract surgery. Homatropine An anticholinergic agent used to dilate the pupil, treat inflammation of the uveal tract, and suppress a cough. Nonivamide Nonivamide is used as a topical analgesic and is also used as a flavoring ingredient , , . Flunixin Flunixin is a non-steroidal anti-inflammatory drug for use in pigs, cattle and horses. It exerts analgesic and antipyretic effects. This drug is often prepared for use in meglumine salt form.... Samidorphan A novel opioid-system modulator, similar to naltrexone, that functions primarily as a μ-opioid receptor antagonist in vivo and is used primarily in combination with antipsychotics to reduce their metabolic dysfunction-associated adverse effects. Aceclidine Aceclidine has been marketed in Europe but has not been used clinically in the United States. It is used in the treatment of open-angle glaucoma and is a parasympathomimetic agent. Fluticasone A corticosteroid indicated in the treatment of corticosteroid responsive dermatoses, asthma, and COPD. Salbutamol A beta-2 adrenergic receptor agonist used to treat asthma, bronchitis, COPD, as well as prevent exercise induced bronchospasms. Dexketoprofen An NSAID that is the R(-)-enantiomer of racemic ketoprofen with analgesic and anti-inflammatory properties used for the treatment of mild to moderate pain. Galcanezumab A calcitonin-gene related peptide antagonist used to prevent migraines and treat cluster headaches. Risdiplam An oral mRNA splicing modifier used in the treatment of spinal muscular atrophy (SMA). Tetramethylammonium Not Available Oliceridine A biased opioid agonist indicated for the management of severe acute pain in adult patients. Through preferential activation of G-protein-coupled signalling pathways, oliceridine provides analgesic effect with a comparable or improved safety profile over conventional opioid agonists. 1,3,5-Trimethoxybenzene A medication indicated for the symptomatic treatment of spastic pain of the urinary tract, renal colic, and painful disorders of the digestive and biliary tract. Ropivacaine An amide-type local anesthetic used for local or regional anesthesia during surgery and for short-term management of acute pain. Methadone An opioid analgesic indicated for management of severe pain that is not responsive to alternative treatments. Also used to aid in detoxification and maintenance treatment of opioid addiction. Meperidine An opioid agonist with analgesic and sedative properties used to manage severe pain. Cinchocaine An anesthetic used for local or regional anesthesia. Butorphanol An opioid agonist-antagonist used to treat moderate to severe pain. Dyclonine An topical anesthetic used prior to examination to suppress the gag reflex or for pain relief from canker sores and fever blisters. Dextropropoxyphene An opioid analgesic used to treat mild to moderate pain. Pentazocine An analgesic used to treat moderate to severe pain. Magnesium sulfate A drug used to treat convulsions during pregnancy, nephritis in children, magnesium deficiency, and tetany. Flurbiprofen An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. Prilocaine A local anesthetic used in dental procedures. Alfentanil An opioid agonist used to induce and maintain anesthesia, as well as an analgesic. Nalbuphine An opioid agonist-antagonist used to treat pain, for pre and postoperative analgesia, and for analgesia in labor and delivery. Levorphanol An opioid analgesic used to treat moderate to severe pain. Oxybuprocaine A local anesthetic used in ophthalmology. Remifentanil An opioid analgesic used in anesthesia. Buprenorphine A partial opioid agonist used for management of severe pain that is not responsive to alternative treatments. Also used for maintenance treatment of opioid addiction. Mepivacaine A local anesthetic used for local or regional analgesia or anesthesia. Levobupivacaine A drug used for nerve block and anesthesia. Diphenoxylate An antidiarrheal medication used with atropine to manage diarrhea. Chloroprocaine A local anesthetic agent indicated for intrathecal injection in adults for the production of subarachnoid block, spinal anesthesia, or ocular surface anesthesia. Oxymorphone An opioid analgesic used in the management of moderate-to-severe pain and for analgesic therapies. Mitoxantrone A chemotherapeutic agent used for the treatment of secondary progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. Dezocine Indicated in the treatment of moderate to severe pain. Ketamine A rapid-acting general anesthetic and NMDA receptor antagonist used for induction of anesthesia diagnostic and surgical procedures typically in combination with a muscle relaxant. Levacetylmethadol For the treatment and management of opiate dependence. It is sometimes used to treat severe pain in terminal patients. Choline magnesium trisalicylate Choline magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults. Methadyl acetate Used mainly in the treatment of narcotic dependence. Dihydroetorphine Not Available Diamorphine An opioid analgesic agent used in the relief of severe pain associated with surgical procedures, myocardial infarction or pain in the terminally ill and for the relief of dyspnea in acute pulmonary edema. Bezitramide A narcotic analgesic once used for the treatment of severe chronic pain. Ethylmorphine An opioid analgesic and antitussive agent used to reduce coughs caused by colds and lung infections in combination with codeine. Etorphine Etorphine is only available for its use in veterinary. This main usage is related to the immobilization of large mammals. Ecgonine Not Available Dextromoramide An opioid analgesic structurally related to methadone and used in the treatment of severe pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1070) Desomorphine Not Available Carfentanil Carfentanil is similar (but more potent) to the opioid analgesic fentanyl. It is used as a tranquilizer for large animals. Drotebanol Not Available Dihydrocodeine An opioid analgesic agent used for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Alphacetylmethadol A narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. [PubChem] Dihydromorphine Dihydromorphine is an opioid analgesic used for moderate to severe pain relief. Ohmefentanyl Ohmefentanyl is an extremely potent opioid analgesic drug which selectively binds to the µ-opioid receptor. The Chinese have recorded ohmefentanyl as having a potency that is 6,300 times morphine. Ohmefentanyl... 