Kinase Inhibitor

Name
Kinase Inhibitor
Accession Number
DBCAT003325  (DBCAT004244)
Description

Not Available

Drugs
DrugDrug Description
GefitinibA tyrosine kinase inhibitor used as first-line therapy to treat non-small cell lung carcinoma (NSCLC) that meets certain genetic mutation criteria.
SorafenibA kinase inhibitor used to treat unresectable liver carcinoma, advanced renal carcinoma, and differentiated thyroid carcinoma.
ErlotinibAn EGFR tyrosine kinase inhibitor used to treat certain small cell lung cancers or advanced metastatic pancreatic cancers.
ImatinibA tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors.
SirolimusAn mTOR inhibitor immunosuppressant used to prevent organ transplant rejections, treat lymphangioleiomyomatosis, and treat adults with perivascular epithelioid cell tumors.
DasatinibA tyrosine kinase inhibitor used for the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia or chronic myeloid leukemia.
LapatinibAn antineoplastic agent and tyrosine kinase inhibitor used for the treatment of advanced or metastatic HER-positive breast cancer in patients who received prior chemotherapeutic treatments.
SunitinibA receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST).
EverolimusA mammalian target of rapamycin (mTOR) kinase inhibitor used to treat various types of malignancies.
NilotinibA kinase inhibitor used for the chronic phase treatment of Chronic Myeloid Leukemia (CML) that is Philadelphia chromosome positive and for the treatment of CML that is resistant to therapy containing imatinib.
CobimetinibAn antineoplastic agent and selective inhibitor of the mitogen-activated extracellular kinase (MEK) pathway used to treat unresectable or metastatic melanoma.
VandetanibAn antineoplastic kinase inhibitor used to treat symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease.
TemsirolimusA antineoplastic agent used in the treatment of renal cell carcinoma (RCC) that works by inhibiting mTOR.
PazopanibAn antineoplastic agent used in the treatment of advanced renal cell cancer and advanced soft tissue sarcoma in patients with prior chemotherapy.
MidostaurinAn antineoplastic agent used to treat high-risk acute myeloid leukemia (AML) with specific mutations, aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematologic neoplasm (SM-AHN), or mast cell leukemia (MCL).
BosutinibAn antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments.
AxitinibAn oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy.
CrizotinibA receptor tyrosine kinase inhibitor used to treat metastatic non-small cell lung cancer (NSCLC) where the tumors have been confirmed to be anaplastic lymphoma kinase (ALK), or ROS1-positive.
CabozantinibA tyrosine kinase inhibitor used to treat advanced renal cell carcinoma, hepatocellular carcinoma, and medullary thyroid cancer.
RuxolitinibA kinase inhibitor used to treat various types of myelofibrosis, polycythemia vera in patients who have not responded to or cannot tolerate hydroxyurea, and to treat graft-versus-host disease in cases that are refractory to steroid treatment.
VemurafenibA kinase inhibitor used to treat patients with Erdheim-Chester Disease who have the BRAF V600 mutation, and melanoma in patients who have the BRAF V600E mutation.
RegorafenibA kinase inhibitor used to treat patients with metastatic colorectal cancer, unresectable, locally advanced, or metastatic gastrointestinal stromal tumors, and hepatocellular carcinoma.
PonatinibA kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML).
TrametinibA kinase inhibitor used alone or in combination with dabrafenib to treat patients with cancers with specific BRAF mutations, such as melanoma and non-small cell lung cancer.
DabrafenibA kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer.
AfatinibAn antineoplastic agent used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) with non-resistant EGFR mutations or resistance to platinum-based chemotherapy.
IbrutinibAn antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia.
IdelalisibAn antineoplastic kinase inhibitor used to treat chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL).
CeritinibAn antineoplastic kinase inhibitor used to treat anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) in patients with inadequate clinical response or intolerance to crizotinib.
PalbociclibAn endocrine-based chemotherapeutic agent used in combination with other antineoplastic agents to treat HER2-negative and HR-positive advanced or metastatic breast cancer.
LenvatinibA receptor tyrosine kinase inhibitor used for the treatment of metastatic thyroid cancer, advanced renal cell carcinoma in combination with everolimus, and unresectable hepatocellular carcinoma.
NintedanibA triple angiokinase inhibitor indicated for the treatment of idiopathic pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and in combination with docetaxel for non-small cell lung cancer.
OsimertinibA tyrosine kinase inhibitor used in the treatment of certain types of non-small cell lung carcinoma.
AlectinibA kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer.
AcalabrutinibA Bruton tyrosine kinase inhibitor used to treat mantle cell lymphoma, chronic lymphocytic leukemia, and small lymphocytic lymphoma.
