Cytochrome P-450 CYP2E1 Inhibitors (weak)

Name
Cytochrome P-450 CYP2E1 Inhibitors (weak)
Accession Number
DBCAT003036
Description

Not Available

Drugs
DrugDrug Description
RheinNo approved indication.
ZucapsaicinA topical analgesic used as an adjunct to relieve severe pain of osteoarthritis of the knee in selected adult patients.
NabiloneA synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy.
TiclopidineA platelet aggregation inhibitor used in the prevention of conditions associated with thrombi, such as stroke and transient ischemic attacks (TIA).
RufinamideAn antiepileptic drug used as adjunctive therapy to treat seizures associated with Lennox-Gastaut Syndrome (LGS).
AdemetionineS-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as...
DexfenfluramineFor the management of obesity including weight loss and maintenance of weight loss in patients on a reduced calorie diet
EtoricoxibA selective COX-2 inhibitor used to relieve moderate post-surgical dental pain as a short-term treatment and inflammatory and painful symptoms of various forms of arthritis.
TegaserodA serotonin-4 (5-HT4) receptor agonist indicated for the treatment of constipation predominant irritable bowel syndrome (IBS-C) specifically in women under the age of 65. There is currently no safety or efficacy data for use of tegaserol in men.
MethimazoleA thionamide antithyroid agent that inhibits the actions of thyroid peroxidase, leading to a reduction in thyroid hormone synthesis and amelioration of hyperthyroidism.
ZafirlukastA leukotriene receptor antagonist used for prophylaxis and chronic treatment of asthma.
DesipramineA tricyclic antidepressant used in the treatment of depression.
ClascoteroneAn androgen receptor antagonist used for the topical treatment of acne vulgaris in patients 12 years of age and older.
FluphenazineA phenothiazine used to treat patients requiring long-term neuroleptic therapy.
ItraconazoleAn antifungal agent used for the treatment of various fungal infections in immunocompromised and non-immunocompromised patients, such as pulmonary and extrapulmonary blastomycosis, histoplasmosis, and onychomycosis.
EthambutolAn antituberculosis agent used in the prophylaxis and treatment of tuberculosis (TB).
QuercetinA natural flavonoid found in foods and natural supplement products.
CariprazineAn atypical antipsychotic used to treat schizophrenia and acute manic or mixed episodes due to bipolar I disorder.
Drugs & Drug Targets
DrugTargetType
RheinOxysterols receptor LXR-alphatarget
RheinOxysterols receptor LXR-betatarget
RheinArylamine N-acetyltransferasetarget
RheinArachidonate 5-lipoxygenasetarget
RheinCytochrome P450 1A2enzyme
RheinCytochrome P450 3A Subfamilyenzyme
RheinCytochrome P450 2E1enzyme
RheinCytochrome P450 2C9enzyme
RheinCytochrome P450 2D6enzyme
ZucapsaicinTransient receptor potential cation channel subfamily V member 1target
ZucapsaicinCytochrome P450 1A2enzyme
ZucapsaicinCytochrome P450 2C19enzyme
ZucapsaicinCytochrome P450 2C9enzyme
ZucapsaicinCytochrome P450 2E1enzyme
NabiloneCannabinoid receptor 2target
NabiloneCannabinoid receptor 1target
NabiloneCytochrome P450 2E1enzyme
NabiloneCytochrome P450 2C8enzyme
NabiloneCytochrome P450 2C9enzyme
NabiloneCytochrome P450 3A4enzyme
NabiloneCytochrome P450 2J2enzyme
TiclopidineP2Y purinoceptor 12target
TiclopidineCytochrome P450 2C19enzyme
TiclopidineCytochrome P450 2B6enzyme
TiclopidineCytochrome P450 2C9enzyme
TiclopidineCytochrome P450 2D6enzyme
TiclopidineMyeloperoxidaseenzyme
TiclopidineCytochrome P450 1A2enzyme
TiclopidineCytochrome P450 2C8enzyme
TiclopidineCytochrome P450 2E1enzyme
RufinamideMetabotropic glutamate receptor 5target
RufinamideLiver carboxylesterase 1enzyme
RufinamideSodium channel protein type 9 subunit alphatarget
RufinamideSerum albumincarrier
RufinamideCytochrome P450 2E1enzyme
RufinamideCytochrome P450 3A4enzyme
AdemetionineGlycine N-methyltransferasetarget
AdemetionineS-adenosylmethionine decarboxylase proenzymetarget
AdemetionineS-adenosylmethionine synthase isoform type-2target