3-Methylfentanyl 3-Methylfentanyl is an opioid analgesic and is an analog of the potent opioid, fentanyl. 3-Methylfentanyl is one of the most powerful opioid drugs sold illegally and is estimated to be... 7-Nitroindazole Not Available Methylecgonine Not Available Licofelone For the management of osteoarthritis. Vapreotide For the treatment of esophageal variceal bleeding in patients with cirrhotic liver disease and has also shown efficacy in the treatment of patients with AIDS-related diarrhea. Pirfenidone An agent used for the treatment of idiopathic pulmonary fibrosis (IPF). Tetrodotoxin For the treatment of chronic and breakthrough pain in advanced cancer patients as well as for the treatment of opioid dependence. Tarenflurbil Investigated for use/treatment in alzheimer's disease and prostate cancer. Ecallantide A kallikrein inhibitor used to prevent and treat acute attacks caused by Hereditary Angioedema (HAE). Canertinib Investigated for use/treatment in breast cancer and lung cancer. RI 624 Investigated for use/treatment in pain (acute or chronic). Tapentadol An opioid used to manage severe pain that has not responded to non-opioid medications, and for which opioid analgesic therapy is appropriate. Gaboxadol Investigated for use/treatment in sleep disorders and insomnia. Flupirtine Investigated for use/treatment in fibromyalgia. Ketobemidone For the treatment of all types of severe pain, such as postoperative, cancer, kidney stones and fractures. Benzyl alcohol An antiparasitic agent used for the topical treatment of head lice infestation in patients 6 months of age and older. Capsaicin A topical analgesic agent used for the symptomatic relief of neuropathic pain associated with post-herpetic neuralgia, as well as other muscle and joint pain. Kelatorphan Not Available DPDPE A heterodetic cyclic peptide that is a cyclic enkephalin analogue, having D-penicillaminyl residues located at positions 2 and 5, which form the heterocycle via a disulfide bond. Etidocaine Etidocaine is marketed under the name Duranest. It is an injectable local anesthetic during surgery, labor, and delivery. Etidocaine has a long duration of activity, but has the main disadvantage... Articaine A local anesthetic used for inducing local, infiltrative, or conductive anesthesia in both simple and complex dental procedures. Tetracaine A local anaesthetic agent used to induce local analgesia in the eyes and skin during medical procedures. Lofentanil Lofentanil is an analog of fentanyl and is one of the most potent opioids available today. It displays most similarity to carfentanil (4-carbomethoxyfentanyl) and is considered to be slightly more... Pholcodine An opioid antitussive used to suppress unproductive coughing. Tolfenamic acid In the information for tolfenamic acid, it is stated that this drug, being an NSAID, is effective in treating the pain associated with the acute attack of migraines in adults. Propacetamol Propacetamol is a paracetamol prodrug of intravenous administration used to control fever and pain of perioperative period in multimodal analgesia therapy. Propoxycaine Propoxycaine is a local anesthetic medication. It was used beginning in the 1950s during dental procedures . It has been combined with procaine to accelerate its onset of action and... Pramocaine A local anesthetic and antipruritic agent found in various topical preparations. Opium A medication used to treat moderate to severe pain. Butamben Anesthesia of mucus membranes other than the eyes. Xylazine A non-opioid and clonidine analog with analgesic and muscle relaxant properties used as a tranquilizer used in veterinary medicine. Butacaine Not Annotated Detomidine Used as a large animal sedative, primarily in horses. Normethadone An opioid antitussive used to treat a cough associated with inflamed mucosa. Tanezumab Tanezumab has been investigated for the treatment of Osteoarthritis, Knee and Neuralgia, Postherpetic. Piritramide A synthetic opioid used in the treatment of severe pain. Spiradoline Spiradoline has been investigated for the basic science of Bipolar Depression. Alphaprodine Not Annotated Bamifylline A methylxanthine derivative indicated in the treatment of bronchial asthma and other conditions with bronchospasm. Ethyl chloride A local anesthetic. Nicomorphine Not Annotated Meptazinol Not Annotated Mebicar Not Annotated Phenoperidine Not Annotated Phenazocine Not Annotated Proquazone Not Annotated Quinisocaine Not Annotated Tilidine A synthetic opioid indicated in the treatment of severe pain. WIN 55212-2 WIN 55,212-2 is a chemical described as an aminoalkylindole derivative, which produces effects similar to those of cannabinoids such as tetrahydrocannabinol (THC) but has an entirely different chemical structure. It... Nabiximols In Canada, Sativex has received a Notice of Compliance (NOC) for use as an as adjunctive treatment for symptomatic relief of spasticity in patients with multiple sclerosis (MS) who have... Palmidrol A cannabinoid receptor-inactive eCB-related molecule used as prophylactic in helping to prevent respiratory viral infection. Palmidrol is available for human use as a supplement (400 mg capsules) and as food... Carfentanil, C-11 Carfentanil, C-11 is under investigation in clinical trial NCT01899170 (Towards Individualized Deep Brain Stimulation Treatment of Chronic Neuropathic Pain). Masoprocol Used for the treatment