Fatty Acids
- Name
- Fatty Acids
- Accession Number
- DBCAT000301
- Description
Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)
- Drugs
Drug Drug Description Travoprost A prostaglandin analog used in the treatment of elevated intraocular pressure due to open angle glaucoma or ocular hypertension. Mupirocin An antibacterial ointment used to treat impetigo and secondary skin infections caused by Staphylococcus aureus and Streptococcus pyogenes. Montelukast A leukotriene receptor antagonist used as part of an asthma therapy regimen, to prevent exercise induced bronchoconstriction, and to treat seasonal allergic rhinitis. Latanoprost An isopropyl ester prodrug used to treat increased intraocular pressure. Mycophenolate mofetil An inosine monophosphate dehydrogenase inhibitor used to prevent the rejection of kidney, heart, or liver transplants. Bimatoprost A prostaglandin analog used to treat hypotrichosis of the eyelashes and intraocular pressure in open angle glaucoma or ocular hypertension. Misoprostol A prostaglandin E1 analogue used to reduce the risk of NSAID-induced gastric ulcers and to terminate pregnancies. Fenofibrate A peroxisome proliferator receptor alpha activator used to lower LDL-C, total-C, triglycerides, and Apo B, while increasing HDL-C in hypercholesterolemia, dyslipidemia, and hypertriglyceridemia. Atorvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Vigabatrin An irreversible GABA transaminase inhibitor used as an adjunct therapy to treat refractory complex partial seizures in patients ≥2 years unresponsive to alternatives. May also be used as monotherapy to treat infantile spasms in infants 1 month to 2 years. Gemfibrozil A lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia. Tirbanibulin A tyrosine kinase and tubulin inhibitor used to treat actinic keratosis on the face or scalp. Unoprostone A prostaglandin analogue used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are clinically unresponsive to other ocular antihypertensive agents. Tafluprost An ophthalmic prostaglandin analog used to lower intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Omega-3-acid ethyl esters A mixture of fatty acids used as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe hypertriglyceridemia. Selexipag A non prostanoid IP prostacyclin receptor agonist used to treat pulmonary arterial hypertension. Clascoterone An androgen receptor antagonist used for the topical treatment of acne vulgaris in patients 12 years of age and older. Morrhuic acid Morrhuic acid is a mixture of unsaturated fatty acids obtained from cod liver oil. Lipoic acid For nutritional supplementation, also for treating dietary shortage or imbalance. Alprostadil A prostaglandin E1 agonist used for the treatment of erectile dysfunction and as an adjunct for its diagnosis. Mycophenolic acid An immunosuppressant used to prevent organ transplant rejections. Fumagillin Not Available Tricosanoic acid Not Available Palmitoleic Acid Not Available C31G Investigated for use/treatment in contraception, HIV infection, and prevention of stdis. Elacytarabine Investigated for use/treatment in leukemia (unspecified) and melanoma. Cobiprostone Investigated for use/treatment in cystic fibrosis. 2-hydroxy-6-oxo-6-phenyl-2,4-hexadienoic acid Metabolic product of biphenyl; from Pseudomonas putida. Gemeprost A prostaglandin E1 analogue used for cervical dilation and, in combination with mifepristone, for pregnancy termination. Limaprost An oral prostaglandin E1 analogue used to improve symptoms associated with thromboangiitis obliterans, acquired lumbar spinal canal stenosis, and other ischemic conditions. VTP-194204 Nrx194204 has been used in trials studying the treatment of Parkinson's Disease and Non-small Cell Lung Cancer. 9CUAB30 9 Cuab30 has been used in trials studying the treatment and prevention of HER2/Neu Positive, HER2/Neu Negative, No Evidence of Disease, Estrogen Receptor Negative, and estrogen receptor positive, among others. Gondoic acid Not Annotated Osbond acid Not Annotated alpha-Linolenic acid A polyunsaturated omega-3 fatty acid found in many supplements. Dihomo-gamma-linolenic acid For nutritional supplementation, also for treating dietary shortage or imbalance Icosapent A polyunsaturated fatty acid, usually found in fish oils, that is used in many supplements. Calcium acetate A phosphate binder used in patients with end-stage renal disease (ESRD) to prevent elevated phosphate levels and resulting ectopic