Amides
- Name
- Amides
- Accession Number
- DBCAT000494
- Description
Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)
- ATC Classification
- Drugs
Drug Drug Description Lidocaine A local anesthetic used in a wide variety of superficial and invasive procedures. Bupivacaine A local anesthetic used in a wide variety of superficial and invasive procedures. Prilocaine A local anesthetic used in dental procedures. Etidocaine Etidocaine is marketed under the name Duranest. It is an injectable local anesthetic during surgery, labor, and delivery. Etidocaine has a long duration of activity, but has the main disadvantage... Levobupivacaine A drug used for nerve block and anesthesia. Butanilicaine Not Annotated Oseltamivir A neuraminidase inhibitor used in the prophylaxis and treatment of influenza. Sildenafil A phosphodiesterase inhibitor used for the treatment of erectile dysfunction. Acetaminophen An analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent. Aztreonam A beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria. Sulpiride A selective D2 dopamine receptor antagonist indicated to treat chronic and acute schizophrenia. Remoxipride An discontinued atypical antipsychotic selective for dopamine D2 receptors. Ampicillin A penicillin derivative used for the treatment of a variety of infections caused by gram-positive and gram-negative bacteria as well as some anaerobes. Phenoxymethylpenicillin A penicillin antibiotic used to prevent and treat mild to moderately severe infections in the respiratory tract, skin, and soft tissues. Ceftazidime An injected broad-spectrum third-generation cephalosporin beta-lactam antibiotic used to treat or prevent a variety of bacterial infections, including pneumonia, gynecological infections, bone and joint infections, and septicemia, among others. Celecoxib An NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis. Flutamide An antiandrogen used for locally confined stage B2-C and D-2 metastatic prostate carcinoma. Cinchocaine An anesthetic used for local or regional anesthesia. Cephalexin A first generation cephalosporin used to treat certain susceptible bacterial infections. Sulfamethizole A sulfonamide antibiotic used to treat a wide variety of susceptible bacterial infections. Labetalol An alpha and beta adrenergic antagonist used to treat hypertension, angina, and sympathetic overactivity syndrome. Linezolid An oxazolidinone antibiotic used to treat infections by susceptible strains of aerobic Gram-positive bacteria. Sumatriptan A serotonin receptor agonist used to treat migraines and cluster headaches. Furosemide A loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension. Tamsulosin An alpha-1A and alpha-1B adrenergic receptor antagonist used to treat benign prostatic hyperplasia, ureteral stones, prostatitis, and female voiding dysfunction. Hydroflumethiazide A thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure and liver cirrhosis. Indapamide A thiazide diuretic used to treat hypertension as well as edema due to congestive heart failure. Dorzolamide A carbonic anhydrase inhibitor used to treat high intraocular pressure in ocular hypertension and open angle glaucoma. Bimatoprost A prostaglandin analog used to treat hypotrichosis of the eyelashes and intraocular pressure in open angle glaucoma or ocular hypertension. Hydrochlorothiazide A thiazide diuretic used to treat edema associated with a number of conditions, and hypertension. Cerulenin For use as a biochemical tool, Cerulenin is shown to cause dramatic weight loss in animals Rifampicin An antibiotic used to treat several types of mycobacterial infections including Mycobacterium avium complex, leprosy, and in combination with other antibacterials to treat latent or active tuberculosis. Benzylpenicillin A penicillin used for the treatment of infections caused by gram-positive cocci, in particular streptococcal infections. This form of penicillin is typically used in intravenous or long-acting injectable formulations due to poor oral absorption. Amoxicillin A penicillin derivative used for the treatment of infections caused by gram-positive bacteria, in particular streptococcal bacteria causing upper respiratory tract infections. Bicalutamide An androgen receptor inhibitor used to treat Stage D2 metastatic carcinoma of the prostate. Cloxacillin An antibiotic agent used for the treatment of beta-hemolytic streptococcal and pneumococcal infections as well as staphylococcal infections. Brinzolamide A carbonic anhydrase inhibitor used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Levetiracetam A novel anticonvulsant agent used as an adjunct medication to manage partial onset, myoclonic, and generalized tonic-clonic seizures in patients with epilepsy. Ceftriaxone A broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, such as in the respiratory tract, skin, soft tissue, and urinary tract. Metoclopramide An antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying. Darunavir A HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. Polythiazide A thiazide diuretic used in the management of hypertension and treatment of edema. Ceftizoxime A third-generation cephalosporin antibiotic used in the treatment of various bacterial infections, including lower respiratory tract infection, urinary tract infection, and gonorrhea. Imipenem A carbapenem antibiotic normally administered with cilastatin to treat a variety of infections. Tazobactam A beta lactamase inhibitor administered with antibiotics such as piperacillin and ceftolozane to prevent their degradation, resulting in increased efficacy. Ticarcillin A beta lactam antibiotic used to treat a variety of infections in the body. Tirbanibulin A tyrosine kinase and tubulin inhibitor used to treat actinic keratosis on the face or scalp. Amisulpride A dopamine D2 receptor antagonist used in the treatment of acute and chronic schizophrenia, and in the prevention and treatment of postoperative nausea and vomiting in adults. Pazopanib An antineoplastic agent used in the treatment of advanced renal cell cancer and advanced soft tissue sarcoma in patients with prior chemotherapy. Nepafenac An ophthalmic NSAID used for the symptomatic treatment of pain and inflammation associated with cataract surgery. Mirabegron A beta-3 adrenergic agonist used to treat overactive bladder and neurogenic detrusor overactivity. Macitentan An endothelin receptor antagonist used to manage pulmonary arterial hypertension to delay disease progression. Ceftolozane A cephalosporin antibiotic used to treat complicated intra-abdominal infections in combination with metronidazole, complicated urinary tract infections, and hospital-acquired pneumonia. Triclocarban An antibacterial agent used in liquid soaps and body washes. Selexipag A non prostanoid IP prostacyclin receptor agonist used to treat pulmonary arterial hypertension. Venetoclax A BCL-2 inhibitor used to treat chronic lymphocytic leukemia, small lymphocytic lymphoma, or acute myeloid leukemia. Acalabrutinib A Bruton tyrosine kinase inhibitor used to treat mantle cell lymphoma, chronic lymphocytic leukemia, and small lymphocytic lymphoma. Lasmiditan An oral 5HT1F agonist used for the acute treatment of migraine headache with or without aura. Revefenacin An anticholinergic agent used to treat COPD. Entrectinib Entrectinib is indicated for the treatment of metastatic ROS1-positive non-small cell lung cancer in adults. Entrectinib is also indicated in adults and children over 12 years old for the treatment... Lorlatinib An anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer. Fedratinib Fedratinib is indicated for the treatment of adult patients with intermediate-2 or high-risk primary or secondary (post-polycythemia vera or post-essential thrombocythemia) myelofibrosis.[L8090,L47016] Grapiprant The effects of grapiprant have been investigated in the area of analgesia and anti-inflammation due to the effects that have been reported about this molecule. This molecule has been approved... Tazemetostat A methyltransferase inhibitor indicated to treat patients 16 years and older with metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Ropivacaine An amide-type local anesthetic used for local or regional anesthesia during surgery and for short-term management of acute pain. Mepivacaine A local anesthetic used for local or regional analgesia or anesthesia. Articaine A local anesthetic used for inducing local, infiltrative, or conductive anesthesia in both simple and complex dental procedures. Afatinib An antineoplastic agent used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) with non-resistant EGFR mutations or resistance to platinum-based chemotherapy. Cefiderocol A cephalosporin antibiotic used in complicated urinary tract infections. Eticlopride Not Annotated Capmatinib A kinase inhibitor targeting c-Met receptor tyrosine kinase in the treatment of non-small cell lung cancer with MET exon 14 skipping. PF-06650833 PF-06650833 is under investigation in clinical trial NCT02609139 (Study to Evaluate Pharmacokinetics of A Modified Release Formulation of PF-06650833 in Healthy Subjects). Nirmatrelvir An oral protease inhibitor with emergency use authorization for the treatment of mild-to-moderate COVID-19. Piperacillin A penicillin antibiotic combined with tazobactam to treat piperacillin-resistant, piperacillin/tazobactam susceptible, β-lactamase generating strains of several bacteria. Trimethobenzamide An antiemetic used to treat postoperative nausea and vomiting and nausea associated with gastroenteritis. Hetacillin Hetacillin is a beta-lactam antibiotic prodrug used to treat bacterial infections. In the body it gets converted to ampicillin. Benzylpenicilloyl polylysine A penicillin derivative used to determine penicillin allergies. Zaleplon A sedative used for short term treatment