AdemetionineCystathionine beta-synthasetarget
AdemetionineS-adenosylmethionine synthase isoform type-1target
AdemetionineCytochrome P450 2E1enzyme
AdemetionineCatechol O-methyltransferasetarget
AdemetionineSpermidine synthaseenzyme
AdemetionineCap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1target
AdemetionineArsenite methyltransferasetarget
DexfenfluramineSodium-dependent serotonin transportertarget
Dexfenfluramine5-hydroxytryptamine receptor 2Ctarget
DexfenfluramineCytochrome P450 2D6enzyme
DexfenfluramineCytochrome P450 1A2enzyme
DexfenfluramineCytochrome P450 2E1enzyme
EtoricoxibProstaglandin G/H synthase 2target
EtoricoxibCytochrome P450 3A4enzyme
EtoricoxibCytochrome P450 2C9enzyme
EtoricoxibCytochrome P450 2D6enzyme
EtoricoxibCytochrome P450 1A2enzyme
EtoricoxibCytochrome P450 2C19enzyme
EtoricoxibCytochrome P450 2E1enzyme
Tegaserod5-hydroxytryptamine receptor 4target
Tegaserod5-hydroxytryptamine receptor 2Btarget
Tegaserod5-hydroxytryptamine receptor 2Ctarget
Tegaserod5-hydroxytryptamine receptor 2Atarget
TegaserodSodium-dependent serotonin transportertransporter
TegaserodCytochrome P450 1A2enzyme
TegaserodCytochrome P450 2C8enzyme
TegaserodCytochrome P450 2D6enzyme
TegaserodCytochrome P450 2E1enzyme
TegaserodATP-binding cassette sub-family G member 2transporter
TegaserodP-glycoprotein 1transporter
MethimazoleThyroid peroxidasetarget
MethimazoleCytochrome P450 1A2enzyme
MethimazoleCytochrome P450 2A6enzyme
MethimazoleCytochrome P450 2B6enzyme
MethimazoleCytochrome P450 2C19enzyme
MethimazoleCytochrome P450 2C9enzyme
MethimazoleCytochrome P450 2D6enzyme
MethimazoleCytochrome P450 2E1enzyme
MethimazoleCytochrome P450 3A4enzyme
MethimazoleDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
ZafirlukastCysteinyl leukotriene receptor 1target
ZafirlukastCytochrome P450 2C9enzyme
ZafirlukastCytochrome P450 2C8enzyme
ZafirlukastProstaglandin G/H synthase 1enzyme
ZafirlukastCytochrome P450 3A4enzyme
ZafirlukastCytochrome P450 1A2enzyme
ZafirlukastCytochrome P450 2C19enzyme
ZafirlukastATP-binding cassette sub-family G member 2transporter
ZafirlukastCytochrome P450 2D6enzyme
ZafirlukastSodium/bile acid cotransportertransporter
DesipramineMuscarinic acetylcholine receptor M1target
DesipramineSodium-dependent noradrenaline transportertarget
DesipramineBeta-2 adrenergic receptortarget
DesipramineMuscarinic acetylcholine receptor M2target
DesipramineSodium-dependent serotonin transportertarget
DesipramineHistamine H1 receptortarget
DesipramineBeta-1 adrenergic receptortarget
DesipramineCytochrome P450 2D6enzyme
DesipramineMuscarinic acetylcholine receptor M3target
DesipramineMuscarinic acetylcholine receptor M4target
DesipramineMuscarinic acetylcholine receptor M5target
DesipramineAlpha-1 adrenergic receptorstarget
Desipramine5-hydroxytryptamine receptor 2Atarget
DesipramineAlpha-1-acid glycoprotein 1carrier
DesipramineCytochrome P450 2B6enzyme
DesipramineCytochrome P450 3A4enzyme
DesipramineSolute carrier family 22 member 2transporter
DesipramineSolute carrier family 22 member 1transporter
DesipramineSolute carrier family 22 member 3transporter
DesipramineSolute carrier family 22 member 5transporter
DesipramineP-glycoprotein 1transporter
DesipramineSolute carrier family 22 member 4transporter
DesipramineCytochrome P450 1A2enzyme
DesipramineCytochrome P450 2E1enzyme
DesipramineSphingomyelin phosphodiesterasetarget
Desipramine5-hydroxytryptamine receptor 1Atarget
Desipramine5-hydroxytryptamine receptor 2Ctarget
DesipramineDopamine D2 receptortarget
DesipramineAlpha-2 adrenergic receptorstarget
ClascoteroneAndrogen receptortarget
ClascoteroneCytochrome P450 1A2enzyme
ClascoteroneCytochrome P450 2B6enzyme
ClascoteroneCytochrome P450 2C8enzyme
ClascoteroneCytochrome P450 2C9enzyme
ClascoteroneCytochrome P450 2C19enzyme
ClascoteroneCytochrome P450 2D6enzyme
ClascoteroneCytochrome P450 2E1enzyme
ClascoteroneCytochrome P450 3A4enzyme
FluphenazineDopamine D2 receptortarget
FluphenazineCalmodulintarget
FluphenazineDopamine D1 receptortarget
FluphenazineCytochrome P450 2D6enzyme
