Trace Elements

Name

Trace Elements

Accession Number

DBCAT001391

Description

A group of chemical elements that are needed in minute quantities for the proper growth, development, and physiology of an organism. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Drugs

Drug	Drug Description
Iron	An essential element commonly used for the treatment of patients with documented iron deficiency.
Zinc	An essential element commonly used for the treatment of patients with documented zinc deficiency.
Iodine	An ingredient of nutritional supplements that is also used for disinfection.
Manganese	A transition metal used for supplementation of manganese during Total Parenteral Nutrition (TPN).
Copper	A transition metal found in a variety of supplements and vitamins, including intravenous solutions for total parenteral nutrition (TPN).
Selenious acid	An ingredient found in supplements, vitamins, parenteral nutrition, and dandruff shampoo.
Cupric oxide	An ingredient found in a variety of supplements and vitamins.
Chromium	An ingredient found in a variety of supplements and vitamins.
Molybdenum	An ingredient found in a variety of supplements and vitamins.
Boron	Boron (B) is a chemical element with an atomic number 5 that belongs in the Period 2 and Group 13 in the periodic table. It is a low-abundant metalloid that...
Silicon	A micronutrient indicated in nutritional products to treat or prevent silicon deficiencies.
Vanadium	A micronutrient used in some multivitamins and parenteral nutrition.
Ferrous fumarate	A medication used to treat iron-deficiency anemia.
Cobalt	A metal element used in various nutritional products.
Selenic acid	An ingredient found in a variety of supplements and vitamins.
Selenium	An ingredient found in a variety of supplements and vitamins.

