COMT Substrates

Name

COMT Substrates

Accession Number

DBCAT002654

Description

Not Available

Drugs

Drug	Drug Description
Diethylstilbestrol	Used in the treatment of prostate cancer. Previously used in the prevention of miscarriage or premature delivery in pregnant women prone to miscarriage or premature delivery.
Conjugated estrogens	A mixture of estrogens used in estrogen replacement therapy for menopause and hypoestrogenism, used in the treatment of various malignancies, and used in the treatment of postmenopausal osteoporosis.
Dobutamine	A beta-1 agonist used to treat cardiac decompensation in patients with organic heart disease or from cardiac surgery.
Methyldopa	A centrally-acting alpha-2 adrenergic agonist used to manage hypertension alone or in combination with hydrochlorothiazide, and to treat hypertensive crises.
Dopamine	A catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension.
Micafungin	An antifungal agent used for the treatment of candidemia, acute disseminated candidiasis, and certain other invasive Candida infections, and for the prophylaxis of Candida infections during stem cell transplantation.
Epinephrine	A hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma.
Norepinephrine	A sympathomimetic used in the control of blood pressure during various hypotensive states and as an adjunct treatment during cardiac arrest.
Quercetin	A natural flavonoid found in foods and natural supplement products.
2-Hydroxyestradiol	2-Hydroxyestradiol is classified as an endogenous steroid, catechol estrogen, and metabolite of estradiol. It is also a positional isomer of estriol.
Echinacoside	A phenylethanoid glycoside plant isolate currently being investigated for anti-apoptotic and neuroprotective effects.
Phenytoin	An anticonvulsant drug used in the prophylaxis and control of various types of seizures.
Estradiol	An estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate.
Ethinylestradiol	An estradiol used as a contraceptive.
Apomorphine	A morphine derivative D2 dopamine agonist used to treat hypomobile "off" episodes of advanced Parkinson's disease.
Isoprenaline	A catecholamine non-selective beta-adrenergic agonist typically used to treat bradycardia and heart block.