of insomnia in adults. Amdinocillin Used in the treatment of urinary tract infections caused by some strains of E. coli and klebsiella and enterobacter species. Used mainly against Gram negative organisms. Bacampicillin An ampicillin prodrug used to treat various susceptible bacterial infections in the body, such as respiratory infections and skin and subcutaneous tissue infections. Pivmecillinam A prodrug of the beta lactam antibiotic mecillinam, indicated for the treatment of uncomplicated urinary tract infections (UTIs). Roflumilast A selective phosphodiesterase-4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) and to treat plaque psoriasis. Piclamilast Piclamilast (RP-73,401), is a selective PDE4 inhibitor comparable to other PDE4 inhibitors for its anti-inflammatory effects. It has been investigated for its applications to the treatment of conditions such as... Oseltamivir acid Not Available Acetamide Not Available 3-Methoxybenzamide Not Available 4-Fluorobenzylamine Not Available Isopenicillin N Not Available 1-(4-Amidinophenyl)-3-(4-Chlorophenyl)Urea Not Available Renzapride For the treatment of constipation-predominant irritable bowel syndrome (IBS-C). Itopride An acetylcholine esterase inhibitor and dopamine D2 receptor antagonist used to treat symptoms of functional dyspepsia such as nausea and vomiting. ADL5859 Investigated for use/treatment in pain (acute or chronic). Asimadoline Investigated for use/treatment in irritable bowel syndrome (IBS). Rilapladib Investigated for use/treatment in atherosclerosis and cardiovascular disorders. INCB3284 Investigated for use/treatment in inflammatory disorders (unspecified). APD791 For the treatment and prophylaxis of arterial thrombosis. Naronapride Investigated for use/treatment in gastroesophageal reflux disease (GERD) and gastroparesis. SB-743921 Investigated for use/treatment in cancer/tumors (unspecified) and lymphoma (non-hodgkin's). Bedoradrine Investigated for use/treatment in asthma and labor and delivery. Faropenem medoxomil Investigated for use/treatment in bacterial infection, bronchitis, otitis media, and pediatric indications. SLx-4090 Investigated for use/treatment in hyperlipidemia. SNX-5422 Investigated for use/treatment in cancer/tumors (unspecified). Indibulin Investigated for use/treatment in solid tumors. Ispinesib Investigated for use/treatment in breast cancer, lung cancer, solid tumors, renal cell carcinoma, pediatric indications, ovarian cancer, and head and neck cancer. Senicapoc Investigated for use/treatment in anemia (sickle cell) and asthma. Onalespib Investigated for use/treatment in cancer/tumors (unspecified). Tucidinostat Investigated for use/treatment in cancer/tumors (unspecified). Avasimibe Investigated for use/treatment in peripheral vascular disease. Remacemide Investigated for use/treatment in epilepsy, huntington's disease, and parkinson's disease. FK-960 Investigated for use/treatment in dementia, alzheimer's disease, schizophrenia and schizoaffective disorders, and memory loss. Tonabersat Investigated for use/treatment in migraine and cluster headaches. Agomelatine Agomelatine is indicated to treat major depressive episodes in adults. Saredutant Investigated for use/treatment in depression and anxiety disorders. Lixivaptan Investigated for use/treatment in hyponatremia and congestive heart failure. Almorexant Investigated for use/treatment in sleep disorders and insomnia. Methenamine A urinary tract antiseptic and antibacterial drug used for the prophylaxis and treatment of frequently recurring urinary tract infections requiring a long-term therapy. m-Hydroxyhippuric acid Not Available Mirdametinib PD-0325901 has been used in trials studying the treatment and basic science of Melanoma, Solid Tumour, Solid Tumors, Advanced Cancer, and Breast Neoplasms, among others. R-95845 R-95845 is an inhibitor of HIV-1 reverse transcriptase. Andarine Andarine is a non-steroidal selective androgen receptor modulator. PH-797804 PH-797804 has been investigated for the treatment of Osteoarthritis. Azidocillin For treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including... Salicylamide Salicylamide is the common name for the substance o-hydroxybenzamide, or amide of salicyl. Salicylamide is a non-prescription drug with analgesic and antipyretic properties. It has similar medicinal uses to aspirin.... Cinitapride A benzamide with gastroprokinetic and antiemetic properties typically used for the treatment of gastrointestinal motility disorders such as gastroesophageal reflux disease (GERD), non-ulcer dyspepsia, and delayed gastric emptying. Enzalutamide A second-generation androgen receptor inhibitor used to treat castration-resistant prostate cancer and metastatic castration-sensitive prostate cancer. Etamivan Etamivan (INN) or ethamivan (USAN) is marketed under the name Analepticon. Etamvin is a respiratory stimulant drug similar to nikethamide. It is no longer used in the United States. Lufenuron Lufenuron is used in veterinary for the control of flea. Masitinib Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in dogs. It has been available in Europe since 2009, under the brand name Masivet. In the... AZD-4877 AZD4877 has been used in trials studying the treatment of NHL, Tumors, Cancer, Lymphoma, and Neoplasms, among others. Mosapride A prokinetic 5-HT4 receptor agonist used to stimulate gastric motility. PF-06282999 Pf 06282999 is under investigation in clinical trial NCT01626976 (A Study To Assess The Safety, Tolerability And Pharmacokinetics Of PF-06282999 Administered Orally In Healthy Adult Subjects). Navarixin Navarixin has been investigated for the treatment of Asthma. Momelotinib A Janus Kinase inhibitor used to treat intermediate or high-risk myelofibrosis. Danusertib Danusertib has been used in trials studying the treatment of Leukemia. Arhalofenate Arhalofenate has been investigated for the treatment of Gout and Hyperuricemia. Danegaptide Danegaptide has been investigated for the treatment of Focus of Study is STEMI. Mocetinostat Mocetinostat has been used in trials studying the treatment of Lymphoma, Urothelial Carcinoma, Relapsed and Refractory, Myelodysplastic Syndrome, and Metastatic Leiomyosarcoma, among others. Entinostat Entinostat is under investigation for the treatment and other of Volunteers, Breast Cancer, Human Volunteers, and Normal Volunteers. Entinostat has been investigated for the treatment of Non-Small Lung Cancer, Epigenetic... Flumatinib Flumatinib has been used in trials studying the treatment of Myelogenous Leukemia, Chronic. Sutezolid Sutezolid has been used in trials studying the treatment of Tuberculosis. Vistusertib Vistusertib is under investigation for the treatment of Advanced Gastric Adenocarcinoma. Tasisulam Tasisulam has been used in trials studying the treatment and basic science of Melanoma, Lymphoma, Solid Tumors, Breast Cancer, and Ovarian Cancer, among others. Axelopran Axelopran has been used in trials studying the treatment of OIC and Opioid-induced Constipation. Tecovirimat An antiviral medication used to treat smallpox, monkeypox, and cowpox. CE-224535 CE-224535 has been used in trials studying the treatment of Osteoarthritis. Sultamicillin A mutual prodrug of ampicillin and sulbactam useful in the treatment of infections caused by beta-lactamase-producing bacteria. Faropenem Faropenem has been used in trials studying the treatment of Tuberculosis, Pulmonary Tuberculosis, and Community Acquired Pneumonia. N-6022 N6022 has been used in trials studying the treatment of Asthma and Cystic Fibrosis. GSK-424887 Gsk424887 has been used in trials studying the basic science and treatment of Depressive Disorder and Anxiety Disorder. Balicatib Balicatib has been used in trials studying the treatment of Osteoporosis and Knee Osteoarthritis. Radiprodil Radiprodil has been used in trials studying the treatment of Infantile Spasms (IS) and Diabetic Peripheral Neuropathic Pain. AZD-5423 AZD5423 has been used in trials studying the basic science and treatment of Asthma, Bioavailability and AUC, and Chronic Obstructive Pulmonary Disease (COPD). Defactinib Defactinib has been investigated for the treatment of Malignant Pleural Mesothelioma. Darexaban Darexaban has been used in trials studying the prevention and basic science of Japanese, Caucasian, Thromboembolism, Pharmacodynamics, and Pharmacokinetics, among others. Tacedinaline Tacedinaline has been used in trials studying the treatment of Lung Cancer, Multiple Myeloma, and Pancreatic Cancer. Bavisant Bavisant has been used in trials studying the basic science and treatment of Alcoholism, Pharmacokinetics, Drug Interactions, Attention Deficit Hyperactivity Disorder, and Attention Deficit Disorders With Hyperactivity. Radotinib Radotinib is indicated for the treatment of different types of cancer, most notably Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) with resistance or intolerance of other Bcr-Abl tyrosine-kinase inhibitors, such... Aticaprant Aticaprant has been used in trials studying the health services research and basic science of Anxiety Disorders and Alcohol Dependence. Temocillin Temocillin has been investigated in Infection, Liver Dysfunction, and Urinary Tract Infection. Betrixaban A Factor Xa inhibitor used for prophylaxis of venous thromboembolism in hospitalized patients. CI-1040 CI-1040 has been used in trials studying the treatment of Lung Cancer, Breast Cancer, Breast Neoplasms, Pancreatic Cancer, and Colorectal Cancer, among others. Acotiamide Acotiamide has been used in trials studying the treatment of Dyspepsia and Functional Dyspepsia. BI-671800 Bi 671800 has been used in trials studying the treatment of Asthma and Rhinitis, Allergic, Perennial. MK-0686 MK0686 has been used in trials studying the treatment of Osteoarthritis, Pain, Postoperative, and Neuralgia, Postherpetic. AZD-9056 AZD9056 has been used in trials studying the basic science and treatment of Rheumatoid Arthritis. JNJ-41443532 JNJ-41443532 has been used in trials studying the basic science and treatment of Diabetes Mellitus, Type 2. Lafutidine Lafutidine has been investigated in Peptic Ulcer, Community-acquired Pneumonia, and Gastroesophageal Reflux Disease (GERD). Relenopride Relenopride has been used in trials studying the treatment of Chronic Idiopathic Constipation. DA-6886 DA-6886 has been used in trials studying the treatment of Irritable Bowel Syndrome. RO-4987655 RO4987655 has been used in trials studying the treatment of Neoplasms. Granotapide Granotapide has been used in trials studying the treatment of Type II Diabetes Mellitus. CEP-37440 CEP-37440 has been used in trials studying the treatment of Solid Tumors. Acoziborole SCYX-7158 has been used in trials studying the treatment of Trypanosomiasis, Parasitic Diseases, Protozoan Infections, and Trypanosomiasis, African. 