calcification and secondary hyperparathyroidism. Valproic acid An anticonvulsant used to control complex partial seizures and both simple and complex absence seizures. Treprostinil A prostacyclin vasodilator for the treatment of pulmonary arterial hypertension to relieve exercise associated symptoms and to prevent clinical deterioration after stopping epoprostenol. Carboprost tromethamine A prostaglandin used to treat postpartum uterine hemorrhage due to atony when other methods of management have not been effective. Candoxatril Candoxatril is the orally-active prodrug of candoxatrilat (UK-73967), a potent neutral endopeptidase (NEP) inhibitor. Dinoprostone A prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease. Lubiprostone A prostaglandin derivative used to treat constipation caused by irritable bowel syndrome and opioid-use. Iloprost A synthetic prostacyclin analog indicated to treat pulmonary arterial hypertension (PAH). Fluvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Dinoprost tromethamine Used for aborting second-trimester pregnancy (between the twelfth to eighteenth week of gestation) and in incomplete abortion or for therapeutic abortion in cases of intrauterine fetal death and congenital abnormalities... Ridogrel Used as an adjunctive therapy to induce thrombolysis in patients suffering acute myocardial infarction. Epoprostenol A vasodilator and platelet aggregation inhibitor used for the management of primary pulmonary hypertension and pulmonary hypertension in patients with heart failure. Aluminium monostearate Aluminium monostearate is a salt of stearic acid and aluminium with the molecular formula Al(OH)2C18H35O2. Also known as dihydroxyaluminium or dihydroxy(stearato)aluminium, it is used to form gels in the packaging... gamma-Hydroxybutyric acid Used as a general anesthetic, to treat conditions such as insomnia, clinical depression, narcolepsy, and alcoholism, and to improve athletic performance. Tiaprofenic acid A nonsteroidal anti-inflammatory (NSAID) used to manage inflammation and analgesia associated with rheumatoid arthritis and osteoarthritis. Propyl acetate Not Available Hexadecanesulfonyl fluoride Not Available Prostaglandin D2 The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important... 4-Oxosebacic Acid Not Available Prostaglandin B2 Not Available 12-Bromododecanoic Acid Not Available 4-(2-Thienyl)Butyric Acid Not Available Methoxy arachidonyl fluorophosphonate Methoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases. It inhibits phospholipase A2 and fatty acid... Isobutyric acid Not Available Indolepropionic acid Not Available Ricinoleic acid Not Available Lauric acid Lauric acid is an inexpensive, non-toxic and safe to handle compound often used in laboratory investigations of melting-point depression. Lauric acid is a solid at room temperature but melts easily... Acetic acid An antimicrobial agent used to treat susceptible infections of the external auditory canal. Stearic acid An ingredient found in topical products as a skin protectant. N-hexadecanoylglycine Not Available Butyric Acid A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester. Capric acid Decanoic acid is a solid. This compound belongs to the straight chain fatty acids. These are fatty acids with a straight aliphatic chain. The proteins that decanoic acid targets include... 12-Hydroxydodecanoic Acid Not Available 2-Methylbutanoic Acid Not Available Isovaleric Acid Not Available Doconexent An omega 3 fatty acid used in a variety of nutritional supplements to support central nervous system and cardiovascular health. Dihydrolipoic Acid Not Available Propanoic acid An antimicrobial food additive. Palmitic Acid A fatty used as a food additive and emollient or surfactant in cosmetics. Prostaglandin G2 A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is further converted by a series of specific enzymes to the series 2 prostaglandins. [PubChem] Isocaproic acid Not Available 5-phenylpentanoic acid Not Available Valpromide A valproic acid derivative used to treat epilepsy and as adjunct therapy for psychomotor agitation, depression, and manic episodes of bipolar disorder. Mdl-29951 Not Available Oleic Acid A naturally occurring fatty acid with antibacterial properties added to a variety of drug products. KH064 Not Available Caprylic acid Caprylic acid is an eight-carbon chain fatty acid, also known systematically as octanoic acid. It is found naturally in coconuts and breast milk. It is an oily liquid with a... Arachidonic Acid A natural fatty acid that plays an essential role in physiological homeostases, such as repair and growth of cells. 