of actinic keratoses (precancerous skin growths that can become malignant if left untreated). Nicotine A stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation. Trospium An antimuscarinic agent used to treat the symptoms of overactive bladder (OAB). Midodrine An alpha-adrenergic agonist used to treat orthostatic hypotension. Bethanidine For the treatment of hypertension. Oxyphenonium For the treatment of visceral spasms Isoetharine For the treatment of asthma, wheezing, and chronic asthmatic bronchitis. Theophylline A xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction. Pimecrolimus A topical calcineurin inhibitor used in the treatment of mild-moderate atopic dermatitis who are not candidates for other types of therapy due to previous lack of response or other reasons. Chlorzoxazone A drug with muscle relaxant properties that is used as an adjunct to physical therapy and analgesics to treat stiffness and pain caused by a variety of musculoskeletal conditions. Norepinephrine A sympathomimetic used in the control of blood pressure during various hypotensive states and as an adjunct treatment during cardiac arrest. Meprobamate An anxiolytic drug used for the short-term management of anxiety symptoms. Thiethylperazine A drug used for the treatment of nausea and vomiting. Palonosetron A serotonin antagonist used in the prophylaxis or management of vomiting that results from emetogenic chemotherapy, and for the management of postoperative nausea and vomiting. Tacrine An anticholinesterase drug used for the management of Alzheimer's disease symptoms. Phenylpropanolamine A sympathomimetic that was previously used in nasal decongestants and weight loss products, but has been withdrawn by the FDA due to safety risks and lack of efficacy. Metocurine iodide For use as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy. Promazine A phenothiazine used to manage schizophrenia. Nitric Oxide A vasodilating agent used in the treatment of hypoxic respiratory failure in premature neonates. Droperidol A butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting. Methscopolamine bromide A muscarinic antagonist used to treat peptic ulcers, nausea, vomiting, and motion sickness. Quinine An alkaloid used to treat uncomplicated Plasmodium falciparum malaria. Tenoxicam An anti inflammatory analgesic used to treat mild to moderate pain as well as the signs and symptoms of rheumatoid arthritis and osteoarthritis. Dronabinol A synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy. Chlorpromazine A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. Gallamine triethiodide A nondepolarizing nerve blocker used in addition to anesthesia to cause skeletal muscle relaxation. Nabilone A synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy. Tolmetin An NSAID used to treat acute flares of various painful conditions and used for the long term management of osteoarthritis, rheumatoid arthritis, and juvenile arthritis. Levallorphan For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids. Triflupromazine Used mainly in the management of psychoses. Also used to control nausea and vomiting. Carteolol A beta adrenergic antagonist used to treat arrhythmia, angina, hypertension, and glaucoma. Rofecoxib A COX-2 inhibitor NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, primary dysmenorrhea, and migraine attacks. Piroxicam An NSAID used to treat the symptoms of osteoarthritis and rheumatoid arthritis. Cisatracurium A skeletal muscle relaxant used to facilitate tracheal intubation, muscle relaxation in surgery, or mechanical ventilation. Atropine A muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs. Fenoprofen An anti-inflammatory analgesic used to treat mild to moderate pain in addition to the signs and symptoms of rheumatoid arthritis and osteoarthritis. Valdecoxib A COX-2 inhibitor used to treat osteoarthritis and dysmenorrhoea. Sulindac An NSAID used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute subacromial bursitis or supraspinatus tendinitis, and acute gouty arthritis. Metaraminol For the treatment and prevention of hypotension due to hemorrhage, spinal anesthesia, and shock associated with brain damage Dexmedetomidine An alpha-2 agonist used for sedation during various procedures. Dyphylline A theophylline derivative used to treat asthma, bronchospasm, and COPD. Mecamylamine A nicotine antagonist used to treat moderate to severe essential hypertension and uncomplicated malignant hypertension. Metaxalone A muscle relaxant used to treat muscle pain or spasm. Trimethobenzamide An antiemetic used to treat postoperative nausea and vomiting and nausea associated with gastroenteritis. Aprepitant A substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery. Ergotamine An alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. Naltrexone A narcotic antagonist used in opioid overdose. Methoxamine An alpha adrenergic agonist used to treat hypotension. Rocuronium A vecuronium analog used to facilitate tracheal intubation and to relax skeletal muscles during surgery. Atracurium besylate A non-depolarizing neuromuscular blocker used to facilitate endotracheal intubation and relax skeletal muscles during surgery. Zileuton A leukotriene synthesis inhibitor used in the prophylaxis and treatment of chronic asthma. Etodolac An NSAID used to treat osteoarthritis and rheumatoid arthritis, as well as acute pain. Dolasetron An antinauseant and antiemetic used in chemotherapy and postoperatively. Clidinium A synthetic anticholinergic used to treat peptic ulcer disease, colicky abdominal pain, diverticulitis, and IBS. Phenylbutazone An NSAID used to treat backache and ankylosing spondylitis. Orciprenaline A beta-2 adrenergic agonist used to treat bronchospasm, asthma, and COPD. Carprofen For use as a pain reliever in the treatment of joint pain and post-surgical pain. Enprofylline Used in the management of symptoms of