4SC-202 4SC-202 has been used in trials studying the treatment of Advanced Hematologic Malignancies. Etofamide Etofamide is used as an antiamoebic agent. Etofamide, under the brand name Kitnos, was marketed in Brazil by Pfizer but has been discontinued . Epicillin Not Annotated Difenpiramide Not Annotated Iobenzamic acid Not Annotated Clebopride A dopamine antagonist used to treat symptoms associated with functional gastrointestinal disorders. Clebopride may also be used to treat nausea and vomiting associated with chemotherapy. Clefamide Not Annotated Penamecillin Not Annotated Aspoxicillin Not Annotated Metampicillin Metampicillin is a penicillin antibiotic prepared by the reaction of ampicillin with formaldehyde. It is hydrolysed in aqueous solution to form ampicillin. Hydrolysis is rapid under acid conditions like the... Iniparib Not Annotated Brovanexine Not Annotated LGD-6972 LGD-6972 is under investigation in clinical trial NCT01919684 (Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LGD-6972 in Healthy Subjects and Subjects With Type 2 Diabetes Mellitus). TAS-116 TAS-116 is under investigation in clinical trial NCT02965885 (A Study of TAS-116 in Patients With Solid Tumors). Selonsertib Selonsertib is under investigation in clinical trial NCT03053050 (Safety and Efficacy of Selonsertib in Adults With Nonalcoholic Steatohepatitis (NASH) and Bridging (F3) Fibrosis). GTX-758 GTX-758 is under investigation in clinical trial NCT01420861 (GTx-758 on Serum Prostate-specific Antigen (PSA) in Men With Castrate Resistant Prostate Cancer). Linrodostat Linrodostat is under investigation in clinical trial NCT03247283 (Pharmacokinetics and Metabolism Study in Healthy Male Participants). Difamilast Difamilast is under investigation in clinical trial NCT01702181 (A Safety Study to Evaluate the Use and Effectiveness of a Topical Ointment to Treat Adults With Atopic Dermatitis). Fallypride Fallypride is under investigation in clinical trial NCT02310360 (Striatal and Extra-striatal Dopamine Release in Response to Food in Healthy Humans). Olorofim Olorofim is under investigation in clinical trial NCT03340597 (Assessment of Varying Oral Dosing Regimens for F901318 in Healthy Subjects). Sulopenem Sulopenem is under investigation in clinical trial NCT03357614 (Sulopenem Followed by Sulopenem-etzadroxil/Probenecid vs Ertapenem Followed by Cipro for Complicated UTI in Adults). Nacubactam Nacubactam is under investigation in clinical trial NCT03174795 (A Study to Investigate the Pharmacokinetics of RO7079901 and Meropenem in Participants With a Complicated Urinary Tract Infection). Acumapimod Acumapimod is under investigation in clinical trial NCT02926326 (The Effect of Azithromycin on BCT197 Exposure in Healthy Male Volunteers). TAK-715 TAK-715 is under investigation in clinical trial NCT00760864 (Safety and Efficacy of TAK-715 in Subjects With Rheumatoid Arthritis). Acetyldinaline Acetyldinaline is under investigation in clinical trial NCT00005624 (CI-994 in Treating Patients With Advanced Myeloma). Apinocaltamide Apinocaltamide is under investigation in clinical trial NCT03239691 (A Study to Evaluate the Effect of ACT-709478 in Photosensitive Epilepsy Patients). Belumosudil An oral inhibitor of rho-associated coiled-coil-containing protein kinases (ROCK) used in the treatment of chronic graft-versus-host disease (GVHD). Dofetilide A class III antiarrhythmic drug used for the maintenance of normal sinus rhythm and cardioversion in cases of atrial fibrillation and atrial flutter. Glimepiride A sulfonylurea drug used to treat type 2 diabetes mellitus. Cefotiam A cephalosporin antibiotic used to treat a variety of bacterial infections. Sulfanilamide A sulfonamide anti-infective used to treat vulvovaginal candidiasis caused by Candida albicans. Carmustine An alkylating agent used in the treatment of various malignancies, including brain tumours and multiple myeloma, among others. Sulfisoxazole A sulfonamide antibiotic used with other antibiotics to prevent and treat a variety of bacterial infections. Cefmenoxime Used to treat female gynecologic and obstetric infections caused by susceptible aerobic (including the gonococcus) and anaerobic bacteria. Cefmetazole A cephalosporin antibiotic used to treat a variety of bacterial infections. Argatroban A synthetic direct thrombin inhibitor used for the prevention and treatment of thrombosis related to heparin use. Flucloxacillin A narrow spectrum penicillin antibiotic that exerts specific activity against Gram positive organisms in skin and soft tissue infections, except those caused by methicillin resistant staphylococcus aureus (MRSA). Ertapenem A carbapenem antibiotic used for the treatment of moderate to severe infections caused by susceptible bacteria. Ibutilide A class III antiarrhythmic agent used to correct atrial fibrillation and atrial flutter, which can be considered as an alternative to cardioversion. Chlorthalidone A diuretic used to treat hypertension or edema caused by heart failure, renal failure, hepatic cirrhosis, estrogen therapy, and other conditions. Ethoxzolamide For use in the treatment of duodenal ulcers, as a diuretic, and in the treatment of glaucoma, and may also be useful in the treatment of seizures associated with epilepsy. Aminohippuric acid A hippuric acid derivative injection utilized in the measurement of effective renal plasma flow (ERPF) and functional capacity of the renal excretory system. Sulfadiazine A sulfonamide antibiotic used in a variety of infections, such as urinary tract infections, trachoma, and chancroid. Sorafenib A kinase inhibitor used to treat unresectable liver carcinoma, advanced renal carcinoma, and differentiated thyroid carcinoma. Acetohexamide Used in the management of diabetes mellitus type 2 (adult-onset). Streptozocin A nitrosourea antineoplastic agent used in the treatment of metastatic pancreatic islet cell carcinoma. Cefpiramide For treatment of severe infections caused by susceptible bacteria such as P. aeruginosa. Loracarbef Used to treat upper respiratory tract bacterial infections, chronic bronchitis, pneumonia, sinusitis, pharyntitis and tonsillitis, skin absceses, urinary tract infections and pyelonephritis caused by E. coli, S. pyogenes, S. aureus,... Cefalotin A broad-spectrum cephalosporin antibiotic used for the treatment of serious bacterial infections in various locations, such as the urinary tract, skin, bone, and lower respiratory tract. Dicloxacillin A penicillin used to treat penicillinase-producing bacterial infections that are susceptible to the drug. Cefotaxime A third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections. Metolazone A thiazide-like diuretic used to treat hypertension. Zafirlukast A leukotriene receptor antagonist used for prophylaxis and chronic treatment of asthma. Bosentan A dual endothelin receptor antagonist used to treat pulmonary arterial hypertension. Carbenicillin For the treatment of acute and chronic infections of the upper and lower urinary tract and in asymptomatic bacteriuria due to susceptible strains of bacteria. Valdecoxib A COX-2 inhibitor used to treat osteoarthritis and dysmenorrhoea. Cisapride A medication used to treat heartburn associated with GERD. Nafcillin A penicillin derivative antibiotic used to treat susceptible staphylococcal infections. Imatinib A tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. Sulfacetamide A sulfonamide used to treat inflammatory ocular conditions and acne vulgaris. Sulfametopyrazine An antibiotic used in the treatment or prevention of bacterial infections and malaria. Cefixime A third generation cephalosporin used to treat susceptible Gram-negative and Gram-positive bacterial infections. Chlorpropamide A sulfonylurea used in the treatment of non insulin dependent diabetes mellitus. Cephaloglycin For treatment of severe infections caused by susceptible bacteria. Amprenavir A protease inhibitor used to treat HIV infection. Oxacillin A penicillin antibiotic used to treat a number of susceptible bacterial infections. Zileuton A leukotriene synthesis inhibitor used in the prophylaxis and treatment of chronic asthma. Meropenem A carbapenem antibiotic used to treat a wide variety of infections in the body. Sulfasalazine A salicylate used to treat Crohn's disease, ulcerative colitis, and rheumatoid arthritis. Cefaclor A second generation cephalosporin used to treat a wide variety of infections in the body. Tolazamide A sulfonylurea used in the treatment of non insulin dependent diabetes mellitus. Bumetanide A sulfamyl diuretic used to treat edema in congestive heart failure, hepatic and renal disease, and nephrotic syndrome. Sulfapyridine A sulfonamide antibiotic used to treat dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum. Zonisamide A sulfonamide anticonvulsant used to treat partial