RibociclibA kinase inhibitor used to treat HR+, HER2- advanced or metastatic breast cancer.
NeratinibA protein kinase inhibitor used to treat breast cancer that over expresses the HER2 receptor.
AbemaciclibA medication used to treat HR+ HER2- advanced or metastatic breast cancer.
BrigatinibAn anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer.
CopanlisibA PI3K inhibitor used to treat relapsed follicular lymphoma in adults.
LorlatinibAn anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer.
PemigatinibA kinase inhibitor used to treat locally advanced or metastatic, unresectable cholangiocarcinoma in previously treated adult patients.
TirbanibulinA tyrosine kinase and tubulin inhibitor used to treat actinic keratosis on the face or scalp.
InfigratinibAn FGFR inhibitor used to treat locally advanced or metastatic cholangiocarcinoma in adults with a fibroblast growth factor receptor 2 (FGFR2) rearrangement.
LarotrectinibA kinase inhibitor used to treat solid tumors with neurotrophic receptor tyrosine kinase gene fusion, are metastatic, high risk for surgery, or have no alternative treatments.
TivozanibA kinase inhibitor to treat adult patients with renal cell carcinoma (RCC) who have failed prior systemic therapies or experienced relapsed disease.
UmbralisibA kinase inhibitor used to treat rare forms of refractory lymphoma.
TucatinibA kinase inhibitor used to treat certain types of unresectable/metastatic HER-2 positive breast cancer.
RipretinibA kinase inhibitor used to treat advanced gastrointestinal stromal tumor (GIST).
TepotinibAn oral tyrosine kinase inhibitor targeted against MET for the treatment of metastatic non-small cell lung cancer in patients exhibiting MET exon 14 skipping mutations.
AvapritinibA selective tyrosine kinase inhibitor being investigated for the treatment of multidrug resistant gastrointestinal tumors.
TrilaciclibA CDK4 and CDK6 inhibitor to reduce the risk of chemotherapy induced myelosuppression.
CapmatinibA kinase inhibitor targeting c-Met receptor tyrosine kinase in the treatment of non-small cell lung cancer with MET exon 14 skipping.
SelpercatinibA RET receptor tyrosine kinase inhibitor for the treatment of RET-driven non-small cell lung cancer, medullary thyroid cancer, and thyroid cancer in appropriate patient populations.
PralsetinibA RET receptor tyrosine kinase inhibitor for the treatment of metastatic RET-driven non-small cell lung cancer.
SelumetinibA MEK 1/2 inhibitor used in pediatric patients to treat neurofibromatosis type 1 (NF1) accompanied by symptomatic, inoperable plexiform neurofibromas (PN).
ZanubrutinibA kinase inhibitor used to treat mantle cell lymphoma, a type of B-cell non-Hodgkin lymphoma, in adults who previously received therapy.
Dimethyl sulfoxideA reversible mitogen-activated extracellular signal-regulated kinase-1 (MEK1) and MEK2 inhibitor used to treat certain types of melanoma, metastatic non-small cell lung cancer, and locally advanced or metastatic anaplastic thyroid cancer.
EncorafenibA kinase inhibitor used to treat unresectable or metastatic melanoma with specific mutations.
DuvelisibAn inhibitor of phosphatidylinositol 3-kinase delta and gamma used to treat relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma.
DacomitinibA medication used to treat non small cell lung cancer with EGFR exon 19 deletion of exon 21 L858R substitution.
BinimetinibA medication used to treat metastatic melanoma with specific mutations.
EntrectinibEntrectinib is indicated for the treatment of metastatic ROS1-positive non-small cell lung cancer in adults. Entrectinib is also indicated in adults and children over 12 years old for the treatment...
FostamatinibA spleen tyrosine kinase inhibitor used to treat chronic immune thrombocytopenia after attempting one other treatment.
AlpelisibAlpelisib is indicated in combination with fulvestrant to treat postmenopausal women, and men, with advanced or metastatic breast cancer. This cancer must be hormone receptor (HR)-positive, human epidermal growth factor...
GilteritinibAn AXL receptor tyrosine kinase inhibitor used to treat relapsed or refractory acute myeloid leukemia.
ErdafitinibA fibroblast growth factor receptor tyrosine kinase inhibitor used to treat locally advanced or metastatic urothelial carcinoma.
FedratinibFedratinib is indicated for the treatment of adult patients with intermediate-2 or high-risk primary or secondary (post-polycythemia vera or post-essential thrombocythemia) myelofibrosis.[L8090,L47016]
PexidartinibAn antitumor agent that is used for the treatment of rare disease tenosynovial giant cell tumors (TGCT) by inhibiting colony-stimulating factor 1 and its receptor.
MobocertinibAn oral kinase inhibitor targeted against EGFR and used in the treatment of NSCLC with EGFR exon 20 insertion mutations.