asthma. Also used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. Phenmetrazine Used as an anorectic in the treatment of obesity. Trifluoperazine A phenothiazine used to treat depression, anxiety, and agitation. Dobutamine A beta-1 agonist used to treat cardiac decompensation in patients with organic heart disease or from cardiac surgery. Chlorphenesin A phenol ether used to treat painful muscular conditions. Diflunisal An NSAID used to treat mild to moderate pain, inflammation, osteoarthritis, and rheumatoid arthritis. Benzphetamine A sympathomimetic used to manage exogenous obesity short term. Alprenolol For the treatment of hypertension, angina, and arrhythmia Ritodrine An adrenergic beta agonist used to treat premature labor. Granisetron A 5HT3 antagonist used to treat nausea and vomiting in cancer therapy and postoperatively. Bitolterol Used to dilate air passages in the lungs that have become narrowed as a result of disease or inflammation. It is used in the treatment of asthma and chronic obstructive... Amantadine A medication used to treat dyskinesia in Parkinson's patients receiving levodopa, as well as extrapyramidal side effects of medications. Salicylic acid An acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. Meclofenamic acid An NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. Physostigmine A cholinesterase inhibitor used to treat glaucoma and anticholinergic toxicity. Dopamine A catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. Oxaprozin An NSAID used to treat osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis. Ketoprofen An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, dysmenorrhea, mild to moderate muscle pain, postoperative pain, and postpartum pain. Balsalazide An aminosalicylate used to treat ulcerative colitis. Pentolinium Used to produce controlled hypotension during surgical procedures and in hypertensive crises. Trimethaphan For the controlled reduction of blood pressure during surgery and in the treatment of hypertensive emergencies. Ambenonium A cholinesterase inhibitor that targets both muscarinic and nicotinic receptors indicated for the treatment of myasthenia gravis. Doxacurium A nondepolarizing neuromuscular blocking agent used as an adjunct to general anesthesia to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgical procedures. Flavoxate A muscarinic antagonist and spasmolytic used for the symptomatic relief of conditions associated with lack of muscle control in the bladder, such as dysuria, urgency, and nocturia. Cilostazol An antiplatelet agent and vasodilator used for the symptomatic relief of intermittent claudication. Chlormezanone Used in the management of anxiety and in the treatment of muscle spasm. Domperidone A dopamine receptor antagonist used as a peristaltic stimulant and anti-emetic agent for dyspepsia, indigestion, epigastric pain, nausea, and vomiting. Acebutolol A selective β1-receptor antagonist used for the management of hypertension and ventricular premature beats in adults. Tubocurarine Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid. Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to... Levobunolol A beta-adrenergic antagonist used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Metipranolol A beta-adrenergic antagonist used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Dantrolene A direct-acting skeletal muscle relaxant used for the treatment of management of the fulminant hypermetabolism of skeletal muscle leading to malignant hyperthermia crisis. Aminophylline A bronchodilator consisting of theophylline that is used for the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis. Mivacurium A short-acting non-depolarizing neuromuscular blocking agent used to induce anesthesia during intubation and promote skeletal muscle relaxation during surgery or mechanical ventilation. Diphenidol An antiemetic agent used for the prevention and symptomatic treatment of nausea and vomiting associated with various conditions as Meniere's disease and surgery of the middle and inner ear. Decamethonium For use as a skeletal muscle relaxant Olsalazine An anti-inflammatory aminosalicylate used in the treatment of inflammatory bowel disease and ulcerative colitis. Arformoterol A beta-2 adrenergic agonist and bronchodilator used for long-term, symptomatic treatment of reversible bronchoconstriction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. Lumiracoxib For the acute and chronic treatment of the signs and symptoms of osteoarthritis of the knee in adults. Fenoterol A beta-2 adrenergic agonist and bronchodilator used for the symptomatic treatment of asthma. Pirbuterol A beta-2 adrenergic agonist and bronchodilator used for the symptomatic treatment of asthma. Oxtriphylline A bronchodilator used for the treatment of asthma, bronchitis, COPD, and emphysema. Metocurine Metocurine is a muscle relaxant. Pancuronium A neuromuscular blocker used as an adjunct to general anesthesia to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Pipecuronium A nondepolarizing neuromuscular blocking agent used to relax muscles during anesthesia and surgical procedures. Vecuronium A nondepolarizing neuromuscular blocking agent used to relax muscles or as an adjunct in general anesthesia during surgical procedures. Mephentermine A sympathomimetic agent used in the treatment of hypotension. Procaterol A beta-2 adrenergic receptor agonist and bronchodilator used for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Yohimbine An alpha-2-adrenergic blocker and sympatholytic found in supplements used to. Magnesium salicylate An NSAID analgesic used in the symptomatic relief of mild to moderate muscular pain. Salsalate A nonsteroidal anti-inflammatory agent used in the symptomatic relief of rheumatoid arthritis, osteoarthritis and related rheumatic disorders. Neostigmine A cholinesterase inhibitor used in the symptomatic treatment of