Hypothalamic Hormones

Hypothalamic Hormones
Accession Number

Peptide hormones produced by NEURONS of various regions in the HYPOTHALAMUS. They are released into the pituitary portal circulation to stimulate or inhibit PITUITARY GLAND functions. VASOPRESSIN and OXYTOCIN, though produced in the hypothalamus, are not included here for they are transported down the AXONS to the POSTERIOR LOBE OF PITUITARY before being released into the portal circulation.

ATC Classification
DrugDrug Description
GonadorelinA synthetic GnRH used to test the function of gonadotropes and the pituitary.
NafarelinA gonadotropin releasing hormone agonist used to treat central precocious puberty.
SomatostatinA natural peptide hormone used to treat acute bleeding from esophageal varices, gastrointestinal ulcers, and gastritis; prevent pancreatic complications after surgery; and restrict secretions of the upper intestine, pancreas, and biliary tract.
CetrorelixA synthetic peptide antagonist of gonadotropin releasing hormone used to prevent luteinizing hormone surges in women undergoing assisted reproduction therapy.
VapreotideFor the treatment of esophageal variceal bleeding in patients with cirrhotic liver disease and has also shown efficacy in the treatment of patients with AIDS-related diarrhea.
PasireotideA somatostatin analog used in the treatment of Cushing’s disease, specifically for those patients whom pituitary surgery is not appropriate.
GanirelixA GnRH antagonist used in assisted reproduction in women undergoing controlled ovarian hyperstimulation to control ovulation by inhibiting the premature LH surges.
LanreotideA somatostatin analog used for the treatment of unresectable, well- or moderately-differentiated, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumors and acromegaly.
LeuprolideA peptide-based GnRH receptor superagonist used for the palliative treatment of prostate cancer, uterine leiomyomata, endometriosis, and central precocious puberty.
SermorelinFor the treatment of dwarfism, prevention of HIV-induced weight loss
GoserelinA synthetic analog of luteinizing hormone-releasing hormone used to treat breast cancer and prostate cancer by reducing secretion of gonadotropins from the pituitary.
CorticorelinA synthetic corticotropin-releasing factor analog used to diagnose causes of excessive adrenocorticotropic hormone (ACTH) production.
BuserelinA LHRH agonist used for the palliative treatment of hormone-dependent advanced carcinoma of the prostate gland in males and treatment of endometriosis in females.
HistrelinA GnRH agonist found in subcutaneous implants used for the treatment of pediatric patients with central precocious puberty and the palliative treatment of advanced prostate cancer.
TriptorelinA GnRH agonist indicated for the palliative treatment of advanced prostate cancer.
TesamorelinA growth hormone releasing factor (GRF) analog used to reduce excessive abdominal fat in HIV patients who have developed lipodystrophy.
Corticorelin ovine triflutateA synthetic corticotropin-releasing hormone used for diagnostic purposes in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome.
ProtirelinA synthetic analogue of thyrotropin-releasing hormone that has been used during diagnostic tests to evaluate function of the thyroid gland.
DeslorelinDeslorelin acetate is an injectable gonadotropin releasing hormone super-agonist also known as an LHRH agonist. It stops the production of sex hormones.
TT-232Tln 232 is under investigation in clinical trial NCT00422786 (Phase II Study of CAP-232 in Patients With Refractory Metastatic Renal Cell Carcinoma).
PentetreotideA somatostatin receptor inhibitor, available in a kit with Indium-111, used as a contrast agent in the visualization of somatostatin receptor-positive neuroendocrine tumours.
Zoptarelin doxorubicinZoptarelin doxorubicin has been used in trials studying the treatment of Breast Cancer, Ovarian Cancer, Prostate Cancer, Endometrial Cancer, and Urothelial Carcinoma, among others.
VeldoreotideSomatoprim is under investigation for the treatment of Acromegaly.
AlsactideNot Annotated
OctreotideA peptide drug used to treat acromegaly as well as diarrhea associated with metastatic carcinoid tumors and vasoactive intestinal peptide secreting tumors.