seizures. Ceforanide For the treatment of infections caused by susceptible organisms. Tipranavir A protease inhibitor used to treat HIV-1 resistant to more than 1 protease inhibitor. Mezlocillin Used to treat serious gram–negative infections of the lungs, urinary tract, and skin. Cyclacillin For the treatment of bacterial infections caused by susceptible organisms. Hydroxyurea An antimetabolite used to treat sickle cell anemia crisis, resistant chronic myeloid leukemia, and Locally advanced squamous cell carcinomas of the head and neck (excluding the lip). Glyburide A sulfonylurea used in the treatment of non insulin dependent diabetes mellitus. Probenecid A medication used to treat gouty arthritis, tophaceous gout, and hyperuricemia. Procainamide A medication used to treat life threatening ventricular arrhythmias. Tocainide An orally active class 1b antiarrhythmic agent that interferes with cardiac sodium channels and typically used to treat ventricular arrhythmias. Azlocillin For the treatment of infections caused by Pseudomonas aeruginosa, Escherichia coli, and Haemophilus influenzae. Cefditoren A broad-spectrum third-generation cephalosporin antibiotic typically used to treat bacterial infections of the skin and respiratory tract. Rosuvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Cefuroxime A cephalosporin indicated for the treatment of a variety of infections including acute bacterial otitis media, several upper respiratory tract infections, skin infections, urinary tract infections, gonorrhea, early Lyme disease, and impetigo. Gliclazide A sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus. Phenacemide Used to control certain seizures in the treatment of epilepsy. Tolbutamide A sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus. Cefapirin A first generation cephalosporin indicated in the treatment of susceptible bacterial infections. Cefadroxil A cephalosporin antibiotic used in the treatment of various bacterial infections, such as urinary tract infections, skin and skin structure infections, and tonsillitis. Diclofenamide A carbonic anhydrase inhibitor used for the management of open-angle and secondary glaucoma, as well as acute angle-closure glaucoma in delayed pre-operative setting requiring a reduction in intraocular pressure. Cefprozil A cephalosporin antibiotic used in the treatment of various bacterial infections, such as pharyngitis, tonsillitis, otitis media, and uncomplicated skin infections. Procarbazine An antineoplastic agent indicated for the treatment of stage III and stage IV Hodgkin's disease in combination with other chemotherapeutic agents. Moclobemide A monoamine oxidase inhibitor used in the treatment of major depressive disorder and bipolar disorder. Lomustine An alkylating agent used as a part of chemotherapeutic regimens for the treatment of primary and metastatic brain tumors as well as refractory or relapsed Hodgkin's disease in addition to surgical and/or radiotherapeutic treatments. Encainide A voltage-gated sodium channel blocker used for management of atrial or ventricular fibrillation, atrial flutter, and ventricular tachycardia, that is no longer used due to proarrhythmic adverse effects. Gliquidone A sulfonylurea drug used in the management of diabetes mellitus type 2. Glisoxepide For the treatment of diabetes mellitus type 2. Practolol Used in the emergency treatment of cardiac arrhythmias. Sulfacytine Used orally in the treatment of acute urinary tract infections. Sulfadoxine A long acting sulfonamide used for the treatment or prevention of malaria. Fosamprenavir An antiretroviral agent used for the treatment and postexposure prophylaxis of human immunodeficiency virus (HIV-1) infection. Quinethazone Used to treat hypertension. Cefamandole A beta-lactam antibiotic used in the treatment of various infections caused by susceptible strains of bacteria, such as lower respiratory infections, urinary tract infections, skin infections, and bone and joint infections. Cefazolin A broad-spectrum cephalosporin antibiotic mainly used for the treatment of skin bacterial infections and other moderate to severe bacterial infections in the lung, bone, joint, stomach, blood, heart valve, and urinary tract. Cefonicid For the treatment of bacterial infections caused by susceptible microorganisms. Cefoperazone A broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, including the respiratory tract, abdomen, skin, and female genital tracts. Cefotetan An antibiotic medication used for the prophylaxis and treatment of various bacterial infections, including urinary tract infections, bone and joint infection, and lower respiratory tract infections. Cefoxitin A semi-synthetic, broad-spectrum antibiotic for parenteral administration used for the treatment of serious bacterial infections, such as urinary tract infection, blood infection, bone and joint infection, and lower respiratory tract infection. Cefradine A first-generation cephalosporin antibiotic used in the treatment of bacterial infections of the respiratory and urinary tracts and of the skin and soft tissues. Glymidine Glycodiazine is used concomitantly with insulin for the treatment of noninsulin-dependent (type 2) diabetes mellitus. Bezafibrate A lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder. Cefepime A fourth-generation cephalosporin antibiotic used in the treatment of infections caused by susceptible bacteria, such as pneumonia, urinary tract infections, and skin infections. Cefacetrile A broad-spectrum first-generation cephalosporin used for the treatment of susceptible bacterial infections. Ceftibuten A third-generation cephalosporin antibiotic commonly used in the treatment of acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsillitis. Cefpodoxime A third-generation cephalosporin antibiotic used in the treatment of various bacterial infections, including gonorrhea, community acquired pneumonia, and sinusitis. Diethyltryptamine Diethyltryptamine (DET) is an orally active hallucinogenic agent and a substituted form of tryptamine. Sulfamerazine An antibacterial agent used in the treatment of various bacterial infections, such as bronchitis, prostatitis, and urinary tract infections. Sulfamethazine An antibacterial agent used in the treatment of various bacterial infections, such as bronchitis, prostatitis, and urinary tract infections. Meticillin Used to treat infections caused by susceptible Gram-positive bacteria, particularly beta-lactamase-producing organisms such as Staphylococcus aureus that would otherwise be resistant to most penicillins. Pivampicillin An ampicillin prodrug used to treat a variety of infections. SC-74020 Not Available N,N-dimethylformamide Not Available AR-AO-14418 Not Available WAY-151693 Not Available Mozenavir Not Available S-Ethylisothiourea S-Ethylisothiourea is a nitric oxide synthase inhibitor. Geldanamycin Not Available N-Benzylformamide Not Available Vorinostat A histone deacetylase (HDAC) inhibitor used for the treatment of cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies. 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide Not Available Piretanide A loop diuretic used to manage essential arterial hypertension and edema cardiac, hepatic, and renal origin. Doramapimod Doramapimod is a P38 MAP kinase inhibitor. N-acetyl-N'-beta-D-glucopyranosyl urea Not Available Cephalosporin C Not Available Cyclohexylformamide Not Available N-phenylthiourea Not Available Phenacetin Used principally as an analgesic. Salicylhydroxamic Acid Not Available ICI-164384 Not Available Urea A keratolytic emollient used to treat hyperkeratotic lesions and moisturize the skin. Deacetoxycephalosporin C Not Available Thiocitrulline Not Available Coelenteramide Not Available Fotemustine An alkylating agent used in the treatment of metastatic melanoma. N-(Benzoylcarbamoyl)-beta-D-glucopyranosylamine Not Available Aminoquinuride Not Available Paratoulene phosphate Not Available N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide Not Available Latamoxef Latamoxef is an oxacephem antibiotic usually grouped with the cephalosporins. It is used to treat bacterial infections. Latamoxef is primarily indicated in conditions like Bone and joint infection, GI infections,... Carboxin A systemic agricultural fungicide and seed treatment agent. Nimesulide A cyclooxygenase 2 inhibitor used to treat acute pain and primary dysmenorrhea. Celiprolol A beta-blocker for the management of hypertension and angina pectoris. Merimepodib For the treatment of hepatitis C virus (HCV) infection. Ceftobiprole A cephalosporin antibiotic used to treat both community and hospital-acquired pneumonia caused by susceptible bacteria. Belinostat A histone deacetylase (HDAC) inhibitor used for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL). Eprotirome Investigated for use/treatment in hyperlipidemia, metabolic disease, and obesity. INCB13739 Investigated for use/treatment in diabetes mellitus type 2 and diabetes prevention. SLV319 Investigated for use/treatment in obesity. Cimicoxib Investigated for use/treatment in depression. AP5280 Investigated for use/treatment in solid tumors. Tanespimycin Investigated for use/treatment in leukemia (myeloid) and solid tumors. AT9283 Investigated for use/treatment in cancer/tumors (unspecified), leukemia (myeloid), and solid tumors. KD3010 Investigated for use/treatment in metabolic disease and obesity. XL765 For the treatment of various forms of cancer. Silver sulfadiazine A topical sulfonamide antibiotic that acts on the bacterial cell wall and cell membrane; approved for the treatment of burns. Pimavanserin A second generation atypical antipsychotic used for the treatment of hallucinations and delusions caused by Parkinson's Disease. Actelion-1 Investigated for use/treatment in cardiovascular disorders, hypertension, and pulmonary