myasthenia gravis by improving muscle tone. Methotrimeprazine A phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder. Clenbuterol A decongestant and bronchodilator used in a variety of respiratory conditions. Bambuterol A long acting beta2-adrenoceptor agonist for the management of lung diseases associated with bronchospasm. Theobromine theobromine is used as a vasodilator, a diuretic, and heart stimulant. And similar to caffeine, it may be useful in management of fatigue and orthostatic hypotension. Alizapride A dopamine antagonist used to prevent nausea and vomiting associated with medical procedures, surgeries, and cancer therapies. Antipyrine An antipyretic agent used for the symptomatic treatment of acute otitis media, most commonly in combination with benzocaine. Diprenorphine Diprenorphine is indicated to reverse the effects of powerful opioids including etorphine and carfentanil, often used for tranquilizing large animals. This drug is not approved for use in humans. Chlorphentermine Used as an appetite suppressant. Fludiazepam Used for the short-term treatment of anxiety disorders. Metamfetamine A sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity. Oxprenolol A non-selective beta-adrenergic antagonist used to treat hypertension, angina pectoris, arrhythmias, and anxiety. Tiaprofenic acid A nonsteroidal anti-inflammatory (NSAID) used to manage inflammation and analgesia associated with rheumatoid arthritis and osteoarthritis. Alverine A smooth muscle relaxant used to relieve abdominal pain associated with gastrointestinal conditions like heartburn, flatulence, and Irritable Bowel Syndrome. Etoricoxib A selective COX-2 inhibitor used to relieve moderate post-surgical dental pain as a short-term treatment and inflammatory and painful symptoms of various forms of arthritis. Castanospermine Not Available Alrestatin Not Available Taxifolin Not Available Colforsin Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant Coleus forskohlii. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities;... Domoic Acid Not Available Zardaverine Not Available Oxyphenbutazone A nonsteroidal anti-inflammatory drug (NSAID) no longer commonly used for the symptomatic relief of musculoskeletal pain. Phenacetin Used principally as an analgesic. Niflumic acid A cyclooxygenase-2 inhibitor used to alleviate inflammation, pain, and edema associated with acute and chronic inflammatory conditions, such as rheumatoid arthritis, osteoarthritis, post-operative inflammatory conditions, and physical trauma. Nimesulide A cyclooxygenase 2 inhibitor used to treat acute pain and primary dysmenorrhea. Benoxaprofen The use of benoxaprofen, formerly marketed as Oraflex tablets, was associated with fatal cholestatic jaundice among other serious adverse reactions. The holder of the approved application voluntarily withdrew Oraflex tablets... Metamizole An antipyretic and analgesic drug used to relieve severe and persistent fever and pain. Zomepirac Zomepirac was indicated for the management of mild to severe pain. Rapacuronium A nondepolarizing neuromuscular blocking agent used as an adjunct to general anesthesia to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgical procedures. Debrisoquine For the treatment of moderate and severe hypertension, either alone or as an adjunct, and for the treatment of renal hypertension. Celiprolol A beta-blocker for the management of hypertension and angina pectoris. Olcegepant For the treatment of migraine headaches. Milnacipran A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of fibromyalgia and a short-term treatment of major depressive disorder. Lofexidine A centrally acting alpha2-adrenergic agonist used for the symptomatic treatment of acute opioid withdrawal syndrome to facilitate abrupt opioid discontinuation in adults. Ularitide Investigated for use/treatment in congestive heart failure. Lobeline Investigated for use/treatment in addictions. Ibudilast For the treatment of multiple sclerosis, asthma, and cerebrovascular disease. Samarium (153Sm) lexidronam A chelated complex of samarium isotope and EDTMP that concentrates in areas with high bone turnover such as sites of metastases to relieve pain associated with osteoblastic metastatic bone lesions. Andrographolide Investigated for use/treatment in ulcerative colitis. Nylidrin A vasodilator used to treat patients with peripheral vascular disorders, and elderly patients with symptoms associated with organic mental disorders. Pizotifen A serotonin and tryptamine antagonist indicated for migraine prophylaxis. Icatibant A bradykinin B2 receptor antagonist used to treat acute episodes of swelling and inflammation associated with hereditary angioedema (HAE). Nalmefene An opioid antagonist used to reduce alcohol consumption in adults with alcohol dependence and treat and prevent opioid overdose. Exisulind Investigated for use/treatment in adenomatous polyposis coli, lung cancer, prostate cancer, colon polyps, Barrett's esophagus disease, and pediatric indications. Tolperisone A muscle relaxant used to relieve spasticity after stroke in adults. Dexanabinol Investigated for use/treatment in traumatic brain injuries and neurologic disorders. Casopitant Investigated for use/treatment in urinary incontinence and adverse effects (chemotherapy). Nitrous oxide An inhalatory gas used as an adjunct to improve oxygenation and reduce the need for extracorporeal membrane oxygenation in certain neonates with hypoxic respiratory failure. Fosaprepitant An antiemetic drug used in combination with other antiemetic agents for the prevention of acute and delayed nausea and vomiting caused by chemotherapy. Lornoxicam An NSAID indicated in the treatment of mild to moderate pain, as well as rheumatoid arthritis and osteoarthritis. Aceclofenac Aceclofenac is indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Zaltoprofen A non-steroidal anti-inflammatory drug approved