PacritinibA kinase inhibitor used for the treatment of primary and secondary myelofibrosis in adult patients with significantly reduced platelet counts.
IKT-001ProNot Annotated
PirtobrutinibA kinase inhibitor used to treat relapsed or refractory mantle cell lymphoma (MCL) after at least two lines of systemic therapy.
LeniolisibA phosphoinositide 3-kinase-delta inhibitor that is used to treat activated phosphoinositide 3-kinase delta syndrome.
FutibatinibA kinase inhibitor used to treat intrahepatic cholangiocarcinoma in previously treated adults.
Drugs & Drug Targets
DrugTargetType
GefitinibEpidermal growth factor receptortarget
GefitinibCytochrome P450 3A4enzyme
GefitinibCytochrome P450 2D6enzyme
GefitinibP-glycoprotein 1transporter
GefitinibATP-binding cassette sub-family G member 2transporter
GefitinibCytochrome P450 3A5enzyme
GefitinibCytochrome P450 1A1enzyme
GefitinibCytochrome P450 2C9enzyme
GefitinibCytochrome P450 2C19enzyme
GefitinibSerum albumincarrier
GefitinibAlpha-1-acid glycoprotein 1carrier
SorafenibSerine/threonine-protein kinase B-raftarget
SorafenibReceptor-type tyrosine-protein kinase FLT3target
SorafenibRAF proto-oncogene serine/threonine-protein kinasetarget
SorafenibVascular endothelial growth factor receptor 3target
SorafenibPlatelet-derived growth factor receptor betatarget
SorafenibMast/stem cell growth factor receptor Kittarget
SorafenibVascular endothelial growth factor receptor 2target
SorafenibCytochrome P450 3A4enzyme
SorafenibUDP-glucuronosyltransferase 1-9enzyme
SorafenibCytochrome P450 2B6enzyme
SorafenibCytochrome P450 2C8enzyme
SorafenibCytochrome P450 3A5enzyme
SorafenibCytochrome P450 3A7enzyme
SorafenibCytochrome P450 2C9enzyme
SorafenibMultidrug resistance-associated protein 4transporter
SorafenibP-glycoprotein 1transporter
SorafenibCanalicular multispecific organic anion transporter 1transporter
SorafenibATP-binding cassette sub-family G member 2transporter
SorafenibCytochrome P450 1A2enzyme
SorafenibCytochrome P450 2C19enzyme
SorafenibCytochrome P450 2D6enzyme
SorafenibUDP-glucuronosyltransferase 1-1enzyme
SorafenibRalA-binding protein 1transporter
SorafenibFibroblast growth factor receptor 1target
SorafenibProto-oncogene tyrosine-protein kinase receptor Rettarget
SorafenibVascular endothelial growth factor receptor 1target
SorafenibSolute carrier organic anion transporter family member 1B1transporter
ErlotinibEpidermal growth factor receptortarget
ErlotinibCytochrome P450 3A4enzyme
ErlotinibATP-binding cassette sub-family G member 2transporter
ErlotinibP-glycoprotein 1transporter
ErlotinibNuclear receptor subfamily 1 group I member 2target
ErlotinibCytochrome P450 3A5enzyme
ErlotinibCytochrome P450 1A1enzyme
ErlotinibCytochrome P450 1A2enzyme
ErlotinibCytochrome P450 1B1enzyme
ErlotinibCytochrome P450 2D6enzyme
ErlotinibCytochrome P450 2C8enzyme
ErlotinibUDP-glucuronosyltransferase 1-1enzyme
ErlotinibSerum albumincarrier
ErlotinibAlpha-1-acid glycoprotein 1carrier
ErlotinibSolute carrier organic anion transporter family member 2B1transporter
ErlotinibEpidermal growth factor receptorenzyme
ImatinibPlatelet-derived growth factor receptor betatarget
ImatinibTyrosine-protein kinase ABL1target
ImatinibMast/stem cell growth factor receptor Kittarget
ImatinibRET proto-oncogenetarget
ImatinibHigh affinity nerve growth factor receptortarget
ImatinibMacrophage colony-stimulating factor 1 receptortarget
ImatinibPlatelet-derived growth factor receptor alphatarget
ImatinibEpithelial discoidin domain-containing receptor 1target
ImatinibCytochrome P450 3A4enzyme
ImatinibBreakpoint cluster region proteintarget
ImatinibCytochrome P450 1A2enzyme
ImatinibCytochrome P450 2D6enzyme
ImatinibCytochrome P450 2C9enzyme
ImatinibCytochrome P450 2C19enzyme
ImatinibCytochrome P450 3A5enzyme
ImatinibCytochrome P450 3A7enzyme
ImatinibSolute carrier family 22 member 1transporter
ImatinibP-glycoprotein 1transporter
ImatinibSolute carrier family 22 member 2transporter