hypertension. NCX 701 Investigated for use/treatment in pain (acute or chronic). VX-702 Investigated for use/treatment in coronary artery disease, inflammatory disorders (unspecified), and rheumatoid arthritis. AMG-131 Investigated for use/treatment in diabetes mellitus type 2. AVN-944 Investigated for use/treatment in cancer/tumors (unspecified), leukemia (unspecified), lymphoma (unspecified), multiple myeloma, and pancreatic cancer. Naluzotan Investigated for use/treatment in anxiety disorders and depression. Retaspimycin Investigated for use/treatment in gastric cancer, lung cancer, and multiple myeloma. Elesclomol Investigated for use/treatment in melanoma. Cefilavancin Investigated for use/treatment in bacterial infection, skin infections/disorders, and staph bacterial infections. Laromustine Investigated for use/treatment in brain cancer, cancer/tumors (unspecified), colorectal cancer, leukemia (lymphoid), leukemia (myeloid), lung cancer, myelodysplastic syndrome, pediatric indications, and solid tumors. NS-3728 Investigated for use/treatment in anemia (sickle cell) and cancer/tumors (unspecified). UC-781 Investigated for use/treatment in HIV infection. Resatorvid Investigated for use/treatment in sepsis and septicemia. Linifanib Investigated for use/treatment in leukemia (myeloid), myelodysplastic syndrome, and solid tumors. VX-148 Investigated for use/treatment in autoimmune diseases, psoriasis and psoriatic disorders, and viral infection. SNS-314 Investigated for use/treatment in solid tumors. Sulfathiazole Sulfathiazole is effective against a wide range of gram positive and gram negative pathogenic microorganisms. Although no longer used in humans, it is used in cattle. Sulfadimethoxine For use in the treatment of infections. Doripenem An antibiotic of the penem class used to treat complicated intra-abdominal and urinary tract infections. Lacosamide An antiepileptic drug used to treat partial-onset seizures and primary generalized tonic-clonic seizures. Udenafil A PDE5 inhibitor used to treat erectile dysfunction. Glesatinib Investigated for use/treatment in cancer/tumors (unspecified). Refametinib Investigated for use/treatment in cancer/tumors (unspecified). AR-9281 Investigated for use/treatment in hypertension. Elinogrel Investigated for use/treatment in cardiovascular disorders and myocardial infarction. Indisulam Investigated for use/treatment in lung cancer. Declopramide Investigated for use/treatment in colorectal cancer and inflammatory bowel disease. Ticalopride Investigated for use/treatment in gastroesophageal reflux disease (GERD) and gastroparesis. Ceftaroline fosamil An antibacterial agent used to treat various bacterial infections, such as acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia. Estradiol sulfamate Investigated for use/treatment in endometriosis. Axitinib An oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy. Clazosentan Investigated for use/treatment in strokes. Sulfaphenazole For the treatment bacterial infections. Capsaicin A topical analgesic agent used for the symptomatic relief of neuropathic pain associated with post-herpetic neuralgia, as well as other muscle and joint pain. Mafenide An antimicrobial topical agent indicated for use as an adjunctive treatment to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds. Niclosamide An anthelmintic indicated in the treatment of beef, pork, fish, and dwarf tapeworm infections in adults and children. Sulfameter Long acting sulfonamide used in leprosy, urinary, and respiratory tract infections. PLX-4720 Not Available TO-901317 TO-901317 is an LXRalpha and LXRbeta agonist. SKF-91488 Not Available Nesbuvir Nesbuvir has been investigated for the treatment of Hepatitis C. GW-813893 Not Available 2-[3-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-ureido]-N-methyl-3-phenyl-propionamide Not Available S-23 An androgen receptor modulator. CGS-27023 Not Available 2-[3-(5-Mercapto-[1,3,4]thiadiazol-2yl)-ureido]-N-methyl-3-pentafluorophenyl-propionamide Not Available H-89 Not Available IDD594 Not Available Platensimycin Not Available 2-(4-(2-((3-(5-(PYRIDIN-2-YLTHIO)THIAZOL-2-YL)UREIDO)METHYL)-1H-IMIDAZOL-4-YL)PHENOXY)ACETIC ACID Not Available 4-(2-AMINOETHYL)BENZENESULFONAMIDE Not Available Sulfamoxole For the treatment of bacterial infection. Metiamide Potential in the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion. Vismodegib A hedgehog pathway inhibitor used to treat patients with locally advanced or metastatic basal cell carcinoma. Cabozantinib A tyrosine kinase inhibitor used to treat advanced renal cell carcinoma, hepatocellular carcinoma, and medullary thyroid cancer. Vemurafenib A kinase inhibitor used to treat patients with Erdheim-Chester Disease who have the BRAF V600 mutation, and melanoma in patients who have the BRAF V600E mutation. Regorafenib A kinase inhibitor used to treat patients with metastatic colorectal cancer, unresectable, locally advanced, or metastatic gastrointestinal stromal tumors, and hepatocellular carcinoma. Indoramin Indoramin is a discontinued piperidine antiadrenergic drug with the trade names Baratol and Doralese. It is a selective alpha-1 adrenergic antagonist with no reflex tachycardia and direct myocardial depression action. Ibuproxam Ibuproxam is a non steroidal anti-inflammatory drug (NSAID). Azosemide Azosemide is a loop diuretic used to treat hypertension, edema, and ascites. Glibornuride Glibornuride is a sulfonylurea-type anti-diabetic drug. Cefaloridine Cephaloridine or cefaloridine is a first generation semisynthetic cephalosporin. It is derived from cephalosporin C and is a zwitterion at physiological pH. Bromopride A substituted benzamide, closely related to metoclopramide, used as an antiemetic. Cefminox Cefminox (INN) is a second generation cephalosporin antibiotic. It is approved for use in Japan. Lenvatinib A receptor tyrosine kinase inhibitor used for the treatment of metastatic thyroid cancer, advanced renal cell carcinoma in combination with everolimus, and unresectable hepatocellular carcinoma. Zucapsaicin A topical analgesic used as an adjunct to relieve severe pain of osteoarthritis of the knee in selected adult patients. Dasabuvir A direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents. Piracetam A nootropic cyclic GABA derivative used in myoclonus, sickle cell disease, alcohol dependence, and as a general cognitive enhancer. Caroxazone For the treatment of depression. Propacetamol Propacetamol is a paracetamol prodrug of intravenous administration used to control fever and pain of perioperative period in multimodal analgesia therapy. Ombitasvir A direct acting antiviral agent used in combination with other antiviral agents for the treatment of Hepatitis C Virus (HCV) infections. Paritaprevir A direct acting antiviral agent used in combination with other antiviral agents for the treatment of Hepatitis C Virus (HCV) infections. Carindacillin A penicillin antibiotic used to treat a variety of infections, but is no longer marketed in the USA. Procaine benzylpenicillin A local anesthetic and antibiotic combination for intramuscular injection to treat a variety of bacterial infections while reducing pain from a deep intramuscular injection. Sulbactam An beta-lactamase inhibitor antibiotic combined with other antibiotics to treat a variety of susceptible bacterial infections. Osimertinib A tyrosine kinase inhibitor used in the treatment of certain types of non-small cell lung carcinoma. Sulfabenzamide A sulfonamide antibacterial used as an ingredient in various topical and vaginal preparations to treat certain infections, but has been discontinued by the FDA. Allantoin An ingredient used in skin care products to relieve irritation and protect minor cuts, scrapes, and burns. Carbamide peroxide A medication used to loosen ear wax, whiten teeth, and clean oral wounds. Diethyltoluamide An insect repellant, also known as DEET. Nonivamide Nonivamide is used as a topical analgesic and is also used as a flavoring ingredient , , . Cefroxadine Was used for the treatment of bacterial infections. Cefalonium Not Annotated Clorsulon Not Annotated Deracoxib Deracoxib is a non-steroidal anti-inflammatory drug of the coxib class, used in veterinary medicine to treat osteoarthritis in dogs. It is sold in tablets, which have added beefy flavour to... Nicarbazin Not Annotated Oclacitinib Not Annotated Sulfachlorpyridazine A sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine. Sulfaethoxypyridazine Not Annotated Sulfanitran Not Annotated Sulfaquinoxaline Sulfaquinoxaline is a veterinary medicine which can be given to cattle and sheep to treat coccidiosis.It is available in Pakistan with Sanna Laboratories in combination with Amprolium and Vitamin K... Zoalene Dinitolmide is a fodder additive for prophylaxis against coccidiosis infections in poultry. Ceftiofur Ceftiofur is a third generation cephalosporin antibiotic, first described in 1987, and now used in veterinary medicine. It is marketed by pharmaceutical company Zoetis as Excenel, and is the active... Cefovecin Cefovecin is a cephalosporin antibiotic used for the treatment of skin infections in cats and dogs. It is the first single-dose injectable antibiotic for dogs and cats that assures owner... Imidocarb Imidocarb is a urea derivative used in veterinary medicine as an antiprotozoal agent for the treatment of infection with Babesia and other parasites. Grazoprevir An antiviral and NS3/4A protease inhibitor used to treat hepatitis C infections. Asunaprevir An NS3 protease inhibitor used to treat hepatitis C genotype 1b. Nitrocefin Nitrocefin is a chromogenic cephalosporin substrate used to detect the presence of beta-lactamase enzymes, an important mediator of bacterial antibiotic resistance. While other detection methods exist, such as PCR, nitrocefin... Rabusertib Rabusertib has been used in trials studying the treatment of Cancer, Solid Tumors, Advanced Cancer, Pancreatic Neoplasms, and Non Small Cell Lung Cancer. Pictilisib Pictilisib has been used in trials studying the treatment of Solid Cancers, Breast Cancer, Advanced Solid Tumours, Metastatic Breast Cancer, and Non-Hodgkin's Lymphoma, Solid Cancers, among others. 