Drugs & Drug Targets

Drug	Target	Type
Diethylstilbestrol	Estrogen receptor alpha	target
Diethylstilbestrol	Estrogen-related receptor gamma	target
Diethylstilbestrol	Transthyretin	carrier
Diethylstilbestrol	Catechol O-methyltransferase	enzyme
Diethylstilbestrol	Cytochrome P450 19A1	enzyme
Diethylstilbestrol	ATP-binding cassette sub-family G member 2	transporter
Diethylstilbestrol	P-glycoprotein 1	transporter
Diethylstilbestrol	Estrogen receptor beta	target
Diethylstilbestrol	Cytochrome P450 3A4	enzyme
Diethylstilbestrol	Cytochrome P450 2C8	enzyme
Diethylstilbestrol	Cytochrome P450 2C9	enzyme
Diethylstilbestrol	Cytochrome P450 2E1	enzyme
Diethylstilbestrol	Steroid hormone receptor ERR1	target
Diethylstilbestrol	Steroid hormone receptor ERR2	target
Diethylstilbestrol	Nuclear receptor coactivator 2	target
Diethylstilbestrol	Nuclear receptor subfamily 1 group I member 2	target
Diethylstilbestrol	Androgen receptor	target
Diethylstilbestrol	Sex hormone-binding globulin	target
Diethylstilbestrol	Solute carrier organic anion transporter family member 1B1	transporter
Diethylstilbestrol	Solute carrier organic anion transporter family member 2B1	transporter
Diethylstilbestrol	Bile salt export pump	transporter
Conjugated estrogens	Estrogen receptor alpha	target
Conjugated estrogens	Cytochrome P450 3A4	enzyme
Conjugated estrogens	Cytochrome P450 1A2	enzyme
Conjugated estrogens	Catechol O-methyltransferase	enzyme
Conjugated estrogens	Canalicular multispecific organic anion transporter 2	transporter
Conjugated estrogens	Multidrug resistance-associated protein 4	transporter
Conjugated estrogens	Multidrug resistance-associated protein 1	transporter
Conjugated estrogens	Solute carrier organic anion transporter family member 1A2	transporter
Conjugated estrogens	Sodium/bile acid cotransporter	transporter
Conjugated estrogens	Solute carrier family 22 member 10	transporter
Conjugated estrogens	Solute carrier family 22 member 8	transporter
Conjugated estrogens	Solute carrier organic anion transporter family member 1C1	transporter
Conjugated estrogens	Solute carrier organic anion transporter family member 1B1	transporter
Conjugated estrogens	Solute carrier organic anion transporter family member 2B1	transporter
Conjugated estrogens	P-glycoprotein 1	transporter
Conjugated estrogens	Solute carrier family 22 member 6	transporter
Conjugated estrogens	Organic solute transporter subunit alpha	transporter
Conjugated estrogens	Organic solute transporter subunit beta	transporter
Conjugated estrogens	Canalicular multispecific organic anion transporter 1	transporter
Conjugated estrogens	Solute carrier organic anion transporter family member 4A1	transporter
Conjugated estrogens	ATP-binding cassette sub-family C member 11	transporter
Conjugated estrogens	Solute carrier organic anion transporter family member 1B3	transporter
Conjugated estrogens	Solute carrier family 22 member 11	transporter
Conjugated estrogens	Solute carrier organic anion transporter family member 3A1	transporter
Conjugated estrogens	ATP-binding cassette sub-family G member 2	transporter
Conjugated estrogens	Thyroxine-binding globulin	carrier
Conjugated estrogens	Sex hormone-binding globulin	carrier
Conjugated estrogens	Serum albumin	carrier
Conjugated estrogens	Estrogen receptor beta	target
Dobutamine	Beta-1 adrenergic receptor	target
Dobutamine	Catechol O-methyltransferase	enzyme
Dobutamine	Beta-2 adrenergic receptor	target
Dobutamine	Alpha-1 adrenergic receptors	target
Dobutamine	Estrogen receptor alpha	target
Methyldopa	Alpha-2A adrenergic receptor	target
Methyldopa	Catechol O-methyltransferase	enzyme
Methyldopa	Solute carrier family 15 member 1	transporter
Methyldopa	Aromatic-L-amino-acid decarboxylase	target
Methyldopa	Serum albumin	carrier
Methyldopa	Sulfotransferase	enzyme
Methyldopa	Dopamine beta-hydroxylase	enzyme
Methyldopa	Phenylethanolamine N-methyltransferase	enzyme
Methyldopa	Aromatic-L-amino-acid decarboxylase	enzyme