BremelanotideBremelanotide is indicated to treat premenopausal women with hypoactive sexual desire disorder that is not due to a medical or psychiatric condition, problems with the relationship, or the effects of...
SetmelanotideSetmelanotide is indicated to treat obesity caused by genetic POMC, PCSK1, or LEPR deficiencies or Bardet-Biedl syndrome.
ElagolixA gonadotropin releasing hormone receptor antagonist used to treat moderate to severe pain in endometriosis.
Indium In-111 pentetreotideIndium In 111 pentetreotide (Octreoscan) has been used in trials studying the diagnostic of SARCOIDOSIS, Solid Tumors, and cushing syndrome.
DopastatinDopastatin is under investigation in clinical trial NCT04335357 (TBR-760 in Adult Patients With Non-functioning Pituitary Adenomas).
NorethisteroneA synthetic second-generation progestin used for contraception, prevention of endometrial hyperplasia in hormone replacement therapy, and in the treatment of other hormone-mediated illnesses such as endometriosis.
EstradiolAn estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate.
RelugolixAn oral GnRH receptor antagonist for androgen deprivation therapy in the treatment of advanced prostate cancer.
LinzagolixA selective gonadotropin-releasing hormone (GnRH) receptor antagonist used for the symptomatic treatment of uterine fibroids.
IntermedineNot Annotated
SomatorelinA synthetic version of growth hormone-releasing hormone used in the diagnosis of growth hormone deficiency.
AP-102Not Annotated
Drugs & Drug Targets
GonadorelinGonadotropin-releasing hormone receptortarget
GonadorelinPutative gonadotropin-releasing hormone II receptortarget
NafarelinGonadotropin-releasing hormone receptortarget
NafarelinPutative gonadotropin-releasing hormone II receptortarget
SomatostatinSomatostatin receptor type 1target
SomatostatinSomatostatin receptor type 2target
SomatostatinSomatostatin receptor type 3target
SomatostatinSomatostatin receptor type 4target
SomatostatinSomatostatin receptor type 5target
SomatostatinP-glycoprotein 1transporter
SomatostatinCytochrome P450 3A4enzyme
CetrorelixLutropin-choriogonadotropic hormone receptortarget
CetrorelixGonadotropin-releasing hormone receptortarget
VapreotideNeurokinin 1 receptortarget
VapreotideSomatostatin receptor type 2target
VapreotideSomatostatin receptor type 5target
VapreotideCytochrome P450 3A4enzyme
PasireotideSomatostatin receptor type 1target
PasireotideSomatostatin receptor type 2target
PasireotideSomatostatin receptor type 3target
PasireotideSomatostatin receptor type 5target
PasireotideCytochrome P450 3A4enzyme
GanirelixGonadotropin-releasing hormone receptortarget
LanreotideSomatostatin receptor type 2target
LanreotideSomatostatin receptor type 5target
LanreotideCytochrome P450 3A4enzyme
LeuprolideGonadotropin-releasing hormone receptortarget
SermorelinGrowth hormone-releasing hormone receptortarget
GoserelinLutropin-choriogonadotropic hormone receptortarget
GoserelinGonadotropin-releasing hormone receptortarget
CorticorelinDopamine beta-hydroxylaseenzyme
BuserelinLutropin-choriogonadotropic hormone receptortarget
BuserelinGonadotropin-releasing hormone receptortarget
BuserelinCytochrome P450 19A1enzyme
HistrelinGonadotropin-releasing hormone receptortarget
TriptorelinGonadotropin-releasing hormone receptortarget
TesamorelinGrowth hormone-releasing hormone receptortarget
Corticorelin ovine triflutateCorticotropin-releasing factor receptor 1target
ProtirelinThyrotropin Releasing Hormone Receptortarget
OctreotideCytochrome P450 3A4enzyme
OctreotideSomatostatin receptortarget
OctreotideSerum albumincarrier
OctreotideP-glycoprotein 1transporter
OctreotideCanalicular multispecific organic anion transporter 1transporter
