Dideoxynucleosides
- Name
- Dideoxynucleosides
- Accession Number
- DBCAT000928
- Description
Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.
- Drugs
Drug Drug Description Zidovudine A dideoxynucleoside used in the treatment of HIV infection. Stavudine A dideoxynucleoside used in the treatment of HIV infection. Emtricitabine A nucleoside reverse transcriptase inhibitor used for the treatment and prophylaxis of HIV. Didanosine A reverse transcriptase inhibitor used to treat HIV. Zalcitabine A dideoxynucleoside used to treat HIV. Lamivudine A reverse transcriptase inhibitor used to treat HIV and hepatitis B infections. Zidovudine monophosphate Not Available Zidovudine diphosphate Not Available Elvucitabine Investigated for use/treatment in hepatitis (viral, B) and HIV infection. Fozivudine Tidoxil Fozivudine Tidoxil has been used in trials studying the treatment of HIV Infections. Dexelvucitabine Dexelvucitabine has been used in trials studying the treatment of HIV Infections and Human Immunodeficiency Virus. Abacavir An antiviral nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals for the treatment of HIV. Stavudine triphosphate Not Available Abacavir hydroxyacetate Prurisol is under investigation for the treatment of Chronic Stable Plaque Psoriasis. Prurisol has been investigated for the treatment of Plaque Psoriasis. Dideoxyadenosine Not Annotated Navuridine Not Annotated - Drugs & Drug Targets