ImatinibATP-binding cassette sub-family G member 2transporter
ImatinibATP-binding cassette sub-family A member 3transporter
ImatinibSerum albumincarrier
ImatinibAlpha-1-acid glycoprotein 1carrier
ImatinibBile salt export pumptransporter
ImatinibCytochrome P450 2C8enzyme
ImatinibCanalicular multispecific organic anion transporter 1transporter
ImatinibMultidrug resistance-associated protein 1transporter
ImatinibSolute carrier family 22 member 5transporter
ImatinibSolute carrier organic anion transporter family member 1B3transporter
ImatinibMultidrug resistance-associated protein 4transporter
ImatinibSolute carrier organic anion transporter family member 1A2transporter
ImatinibDiscoidin domain-containing receptor 2target
SirolimusCytochrome P450 3A4enzyme
SirolimusSerine/threonine-protein kinase mTORtarget
SirolimusCytochrome P450 3A5enzyme
SirolimusCytochrome P450 3A7enzyme
SirolimusP-glycoprotein 1transporter
SirolimusSolute carrier organic anion transporter family member 1B1transporter
SirolimusMultidrug and toxin extrusion protein 1transporter
SirolimusSerum albumincarrier
SirolimusAlpha-1-acid glycoprotein 1carrier
SirolimusApolipoproteinscarrier
DasatinibTyrosine-protein kinase ABL1target
DasatinibTyrosine-protein kinase ABL2target
DasatinibProto-oncogene tyrosine-protein kinase Srctarget
DasatinibTyrosine-protein kinase Fyntarget
DasatinibTyrosine-protein kinase Lcktarget
DasatinibTyrosine-protein kinase Yestarget
DasatinibMast/stem cell growth factor receptor Kittarget
DasatinibPlatelet-derived growth factor receptor betatarget
DasatinibEphrin type-A receptor 2target
DasatinibSignal transducer and activator of transcription 5Btarget
DasatinibCytochrome P450 3A4enzyme
DasatinibP-glycoprotein 1transporter
DasatinibATP-binding cassette sub-family G member 2transporter
DasatinibCytochrome P450 1A1enzyme
DasatinibCytochrome P450 1A2enzyme
DasatinibCytochrome P450 1B1enzyme
DasatinibCytochrome P450 3A5enzyme
DasatinibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DasatinibTyrosine-protein kinase BTKtarget
DasatinibNuclear receptor subfamily 4 group A member 3target
DasatinibBreakpoint cluster region proteintarget
DasatinibTyrosine-protein kinase CSKtarget
DasatinibEphrin type-A receptor 5target
DasatinibEphrin type-B receptor 4target
DasatinibTyrosine-protein kinase Fgrtarget
DasatinibTyrosine-protein kinase FRKtarget
DasatinibHeat shock cognate 71 kDa proteintarget
DasatinibTyrosine-protein kinase Lyntarget
DasatinibMitogen-activated protein kinase kinase kinase MLTtarget
DasatinibMitogen-activated protein kinase 14target
DasatinibAmidophosphoribosyltransferasetarget
LapatinibEpidermal growth factor receptortarget
LapatinibReceptor tyrosine-protein kinase erbB-2target
LapatinibCytochrome P450 3A4enzyme
LapatinibCytochrome P450 2C8enzyme
LapatinibP-glycoprotein 1transporter
LapatinibAntigen peptide transporter 1transporter
LapatinibCytochrome P450 3A5enzyme
LapatinibCytochrome P450 2C19enzyme
SunitinibPlatelet-derived growth factor receptor betatarget
SunitinibVascular endothelial growth factor receptor 1target
SunitinibVascular endothelial growth factor receptor 2target
SunitinibVascular endothelial growth factor receptor 3target
SunitinibMast/stem cell growth factor receptor Kittarget
SunitinibReceptor-type tyrosine-protein kinase FLT3target
SunitinibMacrophage colony-stimulating factor 1 receptortarget
SunitinibPlatelet-derived growth factor receptor alphatarget
SunitinibCytochrome P450 3A4enzyme
SunitinibCytochrome P450 3A5enzyme
SunitinibCytochrome P450 3A7enzyme
SunitinibMultidrug resistance-associated protein 4transporter
SunitinibP-glycoprotein 1transporter
SunitinibCanalicular multispecific organic anion transporter 1transporter
SunitinibATP-binding cassette sub-family G member 2transporter
SunitinibHepatocyte growth factor receptortarget
EverolimusSerine/threonine-protein kinase mTORtarget
EverolimusCytochrome P450 3A4enzyme
EverolimusSolute carrier organic anion transporter family member 1B1transporter