Drugs & Drug Targets

Drug	Target	Type
Iron	Transferrin receptor protein 1	target
Iron	Egl nine homolog 1	target
Iron	Histone deacetylase 8	target
Iron	Alpha-hemoglobin-stabilizing protein	target
Iron	Hemoglobin subunit alpha	target
Iron	Frataxin, mitochondrial	target
Iron	Ferritin heavy chain	target
Iron	Flap endonuclease 1	target
Iron	Endonuclease 8-like 1	target
Iron	Endonuclease 8-like 2	target
Iron	DNA polymerase beta	target
Iron	Ceruloplasmin	target
Iron	Serotransferrin	target
Zinc	B1 bradykinin receptor	target
Zinc	Methylated-DNA--protein-cysteine methyltransferase	target
Zinc	Fructose-bisphosphate aldolase A	target
Zinc	Elongation factor 1-alpha 1	target
Zinc	Alpha-enolase	target
Zinc	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	target
Zinc	Nucleoside diphosphate kinase A	target
Zinc	Protein disulfide-isomerase	target
Zinc	Protein disulfide-isomerase A3	target
Zinc	Peroxiredoxin-1	target
Zinc	Phosphoserine phosphatase	target
Zinc	Triosephosphate isomerase	target
Zinc	Elongation factor Tu, mitochondrial	target
Zinc	Estrogen receptor alpha	target
Zinc	Interleukin-3	target
Zinc	Metallothionein-2	target
Zinc	Copper chaperone for superoxide dismutase	target
Zinc	Histone deacetylase 1	target
Zinc	Histone deacetylase 4	target
Zinc	DNA-3-methyladenine glycosylase	target
Zinc	Semenogelin-1	target
Zinc	Superoxide dismutase [Cu-Zn]	target
Zinc	Histone deacetylase 8	target
Zinc	Apoptosis regulatory protein Siva	target
Zinc	Glycine receptor subunit alpha-1	target
Zinc	E3 ubiquitin-protein ligase Mdm2	target
Zinc	Insulin	target
Zinc	Utrophin	target
Zinc	Aspartoacylase	target
Zinc	Protein S100-A8	target
Zinc	Protein S100-A9	target
Zinc	Matrix metalloproteinase-9	target
Zinc	Tumor protein p73	target
Zinc	Protein S100-A2	target
Zinc	Cellular tumor antigen p53	target
Zinc	Metallothionein-3	target
Zinc	Programmed cell death protein 6	target
Zinc	DAN domain family member 5	target
Zinc	Metallothionein-1A	target
Zinc	Alpha-1B-glycoprotein	target
Zinc	Alpha-2-macroglobulin	target
Zinc	Angiotensinogen	target
Zinc	Alpha-2-HS-glycoprotein	target
Zinc	Serum amyloid P-component	target
Zinc	Apolipoprotein A-I	target
Zinc	Apolipoprotein A-II	target
Zinc	Apolipoprotein A-IV	target
Zinc	Apolipoprotein B receptor	target
Zinc	Apolipoprotein E	target
Zinc	Apolipoprotein L1	target
Zinc	Complement C1q subcomponent subunit B	target
Zinc	Complement C1q subcomponent subunit C	target
Zinc	Complement C1r subcomponent	target
Zinc	Complement C1s subcomponent	target
Zinc	Complement C3	target
Zinc	Complement C4-B	target
Zinc	C4b-binding protein alpha chain	target
Zinc	C4b-binding protein beta chain	target
Zinc	Complement C5	target
Zinc	Lys-63-specific deubiquitinase BRCC36	target
Zinc	Complement component C8 alpha chain	target
Zinc	Complement component C8 beta chain	target
Zinc	Complement component C8 gamma chain	target
Zinc	Complement factor B	target
Zinc	Complement factor H	target
Zinc	Complement factor I	target
Zinc	Clusterin	target
Zinc	Ceruloplasmin	target
Zinc	Carboxypeptidase N catalytic chain	target
Zinc	Carboxypeptidase N subunit 2	target
Zinc	Dermcidin	target
Zinc	Desmoplakin	target
Zinc	Coagulation factor XII	target
Zinc	Coagulation factor XIII B chain	target
Zinc	Prothrombin	target
Zinc	Ficolin-3	target
Zinc	Fibrinogen alpha chain	target
Zinc	Fibronectin	target
Zinc	Gelsolin	target
Zinc	Hemoglobin subunit alpha	target
Zinc	Hemoglobin subunit beta	target
Zinc	Haptoglobin-related protein	target
Zinc	Hornerin	target
Zinc	Insulin-like growth factor-binding protein complex acid labile subunit	target
Zinc	Ig alpha-1 chain C region	target
Zinc	Ig mu chain C region	target
Zinc	Immunoglobulin kappa variable 1-17	target
Zinc	Ig kappa chain V-III region GOL	target
Zinc	Immunoglobulin lambda variable 3-21	target
Zinc	Inter-alpha-trypsin inhibitor heavy chain H1	target
Zinc	Inter-alpha-trypsin inhibitor heavy chain H2	target
Zinc	Inter-alpha-trypsin inhibitor heavy chain H3	target
Zinc	Inter-alpha-trypsin inhibitor heavy chain H4	target
Zinc	Immunoglobulin J chain	target
Zinc	Junction plakoglobin	target
Zinc	Plasma kallikrein	target
Zinc	Kininogen-1	target
Zinc	Keratin, type II cytoskeletal 1	target
Zinc	Keratin, type I cytoskeletal 10	target
Zinc	Keratin, type I cytoskeletal 14	target
Zinc	Keratin, type I cytoskeletal 16	target
Zinc	Keratin, type II cytoskeletal 2 epidermal	target
Zinc	Keratin, type II cytoskeletal 5	target
Zinc	Keratin, type II cytoskeletal 6A	target
Zinc	Keratin, type I cytoskeletal 9	target
Zinc	Alpha-1-acid glycoprotein 2	target
Zinc	N-acetylmuramoyl-L-alanine amidase	target
Zinc	Serum paraoxonase/arylesterase 1	target