Dopamine	Dopamine D1 receptor	target
Dopamine	Dopamine beta-hydroxylase	target
Dopamine	Amine oxidase [flavin-containing] A	enzyme
Dopamine	Amine oxidase [flavin-containing] B	enzyme
Dopamine	Catechol O-methyltransferase	enzyme
Dopamine	Solute carrier family 22 member 2	transporter
Dopamine	Solute carrier family 22 member 1	transporter
Dopamine	Solute carrier family 22 member 3	transporter
Dopamine	Solute carrier family 22 member 5	transporter
Dopamine	POU domain, class 5, transcription factor 1	transporter
Dopamine	Dopamine D5 receptor	target
Dopamine	Dopamine D2 receptor	target
Dopamine	Dopamine D3 receptor	target
Dopamine	Dopamine D4 receptor	target
Dopamine	Sodium-dependent dopamine transporter	target
Dopamine	Dopamine beta-hydroxylase	enzyme
Dopamine	5-hydroxytryptamine receptor 1A	target
Dopamine	5-hydroxytryptamine receptor 7	target
Dopamine	D(1) dopamine receptor	target
Dopamine	Sodium-dependent noradrenaline transporter	target
Dopamine	Sodium-dependent serotonin transporter	target
Dopamine	5-hydroxytryptamine receptor 3A	target
Dopamine	5-hydroxytryptamine receptor 3B	target
Dopamine	Superoxide dismutase [Cu-Zn]	target
Dopamine	Synaptic vesicular amine transporter	target
Micafungin	Arylsulfatase A	enzyme
Micafungin	Catechol O-methyltransferase	enzyme
Micafungin	1,3-beta-glucan synthase component FKS1	target
Epinephrine	Alpha-1A adrenergic receptor	target
Epinephrine	Beta-1 adrenergic receptor	target
Epinephrine	Beta-2 adrenergic receptor	target
Epinephrine	Solute carrier family 22 member 2	transporter
Epinephrine	Solute carrier family 22 member 1	transporter
Epinephrine	Cytochrome P450 2C9	enzyme
Epinephrine	Cytochrome P450 3A4	enzyme
Epinephrine	Alpha-1B adrenergic receptor	target
Epinephrine	Alpha-1D adrenergic receptor	target
Epinephrine	Alpha-2A adrenergic receptor	target
Epinephrine	Alpha-2B adrenergic receptor	target
Epinephrine	Tumor necrosis factor	target
Epinephrine	Catechol O-methyltransferase	enzyme
Epinephrine	Monoamine oxidase	enzyme
Norepinephrine	Phenylalanine-4-hydroxylase	target
Norepinephrine	Alpha-1A adrenergic receptor	target
Norepinephrine	Alpha-1B adrenergic receptor	target
Norepinephrine	Alpha-1D adrenergic receptor	target
Norepinephrine	Alpha-2A adrenergic receptor	target
Norepinephrine	Alpha-2B adrenergic receptor	target
Norepinephrine	Alpha-2C adrenergic receptor	target
Norepinephrine	Beta-1 adrenergic receptor	target
Norepinephrine	Beta-2 adrenergic receptor	target
Norepinephrine	Beta-3 adrenergic receptor	target
Norepinephrine	Solute carrier family 22 member 2	transporter
Norepinephrine	Solute carrier family 22 member 3	transporter
Norepinephrine	Solute carrier family 22 member 5	transporter
Norepinephrine	Solute carrier family 22 member 1	transporter
Norepinephrine	POU domain, class 5, transcription factor 1	transporter
Norepinephrine	Sodium-dependent noradrenaline transporter	transporter
Norepinephrine	Synaptic vesicular amine transporter	target
Norepinephrine	Chromaffin granule amine transporter	target
Quercetin	Tyrosine-protein kinase HCK	target
Quercetin	Cytochrome P450 2C8	enzyme
Quercetin	Multidrug resistance-associated protein 1	transporter
Quercetin	Canalicular multispecific organic anion transporter 1	transporter
Quercetin	Monocarboxylate transporter 2	transporter
Quercetin	Solute carrier organic anion transporter family member 2B1	transporter
Quercetin	P-glycoprotein 1	transporter
Quercetin	Monocarboxylate transporter 1	transporter
Quercetin	ATP-binding cassette sub-family G member 2	transporter
Quercetin	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	target
Quercetin	UDP-glucuronosyltransferase 3A1	target
Quercetin	ATP synthase subunit alpha, mitochondrial	target
Quercetin	ATP synthase subunit beta, mitochondrial	target
Quercetin	ATP synthase subunit gamma, mitochondrial	target
Quercetin	Serine/threonine-protein kinase pim-1	target
Quercetin	HTH-type transcriptional regulator TtgR	target
