Blood Glucose Lowering Agents
- Name
- Blood Glucose Lowering Agents
- Accession Number
- DBCAT002698 (DBCAT000137, DBCAT002199)
- Description
Substances which lower blood glucose levels.
- ATC Classification
- Drugs
Drug Drug Description Insulin human A recombinant form of human insulin used to control hyperglycemia in diabetes mellitus. Insulin lispro A modified form of fast-acting insulin used to control hyperglycemia in diabetes mellitus. Insulin glargine A modified form of long-acting or basal insulin used to control hyperglycemia in diabetes mellitus. Glimepiride A sulfonylurea drug used to treat type 2 diabetes mellitus. Disopyramide A class 1A antiarrhythmic agent used to treat life-threatening ventricular arrhythmias. Acarbose An alpha-glucosidase inhibitor used in adjunctly with diet and exercise for the management of glycemic control in patients with type 2 diabetes mellitus. Metformin A biguanide antihyperglycemic used in conjunction with diet and exercise for glycemic control in type 2 diabetes mellitus. It is also used off-label for insulin resistance in polycystic ovary syndrome (PCOS). Sulfadiazine A sulfonamide antibiotic used in a variety of infections, such as urinary tract infections, trachoma, and chancroid. Rosiglitazone A thiazolidinedione indicated as an adjunct to diet and exercise to maintain glycemic control in type 2 diabetes. Quinine An alkaloid used to treat uncomplicated Plasmodium falciparum malaria. Miglitol An oral alpha-glucosidase inhibitor used to improve glycemic control by delaying the digestion of carbohydrates. Chlorpropamide A sulfonylurea used in the treatment of non insulin dependent diabetes mellitus. Nateglinide A meglitinide used to treat non insulin dependent diabetes mellitus. Pentamidine An antifungal agent used to treat Pneumocystis pneumonia in patients infected with HIV. Mifepristone A cortisol receptor blocker used to treat Cushing's syndrome, and to terminate pregnancies up to 70 days gestation. Tolazamide A sulfonylurea used in the treatment of non insulin dependent diabetes mellitus. Repaglinide A antihyperglycemic used to improve glycemic control in diabetes. Sulfamethoxazole An oral sulfonamide antibiotic, given in combination with trimethoprim, used to treat a variety of infections of the urinary tract, respiratory system, and gastrointestinal tract. Glyburide A sulfonylurea used in the treatment of non insulin dependent diabetes mellitus. Glipizide A sulfonylurea medication used in Type 2 Diabetes to sensitize pancreatic beta cells and stimulate insulin release. Gliclazide A sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus. Tolbutamide A sulfonylurea used to treat hyperglycemia in patients with type 2 diabetes mellitus. Pioglitazone A thiazolidinedione used adjunctively with diet and exercise to normalize glycemic levels in adults with type 2 diabetes mellitus. Bromocriptine A dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome. Sitagliptin An oral dipeptidyl peptidase-4 (DPP-4) inhibitor used for the management of type 2 diabetes mellitus. Sunitinib A receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). Exenatide A GLP-1 agonist used in the management of type 2 diabetes mellitus. Mecasermin A recombinant insulin-like growth factor-1 used for the long-term treatment of growth failure in pediatric patients with primary IGF-1 deficiency or with growth hormone gene deletion due to the development of neutralizing antibodies to GH. Pramlintide An amylin analog used for the management of type 1 and type 2 diabetes mellitus as an adjunct to preprandial insulin therapy in patients without adequate glycemic control of insulin therapy. Insulin aspart A rapid-acting form of insulin used for glycemic control in type 1 and type 2 diabetes mellitus. Insulin detemir A long-acting form of insulin used for glycemic control in type 1 and type 2 diabetes mellitus. Insulin glulisine A short-acting form of insulin used for glycemic control in type 1 and type 2 diabetes mellitus. Alogliptin A dipeptidyl peptidase-4 (DPP-4) inhibitor used to treat hyperglycemia in patients with type 2 diabetes mellitus. Dapagliflozin A sodium-glucose cotransporter 2 inhibitor used in the management of type 2 diabetes mellitus. Saxagliptin An DPP-4 inhibitor used for the management of type 2 diabetes mellitus. Liraglutide A GLP-1 analog