Toxins, Biological
- Name
- Toxins, Biological
- Accession Number
- DBCAT000185
- Description
Specific, characterizable, poisonous chemicals, often PROTEINS, with specific biological properties, including immunogenicity, produced by microbes, higher plants (PLANTS, TOXIC), or ANIMALS.
- Drugs
Drug Drug Description Botulinum toxin type B A purified form of botulinum toxin type B used to block acetylcholine release in the treatment of cervical dystonia and sialorrhea. Botulinum toxin type A A purified form of botulinum toxin type A used to block acetylcholine release in the treatment of chronic sialorrhea, muscle spasticity, and dystonia, as well as in cosmetic applications. Exenatide A GLP-1 agonist used in the management of type 2 diabetes mellitus. Ziconotide An N-type calcium channel antagonist used to manage patients with severe chronic pain who cannot tolerate, or who have not responded adequately to other treatments such as intrathecal morphine and systemic analgesics. Ancrod An anticoagulant purified from the venom of the Malayan pit viper that functions by inactivating circulating plasma fibrinogen. Not currently approved for use or marketed in any country. Serotonin For temporary relief of nervousness, anxiety, mood swings, joint pains, weakness, drowsiness, itching and lethargy. Not evaluated by the FDA, homeopathic product. Cenderitide Cenderitide is under investigation for the treatment of ST Elevation (STEMI) Myocardial Infarction of Anterior Wall. Cilengitide Cilengitide has been used in trials studying the treatment of Sarcoma, Gliomas, Lymphoma, Leukemia, and Lung Cancer, among others. Anfibatide Anfibatide is under investigation in clinical trial NCT01585259 (Anfibatide Phase Ib-IIa Clinical Trial). Denileukin diftitox A recombinant cytotoxic protein based on a combination of diphtheria toxin fragments and interleukin-2 used to treat cutaneous T-cell lymphoma by targeting the interleukin-2 receptor. Bufotenine A hallucinogenic serotonin analog found in frog or toad skins, mushrooms, higher plants, and mammals, especially in the brains, plasma, and urine of schizophrenics. Bufotenin has been used as a... Calyculin A Not Available Eritoran Investigated for use/treatment in sepsis and septicemia. Topsalysin Investigated for use/treatment in benign prostatic hyperplasia, cancer/tumors (unspecified), prostate cancer, prostate disorders, and solid tumors. Tetrodotoxin For the treatment of chronic and breakthrough pain in advanced cancer patients as well as for the treatment of opioid dependence. Cintredekin besudotox Investigated for use/treatment in brain cancer. Chlorotoxin I-131 Investigated for use/treatment in various forms of brain cancer; Malignant Glioma, Glioblastoma Multiforme, GBM, Anaplastic Astrocytoma, Oligo-Astrocytoma, Gliosarcoma Praconase Investigated for use/treatment in spinal cord injuries. alpha-Conotoxin VC 1.1 Investigated for use/treatment in pain (acute or chronic). E5531 Investigated for use/treatment in sepsis and septicemia. Hypothemycin Not Available Batroxobin No approved indications. Batroxobin is a defibrongenating agent which has been observed to reduce fibrinogen levels and thus reduce clot risk when used intravenously. Bordetella pertussis pertactin antigen Bordetella pertussis pertactin antigen is a vaccine for the prophylaxis of whooping cough that contains pertactin, a membrane-associated antigen of Bordetella pertussis . Recombinant Cholera Toxin B Subunit Recombinant Cholera Toxin B Subunit is an ingredient in the EMA-authorised product Dukoral. Bombesin Bombesin is under investigation in clinical trial NCT01205321 (PET/CT Imaging for Radiation Dosimetry, Plasma Pharmacokinetics, Biodistribution, Safety and Tolerability and Diagnostic Performance of BAY86-7548 in Patients With Prostate Cancer and... Muscimol Muscimol has been used in trials studying the treatment of Epilepsy and Parkinson's Disease. Naptumomab estafenatox Naptumomab Estafenatox has been used in trials studying the treatment of Pancreatic Cancer, Renal Cell Carcinoma, and Non-Small-Cell Lung Carcinoma. Neosaxitoxin Neosaxitoxin is under investigation in clinical trial NCT01786655 (Safety Study of Long-Acting Local Anesthetic). Chlorotoxin Chlorotoxin is under investigation in clinical trial NCT00733798 (A Safety and Efficacy Study of Intravenous 131I-TM601 in Adult Patients With Malignant Melanoma). Tozuleristide Tozuleristide is under investigation in clinical trial NCT02464332 (Safety Study of BLZ-100 in Adult Subjects With Sarcoma Undergoing Surgery). Patulin Not Annotated Cytochalasin B Not Annotated Botulinum toxin type F Not Annotated SOT-107 Investigated for use/treatment in brain cancer. Bizaxofusp Not Annotated Picrotoxin Used internally for relieving respiratory distress. Also for use as an antidote in poisoning by CNS depressants, especially barbiturates. Sakuranetin Not Available GsMtx-4 GsMtx-4 is a peptide found in tarantula venom that inhibits mechanosensitive ion channel (MSC) activity. Bryostatin 1 Bryostatin 1 has been investigated for the treatment of HIV Infection and Alzheimer's Disease. - Drugs & Drug Targets