GABA-A Receptor Agonists

Name
GABA-A Receptor Agonists
Accession Number
DBCAT000850
Description

Endogenous compounds and drugs that bind to and activate GABA-A RECEPTORS.

Drugs
DrugDrug Description
ZolpidemA sedative hypnotic used for the short-term treatment of insomnia to improve sleep latency.
AZD 3355Investigated for use/treatment in gastroesophageal reflux disease (GERD).
LesogaberanLesogaberan has been used in trials studying the treatment and basic science of GERD, Reflux, Heartburn, Regurgitation, and Reflux Disease, among others.
MuscimolMuscimol has been used in trials studying the treatment of Epilepsy and Parkinson's Disease.
ZaleplonA sedative used for short term treatment of insomnia in adults.
ClobazamA benzodiazepine used as adjunct treatment in seizures associated with Lennox-Gastaut syndrome.
ABP-700ABP-700 is under investigation in clinical trial NCT02800590 (Study to Investigate the Safety and Efficacy of 3 Dosing Regimens of ABP-700 for Procedural Sedation in Adult Participants Undergoing Colonoscopy).
Drugs & Drug Targets
DrugTargetType
ZolpidemGamma-aminobutyric acid receptor subunit alpha-1target
ZolpidemCytochrome P450 3A4enzyme
ZolpidemCytochrome P450 1A2enzyme
ZolpidemGamma-aminobutyric acid receptor subunit alpha-2target
ZolpidemGamma-aminobutyric acid receptor subunit alpha-3target
ZolpidemCytochrome P450 2C9enzyme
ZolpidemCytochrome P450 2C19enzyme
ZolpidemCytochrome P450 2D6enzyme
ZolpidemGamma-aminobutyric acid receptor subunit gamma-2target
AZD 3355Cellular tumor antigen p53target
MuscimolGamma-aminobutyric acid receptor subunit alpha-1target
MuscimolGamma-aminobutyric acid receptor subunit beta-3target
MuscimolGamma-aminobutyric acid receptor subunit gamma-2target
ZaleplonGamma-aminobutyric acid receptor subunit alpha-1target
ZaleplonCytochrome P450 3A4enzyme
ZaleplonAldehyde oxidaseenzyme
ZaleplonCytochrome P450 3A5enzyme
ZaleplonCytochrome P450 3A7enzyme
ClobazamCytochrome P450 2C19enzyme
ClobazamCytochrome P450 3A4enzyme
ClobazamCytochrome P450 2B6enzyme
ClobazamCytochrome P450 2C18enzyme
ClobazamP-glycoprotein 1transporter
ClobazamGABA(A) Receptortarget
ClobazamCytochrome P450 2D6enzyme
ClobazamGABA(A) Receptor Benzodiazepine Binding Sitetarget
ClobazamSerum albumincarrier
ClobazamAlpha-1-acid glycoprotein 1carrier
ClobazamCytochrome P450 2C9enzyme
ClobazamUDP-glucuronosyltransferase 1-4enzyme
ClobazamUDP-glucuronosyltransferase 1-6enzyme
ClobazamUDP-glucuronosyltransferase 2B4enzyme
ClobazamUDP-glucuronosyltransferase 1-1enzyme
ClobazamCytochrome P450 1A2enzyme
ClobazamCytochrome P450 2C8enzyme
ClobazamCytochrome P450 3A5enzyme
ClobazamCytochrome P450 3A7enzyme