used in the management of type 2 diabetes mellitus and prevention of cardiovascular complications associated with diabetes. Canagliflozin A sodium-glucose co-transporter 2 (SGLT2) inhibitor used to manage hyperglycemia in type 2 diabetes mellitus (DM). Also used to reduce the risk of major cardiovascular events in patients with established cardiovascular disease and type 2 DM. Empagliflozin An SGLT2 inhibitor used to manage type 2 diabetes mellitus. Albiglutide A GLP-1 agonist used to manage type 2 diabetes mellitus. Dulaglutide A GLP-1 agonist used to manage type 2 diabetes mellitus. Phenformin For the reatment of type II diabetes mellitus. Mitiglinide For the treatment of type 2 diabetes. Glymidine Glycodiazine is used concomitantly with insulin for the treatment of noninsulin-dependent (type 2) diabetes mellitus. Buformin Buformin is an anti-diabetic drug of the biguanide class, chemically related to metformin and phenformin. It was withdrawn from the market in most countries due to a high risk of... Voglibose An alpha-glucosidase inhibitor indicated in the management of postprandial blood glucose in patients with type II diabetes. Benfluorex Benfluorex is an anorectic and hypolipidemic agent that is structurally related to fenfluramine. It was patented and manufactured by a French pharmaceutical company Servier. The European Medicines Agency (EMA) recommended... Guar gum Not Annotated 2,4-thiazolidinedione Thiazolidinedione has been investigated for the treatment of Type 2 Diabetes, Diabetes Mellitus, and DIABETES MELLITUS, TYPE 2. Sotagliflozin An orally administered dual SGLT1/2 inhibitor used alongside insulin to improve glycemic control in patients with type 1 diabetes mellitus. Englitazone Englitazone is a hypoglycemic agent. Sulfisoxazole A sulfonamide antibiotic used with other antibiotics to prevent and treat a variety of bacterial infections. Insulin peglispro Not Annotated Insulin pork A purified form of porcine insulin used to control hyperglycemia in diabetes mellitus. Insulin degludec A long acting insulin used to treat hyperglycemia caused by type 1 and 2 diabetes mellitus. NN344 Investigated for use/treatment in diabetes mellitus type 1 and 2. Linagliptin A dipeptidyl peptidase-4 (DPP-4) inhibitor used to manage hyperglycemia in patients with type 2 diabetes mellitus. Insulin beef Insulin beef has been discontinued in the US and Canada since 2017. Ciglitazone Developed by Takeda Pharmaceuticals in the early 1980s, it is considered the prototypical compound for the thiazolidinedione class. Ciglitazone was never used as a medication, but it sparked interest in... Lobeglitazone Lobeglitazone was approved by the Ministry of Food and Drug Safety (South Korea) in 2013, and is being monitored by postmarketing surveillance until 2019. Lobeglitazone is not approved for use... Rivoglitazone Rivoglitazone (INN) is a thiazolidinedione undergoing research for use in the treatment of type 2 diabetes. It is being developed by Daiichi Sankyo Co. Netoglitazone Netoglitazone (MCC-555) is a hypoglycemic agent. Balaglitazone Balaglitazone has been used in trials studying the treatment of Diabetes Mellitus, Type 2. Troglitazone For the treatment of Type II diabetes mellitus. It is used alone or in combination with a sulfonylurea, metformin, or insulin as an adjunct to diet and exercise. Acetohexamide Used in the management of diabetes mellitus type 2 (adult-onset). Gliquidone A sulfonylurea drug used in the management of diabetes mellitus type 2. Glisoxepide For the treatment of diabetes mellitus type 2. Glibornuride Glibornuride is a sulfonylurea-type anti-diabetic drug. Carbutamide Not Annotated Metahexamide Not Annotated Gemigliptin A dipeptidyl peptidase-4 (DPP-4) inhibitor used to manage hyperglycemia in patients with type 2 diabetes mellitus. Evogliptin Evogliptin has been used in trials studying the treatment and screening of Osteoporosis, Renal Impairment, Type 2 Diabetes Mellitus, Diabetes Mellitis Type 2, and Diabetes Mellitus, Type 2. Gosogliptin Gosogliptin has been used in trials studying the treatment of Renal Insufficiency, Chronic. Dutogliptin Dutogliptin has been investigated for the treatment of Diabetes Mellitus, Type II. Carmegliptin Carmegliptin has been used in trials studying the treatment of Diabetes Mellitus Type 2. Bisegliptin Investigated for use/treatment