Zinc	Pregnancy zone protein	target
Zinc	Protein S100-A7	target
Zinc	Selenoprotein P	target
Zinc	Alpha-1-antitrypsin	target
Zinc	Alpha-1-antichymotrypsin	target
Zinc	Kallistatin	target
Zinc	Corticosteroid-binding globulin	target
Zinc	Heparin cofactor 2	target
Zinc	Sex hormone-binding globulin	target
Zinc	Serotransferrin	target
Zinc	Transthyretin	target
Zinc	Vitronectin	target
Zinc	Amyloid-like protein 1	target
Zinc	Amyloid-like protein 2	target
Zinc	Amyloid beta A4 protein	target
Zinc	Poly [ADP-ribose] polymerase 1	target
Zinc	Carbonic anhydrase 1	enzyme
Iodine	Sodium/iodide cotransporter	transporter
Iodine	Serum albumin	carrier
Iodine	Thyroglobulin	carrier
Iodine	Thyroid peroxidase	enzyme
Iodine	Sodium/iodide cotransporter	target
Iodine	Pendrin	transporter
Iodine	Microbial proteins	target
Manganese	Cytoplasmic aconitate hydratase	enzyme
Manganese	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	target
Manganese	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	target
Manganese	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	target
Manganese	Arginase-1	target
Manganese	Serotransferrin	target
Copper	Superoxide dismutase [Cu-Zn]	enzyme
Copper	Amiloride-sensitive amine oxidase [copper-containing]	enzyme
Copper	Protein-lysine 6-oxidase	enzyme
Copper	High affinity copper uptake protein 1	transporter
Copper	Natural resistance-associated macrophage protein 2	transporter
Copper	Serum albumin	carrier
Copper	Alpha-2-macroglobulin	carrier
Copper	Ceruloplasmin	carrier
Copper	Copper transport protein ATOX1	carrier
Copper	Copper-transporting ATPase 1	transporter
Copper	Copper-transporting ATPase 2	transporter
Copper	Copper chaperone for superoxide dismutase	carrier
Copper	Cytochrome c oxidase copper chaperone	carrier
Copper	Cytochrome c oxidase subunit 1	enzyme
Copper	Tyrosinase	enzyme
Copper	Dopamine beta-hydroxylase	enzyme
Copper	Peptidyl-glycine alpha-amidating monooxygenase	enzyme
Copper	Monoamine oxidase	enzyme
Copper	Angiogenin	enzyme
Copper	Amyloid beta A4 protein	target
Copper	Hephaestin	carrier
Copper	Major prion protein	enzyme
Copper	Adenosylhomocysteinase	target
Copper	Coagulation factor V	carrier
Copper	Coagulation factor VIII	carrier
Copper	Metallothionein	carrier
Copper	Probable low affinity copper uptake protein 2	transporter
Copper	Histone H2B type 1-C/E/F/G/I	target
Copper	Glyceraldehyde-3-phosphate dehydrogenase	target
Copper	Nucleoside diphosphate kinase A	target
Copper	Histone H1.4	target
Copper	Peroxiredoxin-1	target
Copper	Protein S100-A8	target
Copper	40S ribosomal protein SA	target
Copper	Actin, cytoplasmic 2	target
Copper	Alpha-enolase	target
Copper	Elongation factor 1-alpha 1	target
Copper	Keratin, type II cytoskeletal 8	target
Copper	Protein disulfide-isomerase	target
Copper	Protein disulfide-isomerase A3	target
Copper	60 kDa heat shock protein, mitochondrial	target
Copper	Heat shock 70 kDa protein 13	target
Copper	78 kDa glucose-regulated protein	target
Copper	Endoplasmin	target
Copper	Serotransferrin	target
Copper	Cell growth-regulating nucleolar protein	target
Copper	40S ribosomal protein S2	target
Copper	Serine/arginine-rich splicing factor 1	target
Copper	Heterogeneous nuclear ribonucleoproteins A2/B1	target
Copper	Heterogeneous nuclear ribonucleoprotein H	target
Copper	Heterogeneous nuclear ribonucleoprotein H3	target
Copper	Cobalt-precorrin-5B C(1)-methyltransferase	target
Copper	Heterogeneous nuclear ribonucleoprotein L	target
Copper	Splicing factor, proline- and glutamine-rich	target
Copper	Splicing factor 3A subunit 2	target
Copper	Receptor of activated protein C kinase 1	target
Copper	Alpha-actinin-1	target
Copper	Aminoacylase-1	target
Copper	Annexin A4	target
Copper	Annexin A5	target
Copper	Calreticulin	target
Copper	Pyruvate kinase PKM	target
Copper	Alcohol dehydrogenase [NADP(+)]	target
Copper	NADH-cytochrome b5 reductase 3	target
Copper	Glutathione reductase, mitochondrial	target
Copper	Transketolase	target
Copper	Peroxiredoxin-2	target
Copper	Peroxiredoxin-6	target
Copper	Peptidyl-prolyl cis-trans isomerase A	target
Copper	Heat shock cognate 71 kDa protein	target
Copper	Heat shock protein HSP 90-alpha	target
Copper	Prostaglandin E synthase 3	target
Copper	Stress-induced-phosphoprotein 1	target
Copper	Translation elongation factor 1 alpha 1-like 14	target
Copper	Eukaryotic translation initiation factor 6	target
Copper	Eukaryotic initiation factor 4A-I	target
Copper	Glucose-6-phosphate isomerase	target
Copper	L-lactate dehydrogenase A chain	target
Copper	Phosphoglycerate kinase 1	target
Copper	Tubulin alpha 3C/D chain	target
Copper	Tubulin beta chain	target
Copper	Cofilin-1	target