4,7-Dioxosebacic Acid Not Available 5-hydroxyvaleric acid Not Available cis-Vaccenic acid Not Available Benoxaprofen The use of benoxaprofen, formerly marketed as Oraflex tablets, was associated with fatal cholestatic jaundice among other serious adverse reactions. The holder of the approved application voluntarily withdrew Oraflex tablets... Dexloxiglumide For the treatment of Irritable Bowel Syndrome (IBS) and Gastroesophageal Reflux Disease (GERD). Oleoyl-estrone For the treatment of obesity. AN-9 Investigated for use/treatment in liver cancer, lung cancer, melanoma, and leukemia (lymphoid). Gemcabene Investigated for use/treatment in atherosclerosis, cardiovascular disorders, and hyperlipidemia. Elafibranor Investigated for use/treatment in atherosclerosis and diabetes mellitus type 2. AM103 For the treatment of asthma and cardiovascular disease. Beraprost For the treatment of pulmonary hypertension. Fenoxaprop-ethyl Chronic angina and Coronary Artery Disease Caprospinol Alzheimer's Disease Arundic acid Investigated for use/treatment in cerebral ischemia. Emricasan Investigated for use/treatment in hepatitis (viral, C), liver disease, and transplantation (organ or tissue). AZD-9684 Investigated for use/treatment in thrombosis. Varespladib methyl Investigated for use/treatment in atherosclerosis and coronary artery disease. DP-VPA Investigated for use/treatment in bipolar disorders, epilepsy, and migraine and cluster headaches. AGI-1096 Investigated for use/treatment in transplant (rejection). Fiboflapon Investigated for use/treatment in inflammatory disorders (unspecified). Priralfinamide Investigated for use/treatment in pain (acute or chronic). Ethanolamine oleate A mild sclerosing agent used in the treatment of esophageal varices with recent bleeding episodes. Zaltoprofen A non-steroidal anti-inflammatory drug approved for use in Japan in 1993. Seratrodast Seratrodast (INN) is a thromboxane receptor antagonist used primarily in the treatment of asthma. Monoctanoin Monoctanoin is used to dissolve cholesterol gallstones. GW-590735 Not Available Sobetirome Not Available Sebacic acid Not Available IDD594 Not Available Myristic acid Not Available Efaproxiral Not Available Leukotriene C4 The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates... Teriflunomide A pyrimidine synthesis inhibitor with anti-inflammatory and immunomodulatory properties used to treat patients with the relapsing-remitting form of multiple sclerosis. Icosapent ethyl An ethyl ester of eicosapentaenoic acid (EPA) that reduces synthesis and enhances clearance of triglycerides that is used to treat patients with severe hypertriglyceridemia. Beclamide Has been used in the management of epilepsy and epilepsy related behavioural disorders. It was used for generalised tonic-clonic seizures, and was not effective for absence seizures. More recently focus... Zucapsaicin A topical analgesic used as an adjunct to relieve severe pain of osteoarthritis of the knee in selected adult patients. Uridine triacetate A pyrimidine analog used for the reversal of overdose, regardless of the presence of symptoms, and early-onset, severe or life-threatening CNS toxicity or cardiotoxicity of fluorouracil or capecitabine. Pivhydrazine For the treatment of depression. Undecylenic acid An antifungal used to treat tinea species infections. Omega-3 fatty acids An ingredient found in a variety of supplements and vitamins. Calcium threonate No approved therapeutic indications. L-threonic acid Not Annotated Borage oil Borage oil, or borage seed oil, is a rich source of gamma-linolenic acid (GLA) that is obtained from the seeds of the Borago officinalis (borage). Borage oil is used as... Nonivamide Nonivamide is used as a topical analgesic and is also used as a flavoring ingredient , , . Evening primrose oil Evening primrose oil is used as part of over-the-counter dietary supplements. It is also used for the treatment of systemic inflammatory diseases and for women's health conditions such as cyclical... Fenprostalene Not Annotated Luprostiol Not Annotated Monensin Monensin is a polyether isolated from Streptomyces cinnamonensis that presents antibiotic properties. It is widely used in ruminant animal feeds. Prostalene Analog of prostaglandin F2 alpha. Cloprostenol Not Annotated Fluprostenol Not