Quercetin	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	target
Quercetin	3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ	target
Quercetin	Serine/threonine-protein kinase 17B	target
Quercetin	Estrogen receptor alpha	target
Quercetin	Estrogen receptor beta	target
Quercetin	Ribosyldihydronicotinamide dehydrogenase [quinone]	target
Quercetin	Serum albumin	carrier
Quercetin	Aryl hydrocarbon receptor	target
Quercetin	Cytochrome P450 1B1	target
Quercetin	Actin, cytoplasmic 1	target
Quercetin	Casein kinase II subunit alpha	target
Quercetin	Casein kinase II subunit beta	target
Quercetin	Eukaryotic translation initiation factor 3 subunit F	target
Quercetin	Heat shock protein HSP 90-alpha	target
Quercetin	Heat shock-related 70 kDa protein 2	target
Quercetin	RuvB-like 2	target
Quercetin	Splicing factor 3B subunit 3	target
Quercetin	Ubiquitin-like modifier-activating enzyme 1	target
Quercetin	Sex hormone-binding globulin	target
Quercetin	Carbonyl reductase [NADPH] 1	target
Quercetin	CCAAT/enhancer-binding protein beta	target
Quercetin	Nuclear receptor subfamily 1 group I member 2	target
Quercetin	Solute carrier organic anion transporter family member 1B1	transporter
Quercetin	Cytochrome P450 2C9	enzyme
Quercetin	Cytochrome P450 1A2	enzyme
Quercetin	Cytochrome P450 2E1	enzyme
Quercetin	Cytochrome P450 2C19	enzyme
Quercetin	Cytochrome P450 3A Subfamily	enzyme
Quercetin	Cytochrome P450 2D6	enzyme
2-Hydroxyestradiol	Adenylate cyclase	target
Echinacoside	Growth hormone secretagogue receptor type 1	target
Echinacoside	Androgen receptor	target
Echinacoside	Catechol O-methyltransferase	enzyme
Phenytoin	Sodium channel protein type 5 subunit alpha	target
Phenytoin	Sodium channel protein type 1 subunit alpha	target
Phenytoin	Cytochrome P450 2C8	enzyme
Phenytoin	Cytochrome P450 2C19	enzyme
Phenytoin	Cytochrome P450 2C9	enzyme
Phenytoin	Cytochrome P450 2B6	enzyme
Phenytoin	Cytochrome P450 3A5	enzyme
Phenytoin	Serum albumin	carrier
Phenytoin	Cytochrome P450 3A4	enzyme
Phenytoin	Solute carrier organic anion transporter family member 1C1	transporter
Phenytoin	P-glycoprotein 1	transporter
Phenytoin	Canalicular multispecific organic anion transporter 1	transporter
Phenytoin	Cytochrome P450 11B1, mitochondrial	enzyme
Phenytoin	Cytochrome P450 3A7	enzyme
Phenytoin	Nuclear receptor subfamily 1 group I member 2	target
Phenytoin	Sodium channel subunit beta-1	target
Phenytoin	Sodium channel protein type 3 subunit alpha	target
Phenytoin	UDP-glucuronosyltransferase 1-1	enzyme
Phenytoin	UDP-glucuronosyltransferase 1-6	enzyme
Phenytoin	UDP-glucuronosyltransferase 1-9	enzyme
Phenytoin	Thyroxine-binding globulin	carrier
Phenytoin	Potassium voltage-gated channel subfamily H member 2	target
Phenytoin	Voltage-dependent L-type calcium channel	target
Phenytoin	Sodium channel protein type 2 subunit alpha	target
Phenytoin	Sodium channel protein type 8 subunit alpha	target
Phenytoin	GABA(A) Receptor	target
Phenytoin	Cytochrome P450 1A2	enzyme
Phenytoin	Cytochrome P450 2A6	enzyme
Phenytoin	Cytochrome P450 2D6	enzyme
Phenytoin	Cytochrome P450 2E1	enzyme
Phenytoin	Epoxide hydrolase 1	enzyme
Phenytoin	UDP-glucuronosyltransferase 1-4	enzyme
Phenytoin	Catechol O-methyltransferase	enzyme
Phenytoin	NAD(P)H dehydrogenase [quinone] 1	enzyme
Phenytoin	Cytochrome P450 2C18	enzyme
Estradiol	Estrogen receptor alpha	target
Estradiol	Nuclear receptor subfamily 1 group I member 2	target
Estradiol	Sex hormone-binding globulin	carrier
Estradiol	Estrogen receptor beta	target
Estradiol	Cytochrome P450 1A2	enzyme
Estradiol	UDP-glucuronosyltransferase 1-1	enzyme
Estradiol	Serum albumin	carrier
Estradiol	Fatty acid-binding protein, intestinal	carrier
Estradiol	Cytochrome P450 3A4	enzyme
Estradiol	Cytochrome P450 3A5	enzyme
Estradiol	Cytochrome P450 3A7	enzyme
Estradiol	Solute carrier family 22 member 2	transporter
Estradiol	Solute carrier family 22 member 3	transporter