for use in Japan in 1993. Seratrodast Seratrodast (INN) is a thromboxane receptor antagonist used primarily in the treatment of asthma. Cupric sulfate A compound used as an intravenous copper supplement for Total Parenteral Nutrition (TPN). Methylnaltrexone A μ-opioid antagonist used for the treatment of opioid-induced constipation in palliative patients that are inadequately responding to laxative therapy. Azapropazone Not Available Felbinac Not Available Tranilast For the treatment of bronchial asthma, keloid and hypertrophic scar, and allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. Epibatidine Not Available Ferulic acid Not Available Parecoxib A selective COX-2 inhibitor and NSAID used for the short-term management of perioperative pain. Y-27632 Y-27632 is an inhibitor of Rho-associated protein kinase. It inhibits calcium sensitization to affect smooth muscle relaxation. Salicylamide Salicylamide is the common name for the substance o-hydroxybenzamide, or amide of salicyl. Salicylamide is a non-prescription drug with analgesic and antipyretic properties. It has similar medicinal uses to aspirin.... Tyramine Tyramine (4-hydroxyphenethylamine; para-tyramine, mydrial or uteramin) is a naturally occurring monoamine compound and trace amine derived from the amino acid tyrosine. Tyramine acts by inducing the release of catecholamine. An... Teriflunomide A pyrimidine synthesis inhibitor with anti-inflammatory and immunomodulatory properties used to treat patients with the relapsing-remitting form of multiple sclerosis. Arbaclofen Placarbil Investigated for the treatment of spasticity in multiple sclerosis, acute back spasms, and GERD. Kebuzone Kebuzone (also known as ketophenylbutazone ) is a non-steroidal anti-inflammatory drug. Isoxsuprine A beta-adrenergic agonist used in the symptomatic treatment of cerebrovascular insufficiency, peripheral vascular disease of arteriosclerosis obliterans, thromboangiitis obliterans (Buerger's disease) and Raynaud's disease. Isoxicam Isoxicam is a non-steroidal anti-inflammatory drug that is not marketed in the United States. Indoprofen A drug that has analgesic and anti-inflammatory properties. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market worldwide. Ibuproxam Ibuproxam is a non steroidal anti-inflammatory drug (NSAID). Hexoprenaline Hexoprenaline is a stimulant of beta 2 adrenergic receptors. It is used as a bronchodilator, antiasthmatic, and tocolytic agent. Hexamethonium A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been... Glafenine An anthranilic acid derivative with analgesic properties used for the relief of all types of pain. Glafenine is withdrawn from the American market. Floctafenine An anti-inflammatory analgesic used to manage mild to moderate acute pain. Fenspiride An oxazolidinone spiro compound with antispasmodic and bronchodilator effects used in the treatment of ENT and respiratory diseases. Fenbufen Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. Fenbufen is... Etofenamate An NSAID used to treat muscle and joint pain. Etilefrine An adrenergic agonist primarily of α1 and β1 receptors used as an anti-hypotensive. Epirizole Epirizole is an oral nonsteroidal anti-inflammatory drug (NSAID) used for muscle and joint pain. Eperisone An antispasmodic that functions through voltage-gated channel blockade, notably with little to no sedation, effective in relaxing skeletal muscles and vascular smooth muscles. Dexetimide A muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Benzetimide is the (-)-enantimorph of dexetimide. Bromopride A substituted benzamide, closely related to metoclopramide, used as an antiemetic. Benactyzine Benactyzine is an anticholinergic drug used as an antidepressant in the treatment of depression and associated anxiety. Benactyzine is no longer widely used in medicine, although it is still a... Naloxegol A peripherally-selective opioid antagonist used to treat opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain. Olodaterol A long-acting beta2-adrenergic agonist used in the management of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema. Trimebutine A spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery. Pinaverium A spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and functional disorders of the biliary tract. Synephrine Synephrine, also referred to as, p-synephrine, is naturally occurring alkaloid. It is present in approved drug products as neo-synephrine, its m-substituted analog. p-synephrine and m-synephrine are known for their longer... Moxisylyte By the WHO, moxisylyte is indicated for the symptomatic management of sequelae of cerebral infarction or hemorrhage. The cerebral infarction is characterized by the blockage of the artery either by... Loxoprofen An NSAID used to treat pain and inflammation in musculoskeletal conditions. Droxicam Droxicam is an NSAID previously used for the treatment of inflammation and rheumatoid arthritis . Clonixin An NSAID used to relieve pain associated with arthritis, migraines, and various soft tissue disorders. Cimetropium Cimetropium is a semi-synthetic belladonna alkaloid and derivative of scopolamine. It is a potent antimuscarinic and an effective antispasmodic drug. It is also endowed of a direct myolitic action which... Doxofylline A methylxanthine derivative used in chronic obstructive pulmonary disease, asthma, and bronchospasms. Ramosetron A selective 5-HT3 antagonist used as an antiemetic for chemotherapy- and postoperative-associated nausea and vomiting. It may also possess efficacy in irritable bowel syndrome. Butylscopolamine An antispasmodic and anticholinergic agent used for the symptomatic treatment of abdominal cramping and pain. Hydroxyamphetamine An indirectly acting sympathomimetic agent producing mydriasis for diagnostic purposes. Racepinephrine A bronchodilator used to treat intermittent asthma. Pyrantel An anthelmintic used to