Annotated Latanoprostene bunod A prostaglandin analog used to reduce ocular hypertension or treat open-angle glaucoma. Leukotriene D4 Leukotriene D4 has been used in trials studying the diagnostic of Asthma and Allergic Rhinitis. Verinurad Verinurad has been used in trials studying the basic science and treatment of Gout, Gout and Hyperuricemia, and Gout and Asymptomatic Hyperuricemia. Varespladib Varespladib has been investigated for the treatment and prevention of Sickle Cell Disease, Vaso-occlusive Crisis, and Acute Coronary Syndrome. Ingavirin Ingavirin has been used in trials studying the treatment of Influenza and Common Cold. Atagabalin Atagabalin has been used in trials studying the treatment of Insomnia, Primary Insomnia, and Nonrestorative Sleep. Letermovir An antiviral medication used for prophylaxis in adult transplant recipients at risk of cytomegalovirus (CMV) infection and disease. Orantinib Orantinib has been used in trials studying the treatment of Lung Cancer, Breast Cancer, Kidney Cancer, Gastric Cancer, and Prostate Cancer, among others. Gefarnate Gefarnate has been investigated for the treatment and prevention of Stomach Ulcer, Duodenal Ulcer, and Cardio-cerebrovascular Disease. Ritobegron Ritobegron is under investigation in clinical trial NCT02256735 (Study to Investigate the Effect of KUC 7483 CL on the QT/QTc Interval of the ECG in Comparison to Placebo and Moxifloxacin... Devimistat Devimistat (CPI-613) has been used in trials studying the treatment of Cancer, Lymphoma, Solid Tumors, Advanced Cancer, and Pancreatic Cancer, among others. Tricaprylin Tricaprilin has been used in trials studying the supportive care and treatment of Alzheimer's Disease. Seladelpar Seladelpar (MBX-8025) has been used in trials studying the treatment of Hyperlipidemia. Ralinepag Ralinepag has been used in trials studying the treatment of Pulmonary Arterial Hypertension. Imiglitazar Imiglitazar has been used in trials studying the treatment of Diabetes Mellitus. Taprenepag Taprenepag has been used in trials studying the treatment of Ocular Hypertension and Glaucoma, Open-Angle. 3,5-diiodothyropropionic acid DITPA has been investigated in Congestive Heart Failure. Sulprostone A prostaglandin analogue used to treat post-partum hemorrhaging, induce medical abortion, and induce labour in instances of in utero fetal death. Bindarit Bindarit has been used in trials studying the prevention and treatment of Coronary Restenosis and Diabetic Nephropathy. Dinoprost A medication used to induce a second trimester abortion. CMX-2043 CMX-2043 has been used in trials studying the treatment and prevention of Non STEMI, Unstable Angina, Stable Coronary Artery Disease, and Percutaneous Coronary Intervention. MK-0752 Mk 0752 is under investigation in clinical trial NCT00572182 (MK0752 in Treating Young Patients With Recurrent or Refractory CNS Cancer). Pradigastat Pradigastat has been used in trials studying the treatment of Non-alcoholic Fatty Liver Disease (NAFLD). Leukotriene B4 Leukotriene B4 has been used in trials studying the treatment of HIV Infections. LY-518674 LY518674 has been used in trials studying the treatment of Metabolic Syndrome X. Icosabutate Icosabutate is under investigation in clinical trial NCT02373176 ([14C] Icosabutate -A Phase I Absorption, Metabolism and Excretion Study). MK-8245 MK-8245 has been used in trials studying the treatment of Type 2 Diabetes Mellitus. Resolvin E1 Resolvin E1 (RX 10001) is under investigation in clinical trial NCT00941018 (Single and Multiple Ascending Oral Dose Study of Resolvin E1 in Healthy Volunteers). Glycovir Glycovir has been used in trials studying the treatment of HIV Infections. Omega-6 fatty acids There are no current pharmacotherapeutic products based on omega-6 fatty acids. Fentiazac Not Annotated Alminoprofen Alminoprofen is a non-steroidal anti-inflammatory drug (NSAID) whose physiochemical characteristics make it a member of the phenylpropionic acid class of chemical substances. Cyclobutyrol Not Annotated Pranoprofen A topical anti-inflammatory agent used for the treatment of non-infectious inflammatory conditions such as blepharitis and conjunctivitis. Pranoprofen ophthalmic solution may also be used post-operatively to manage inflammation. Enprostil Not Annotated Gamolenic acid An ingredient found in a variety of nutritional products. Isopropyl myristate A polar skin moisturizer that is used to enhance skin penetration of drugs. Magnesium acetate Not