in diabetes mellitus type 2. AMG-222 Investigated for use/treatment in diabetes mellitus type 2. Teneligliptin Teneligliptin has been investigated for the treatment of Type 2 Diabetes Mellitus. Omarigliptin Omarigliptin has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Chronic Renal Insufficiency. Anagliptin Anagliptin is under investigation for the treatment of LDL Cholesterol, Coronary Disease, Diabetes Mellitus, Glycosylated Hemoglobin, and Dipeptidyl-Peptidase 4 Inhibitors. Vildagliptin A once-daily dipeptidyl peptidase 4 (DPP-4) inhibitor used in the management of type 2 diabetes mellitus. Taspoglutide Taspoglutide is a pharmaceutical drug, a glucagon-like peptide-1 agonist (GLP-1 agonist), under investigation for treatment of type 2 diabetes being codeveloped by Ipsen and Roche. In September 2010 Roche halted... Lixisenatide A GLP-1 receptor agonist used for the management of type 2 diabetes mellitus. Semaglutide A glucagon-like peptide 1 receptor agonist used to improve glycemic control in type 2 diabetes mellitus. AICA ribonucleotide 5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) is an intermediate in the generation of inosine monophosphate and analog of adenosine monophosphate (AMP) that is capable of stimulating AMP-dependent protein kinase (AMPK) activity. AICAR has... Allicin Allicin has been used in trials studying the treatment of Follicular Lymphoma. Ipragliflozin Ipragliflozin is under investigation in Type 2 Diabetes and Diabetes Mellitus, Type 2. Ertugliflozin An SGLT2 inhibitor used to treat type 2 diabetes mellitus alone or in combination with other antidiabetic drugs. Gastric inhibitory polypeptide Gastric inhibitory polypeptide is under investigation in clinical trial NCT03081676 (The Effect of GIP and GLP-1 on Insulin and Glucagon Secretion in Patients With HNF1A-diabetes Treated With or Without Sulphonylurea). Insulin tregopil code text here Tofogliflozin Tofogliflozin has been used in trials studying the treatment and prevention of Diabetes Mellitus Type 2. Remogliflozin etabonate Remogliflozin etabonate has been used in trials studying the treatment and basic science of Type 2 Diabetes Mellitus and Diabetes Mellitus, Type 2. Tirzepatide A dual GIP and GLP-1 receptor agonist used for the treatment of type II diabetes in adults as an adjunct to diet and exercise. Insulin argine Not Annotated Zopolrestat Not Available Volagidemab Volagidemab is under investigation in clinical trial NCT03117998 (Multiple Dose Study to Evaluate the Efficacy, Safety and Pharmacodynamics of REMD-477 in Subjects With Type 1 Diabetes Mellitus). Glutazumab Glutazumab is a novel long-lasting GLP-1/anti-GLP-1R antibody fusion protein exerting anti-diabetic effects. Biguanide Biguanide has been investigated for the treatment of Diabetes Mellitus. Bexagliflozin A sodium-glucose co-transporter 2 inhibitor used to improve glycemic control in patients with type 2 diabetes mellitus. Efpeglenatide Efpeglenatide is under investigation in clinical trial NCT03713684 (Efficacy and Safety of Efpeglenatide Versus Placebo in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Basal Insulin Alone or in... Licogliflozin Licogliflozin is under investigation in clinical trial NCT03320941 (A Dose-finding Study to Evaluate the Change in Weight After Treatment With LIK066 in Japanese Patients With Obesity). C-peptide C-peptide is under investigation in clinical trial NCT00278980 (Effect of C-peptide on Diabetic Peripheral Neuropathy). Pegylated synthetic human c-peptide Not Annotated Insulin icodec Not Annotated Luseogliflozin An SGLT2 inhibitor used to manage type 2 diabetes mellitus. Imeglimin Imeglimin has been used in trials studying the treatment of Type 2 Diabetes Mellitus. Beinaglutide Beinaglutide is under investigation in clinical trial NCT03829891 (Study for Beinaglutide Versus Glargine Therapy in Glycemic Variability of Type 2 Diabetes Mellitus). Diphenyleneiodonium An NADPH oxidase 2 (NOX2) inhibitor. Dorzagliatin Dorzagliatin is under investigation in clinical trial NCT03173391 (Long-term Efficacy and Safety of HMS5552 in T2DM). Proinsulin human Not Annotated Livoletide Livoletide is under investigation in clinical trial NCT03790865 (Effects of Livoletide (AZP-531) on Food-related Behaviors in Patients With Prader-Willi Syndrome). TQS-168 Not Annotated - Drugs & Drug Targets