treat helminth infections. Peppermint oil An ingredient used in a variety of natural health products and is not an approved medication. Methscopolamine Methscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The... Evening primrose oil Evening primrose oil is used as part of over-the-counter dietary supplements. It is also used for the treatment of systemic inflammatory diseases and for women's health conditions such as cyclical... Maropitant Maropitant, used as maropitant citrate, is a neurokinin receptor antagonist, which was developed by Zoetis specifically for the treatment of motion sickness and vomiting in dogs. It was approved by... Medetomidine Medetomidine is a synthetic compound used as a surgical anesthetic and analgesic. It is normally found as its hydrochloride salt, medetomidine hydrochloride. Medetomidine is an intravenously available alpha-2 adrenergic agonist.... Orgotein Superoxide is a natural byproduct of oxygen metabolism which, if left unchecked, leads to cell damage. Superoxide dismutase (SOD) is an enzyme that alternately catalyzes the dismutation of the superoxide... Tepoxalin Tepoxalin is a nonsteroidal anti-inflammatory drug approved for veterinary use in the United States and many other countries. It is primarily used to reduce inflammation and relief of pain caused... Nalorphine Used to reverse opioid overdose. Amifampridine A voltage gated potassium channel blocker used to treat Lambert-Eaton myasthenic syndrome. Curcumin No approved therapeutic indications. Tropisetron A 5HT-3 receptor antagonist used as an antiemetic in the treatment of chemotherapy-induced nausea and vomiting. Rilmenidine An I1-imidazoline receptor agonist used to treat hypertension. Anisodamine Anisodamine has been investigated for the treatment of Intestinal Diseases. Oxitropium Oxitropium has been investigated for the treatment of Pulmonary Disease, Chronic Obstructive. Tetrahydropalmatine Tetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity). Semapimod Semapimod has been used in trials studying the treatment of Crohn Disease. Fasinumab A monoclonal antibody targeting nerve growth factor which is under investigation for the treatment of chronic cancer and non-cancer pain. Bucillamine Bucillamine has been used in trials studying the treatment and prevention of Gout and Rheumatoid Arthritis. Tulobuterol An inhaled long-acting beta2-adrenergic receptor agonist used as a bronchodilator in the management of asthma and COPD. Moxaverine Moxaverine has been investigated for the treatment of Retina, Ocular Physiology, and Regional Blood Flow. Propiverine An antimuscarinic agent used to treat urinary incontinence or increased urinary frequency or urgency. Nefopam A non-opioid analgesic used for moderate to severe pain, especially post-surgical pain. Aticaprant Aticaprant has been used in trials studying the health services research and basic science of Anxiety Disorders and Alcohol Dependence. Lisofylline Lisofylline has been investigated for the treatment of Type 1 Diabetes Mellitus. Vofopitant Vofopitant has been used in trials studying the treatment of PTSD, Primary Insomnia, and Sleep Initiation and Maintenance Disorders. Nitroaspirin Nitroaspirin has been investigated for the treatment of Intermittent Claudication. Betulinic Acid Betulinic Acid has been used in trials studying the treatment of Dysplastic Nevus Syndrome. Nepadutant Nepadutant has been used in trials studying the treatment of Colic, Infantile Colic, and Infantile Functional Gastrointestinal Disorders. Indobufen A reversible platelet aggregation inhibitor used to prevent coronary and peripheral artery occlusion. Mebeverine An antispasmodic used for the symptomatic treatment of stomach pain and spasms associated with irritable bowel syndrome and other gastrointestinal illnesses. Nafamostat Used as an anticoagulant in patients with disseminative blood vessel coagulation, hemorrhagic lesions, and hemorrhagic tendencies. It prevents blood clot formation during extracorporeal circulation in patients undergoing continuous renal replacement... Ebselen Ebselen has been investigated for the treatment and basic science of Meniere's Disease, Type 2 Diabetes Mellitus, and Type 1 Diabetes Mellitus. Mizoribine Mizoribine has been investigated for the treatment of Rheumatoid Arthritis. Apocynin Acetovanillone has been used in trials studying the treatment of Bronchial Asthma and Chronic Obstructive Pulmonary Disease. Bucindolol Bucindolol has been investigated in Heart Failure. Higenamine Higenamine is under investigation in clinical trial NCT01451229 (Pharmacokinetics and Pharmacodynamics of Higenamine in Chinese Healthy Subjects). Reproterol A short-acting β2 adrenoreceptor agonist used to treat various types of asthma including allergic asthma, non-allergic asthma, and exercise-induced asthma. Neosaxitoxin Neosaxitoxin is under investigation in clinical trial NCT01786655 (Safety Study of Long-Acting Local Anesthetic). Tinoridine Tinoridine is under investigation in clinical trial NCT01224756 (Efficacy of Tinoridine in Treating Pain and Inflammation in Adults). Fenoverine A phenothiazine based anti-spasmodic agent indicated in the treatment of irritable bowel syndrome. Parthenolide Parthenolide has been used in trials studying the diagnostic of Allergic Contact Dermatitis. Tramazoline A sympathomimetic indicated for nasal decongestion. Tiropramide A medication indicated in the treatment of spastic pain of the gastrointestinal system. Serrapeptase A protease indicated in the treatment of post-surgical inflammation. Alclofenac Alclofenac is indicated in rheumatology, in particular for the treatment of rheumatoid arthritis, ankylosing spondylitis and, as an analgesic, in painful arthritic pathologies. Fentiazac Not Annotated Tribenoside An anti-inflammatory agent that reduces vascular permeability and causes vasoconstriction to treat internal and external