2-chloroethyl-3-sarcosinamide-1-nitrosourea 2-chloroethyl-3-sarcosinamide-1-nitrosourea has been used in trials studying the treatment of Colorectal Cancer, Brain and Central Nervous System Tumors, and Unspecified Adult Solid Tumor, Protocol Specific. Pavinetant Pavinetant has been used in trials studying the basic science and treatment of Safety and Schizophrenia. Ilorasertib Ilorasertib has been used in trials studying the treatment of Myelodysplasia, Solid Neoplasm, Advanced Cancers, Advanced Solid Tumors, and Acute Myelogenous Leukemia, among others. Antineoplaston A10 Antineoplaston A10 has been used in trials studying the treatment of Sarcoma, Lymphoma, Lung Cancer, Liver Cancer, and Kidney Cancer, among others. Epacadostat Epacadostat has been used in trials studying the treatment of HL, Melanoma, Glioblastoma, Mucosal Melanoma, and Ovarian Carcinoma, among others. Encorafenib A kinase inhibitor used to treat unresectable or metastatic melanoma with specific mutations. PF-00489791 PF-00489791 has been used in trials studying the treatment of Hypertension, Raynaud's Disease, Diabetic Nephropathies, Hypertension, Pulmonary, and Peripheral Vascular Disease. Vonoprazan A potassium-competitive acid blocker used in the treatment of acid-related disorders and as an adjunct to Helicobacter pylori eradication. Spebrutinib Spebrutinib has been used in trials studying the treatment of Rheumatoid Arthritis, Lymphoma, Large B-Cell, Diffuse, and Leukemia Lymphocytic Chronic B-Cell. Pilaralisib Pilaralisib is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K). Pilaralisib has been used in trials studying the treatment of Cancer, Lymphoma, Solid Tumors,... Danoprevir Danoprevir has been used in trials studying the treatment of Hepatitis C, Chronic. Mirodenafil Mirodenafil has been used in trials studying the treatment and supportive care of Kidney Diseases, Urologic Diseases, Renal Insufficiency, Erectile Dysfunction, and Male Erectile Dysfunction. Tivozanib A kinase inhibitor to treat adult patients with renal cell carcinoma (RCC) who have failed prior systemic therapies or experienced relapsed disease. AZD-5672 Azd5672 has been used in trials studying the basic science and treatment of Pharmacokinetics, Renal Impairment, and Rheumatoid Arthritis. Omecamtiv Mecarbil Omecamtiv Mecarbil has been used in trials studying the treatment and basic science of Heart Failure, Echocardiogram, Pharmacokinetics, Chronic Heart Failure, and History of Chronic Heart Failure, among others. Baricitinib A Janus kinase inhibitor used to treat moderate to severe rheumatoid arthritis that has responded poorly to at least one TNF antagonist. TMC-647055 TMC647055 has been used in trials studying the treatment of Hepatitis C, Chronic Hepatitis C, Hepatitis C, Chronic, and Chronic Hepatitis C Virus. PF-04958242 PF-04958242 has been used in trials studying the basic science and treatment of Schizophrenia and Hearing Loss, Sensorineural. Pritelivir Pritelivir has been used in trials studying the prevention of HSV-2 and Genital Herpes. Relugolix An oral GnRH receptor antagonist for androgen deprivation therapy in the treatment of advanced prostate cancer. Litronesib Litronesib has been used in trials studying the treatment of Solid Tumors, Ovarian Cancer, Gastric Cancer, Prostate Cancer, and Acute Leukaemia, among others. Etiracetam Etiracetam is under investigation in clinical trial NCT01137110 (Comparison of Short Duration Levetiracetam to Extended Course for Seizure Prophylaxis After Subarachnoid Hemorrhage (SAH)). PF-00610355 PF-00610355 has been used in trials studying the treatment of Lung Disease, Moxifloxacin, Pulmonary Disease, Asthma, Bronchial, and Bronchial Diseases, among others. SB-705498 SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis. Infigratinib An FGFR inhibitor used to treat locally advanced or metastatic cholangiocarcinoma in adults with a fibroblast growth factor receptor 2 (FGFR2) rearrangement. Avagacestat Avagacestat has been investigated for the basic science and treatment of Alzheimer Disease. Gisadenafil Gisadenafil has been investigated for the treatment of Prostatic Hyperplasia. Rociletinib Rociletinib has been used in trials studying the treatment and prevention of Nonsmall Cell Lung Cancer, Non-small Cell Lung Cancer, and Locally Advanced or Metastatic Non-small Cell Lung Cancer. Vaniprevir Vaniprevir has been used in trials studying the treatment and diagnostic of Hepatitis C, Chronic Hepatitis C, Hepatitis C, Chronic, Chronic Hepatitis C Infection, and Chronic Genotype 1 Hepatitis C... Flomoxef Flomoxef has been used in trials studying the treatment of Urinary Tract Infection. AZD-1236 AZD1236 has been used in trials studying the basic science and treatment of Cystic Fibrosis and Chronic Obstructive Pulmonary Disease. Glasdegib A sonic hedgehog receptor inhibitor used to treat newly diagnosed acute myeloid leukemia in patients over 75 years who cannot receive intense chemotherapy. PF-04457845 PF-04457845 is under investigation in Fear Conditioning. PF-04457845 has been investigated for the treatment of Tourette Syndrome and Cannabis Dependence. Voxilaprevir A nonstructural protein 3 and 4a protease inhibitor used to treat Hepatitis C infections. T-900607 T900607 has been used in trials studying the treatment of Liver Cancer and Gastric Cancer. Enobosarm Enobosarm has been used in trials studying the treatment of Stress Urinary Incontinence and Triple Negative Breast Cancer. Figopitant Figopitant is under investigation in clinical trial NCT02209714 (Safety, Tolerability and Pharmacodynamics After Oral Administration of BIIF 1149 BS in Healthy Male Volunteers). Elubrixin Elubrixin has been used in trials studying the treatment of Cystic Fibrosis, Colitis, Ulcerative, and Chronic Obstructive Pulmonary Disease (COPD). PF-03715455 PF-03715455 has been used in trials studying the treatment of Asthma, Pulmonary Disease, Chronic Obstructive, and Chronic Obstructive Pulmonary Disease (COPD). Presatovir Presatovir has been used in trials studying the treatment of RSV Infection, Respiratory Syncytial Virus (RSV), Respiratory Syncytial Virus Infections, and Respiratory Syncytial Virus (RSV) Infections. Verdinexor Kpt 335 is under investigation in clinical trial NCT02431364 (Trial of Safety and Tolerability of Oral Verdinexor (Verdinexor) in Healthy Adults). Landiolol An ultra short-acting selective beta-blocker used for rapid ventricular rate control in cases of supraventricular tachycardia. KRN-7000 KRN7000 has been used in trials studying the treatment of Lung Cancer, Chronic Hepatitis C, Hepatitis B, Chronic, Unspecified Adult Solid Tumor, Protocol Specific, and Prevention of GvHD in Patients... Iguratimod Iguratimod is under investigation in Rheumatoid Arthritis. AZD-7762 AZD7762 has been investigated for the treatment of Cancer, Solid Tumors, and Advanced Solid Malignancies. ABT-751 ABT-751 has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer. Begacestat Begacestat has been used in trials studying the treatment and basic science of Alzheimer Disease. Vidupiprant Vidupiprant has been used in trials studying the treatment and basic science of Asthma. GLPG-0187 GLPG0187 has been used in trials studying the treatment of Solid Tumors. Foretinib Foretinib has been used in trials studying the treatment of Cancer, Breast Cancer, Carcinoma, Renal Cell, Recurrent Breast Cancer, and Neoplasms, Head and Neck, among others. Foretinib is an orally... Navitoclax Navitoclax has been used in trials studying the treatment and basic science of Solid Tumors, Non-Hodgkin's Lymphoma, EGFR Activating Mutation, Chronic Lymphoid Leukemia, and Hematological Malignancies, among others. Navitoclax is... Bizelesin Bizelesin has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific. Netazepide Netazepide has been used in trials studying the prevention and treatment of Dyspepsia, Hypergastrinaemia, Barrett's Esophagus, ECL-cell Hyperplasia, and Rebound Hyperacidity, among others. Apricoxib Apricoxib has been used in trials studying the treatment and prevention of Lung Cancer, Breast Cancer, Pancreatic Cancer, Non Small Cell Lung Cancer, and Metastatic Pancreatic Cancer, among others. Resminostat Resminostat has been used in trials studying the treatment of Sezary Syndrome, Mycosis fungoides, Hodgkin's Lymphoma, Hepatocellular Carcinoma, and Lymphoma, T-Cell, Cutaneous, among others. Polmacoxib Polmacoxib has been used in trials studying the treatment of Osteoarthritis, Osteoarthritis, Hip, Osteoarthritis, Knee, Localized Primary Osteoarthritis of Hip, and Localized Primary Osteoarthritis of Knee. Voxtalisib Voxtalisib has been used in trials studying the treatment of Cancer, Melanoma, Lymphoma, Glioblastoma, and Breast Cancer, among others. PAC-14028 PAC-14028 has been used in trials studying the treatment of Skin Pruritus, Papulopustular Rosacea, and Erythematotelangiectatic Rosacea. Ioforminol Ioforminol has been used in trials studying the diagnostic of Cardio Renal Safety in High-risk Elderly Subjects Undergoing a Coronary CATH With or Without PCI. Alvespimycin Investigated for use as an antineoplastic agent for solid tumors, advanced solid tumours or acute myeloid leukaemia. E-7820 E7820 has been investigated for the treatment of Colon Cancer and Rectal Cancer. Iofolastat I-123 Iofolastat I-123 is under investigation in clinical trial NCT00992745 (A Phase I Pilot Study Comparing 123I MIP 1072 Versus 111In Capromab Pendetide in Subjects