Detoxifying Agents for Antineoplastic Treatment

Name
Detoxifying Agents for Antineoplastic Treatment
Accession Number
DBCAT002110
Description

Not Available

ATC Classification
Drugs
DrugDrug Description
PaliferminA form of recombinant human keratinocyte growth factor used to prevent and treat oral mucositis following radiation or chemotherapy.
DexrazoxaneA cytoprotective drug used to prevent and improve cardiomyopathy associated with doxorubicin treatment for metastatic breast cancer.
LeucovorinA folate analog used to treat the toxic effects of methotrexate and other folate antagonists, to treat megaloblastic anemia, and to provide palliative treatment of colorectal cancer.
AmifostineA cytoprotective adjuvant used for reduction in the cumulative renal toxicity in patients with ovarian cancer and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.
GlucarpidaseA carboxypeptidase enzyme used to reduce plasma concentrations of methotrexate in patients with impaired renal function.
Coenzyme MA uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract.
LevoleucovorinA folate analog used after high dose methotrexate for osteosarcoma, to reduce the toxic effects of folate analogs, and with 5-fluorouracil in palliative treatment of advanced metastatic colorectal cancer.
RasburicaseA recombinant form of urate-oxidase enzyme used to treat hyperuricemia following chemotherapy for leukemias and non-Hodgkin's lymphoma.
LysineAn amino acid commonly found as a component of total parenteral nutrition.
ArginineAn amino acid commonly found as a component of total parenteral nutrition.
TrilaciclibA CDK4 and CDK6 inhibitor to reduce the risk of chemotherapy induced myelosuppression.
Drugs & Drug Targets
DrugTargetType
PaliferminFibroblast growth factor receptor 2target
PaliferminFibroblast growth factor receptor 1target
PaliferminBasement membrane-specific heparan sulfate proteoglycan core proteintarget
DexrazoxaneDNA topoisomerase 2-alphatarget
DexrazoxaneDNA topoisomerase 2-betatarget
LeucovorinSolute carrier family 22 member 8transporter
AmifostineAlkaline phosphatase, germ cell typetarget
AmifostineAlkaline phosphatase, tissue-nonspecific isozymeenzyme
LevoleucovorinSerine hydroxymethyltransferasetarget
RasburicaseUric acidtarget
LysineHigh affinity cationic amino acid transporter 1target
LysineCationic amino acid transporter 4target
LysineCationic amino acid transporter 3target
LysineLow affinity cationic amino acid transporter 2target
LysineLysine--tRNA ligasetarget
LysineMonocarboxylate transporter 10transporter
LysineSolute carrier family 22 member 4transporter
ArginineCationic amino acid transporter 3target
ArginineArginine decarboxylasetarget
ArginineArgininosuccinate lyasetarget
ArginineNitric oxide synthase, inducibletarget
ArginineHigh affinity cationic amino acid transporter 1target
ArginineArginase-2, mitochondrialtarget
ArginineCationic amino acid transporter 4target
ArginineArgininosuccinate synthasetarget
ArginineNitric oxide synthase, endothelialtarget
ArginineSolute carrier family 22 member 5transporter
ArginineMonocarboxylate transporter 10transporter
ArginineSolute carrier family 22 member 4transporter
TrilaciclibSolute carrier family 22 member 2transporter
TrilaciclibMultidrug and toxin extrusion protein 1transporter
TrilaciclibMultidrug and toxin extrusion protein 2transporter
TrilaciclibCytochrome P450 1A2enzyme
TrilaciclibATP-binding cassette sub-family G member 2transporter
TrilaciclibP-glycoprotein 1transporter
TrilaciclibCyclin-dependent kinase 4target
TrilaciclibCyclin-dependent kinase 6target
TrilaciclibCyclin-dependent kinase 9target
TrilaciclibCyclin-dependent kinase 2target
TrilaciclibCyclin-dependent kinase 5target
TrilaciclibCyclin-dependent kinase 7target