BremelanotideMelanocyte-stimulating hormone receptortarget
BremelanotideMelanocortin receptor 4target
BremelanotideMelanocortin receptor 3target
BremelanotideMelanocortin receptor 5target
BremelanotideAdrenocorticotropic hormone receptortarget
SetmelanotideMelanocortin receptor 4target
ElagolixGonadotropin-releasing hormone receptortarget
ElagolixCytochrome P450 3A Subfamilyenzyme
ElagolixCytochrome P450 2D6enzyme
ElagolixCytochrome P450 2C8enzyme
ElagolixP-glycoprotein 1transporter
ElagolixSolute carrier organic anion transporter family member 1B1transporter
NorethisteroneProgesterone receptortarget
NorethisteroneP-glycoprotein 1transporter
NorethisteroneCytochrome P450 2C19enzyme
NorethisteroneSerum albumincarrier
NorethisteroneSex hormone-binding globulincarrier
NorethisteroneAldo-keto reductase family 1 member C4enzyme
Norethisterone3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
Norethisterone3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
Norethisterone3-oxo-5-beta-steroid 4-dehydrogenaseenzyme
NorethisteroneCytochrome P450 3A4enzyme
NorethisteroneCytochrome P450 1A2enzyme
NorethisteroneCytochrome P450 2A6enzyme
NorethisteroneGlucocorticoid receptortarget
NorethisteroneAndrogen receptortarget
EstradiolEstrogen receptor alphatarget
EstradiolNuclear receptor subfamily 1 group I member 2target
EstradiolSex hormone-binding globulincarrier
EstradiolEstrogen receptor betatarget
EstradiolCytochrome P450 1A2enzyme
EstradiolUDP-glucuronosyltransferase 1-1enzyme
EstradiolSerum albumincarrier
EstradiolFatty acid-binding protein, intestinalcarrier
EstradiolCytochrome P450 3A4enzyme
EstradiolCytochrome P450 3A5enzyme
EstradiolCytochrome P450 3A7enzyme
EstradiolSolute carrier family 22 member 2transporter
EstradiolSolute carrier family 22 member 3transporter
EstradiolMultidrug resistance-associated protein 7transporter
EstradiolSolute carrier family 22 member 11transporter
EstradiolATP-binding cassette sub-family G member 2transporter
EstradiolSolute carrier organic anion transporter family member 1B1transporter
EstradiolP-glycoprotein 1transporter
EstradiolCytochrome P450 1A1enzyme
EstradiolCytochrome P450 1B1enzyme
EstradiolCytochrome P450 2C19enzyme
EstradiolCytochrome P450 2C8enzyme
EstradiolCytochrome P450 2C9enzyme
EstradiolSolute carrier family 22 member 8transporter
EstradiolSolute carrier organic anion transporter family member 1B3transporter
EstradiolSolute carrier organic anion transporter family member 1C1transporter
EstradiolNeuronal acetylcholine receptor subunit alpha-4target
EstradiolG-protein coupled estrogen receptor 1target
EstradiolATP synthase subunit atarget
EstradiolUDP-glucuronosyltransferase 2B15enzyme
EstradiolCatechol O-methyltransferaseenzyme
EstradiolUDP-glucuronosyltransferases (UGTs)enzyme
EstradiolCytochrome P450 19A1enzyme
RelugolixSerum albumincarrier
RelugolixAlpha-1-acid glycoprotein 1carrier
RelugolixP-glycoprotein 1transporter
RelugolixATP-binding cassette sub-family G member 2transporter
RelugolixCytochrome P450 3A Subfamilyenzyme
RelugolixCytochrome P450 2C8enzyme
RelugolixCytochrome P450 2B6enzyme
RelugolixGonadotropin-releasing hormone receptortarget
LinzagolixCytochrome P450 2C8enzyme
LinzagolixGonadotropin-releasing hormone receptortarget
LinzagolixSerum albumincarrier
LinzagolixCytochrome P450 2C9enzyme
LinzagolixCytochrome P450 3A4enzyme
LinzagolixSolute carrier organic anion transporter family member 1B1transporter
LinzagolixSolute carrier organic anion transporter family member 1B3transporter
LinzagolixSolute carrier family 22 member 8transporter
LinzagolixATP-binding cassette sub-family G member 2transporter
LinzagolixSolute carrier family 22 member 6transporter