Available Palmidrol A cannabinoid receptor-inactive eCB-related molecule used as prophylactic in helping to prevent respiratory viral infection. Palmidrol is available for human use as a supplement (400 mg capsules) and as food... Magnesium stearate Not Annotated Triethylhexanoin Triethylhexanoin is an ingredient of cosmetic products as a fragrant solvent. Linoleic acid Not Annotated Threonic acid Not Annotated Acetate Not Annotated Aluminum acetate A medication used for temporary relief of skin irritation. Acetyl chloride Not Annotated Etrasimod An S1P receptors modulator used to treat moderate to severely active ulcerative colitis in adults AZD-7687 AZD-7687 is under investigation in clinical trial NCT01119352 (AZD7687 Multiple Ascending Dose Study). Edasalonexent Edasalonexent is under investigation in clinical trial NCT01511900 (A Multiple Ascending Dose Study of CAT-1004 in Patients With Type 2 Diabetes). CXA-10 CXA-10 is under investigation in clinical trial NCT03422510 (FIRSTx - A Study of Oral CXA-10 in Primary Focal Segmental Glomerulosclerosis (FSGS)). Pemafibrate Pemafibrate is under investigation in clinical trial NCT03350165 (A Study of Pemafibrate in Patients With Nonalcoholic Fatty Liver Disease (NAFLD)). Navtemadlin Navtemadlin (AMG-232) is under investigation in clinical trial NCT03041688 (MDM2 Inhibitor AMG-232 and Decitabine in Treating Patients With Relapsed, Refractory, or Newly-Diagnosed Acute Myeloid Leukemia). beta-Hydroxyisovaleric acid beta-Hydroxyisovaleric acid is under investigation in clinical trial NCT03018496 (Investigating the Effects of Beta-Hydroxy-Beta-Methylbutyrate on Glucose Handling in Older and Younger Men.). Dihydrocapsiate Dihydrocapsiate is under investigation in clinical trial NCT00999297 (Effect of 4-week Dihydrocapsiate Ingestion on Resting Metabolic Rate). GLPG-0974 GLPG-0974 is under investigation in clinical trial NCT01721980 (Multiple Ascending Dose Study of GLPG0974 in Healthy Subjects). Setogepram Setogepram is under investigation in clinical trial NCT03184584 (Open-Label Rollover Study of PBI 4050 in Subjects With Alström Syndrome). Cetyl palmitate Not Annotated Thioctamide An ingredient in nutritional products for liver health. alpha-Hydroxylinoleic acid alpha-Hydroxylinoleic acid is under investigation in clinical trial NCT04431258 (ABTL0812 in Combination With FOLFIRINOX for First-line Treatment of Metastatic Pancreatic Study). AK106-001616 AK106-001616 is under investigation in clinical trial NCT01285752 (A Study of AK106-001616 in Patients With Rheumatoid Arthritis (RA)). Adelmidrol Adelmidrol is under investigation in clinical trial NCT01420510 (Saginil in vs. Placebo for Gynecologic Oncology Patients Affected by Vaginitis). Ecraprost Ecraprost is under investigation in clinical trial NCT00059657 (Efficacy/safety of Ecraprost in Lipid Emulsion for Treatment of Critical Leg Ischemia Due to Peripheral Arterial Disease). Firsocostat Firsocostat is under investigation in clinical trial NCT02781584 (Safety, Tolerability, and Efficacy of Selonsertib, Firsocostat, and Cilofexor in Adults With Nonalcoholic Steatohepatitis (NASH)). Nangibotide Nangibotide is under investigation in clinical trial NCT04055909 (Efficacy, Safety and Tolerability of Nangibotide in Patients With Septic Shock). Odevixibat An ileal sodium/bile acid cotransporter inhibitor indicated in the treatment of pruritus in patients with progressive familial intrahepatic cholestasis. Rivenprost Rivenprost is under investigation in clinical trial NCT00296556 (Therapeutic Study of ONO-4819CD for Ulcerative Colitis). Oleic monoethanolamide Not Available Glyceryl laurate Not Annotated Arachidonyltrifluoromethane Specific inhibitor of phospholipase A2. Incomplete Freund's adjuvant Not Annotated Amibegron Investigated for use/treatment in depression, irritable bowel syndrome (IBS), and obesity. Zatolmilast BPN-14770 is under investigation in clinical trial NCT02840279 (A Multiple Ascending Dose Study of BPN14770 in Healthy Young and Elderly Male or Female Subjects). Propagermanium Not Annotated Arginine An amino acid commonly found as a component of total parenteral nutrition. 2,2-Dimethylbutyrate Not Annotated TP-252 TP-252 consists of magnesium L-lysinate bis-eicosapentaenoate, an ionizable salt of eicosapentaenoic acid (EPA), currently being investigated to treat familial adenomatous polyposis. Epeleuton Not Annotated Idroxioleic acid Not Annotated AP-001 Not Annotated - Drugs & Drug Targets