EverolimusSolute carrier organic anion transporter family member 1B3transporter
EverolimusSolute carrier organic anion transporter family member 1A2transporter
EverolimusCytochrome P450 2D6enzyme
EverolimusP-glycoprotein 1transporter
NilotinibTyrosine-protein kinase ABL1target
NilotinibMast/stem cell growth factor receptor Kittarget
NilotinibCytochrome P450 2D6enzyme
NilotinibCytochrome P450 2C8enzyme
NilotinibCytochrome P450 2C9enzyme
NilotinibCytochrome P450 3A4enzyme
NilotinibP-glycoprotein 1transporter
NilotinibATP-binding cassette sub-family G member 2transporter
NilotinibUDP-glucuronosyltransferase 1-1transporter
NilotinibCytochrome P450 2B6enzyme
NilotinibSolute carrier organic anion transporter family member 1B1transporter
CobimetinibDual specificity mitogen-activated protein kinase kinase 1target
CobimetinibCytochrome P450 3A4enzyme
CobimetinibSolute carrier organic anion transporter family member 1B1transporter
CobimetinibSolute carrier organic anion transporter family member 1B3transporter
CobimetinibATP-binding cassette sub-family G member 2transporter
CobimetinibP-glycoprotein 1transporter
CobimetinibUDP-glucuronosyltransferase 2B7enzyme
CobimetinibCytochrome P450 2D6enzyme
CobimetinibCytochrome P450 3A5enzyme
CobimetinibAlpha-1-acid glycoprotein 1carrier
VandetanibVascular endothelial growth factor Atarget
VandetanibEpidermal growth factor receptortarget
VandetanibMultidrug resistance-associated protein 1transporter
VandetanibATP-binding cassette sub-family G member 2transporter
VandetanibProto-oncogene tyrosine-protein kinase receptor Rettarget
VandetanibDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
VandetanibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
VandetanibProtein-tyrosine kinase 6target
VandetanibAngiopoietin-1 receptortarget
VandetanibAlpha-1-acid glycoprotein 1carrier
VandetanibSerum albumincarrier
VandetanibCytochrome P450 3A4enzyme
VandetanibSolute carrier family 22 member 2transporter
VandetanibP-glycoprotein 1transporter
TemsirolimusSerine/threonine-protein kinase mTORtarget
TemsirolimusCytochrome P450 3A4enzyme
TemsirolimusCytochrome P450 3A5enzyme
TemsirolimusCytochrome P450 3A7enzyme
TemsirolimusCytochrome P450 2D6enzyme
TemsirolimusP-glycoprotein 1transporter
PazopanibVascular endothelial growth factor receptor 1target
PazopanibVascular endothelial growth factor receptor 2target
PazopanibVascular endothelial growth factor receptor 3target
PazopanibPlatelet-derived growth factor receptor alphatarget
PazopanibPlatelet-derived growth factor receptor betatarget
PazopanibMast/stem cell growth factor receptor Kittarget
PazopanibCytochrome P450 3A4enzyme
PazopanibCytochrome P450 2D6enzyme
PazopanibCytochrome P450 2C8enzyme
PazopanibCytochrome P450 1A2enzyme
PazopanibP-glycoprotein 1transporter
PazopanibATP-binding cassette sub-family G member 2transporter
PazopanibSolute carrier organic anion transporter family member 1B1transporter
PazopanibUDP-glucuronosyltransferase 1-1transporter
PazopanibFibroblast growth factor receptor 3target
PazopanibTyrosine-protein kinase ITK/TSKtarget
PazopanibFibroblast growth factor 1target
PazopanibSH2B adapter protein 3target
MidostaurinProtein kinase C alpha typetarget
MidostaurinVascular endothelial growth factor receptor 2target
MidostaurinMast/stem cell growth factor receptor Kittarget
MidostaurinPlatelet-derived growth factor receptor alphatarget
MidostaurinPlatelet-derived growth factor receptor betatarget
MidostaurinReceptor-type tyrosine-protein kinase FLT3target
MidostaurinCytochrome P450 3A Subfamilyenzyme
MidostaurinCytochrome P450 1A2enzyme
MidostaurinCytochrome P450 2B6enzyme
MidostaurinCytochrome P450 2C8enzyme
MidostaurinCytochrome P450 2C9enzyme
MidostaurinCytochrome P450 2C19enzyme
MidostaurinCytochrome P450 2D6enzyme
MidostaurinCytochrome P450 2E1enzyme
MidostaurinCytochrome P450 3A4enzyme
MidostaurinCytochrome P450 3A5enzyme
MidostaurinCytochrome P450 3A7enzyme