Estradiol	Multidrug resistance-associated protein 7	transporter
Estradiol	Solute carrier family 22 member 11	transporter
Estradiol	ATP-binding cassette sub-family G member 2	transporter
Estradiol	Solute carrier organic anion transporter family member 1B1	transporter
Estradiol	P-glycoprotein 1	transporter
Estradiol	Cytochrome P450 1A1	enzyme
Estradiol	Cytochrome P450 1B1	enzyme
Estradiol	Cytochrome P450 2C19	enzyme
Estradiol	Cytochrome P450 2C8	enzyme
Estradiol	Cytochrome P450 2C9	enzyme
Estradiol	Solute carrier family 22 member 8	transporter
Estradiol	Solute carrier organic anion transporter family member 1B3	transporter
Estradiol	Solute carrier organic anion transporter family member 1C1	transporter
Estradiol	Neuronal acetylcholine receptor subunit alpha-4	target
Estradiol	G-protein coupled estrogen receptor 1	target
Estradiol	ATP synthase subunit a	target
Estradiol	Beclin-1	target
Estradiol	UDP-glucuronosyltransferase 2B15	enzyme
Estradiol	Catechol O-methyltransferase	enzyme
Estradiol	UDP-glucuronosyltransferases (UGTs)	enzyme
Estradiol	Cytochrome P450 19A1	enzyme
Ethinylestradiol	Estrogen receptor alpha	target
Ethinylestradiol	Nuclear receptor subfamily 1 group I member 2	target
Ethinylestradiol	Cytochrome P450 3A4	enzyme
Ethinylestradiol	Cytochrome P450 2C8	enzyme
Ethinylestradiol	Bile salt export pump	transporter
Ethinylestradiol	Sodium/bile acid cotransporter	transporter
Ethinylestradiol	Canalicular multispecific organic anion transporter 1	transporter
Ethinylestradiol	P-glycoprotein 1	transporter
Ethinylestradiol	UDP-glucuronosyltransferase 1-1	enzyme
Ethinylestradiol	Cytochrome P450 2C19	enzyme
Ethinylestradiol	UDP-glucuronosyltransferase 1-4	enzyme
Ethinylestradiol	UDP-glucuronosyltransferase 1-9	enzyme
Ethinylestradiol	Cytochrome P450 2C9	enzyme
Ethinylestradiol	Cytochrome P450 1A2	enzyme
Ethinylestradiol	Estrogen sulfotransferase	enzyme
Ethinylestradiol	Sulfotransferase 1A3/1A4	enzyme
Ethinylestradiol	Cytochrome P450 3A5	enzyme
Ethinylestradiol	UDP-glucuronosyltransferase 2B7	enzyme
Ethinylestradiol	UDP-glucuronosyltransferase 1-3	enzyme
Ethinylestradiol	Catechol O-methyltransferase	enzyme
Ethinylestradiol	Solute carrier organic anion transporter family member 1A2	transporter
Ethinylestradiol	Serum albumin	carrier
Ethinylestradiol	Sex hormone-binding globulin	carrier
Apomorphine	Dopamine D2 receptor	target
Apomorphine	Dopamine D1 receptor	target
Apomorphine	Dopamine D4 receptor	target
Apomorphine	Dopamine D3 receptor	target
Apomorphine	Dopamine D5 receptor	target
Apomorphine	Alpha-2C adrenergic receptor	target
Apomorphine	Alpha-2B adrenergic receptor	target
Apomorphine	5-hydroxytryptamine receptor 2C	target
Apomorphine	5-hydroxytryptamine receptor 1A	target
Apomorphine	5-hydroxytryptamine receptor 2A	target
Apomorphine	5-hydroxytryptamine receptor 2B	target
Apomorphine	Alpha-2A adrenergic receptor	target
Apomorphine	5-hydroxytryptamine receptor 1D	target
Apomorphine	5-hydroxytryptamine receptor 1B	target
Apomorphine	Catechol O-methyltransferase	enzyme
Apomorphine	Sulfotransferase 1A1	enzyme
Apomorphine	Sulfotransferase 1A2	enzyme
Apomorphine	Sulfotransferase 1A3/1A4	enzyme
Apomorphine	Estrogen sulfotransferase	enzyme
Apomorphine	Sulfotransferase family cytosolic 1B member 1	enzyme
Apomorphine	Cytochrome P450 2B6	enzyme
Apomorphine	Cytochrome P450 2C8	enzyme
Apomorphine	Cytochrome P450 3A4	enzyme
Apomorphine	Cytochrome P450 3A5	enzyme
Apomorphine	UDP-glucuronosyltransferases (UGTs)	enzyme
Apomorphine	Serum albumin	carrier
Apomorphine	Synaptic vesicular amine transporter	transporter
Isoprenaline	Beta-1 adrenergic receptor	target
Isoprenaline	Beta-2 adrenergic receptor	target
Isoprenaline	Beta-3 adrenergic receptor	target
Isoprenaline	Cytochrome P450 1A1	enzyme
Isoprenaline	Superoxide dismutase [Cu-Zn]	target
Isoprenaline	Cytochrome P450 1B1	enzyme
Isoprenaline	Serum albumin	carrier
Isoprenaline	Catechol O-methyltransferase	enzyme
Isoprenaline	Cholinesterase	enzyme