With Metastatic Prostate Cancer). Raclopride Raclopride has been used in trials studying Parkinson Disease. Sparsentan An endothelin and angiotensin II receptor antagonist indicated to reduce proteinuria in adults with primary immunoglobulin A nephropathy at risk of rapid disease progression. Nelotanserin Nelotanserin has been used in trials studying the treatment of Lewy Body Dementia, Visual Hallucinations, Dementia With Lewy Bodies, and REM Sleep Behavior Disorder. It is a highly selective antagonist... LY-295501 ILX-295501 has been used in trials studying the treatment of Ovarian Cancer, Metastatic Cancer, Fallopian Tube Cancer, and Primary Peritoneal Cavity Cancer. Piperine Bioperine has been used in trials studying the treatment of Multiple Myeloma and Deglutition Disorders. Razupenem Razupenem has been used in trials studying the treatment of Skin Infections. Reparixin Reparixin has been used in trials studying the treatment and prevention of Breast Cancer, Metastatic Breast Cancer, Pancreatectomy for Chronic Pancreatitis, Islet Transplantation in Diabetes Mellitus Type 1, and Pancreatic... Taprenepag Taprenepag has been used in trials studying the treatment of Ocular Hypertension and Glaucoma, Open-Angle. Ibipinabant Ibipinabant has been used in trials studying the treatment of Obesity and Obesity and Type 2 Diabetes. K-134 K-134 has been used in trials studying the treatment of Intermittent Claudication. Omipalisib Omipalisib has been used in trials studying the treatment of CANCER, Solid Tumours, and Idiopathic Pulmonary Fibrosis. Pilsicainide Pilsicainide has been investigated for the treatment of Paroxysmal Atrial Fibrillation. Mibampator Mibampator has been used in trials studying the treatment of Alzheimer's Disease. Daporinad Daporinad has been used in trials studying the treatment of Melanoma, Cutaneous T-cell Lymphoma, and B-cell Chronic Lymphocytic Leukemia. Amuvatinib Amuvatinib is a selective multi-targeted tyrosine kinase inhibitor that suppresses c-MET, c-RET and the mutant forms of c-KIT, PDGFR and FLT3. Amuvatinib also suppresses Rad51 protein, a critical component of... CGI-1842 JI-101 has been used in trials studying the treatment of Cancer, Colon Cancer, Neuroendocrine, Ovarian Cancer, and Advanced Solid Tumors. Atreleuton Atreleuton has been used in trials studying the treatment of Atherosclerosis and Coronary Artery Disease. CHF-6001 CHF6001 has been used in trials studying the treatment of Asthma and Chronic Obstructive Pulmonary Disease. Ataciguat Ataciguat has been investigated for the basic science of Aortic Valve Stenosis. Sivelestat Sivelestat has been used in trials studying the treatment of Acute Lung Injury and Respiratory Distress Syndrome, Adult. Quizartinib A FLT3 inhibitor used in combination with cytarabine and anthracycline to treat acute myeloid leukemia with FLT3 internal tandem duplication Chlorsulfaquinoxaline Chlorsulfaquinoxaline has been used in trials studying the treatment of Lung Cancer and Colorectal Cancer. CP-547632 CP-547632 has been used in trials studying the treatment of Ovarian Cancer, Lung Neoplasms, Ovarian Neoplasms, Peritoneal Neoplasms, and Fallopian Tube Cancer, among others. DONU Donu has been used in trials studying the treatment of Psychosis. IPI-493 IPI-493 has been used in trials studying the treatment of Advanced Malignancies. Biapenem A carbapenem antibiotic indicated in the treatment of bacterial infections. Ramatroban Ramatroban has been used in trials studying the treatment of Asthma. CH-5132799 CH5132799 has been used in trials studying the treatment of Solid Tumors. Upamostat Upamostat has been used in trials studying the treatment of Pancreatic Cancer. ACT-451840 ACT-451840 has been used in trials studying Malaria. Nimustine Nimustine has been used in trials studying the treatment of Glioblastoma. GDC-0349 GDC-0349 has been used in trials studying the treatment of Non-Hodgkin's Lymphoma, Solid Tumor. PKI-179 PKI-179 has been used in trials studying the treatment of Advanced Malignant Solid Tumors. Inosine pranobex A medication used to treat subacute sclerosing panencephalitis. Ripasudil A rho kinase inhibitor indicated to treat ocular hypertension and open-angle glaucoma. Apronalide Apronalide is approved in Japan. Apronalide has been withdrawn from the market in many other countries due to patient development of thrombocytopenic purpura . Phthalylsulfathiazole A sulfonamide antibacterial indicated in the treatment of gastrointestinal infections. Penimepicycline Penimepicycline is a tetracycline-class antibiotic. It is mentioned on List A produced by the Government of Canada, which is a list of antimicrobial active pharmaceutical ingredients . In the classification... Cefatrizine Not Annotated Sultopride Sultopride is used in Japan, Hong Kong, and Europe to treat schizophrenia. It is of the drug class atypical antipsychotics . Sulfaisodimidine Sulfaisodimidine also called sulfisomidine is an antibacterial product that has been studied for the treatment of urinary tract infections in the 1950s, however, it is unclear whether this drug has... Bufexamac An NSAID used to treat skin conditions like atopic eczema and inflammatory dermatoses. Pheneturide Not Annotated Bromisoval Not Annotated Mefruside Not Annotated Carbutamide Not Annotated Cefodizime A broad-spectrum, third-generation cephalosporin used to treat serious infections caused by susceptible bacteria. Cefsulodin Not Annotated Cefetamet Not Annotated Carfecillin Not Annotated Mebicar Not Annotated Veralipride Not Annotated Ethenzamide Not Annotated Sulfatolamide Not Annotated Carumonam Not Annotated Succinylsulfathiazole Not Annotated Carbaspirin calcium An NSAID indicated in the treatment of short term pain and fever. Clorexolone Not Annotated Cefbuperazone Not Annotated Semustine Not Annotated Lorcainide Not Annotated Benorilate Not Annotated Propicillin Not Annotated Cefozopran Not Annotated Metahexamide Not Annotated Cefpirome An antibiotic indicated in the treatment of a wide variety of infections in the body. Sulbenicillin Not Annotated Sulfathiourea Not Annotated Sulfaguanidine Not Annotated Epanolol Epanolol is an beta blocker. Sulfamethoxypyridazine A sulphonamide antibiotic indicated in the treatment of gonorrhea, inflammation, urinary tract ulcers, and bronchitis. Cefazedone Not Annotated Clopamide Clopamide is an oral diuretic agent with antihypertensive activity. Like thiazide diuretics, it has an aromatic sulfonamide base but with no double-ring structure. Xipamide A diuretic indicated in the treatment of edema. Talampicillin Not Annotated Carbromal Not Annotated Ceftezole Not Annotated Ranimustine Not Annotated Noxytiolin Local antibacterial that probably acts by releasing formaldehyde in aqueous solutions. It is used for THERAPEUTIC IRRIGATION of infected body cavities - bladder, peritoneum, etc. and as a spray for... Glecaprevir A Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C. SB-269970 SB-269970 is an experimental drug developed by GlaxoSmithKline. In the studies performed with this agent, it has been suggested that SB-269970 acts either as a selective antagonist or inverse agonist... Acetyl sulfisoxazole Acute, recurrent or chronic urinary tract infections (primarily pyelonephritis, pyelitis and cystitis) due to susceptible organisms (usually Escherichia coli, Klebsiella-Enterobacter, staphylococcus, Proteus mirabilis and, less frequently, Proteus vulgaris) in the... SC-236 SC-236 is a potent, selective, orally active inhibitor of cyclooxygenase-2 (COX-2) that has been studied in cancer therapy , lower back pain , and inflammation , , , . NS-398 NS-398 is a COX-2 inhibitor. It was developed as part of the mechanistic study of the cyclooxygenases. Imidurea Imidurea is an antimicrobial preservative used in cosmetics. It acts as a formaldehyde releaser. 7-Aminodesacetoxycephalosporanic acid Not Annotated Diazolidinylurea An ingredient used in hospitals for disinfection. Ceramide AP Not Annotated Ceramide NG Not Annotated Cefamandole nafate A second generation cephalosporin indicated in the prevention of infections during surgery. Mebenil An obsolete fungicide used to control various pathogens on cereals and seed potatoes. Ceftobiprole medocaril A cephalosporin indicated in the treatment of pneumonia. Narlaprevir Not Annotated Lanifibranor Lanifibranor is under investigation in clinical trial NCT03008070 (Phase 2b Study in NASH to Assess IVA337). Piflufolastat F 18 A radiopharmaceutical diagnostic agent used with PET to image PSMA-positive lesions for the diagnosis of metastatic or recurrent prostate cancer. Ripretinib A kinase inhibitor used to treat advanced gastrointestinal stromal tumor (GIST). PF-05089771 PF-05089771 is under investigation in clinical trial NCT01529671 (A Safety And Tolerability Study Of PF-05089771 In Healthy Subjects And In Subjects With Otseoarthritis Of The Knee). Ceralasertib Ceralasertib is under investigation in clinical trial NCT03682289 (Phase II Trial of AZD6738 Alone and in Combination With Olaparib). Elsulfavirine Elsulfavirine is under investigation in clinical trial NCT03706898 (Study to Evaluate the Safety and PK of Elpida® in Healthy Subjects and Patients With Hepatic Impairment and to Assess the Impact... BMS-817399 BMS-817399 is under investigation in clinical trial NCT01404585 (Proof-of-Concept Study With BMS-817399 to Treat Moderate to Severe Rheumatoid Arthritis). Abrocitinib A kinase inhibitor used to treat moderate-to-severe atopic dermatitis in adults. Pyrotinib Pyrotinib is under investigation in clinical trial NCT03756064 (Neoadjuvant Study of Pyrotinib in Patients With HER2 Positive Breast Cancer). Flufenoxuron Flufenoxuron is under investigation in clinical trial NCT00922870 (Evaluation of Hemodynamic Effects of Cascade Hemofiltration in Septic Shock). Edasalonexent