MidostaurinCytochrome P450 3A43enzyme
BosutinibTyrosine-protein kinase ABL1target
BosutinibTyrosine-protein kinase Lyntarget
BosutinibProto-oncogene tyrosine-protein kinase Srctarget
BosutinibP-glycoprotein 1transporter
BosutinibCytochrome P450 3A4enzyme
BosutinibDual specificity mitogen-activated protein kinase kinase 1target
BosutinibDual specificity mitogen-activated protein kinase kinase 2target
BosutinibMitogen-activated protein kinase kinase kinase 2target
BosutinibCalcium/calmodulin-dependent protein kinase type II subunit gammatarget
BosutinibCytochrome P450 2C8enzyme
BosutinibTyrosine-protein kinase Fgrtarget
BosutinibTyrosine-protein kinase HCKtarget
BosutinibTyrosine-protein kinase Tectarget
BosutinibSTE20-like serine/threonine-protein kinasetarget
AxitinibVascular endothelial growth factor receptor 1target
AxitinibVascular endothelial growth factor receptor 2target
AxitinibVascular endothelial growth factor receptor 3target
AxitinibCytochrome P450 3A4enzyme
AxitinibCytochrome P450 3A5enzyme
AxitinibCytochrome P450 1A2enzyme
AxitinibCytochrome P450 2C19enzyme
AxitinibUDP-glucuronosyltransferase 1-1enzyme
AxitinibP-glycoprotein 1transporter
AxitinibSolute carrier organic anion transporter family member 1B1transporter
CrizotinibCytochrome P450 3A4enzyme
CrizotinibCytochrome P450 3A5enzyme
CrizotinibP-glycoprotein 1transporter
CrizotinibALK tyrosine kinase receptortarget
CrizotinibHepatocyte growth factor receptortarget
CrizotinibCytochrome P450 2B6enzyme
CrizotinibCytochrome P450 3A Subfamilyenzyme
CrizotinibSerum albumincarrier
Crizotinibalpha1-acid glycoproteincarrier
CrizotinibProto-oncogene tyrosine-protein kinase ROStarget
CrizotinibMacrophage-stimulating protein receptortarget
CabozantinibCytochrome P450 3A4enzyme
CabozantinibCytochrome P450 2C9enzyme
CabozantinibHepatocyte growth factor receptortarget
CabozantinibVascular endothelial growth factor receptor 2target
CabozantinibProto-oncogene tyrosine-protein kinase receptor Rettarget
CabozantinibCytochrome P450 2C8enzyme
RuxolitinibTyrosine-protein kinase JAK1target
RuxolitinibTyrosine-protein kinase JAK2target
RuxolitinibCytochrome P450 3A4enzyme
RuxolitinibCytochrome P450 2C9enzyme
RuxolitinibSerum albumincarrier
RuxolitinibTyrosine-protein kinase JAK3target
RuxolitinibNon-receptor tyrosine-protein kinase TYK2target
VemurafenibSerum albumincarrier
VemurafenibAlpha-1-acid glycoprotein 1carrier
VemurafenibCytochrome P450 1A2enzyme
VemurafenibCytochrome P450 2D6enzyme
VemurafenibCytochrome P450 3A4enzyme
VemurafenibSerine/threonine-protein kinase B-raftarget
VemurafenibMultidrug resistance-associated protein 1transporter
VemurafenibATP-binding cassette sub-family G member 2transporter
VemurafenibCytochrome P450 2C9enzyme
VemurafenibCytochrome P450 2C8enzyme
VemurafenibCytochrome P450 2B6enzyme
VemurafenibP-glycoprotein 1transporter
RegorafenibCytochrome P450 3A4enzyme
RegorafenibUDP-glucuronosyltransferase 1-9enzyme
RegorafenibProto-oncogene tyrosine-protein kinase receptor Rettarget
RegorafenibVascular endothelial growth factor receptor 1target
RegorafenibVascular endothelial growth factor receptor 2target
RegorafenibVascular endothelial growth factor receptor 3target
RegorafenibMast/stem cell growth factor receptor Kittarget
RegorafenibPlatelet-derived growth factor receptor alphatarget
RegorafenibPlatelet-derived growth factor receptor betatarget
RegorafenibFibroblast growth factor receptor 1target
RegorafenibFibroblast growth factor receptor 2target
RegorafenibAngiopoietin-1 receptortarget
RegorafenibDiscoidin domain-containing receptor 2target
RegorafenibHigh affinity nerve growth factor receptortarget
RegorafenibEphrin type-A receptor 2target
RegorafenibRAF proto-oncogene serine/threonine-protein kinasetarget
RegorafenibSerine/threonine-protein kinase B-raftarget
RegorafenibCytochrome P450 2C8enzyme
RegorafenibCytochrome P450 2C9enzyme
RegorafenibCytochrome P450 2B6enzyme
RegorafenibMitogen-activated protein kinase 11target