hemorrhoids. Suxibuzone Not Annotated Bumadizone Bumadizone has been approved for use in Germany and Austria, it is a drug with anti-inflammatory, antipyretic, and analgesic properties, and was marketed for the treatment of both rheumatoid arthritis... Ipecac An emetic agent used to induce vomiting in poisoning. Atracurium A neuromuscular blocker indicated to relax muscles during mechanical ventilation under general anesthesia or intubation. Alminoprofen Alminoprofen is a non-steroidal anti-inflammatory drug (NSAID) whose physiochemical characteristics make it a member of the phenylpropionic acid class of chemical substances. Ibopamine A sympathomimetic, indicated in the induction of mydriasis and treatment of pos-surgical ocular hypotonia. Flunoxaprofen Not Annotated Tetrazepam Not Annotated Fenozolone Not Annotated Bufexamac An NSAID used to treat skin conditions like atopic eczema and inflammatory dermatoses. Feprazone Not Annotated Difenpiramide Not Annotated Chlorproethazine Not Annotated Emetine Not Annotated Nifenazone Not Annotated Lonazolac Not Annotated Medazepam A long-acting benzodiazepine used for its sedative and anxiolytic properties. Proxyphylline Not Annotated Tenidap Not Annotated Otilonium A spasmolytic medication used to treat irritable bowel syndrome (IBS). Bendazac A non-steroidal anti-inflammatory drug (NSAID) available as an eye drop for the treatment of cataracts and as a topical cream for the treatment of dermatitis, eczema, hives, skin ulcers and other inflammatory skin conditions. Emepronium Not Annotated Clebopride A dopamine antagonist used to treat symptoms associated with functional gastrointestinal disorders. Clebopride may also be used to treat nausea and vomiting associated with chemotherapy. Pranoprofen A topical anti-inflammatory agent used for the treatment of non-infectious inflammatory conditions such as blepharitis and conjunctivitis. Pranoprofen ophthalmic solution may also be used post-operatively to manage inflammation. Propyphenazone Not Annotated Proglumetacin A non-steroidal anti-inflammatory medication used to manage pain associated with various inflammatory conditions including rheumatoid arthritis and osteoarthritis. Guacetisal Not Annotated Bevonium Not Annotated Ethenzamide Not Annotated Rociverine An antispasmodic indicated in the treatment of urinary, gastrointestinal, and biliary tract spasms. Mephenesin A cresol glyceryl ether used to treat muscle spasticity in Parkinson's and Multiple Sclerosis. Gallamine Not Annotated Metopimazine Not Annotated Etamiphylline Not Annotated Carbaspirin calcium An NSAID indicated in the treatment of short term pain and fever. Mofebutazone Not Annotated Alcuronium A non-depolarizing skeletal muscle relaxant similar to tubocurarine. It is used as an anesthesia adjuvant. Benorilate Not Annotated Tretoquinol Not Annotated Hydroquinine Not Annotated Diphemanil Used in the treatment of peptic ulcer, gastric hyperacidity, and hypermotility in gastritis and pylorospasm, and in the treatment of hyperhidrosis (excessive perspiration). Pirprofen Not Annotated Terodiline Not Annotated Camylofin Not Annotated Epanolol Epanolol is an beta blocker. Prenalterol Not Annotated Acemetacin A NSAID indicated in the treatment of pain and inflammation. Dixyrazine Not Annotated Bufylline Not Annotated Methylatropine Not Annotated Mefenorex Not Annotated Imidazole salicylate Not Annotated Thiosalicylic acid Not Annotated Erenumab A calcitonin-gene related peptide antagonist used to prevent migraines. SC-236 SC-236 is a potent, selective, orally active inhibitor of cyclooxygenase-2 (COX-2) that has been studied in cancer therapy , lower back pain , and inflammation , , , . NS-398 NS-398 is a COX-2 inhibitor. It was developed as part of the mechanistic study of the cyclooxygenases. Human interleukin-2 Human interleukin-2 is under investigation in clinical trial NCT03475134 (TIL-ACT After NMA Chemo With IL-2 and Nivo Rescue in mMEL). Flurbiprofen axetil Flurbiprofen axetil is under investigation in clinical trial NCT02043366 (Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Hyperalgesia Induced by Remifentanil in Patients). Dextromethadone Dextromethadone is under investigation in clinical trial NCT00588640 (Study of D-Methadone in Patients With Chronic Pain). Hydroquinidine A medication indicated in the maintenance of a normal sinus rhythm, as well as the treatment and prevention of abnormal rhythm. Xanomeline Xanomeline is under investigation in clinical trial NCT02831231 (Pilot Study Comparing Effects of Xanomeline Alone to Xanomeline Plus Trospium). Teceleukin Teceleukin is under investigation in clinical trial NCT03610490 (Autologous Tumor Infiltrating Lymphocytes MDA-TIL in Treating Patients With Recurrent or Refractory Ovarian Cancer, Osteosarcoma, or Pancreatic Ductal Adenocarcinoma). Ursolic acid Not Annotated Sodium metabisulfite An ingredient used in products to treat dehydration and replace electrolytes. Fepradinol Not Annotated Peoniflorin Peoniflorin is under investigation in clinical trial NCT02878863 (Paeoniflorin Combination of Hepatoprotective Drugs Versus Hepatoprotective Drugs Only for Auto-immune Hepatitis). Veliflapon Veliflapon is under investigation in clinical trial NCT00353067 (Veliflapon (Dg-031)to Prevent Heart Attacks or Stroke in Patients With a History of Heart Attack or Unstable Angina). CP-96345 Not Annotated Cepharanthine Not Annotated Azasetron Not Annotated Caryophyllene Not Annotated Rosmarinic acid Not Annotated Tanshinone I Not Annotated Botulinum toxin type F Not Annotated SC 41930 Not Annotated Deracoxib Deracoxib is a non-steroidal anti-inflammatory drug of the coxib class, used in veterinary medicine to treat osteoarthritis in dogs. It is sold in tablets, which have added beefy flavour to... S-Nitrosoglutathione Not Annotated Senlizumab Not Annotated Berbamine Not Annotated Denatonium Not Available - Drugs & Drug Targets