Edasalonexent is under investigation in clinical trial NCT01511900 (A Multiple Ascending Dose Study of CAT-1004 in Patients With Type 2 Diabetes). TAK-243 TAK-243 is under investigation in clinical trial NCT03816319 (TAK-243 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Refractory Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia). Apararenone Apararenone is under investigation in clinical trial NCT02531568 (Drug Interaction Study of Warfarin and MT-3995). Sitravatinib Sitravatinib is under investigation in clinical trial NCT03680521 (Neoadjuvant Sitravatinib in Combination With Nivolumab in Patients With Clear Cell Renal Cell Carcinoma). ABT-639 ABT-639 is under investigation in clinical trial NCT01345045 (A Multicenter Study Comparing the Analgesic Effects and Safety of ABT-639 Compared to Placebo in Subjects With Diabetic Neuropathic Pain). Aprocitentan Aprocitentan is under investigation in clinical trial NCT03541174 (A Research Study to Show the Effect of Aprocitentan in the Treatment of Difficult to Control (Resistant) High Blood Pressure (Hypertension) and... Agerafenib Agerafenib is under investigation in clinical trial NCT03052569 (Expanded Access to RXDX-105 for Cancers With RET Alterations). Gefapixant A P2X3 receptor antagonist that reduces the cough reflex in patients with refractory or unexplained chronic cough. Surufatinib Surufatinib is under investigation in clinical trial NCT02588170 (Phase III Study of Surufatinib in Treating Advanced Extrapancreatic Neuroendocrine Tumors). Tipranavir C-14 Tipranavir C-14 is under investigation in clinical trial NCT02253797 (Pharmacokinetics of Tipranavir/Ritonavir and Its Metabolites in Healthy Male Subjects). ABT-072 ABT-072 is under investigation in clinical trial NCT00890318 (A Study in Healthy Adult Subjects to Evaluate the Safety, Tolerability, and Pharmacokinetic Profiles of Multiple Doses of ABT-072 Used to Treat... Dubermatinib Dubermatinib is under investigation in clinical trial NCT03572634 (Phase 1/2 Study of TP-0903 (an Inhibitor of AXL Kinase) in Patients With Previously Treated CLL). Birabresib Birabresib is under investigation in clinical trial NCT02698176 (A Dose Exploration Study With MK-8628 in Participants With Selected Advanced Solid Tumors (MK-8628-006)). RSV-604 RSV-604 is under investigation in clinical trial NCT00416442 (Safety, Tolerability and Pharmacokinetic Study of Single and Multiple Intravenous Doses of RSV604 in Healthy Subjects.). JNJ-26489112 JNJ-26489112 is under investigation in clinical trial NCT00579384 (A Study of the Effects of JNJ-26489112 on the Photic Induced Paroxysmal Electroencephalogram (EEG) Response in Patients With Photosensitive Epilepsy). Telaglenastat Telaglenastat is under investigation in clinical trial NCT02071862 (Study of the Glutaminase Inhibitor CB-839 in Solid Tumors). Vercirnon Vercirnon is a novel, orally active anti-inflammatory agent that targets a chemokine receptor protein implicated in both Crohn's disease and ulcerative colitis, the two principal forms of IBD. It is... Florasulam Florasulam is under investigation in clinical trial NCT01193465 (Temperature and Humidity Among Different Anesthesia Work-station). VM4-037 VM4-037 is under investigation in clinical trial NCT00884520 (An Exploratory, Open Label, Multi-Center, Non-Randomized Study of [F-18]VM4-037). Tefinostat Tefinostat is under investigation in clinical trial NCT02759601 (Dose Escalation Trial of Tefinostat for Cancer Associated Inflamation in Hepatocellular Carcinoma (HCC)). SAR-125844 SAR-125844 is under investigation in clinical trial NCT01391533 (Study of SAR125844 Single Agent Administered as Slow Intravenous Infusion in Adult Patients With Advanced Malignant Solid Tumors). Dihydrocapsiate Dihydrocapsiate is under investigation in clinical trial NCT00999297 (Effect of 4-week Dihydrocapsiate Ingestion on Resting Metabolic Rate). Giripladib Giripladib is under investigation in clinical trial NCT00396955 (A Study Comparing 4 Dose Regimens of PLA-695, Naproxen, and Placebo In Subjects With Osteoarthritis Of The Knee). Iodohippuric acid Iodohippuric acid is under investigation in clinical trial NCT02599844 (Impact of Pediatric Acute Renal Injury in Severe Sepsis in Young Adults). Fluazuron Fluazuron is a benzoyl phenylurea compound. TMC-310911 TMC-310911 (also known as ASC-09) is a novel investigational protease inhibitor (PI) that is structurally similar to the currently available darunavir. It is being investigated for use in HIV-1 infections.... Fasitibant Fasitibant is under investigation in clinical trial NCT02205814 (Fasitibant Intra-articular Injection in Patients With Symptomatic Osteoarthritis of the Knee). Sulbactam pivoxil A prodrug of a beta-lactamase inhibitor used to improve the efficacy of beta lactam antibiotics Sulfametrole An antibiotic indicated in combination intravenous products for various bacterial infections. Salicylamide O-acetic acid A salicylate indicated in combination with local anesthetics and corticosteroids for short term treatment of inflammation. Levosulpiride indicated to treat dyspepsia, symptoms of Meniere's syndrome, and second line in the treatment of drug-induced nausea and vomiting. PLX8394 PLX8394 is under investigation in clinical trial NCT02428712 (A Study of PLX8394 as a Single Agent in Patients With Advanced Unresectable Solid Tumors). APG-1387 APG-1387 is under investigation in clinical trial NCT04568265 (A Clinical Study of APG-1387 in Combination With Entecavir in Patients With Chronic Hepatitis B). Batabulin Batabulin is under investigation in clinical trial NCT00057382 (T138067 Versus Doxorubicin in Chemotherapy-naive, Unresectable, Hepatocellular Carcinoma Patients). Ladarixin Ladarixin is under investigation in clinical trial NCT04628481 (A Study of Oral Ladarixin in New-onset Type 1 Diabetes and a Low Residual Β-Cell Function). Methfuroxam Methfuroxam is under investigation in clinical trial NCT01213407 (Dendritic Cell Cancer Vaccine for High-grade Glioma). Nevanimibe Nevanimibe is under investigation in clinical trial NCT03053271 (A Study of ATR-101 for the Treatment of Endogenous Cushing's Syndrome). Pexmetinib Pexmetinib is under investigation in clinical trial NCT04074967 (Study of ARRY-614 Plus Either Nivolumab or Ipilimumab). GSK-2981278 GSK-2981278 is under investigation in clinical trial NCT03004846 (A Study of GSK2981278 Ointment in Subjects With Plaque Psoriasis). ABX-196 ABX-196 is under investigation in clinical trial NCT03897543 (ABX196 in Combination With Nivolumab in Patients With Hepatocellular Carcinoma). Almonertinib Almonertinib is a third-generation EGFR tyrosine kinase inhibitor targeting EGFR-sensitizing and T790M resistance mutations.[A231859, A231864, A231869] It is being investigated against advanced or metastatic EGFR-mutated non-small cell lung cancer (NSCLC). Fasentin Not Annotated AZD-5069 Not Annotated Tebipenem pivoxil Not Annotated Hippuric acid Not Annotated BMS-833923 Not Annotated S-38093 Not Annotated Meloxicam An NSAID used to treat osteoarthritis in adults, rheumatoid arthritis in adults, and juvenile rheumatoid arthritis in pediatrics. RG-2833 Not Annotated ABT-737 An inhibitor of members of the Bcl‑2 family of apoptosis regulators. JTC-801 free base An antagonist of nociceptin receptor and analgesic agent, evaluated for its use in cancer treatment. PIK-75 PIK-75 is a preferential p110 alpha/gamma PI3K inhibitor. NRC-AN-019 Not Annotated KX-2361 Not Annotated Altiratinib Not Annotated Redaporfin Not Available p-Toluenesulfonamide Not Available Domatinostat Not Annotated TTI-101 Not Annotated Casopitant Investigated for use/treatment in urinary incontinence and adverse effects (chemotherapy). Netupitant An antiemetic agent used in combination with palonosetron to prevent acute and delayed vomiting and nausea caused by chemotherapy. SP-8203 SP-8203 has been used in trials studying the treatment of Ischemic Stroke. Semapimod Semapimod has been used in trials studying the treatment of Crohn Disease. Avoralstat Avoralstat has been used in trials studying the prevention of HAE and Hereditary Angioedema. Fosdagrocorat Fosdagrocorat has been used in trials studying the treatment and basic science of Rheumatoid Arthritis. PCI-27483 PCI-27483 has been used in trials studying the treatment of Pancreatic Cancer, Ductal Adrenocarcinoma, and Exocrine Pancreatic Cancer. Fagrocorat Not Annotated Abivertinib Abivertinib is a tyrosine kinase inhibitor targeted against mutant forms of both human epidermal growth factor receptor (EGFR) and Bruton's tyrosine kinase (BTK). It has been investigated for use in... GC-376 free acid GC-376 is a 3C-like protease (3CLpro or Mpro) inhibitor that stops the cleavage and activation of functional viral proteins required for replication and transcription in host cells . The compound... GC-373 GC-373 is a peptide aldehyde which is metabolized from the bisulfide adduct, GC-376 free acid[A219031,A219036]. It is an inhibitor of Mpro (otherwise known as 3CLpro), a viral encoded protease that... HQP1351 HQP1351 is under investigation in clinical trial NCT03883100 (A Pivotal Study of HQP1351 in Patients of Chronic Myeloid Leukemia in Accelerated Phase With T315I Mutation). Isoindolin-1,3-Dithione Not Annotated BLU-9931 Not Annotated Buloxibutid Not Annotated Fipaxalparant Not Annotated VLX-1005 Not Annotated ABSK-091 Not Annotated Sulthiame A carbonic anhydrase inhibitor used primarily in benign focal epilepsies of childhood that may be useful as an adjunct therapy in a variety of other refractory epilepsies. BMS-986141 BMS-986141 is under investigation in clinical trial NCT02985632 (A Study to Evaluate the Pharmacokinetics of BMS-986141 in Participants With Hepatic Impairment Compared to Healthy Participants). Danavorexton Not Annotated Revumenib Not Annotated - Drugs & Drug Targets