RegorafenibTyrosine-protein kinase FRKtarget
RegorafenibTyrosine-protein kinase ABL1target
RegorafenibP-glycoprotein 1transporter
RegorafenibATP-binding cassette sub-family G member 2transporter
RegorafenibUDP-glucuronosyltransferase 1-1enzyme
RegorafenibCytochrome P450 2C19enzyme
PonatinibTyrosine-protein kinase ABL1target
PonatinibBreakpoint cluster region proteintarget
PonatinibMast/stem cell growth factor receptor Kittarget
PonatinibProto-oncogene tyrosine-protein kinase receptor Rettarget
PonatinibAngiopoietin-1 receptortarget
PonatinibReceptor-type tyrosine-protein kinase FLT3target
PonatinibCytochrome P450 3A4enzyme
PonatinibCytochrome P450 2C8enzyme
PonatinibCytochrome P450 2D6enzyme
PonatinibCytochrome P450 3A5enzyme
PonatinibP-glycoprotein 1transporter
PonatinibATP-binding cassette sub-family G member 2transporter
PonatinibFibroblast growth factor receptor 1target
PonatinibFibroblast growth factor receptor 2target
PonatinibFibroblast growth factor receptor 3target
PonatinibFibroblast growth factor receptor 4target
PonatinibTyrosine-protein kinase Lcktarget
PonatinibProto-oncogene tyrosine-protein kinase Srctarget
PonatinibTyrosine-protein kinase Lyntarget
PonatinibVascular endothelial growth factor receptor 2target
PonatinibPlatelet-derived growth factor receptor alphatarget
TrametinibCytochrome P450 2C8enzyme
TrametinibCytochrome P450 3A4enzyme
TrametinibDual specificity mitogen-activated protein kinase kinase 1target
TrametinibDual specificity mitogen-activated protein kinase kinase 2target
DabrafenibCytochrome P450 3A4enzyme
DabrafenibCytochrome P450 2C8enzyme
DabrafenibP-glycoprotein 1transporter
DabrafenibATP-binding cassette sub-family G member 2transporter
DabrafenibSolute carrier organic anion transporter family member 1B1transporter
DabrafenibSolute carrier organic anion transporter family member 1B3transporter
DabrafenibSolute carrier family 22 member 6transporter
DabrafenibSolute carrier family 22 member 8transporter
DabrafenibSerine/threonine-protein kinase B-raftarget
DabrafenibRAF proto-oncogene serine/threonine-protein kinasetarget
DabrafenibSerine/threonine-protein kinase SIK1target
DabrafenibSerine/threonine-protein kinase Nek11target
DabrafenibLIM domain kinase 1target
DabrafenibCytochrome P450 2B6enzyme
DabrafenibCytochrome P450 2C9enzyme
DabrafenibCytochrome P450 2C19enzyme
DabrafenibCytochrome P450 1A2enzyme
DabrafenibSerum albumincarrier
DabrafenibSolute carrier organic anion transporter family member 1A2transporter
DabrafenibSolute carrier family 22 member 2transporter
DabrafenibUDP-glucuronosyltransferase 1-1enzyme
AfatinibEpidermal growth factor receptortarget
AfatinibReceptor tyrosine-protein kinase erbB-2target
AfatinibReceptor tyrosine-protein kinase erbB-4target
AfatinibP-glycoprotein 1transporter
AfatinibATP-binding cassette sub-family G member 2transporter
IbrutinibTyrosine-protein kinase BTKtarget
IbrutinibCytochrome P450 3A4enzyme
IbrutinibCytochrome P450 3A5enzyme
IbrutinibSerum albumincarrier
Ibrutinibalpha1-acid glycoproteincarrier
IbrutinibCytochrome P450 2D6enzyme
IdelalisibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
IdelalisibATP-binding cassette sub-family G member 2transporter
IdelalisibP-glycoprotein 1transporter
IdelalisibAldehyde oxidaseenzyme
IdelalisibCytochrome P450 2C8enzyme
IdelalisibCytochrome P450 2C19enzyme
IdelalisibCytochrome P450 2B6enzyme
IdelalisibCytochrome P450 3A4enzyme
IdelalisibSolute carrier organic anion transporter family member 1B1transporter
IdelalisibSolute carrier organic anion transporter family member 1B3transporter
IdelalisibCytochrome P450 3A5enzyme
IdelalisibCytochrome P450 3A43enzyme
IdelalisibCytochrome P450 3A7enzyme
IdelalisibUDP-glucuronosyltransferase 1-4enzyme
CeritinibALK tyrosine kinase receptortarget
CeritinibP-glycoprotein 1transporter
CeritinibCytochrome P450 2C9enzyme
CeritinibCytochrome P450 3A4enzyme
PalbociclibCyclin-dependent kinase 4target
