Sleep Aids, Pharmaceutical

Name
Sleep Aids, Pharmaceutical
Accession Number
DBCAT001256
Description

Drugs used to induce SLEEP, prevent SLEEPLESSNESS, or treat SLEEP INITIATION AND MAINTENANCE DISORDERS.

Drugs
DrugDrug Description
DiphenhydramineA H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.
DoxepinA psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia.
MepyramineAn antihistamine agent used for the symptomatic treatment of allergy, hypersensitivity reactions, and pruritic skin disorders.
SuvorexantA orexin receptor antagonist used to treat insomnia that is characterized by difficulties with sleep onset and/or sleep maintenance.
ZolpidemA sedative hypnotic used for the short-term treatment of insomnia to improve sleep latency.
LemborexantA dual orexin antagonist indicated for the treatment of sleep-onset and/or sleep maintenance insomnia.
Drugs & Drug Targets
DrugTargetType
DiphenhydramineHistamine H1 receptortarget
DiphenhydramineCytochrome P450 2D6enzyme
DiphenhydramineCytochrome P450 2C9enzyme
DiphenhydramineCytochrome P450 2C19enzyme
DiphenhydramineSolute carrier family 22 member 2transporter
DiphenhydramineSolute carrier family 22 member 5transporter
DiphenhydramineProstaglandin G/H synthase 1enzyme
DiphenhydramineMuscarinic acetylcholine receptor M2target
DoxepinSodium-dependent serotonin transportertarget
DoxepinSodium-dependent noradrenaline transportertarget
DoxepinHistamine H1 receptortarget
DoxepinHistamine H2 receptortarget
DoxepinCytochrome P450 2D6enzyme
DoxepinMuscarinic acetylcholine receptor M1target
DoxepinMuscarinic acetylcholine receptor M2target
DoxepinMuscarinic acetylcholine receptor M3target
DoxepinMuscarinic acetylcholine receptor M4target
DoxepinMuscarinic acetylcholine receptor M5target
DoxepinAlpha-1A adrenergic receptortarget
Doxepin5-hydroxytryptamine receptor 1Atarget
Doxepin5-hydroxytryptamine receptor 2Atarget
DoxepinCytochrome P450 2C19enzyme
DoxepinCytochrome P450 2C9enzyme
DoxepinCytochrome P450 1A2enzyme
DoxepinP-glycoprotein 1transporter
Doxepin5-hydroxytryptamine receptor 2Btarget
Doxepin5-hydroxytryptamine receptor 2Ctarget
DoxepinAlpha-1B adrenergic receptortarget
DoxepinAlpha-1D adrenergic receptortarget
DoxepinCytochrome P450 3A4enzyme
Doxepin5-hydroxytryptamine receptor 6target
DoxepinHistamine H4 receptortarget
DoxepinPotassium voltage-gated channel subfamily H member 2target
DoxepinSerum albumincarrier
DoxepinAlpha-1-acid glycoprotein 1carrier
MepyramineCytochrome P450 2D6enzyme
MepyramineHistamine H1 receptortarget
MepyramineSolute carrier family 22 member 4transporter
MepyramineSolute carrier family 22 member 5transporter
SuvorexantOrexin receptor type 1target
SuvorexantOrexin receptor type 2target
SuvorexantCytochrome P450 3A4enzyme
SuvorexantP-glycoprotein 1transporter
ZolpidemGamma-aminobutyric acid receptor subunit alpha-1target
ZolpidemCytochrome P450 3A4enzyme
ZolpidemCytochrome P450 1A2enzyme
ZolpidemGamma-aminobutyric acid receptor subunit alpha-2target
ZolpidemGamma-aminobutyric acid receptor subunit alpha-3target
ZolpidemCytochrome P450 2C9enzyme
ZolpidemCytochrome P450 2C19enzyme
ZolpidemCytochrome P450 2D6enzyme
ZolpidemGamma-aminobutyric acid receptor subunit gamma-2target
LemborexantOrexin receptor type 1target
LemborexantOrexin receptor type 2target
LemborexantCytochrome P450 3A4enzyme
LemborexantCytochrome P450 3A5enzyme
LemborexantCytochrome P450 3A Subfamilyenzyme
LemborexantCytochrome P450 2B6enzyme
LemborexantP-glycoprotein 1transporter