FluphenazineP-glycoprotein 1transporter
FluphenazineCytochrome P450 2E1enzyme
FluphenazineAndrogen receptortarget
Fluphenazine5-hydroxytryptamine receptor 2Atarget
Fluphenazine5-hydroxytryptamine receptor 2Ctarget
ItraconazoleLanosterol 14-alpha demethylasetarget
ItraconazoleLanosterol 14-alpha demethylasetarget
ItraconazoleCytochrome P450 3A4enzyme
ItraconazoleCytochrome P450 3A5enzyme
ItraconazoleCytochrome P450 3A7enzyme
ItraconazoleCytochrome P450 2B6enzyme
ItraconazoleP-glycoprotein 1transporter
ItraconazoleCytochrome P450 1A1enzyme
ItraconazoleCytochrome P450 2E1enzyme
ItraconazoleSolute carrier organic anion transporter family member 2B1transporter
ItraconazoleCytochrome P450 3A Subfamilyenzyme
EthambutolProbable arabinosyltransferase Btarget
EthambutolProbable arabinosyltransferase Atarget
EthambutolProbable arabinosyltransferase Ctarget
EthambutolCytochrome P450 1A2enzyme
EthambutolCytochrome P450 2E1enzyme
EthambutolCytochrome P450 2C19enzyme
EthambutolCytochrome P450 2D6enzyme
EthambutolCytochrome P450 2A6enzyme
EthambutolCytochrome P450 2C9enzyme
EthambutolCytochrome P450 3A4enzyme
QuercetinTyrosine-protein kinase HCKtarget
QuercetinCytochrome P450 2C8enzyme
QuercetinMultidrug resistance-associated protein 1transporter
QuercetinCanalicular multispecific organic anion transporter 1transporter
QuercetinMonocarboxylate transporter 2transporter
QuercetinSolute carrier organic anion transporter family member 2B1transporter
QuercetinP-glycoprotein 1transporter
QuercetinMonocarboxylate transporter 1transporter
QuercetinATP-binding cassette sub-family G member 2transporter
QuercetinPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformtarget
QuercetinUDP-glucuronosyltransferase 3A1target
QuercetinATP synthase subunit alpha, mitochondrialtarget
QuercetinATP synthase subunit beta, mitochondrialtarget
QuercetinATP synthase subunit gamma, mitochondrialtarget
QuercetinSerine/threonine-protein kinase pim-1target
QuercetinHTH-type transcriptional regulator TtgRtarget
Quercetin3-hydroxyisobutyryl-CoA hydrolase, mitochondrialtarget
Quercetin3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZtarget
QuercetinSerine/threonine-protein kinase 17Btarget
QuercetinEstrogen receptor alphatarget
QuercetinEstrogen receptor betatarget
QuercetinRibosyldihydronicotinamide dehydrogenase [quinone]target
QuercetinSerum albumincarrier
QuercetinAryl hydrocarbon receptortarget
QuercetinCytochrome P450 1B1target
QuercetinActin, cytoplasmic 1target
QuercetinCasein kinase II subunit alphatarget
QuercetinCasein kinase II subunit betatarget
QuercetinEukaryotic translation initiation factor 3 subunit Ftarget
QuercetinHeat shock protein HSP 90-alphatarget
QuercetinHeat shock-related 70 kDa protein 2target
QuercetinRuvB-like 2target
QuercetinSplicing factor 3B subunit 3target
QuercetinUbiquitin-like modifier-activating enzyme 1target
QuercetinSex hormone-binding globulintarget
QuercetinCarbonyl reductase [NADPH] 1target
QuercetinCCAAT/enhancer-binding protein betatarget
QuercetinNuclear receptor subfamily 1 group I member 2target
QuercetinSolute carrier organic anion transporter family member 1B1transporter
QuercetinCytochrome P450 2C9enzyme
QuercetinCytochrome P450 1A2enzyme
QuercetinCytochrome P450 2E1enzyme
QuercetinCytochrome P450 2C19enzyme
QuercetinCytochrome P450 3A Subfamilyenzyme
QuercetinCytochrome P450 2D6enzyme
CariprazineCytochrome P450 3A4enzyme
CariprazineCytochrome P450 2D6enzyme
CariprazineP-glycoprotein 1transporter
CariprazineCytochrome P450 3A5enzyme
CariprazineDopamine D3 receptortarget
CariprazineDopamine D2 receptortarget
Cariprazine5-hydroxytryptamine receptor 1Atarget
Cariprazine5-hydroxytryptamine receptor 2Btarget
Cariprazine5-hydroxytryptamine receptor 2Atarget
CariprazineHistamine H1 receptortarget
Cariprazine5-hydroxytryptamine receptor 2Ctarget
CariprazineAlpha-1A adrenergic receptortarget
CariprazineCytochrome P450 1A2enzyme
CariprazineCytochrome P450 2C9enzyme
CariprazineCytochrome P450 2C19enzyme
CariprazineCytochrome P450 2E1enzyme