Copper	14-3-3 protein beta/alpha	target
Copper	Aspartate aminotransferase, cytoplasmic	target
Copper	Glutathione synthetase	target
Copper	Hepatoma-derived growth factor	target
Copper	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	target
Copper	Chloride intracellular channel protein 1	target
Copper	Proteasome activator complex subunit 1	target
Copper	Phosphatidylethanolamine-binding protein 1	target
Copper	Phosphoglycerate mutase 1	target
Copper	Ran-specific GTPase-activating protein	target
Copper	UDP-glucose 6-dehydrogenase	target
Copper	Beta-2-microglobulin	target
Copper	Protein SCO1 homolog, mitochondrial	target
Copper	Alternative prion protein	target
Copper	Glycine receptor subunit alpha-1	target
Copper	Huntingtin	target
Copper	Endonuclease 8-like 1	target
Copper	Endonuclease 8-like 2	target
Copper	Hephaestin-like protein 1	target
Copper	Plasminogen activator inhibitor 1	target
Copper	Protein S100-A2	target
Copper	Protein S100-A4	target
Copper	Alpha-synuclein	target
Copper	Brain-derived neurotrophic factor	target
Copper	Protein DJ-1	target
Copper	Islet amyloid polypeptide	target
Copper	Tachykinin-3	target
Copper	Alpha-1B-glycoprotein	target
Copper	Afamin	target
Copper	Angiotensinogen	target
Copper	Alpha-2-HS-glycoprotein	target
Copper	Serum amyloid P-component	target
Copper	Apolipoprotein A-I	target
Copper	Apolipoprotein A-II	target
Copper	Apolipoprotein A-IV	target
Copper	Apolipoprotein B receptor	target
Copper	Apolipoprotein C-II	target
Copper	Apolipoprotein C-III	target
Copper	Apolipoprotein D	target
Copper	Apolipoprotein E	target
Copper	Beta-2-glycoprotein 1	target
Copper	Zinc-alpha-2-glycoprotein	target
Copper	Complement C1q subcomponent subunit C	target
Copper	Complement C1s subcomponent	target
Copper	Complement C3	target
Copper	Complement C4-B	target
Copper	C4b-binding protein alpha chain	target
Copper	Complement C5	target
Copper	Complement component C8 beta chain	target
Copper	Complement component C9	target
Copper	Complement factor H	target
Copper	Complement factor I	target
Copper	Tetranectin	target
Copper	Clusterin	target
Copper	Prothrombin	target
Copper	Complement component 1 Q subcomponent-binding protein, mitochondrial	target
Copper	Gelsolin	target
Copper	Hemoglobin subunit alpha	target
Copper	Hemoglobin subunit beta	target
Copper	Chromobox protein homolog 5	target
Copper	Haptoglobin-related protein	target
Copper	Insulin-like growth factor-binding protein complex acid labile subunit	target
Copper	Ig gamma-1 chain C region	target
Copper	Ig gamma-4 chain C region	target
Copper	Ig kappa chain V-III region GOL	target
Copper	Immunoglobulin lambda-like polypeptide 1	target
Copper	Inter-alpha-trypsin inhibitor heavy chain H2	target
Copper	Kininogen-1	target
Copper	Keratin, type II cytoskeletal 1	target
Copper	Keratin, type I cytoskeletal 10	target
Copper	Keratin, type II cytoskeletal 2 epidermal	target
Copper	Keratin, type I cytoskeletal 9	target
Copper	Leucine-rich alpha-2-glycoprotein	target
Copper	Lumican	target
Copper	N-acetylmuramoyl-L-alanine amidase	target
Copper	Plasminogen	target
Copper	Serum paraoxonase/arylesterase 1	target
Copper	Platelet basic protein	target
Copper	Alpha-1-antitrypsin	target
Copper	Kallistatin	target
Copper	Corticosteroid-binding globulin	target
Copper	Thyroxine-binding globulin	target
Copper	Antithrombin-III	target
Copper	Heparin cofactor 2	target
Copper	Pigment epithelium-derived factor	target
Copper	Alpha-2-antiplasmin	target
Copper	Plasma protease C1 inhibitor	target
Copper	Transthyretin	target
Copper	Vitronectin	target
Copper	Amyloid-like protein 1	target
Selenious acid	Glutathione peroxidase 1	enzyme
Selenious acid	Selenoprotein P	transporter
Selenious acid	Thioredoxin reductase 1, cytoplasmic	enzyme
Cupric oxide	Serum albumin	carrier
Cupric oxide	Ceruloplasmin	carrier
Chromium	Serotransferrin	carrier
Chromium	Cytochrome b5	target
Ferrous fumarate	Transferrin receptor protein 1	target
Ferrous fumarate	Egl nine homolog 1	target
Ferrous fumarate	Histone deacetylase 8	target
Ferrous fumarate	Alpha-hemoglobin-stabilizing protein	target
Ferrous fumarate	Hemoglobin subunit alpha	target
Ferrous fumarate	Frataxin, mitochondrial	target
Ferrous fumarate	Ferritin heavy chain	target
Ferrous fumarate	Flap endonuclease 1	target
Ferrous fumarate	Endonuclease 8-like 1	target
Ferrous fumarate	Endonuclease 8-like 2	target
Ferrous fumarate	DNA polymerase beta	target
Ferrous fumarate	Ceruloplasmin	target
Ferrous fumarate	Serotransferrin	target
Selenium	Selenocysteine lyase	enzyme
Selenium	Glutathione reductase, mitochondrial	enzyme
Selenium	Thioredoxin reductase 1, cytoplasmic	enzyme