Purine Nucleosides
- Name
- Purine Nucleosides
- Accession Number
- DBCAT000252
- Description
Purines with a RIBOSE attached that can be phosphorylated to PURINE NUCLEOTIDES.
- Drugs
Drug Drug Description Vidarabine An antiviral agent used to treat various viral infections. Cladribine A purine antimetabolite used for the management of relapsing forms of Multiple Sclerosis (MS), used in patients who have not responded to or who were unable to tolerate alternative MS drugs. Adenosine A medication used in myocardial perfusion scintigraphy and to treat supraventricular tachycardia. Didanosine A reverse transcriptase inhibitor used to treat HIV. Guanosine Guanosine is a nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine can be phosphorylated to become GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP... Tubercidin An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic... Inosine A nutritional supplement touted to improve athletic performance and a drug used in vitro as a red blood cell rejuvenator for a unit of red blood cells that will be used in a clinical setting. Ticagrelor A P2Y12 platelet inhibitor used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death. Nebularine Not Available Ademetionine S-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as... Fludarabine A purine analog antimetabolite that inhibits DNA synthesis. S-adenosyl-L-homocysteine 5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions. Sinefungin Sinefungin is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. The proteins that adenosyl-ornithine target include... 5'-S-methyl-5'-thioadenosine Not Available Deoxyinosine Not Available 8-hydroxy-2'-deoxyguanosine Not Available 9-deazainosine Not Available S-Adenosyl-1,8-Diamino-3-Thiooctane Not Available Methylthioinosine An analog of inosine with a methylthio group replacing the hydroxyl group in the 6-position. Deoxycytidylyl-3',5'-guanosine Not Available 5'-O-(N-(Alanyl)sulfamoyl)adenosine Not Available 7-Methylguanosine Not Available 5'-Fluoro-5'-Deoxyadenosine Not Available 2-Fluoroadenosine Not Available 3-Deazaadenosine Not Available 5-iodotubercidin Not Available Binodenoson For cardiac pharmacologic stress SPECT imaging, which is used to diagnose coronary artery disease. Isatoribine For the treatment of Hepatitis C. Tecadenoson Investigated for use/treatment in arrhythmia and atrial fibrillation. Piclidenoson Investigated for use/treatment in cancer/tumors (unspecified), eye disorders/infections, psoriasis and psoriatic disorders, and rheumatoid arthritis. Can-Fite BioPharma has reported that by targeting the adenosine A3-receptor, CF101 may also be used... Puromycin Puromycin is an antibiotic that prevents bacterial protein translation. It is utilized as a selective agent in laboratory cell cultures. Puromycin is toxic to both prokaryotic and eukaryotic cells, resulting... N(6)-dimethylallyladenine Not Available Galidesivir Galidesivir is an adenosine analogue that has been investigated for use against Zaire Ebolavirus. In animal studies, galidesivir was effective in increasing the survival rates from infections caused by various... Cordycepin Cordycepin has been used in trials studying the treatment of Leukemia. Sonedenoson Sonedenoson has been used in trials studying the treatment of Foot Ulcer, Diabetic and Diabetes Complications. UK-432097 UK-432,097 has been used in trials studying the treatment of Pulmonary Disease, Chronic Obstructive. Trabodenoson Trabodenoson has been used in trials studying the treatment of Ocular Hypertension (OHT) and Primary Open-Angle Glaucoma (POAG). Inosine pranobex A medication used to treat subacute sclerosing panencephalitis. AZD-8848 AZD-8848 is under investigation in clinical trial NCT01818869 (To Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses AZD8848 in Healthy Subjects). GS-6620 GS-6620 is under investigation in clinical trial NCT01316237 (A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of GS-6620 in Treatment Naïve Subjects With Chronic Hepatitis C Virus Infection). CYC-065 CYC-065 is under investigation in clinical trial NCT03739554 (CYC065 CDK Inhibitor and Venetoclax Study in Relapsed/Refractory CLL). Islatravir Islatravir is under investigation in clinical trial NCT04233216 (Doravirine/islatravir (DOR/ISL) in Heavily Treatment-experienced (HTE) Participants for Human Immunodeficiency Virus Type 1 (HIV-1) Infection (MK-8591A-019)). GS-441524 An experimental nucleoside analog antiviral investigated for its use in the treatment of Ebola and SARS-CoV-2 infections. 8-Chloroadenosine 8-Chloroadenosine is under investigation in clinical trial NCT02509546 (8-chloroadenosine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia). Selodenoson Selodenoson is under investigation in clinical trial NCT00040001 (Safety and Efficacy Study of an A1-adenosine Receptor Agonist to Slow Heart Rate in Atrial Fibrillation). Bentracimab Bentracimab is under investigation in clinical trial NCT04286438 (Bentracimab (PB2452) in Ticagrelor-treated Patients With Uncontrolled Major or Life-threatening Bleeding or Requiring Urgent Surgery or Invasive Procedure). AMG-319 Not Annotated Namodenoson Namodenoson has been used in trials studying the treatment of Chronic Hepatitis C and Hepatocellular Carcinoma. Loxoribine Not Available Abacavir An antiviral nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals for the treatment of HIV. Abacavir hydroxyacetate Prurisol is under investigation for the treatment of Chronic Stable Plaque Psoriasis. Prurisol has been investigated for the treatment of Plaque Psoriasis. Dideoxyadenosine Not Annotated 2'-deoxythioguanosine Not Annotated - Drugs & Drug Targets