PalbociclibCyclin-dependent kinase 6target
PalbociclibCytochrome P450 3A4enzyme
PalbociclibBile salt sulfotransferaseenzyme
PalbociclibP-glycoprotein 1transporter
PalbociclibATP-binding cassette sub-family G member 2transporter
PalbociclibSerum albumincarrier
PalbociclibSolute carrier family 22 member 1transporter
LenvatinibVascular endothelial growth factor receptor 1target
LenvatinibVascular endothelial growth factor receptor 2target
LenvatinibVascular endothelial growth factor receptor 3target
LenvatinibFibroblast growth factor receptor 1target
LenvatinibFibroblast growth factor receptor 2target
LenvatinibFibroblast growth factor receptor 3target
LenvatinibFibroblast growth factor receptor 4target
LenvatinibPlatelet-derived growth factor receptor alphatarget
LenvatinibProto-oncogene tyrosine-protein kinase receptor Rettarget
LenvatinibMast/stem cell growth factor receptor Kittarget
LenvatinibP-glycoprotein 1transporter
LenvatinibATP-binding cassette sub-family G member 2transporter
LenvatinibCytochrome P450 3A4enzyme
LenvatinibAldehyde oxidaseenzyme
LenvatinibCytochrome P450 2C8enzyme
LenvatinibCytochrome P450 2C9enzyme
LenvatinibCytochrome P450 1A2enzyme
LenvatinibCytochrome P450 2B6enzyme
LenvatinibCytochrome P450 2C19enzyme
LenvatinibSolute carrier family 22 member 6transporter
LenvatinibSolute carrier family 22 member 8transporter
LenvatinibSolute carrier family 22 member 2transporter
LenvatinibSolute carrier organic anion transporter family member 1B1transporter
LenvatinibBile salt export pumptransporter
LenvatinibCytochrome P450 2D6enzyme
LenvatinibSolute carrier organic anion transporter family member 1B3transporter
NintedanibVascular endothelial growth factor receptor 1target
NintedanibVascular endothelial growth factor receptor 2target
NintedanibVascular endothelial growth factor receptor 3target
NintedanibPlatelet-derived growth factor receptor alphatarget
NintedanibPlatelet-derived growth factor receptor betatarget
NintedanibFibroblast growth factor receptor 1target
NintedanibFibroblast growth factor receptor 2target
NintedanibFibroblast growth factor receptor 3target
NintedanibReceptor-type tyrosine-protein kinase FLT3target
NintedanibTyrosine-protein kinase Lcktarget
NintedanibTyrosine-protein kinase Lyntarget
NintedanibProto-oncogene tyrosine-protein kinase Srctarget
NintedanibP-glycoprotein 1transporter
NintedanibCytochrome P450 3A4enzyme
NintedanibSolute carrier family 22 member 1transporter
NintedanibSerum albumincarrier
NintedanibUDP-glucuronosyltransferase 1-1enzyme
NintedanibUDP-glucuronosyltransferase 1-7enzyme
NintedanibUDP-glucuronosyltransferase 1-8enzyme
NintedanibUDP-glucuronosyltransferase 1-10enzyme
NintedanibATP-binding cassette sub-family G member 2transporter
OsimertinibEpidermal growth factor receptortarget
OsimertinibP-glycoprotein 1transporter
OsimertinibATP-binding cassette sub-family G member 2transporter
OsimertinibCytochrome P450 3A4enzyme
OsimertinibCytochrome P450 1A2enzyme
AlectinibALK tyrosine kinase receptortarget
AlectinibATP-binding cassette sub-family G member 2transporter
AlectinibP-glycoprotein 1transporter
AcalabrutinibTyrosine-protein kinase BTKtarget
AcalabrutinibCytochrome P450 3A4enzyme
AcalabrutinibCytochrome P450 3A5enzyme
AcalabrutinibCytochrome P450 3A Subfamilyenzyme
AcalabrutinibSerum albumincarrier
Acalabrutinibalpha1-acid glycoproteincarrier
RibociclibCyclin-dependent kinase 4target
RibociclibCyclin-dependent kinase 6target
RibociclibCytochrome P450 3A4enzyme
NeratinibCytochrome P450 3A4enzyme
NeratinibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
NeratinibP-glycoprotein 1transporter
NeratinibEpidermal growth factor receptortarget
NeratinibSerum albumincarrier
Neratinibalpha1-acid glycoproteincarrier
AbemaciclibMultidrug and toxin extrusion protein 1transporter
AbemaciclibMultidrug and toxin extrusion protein 2transporter
AbemaciclibCyclin-dependent kinase 4target
AbemaciclibCyclin-dependent kinase 6target
AbemaciclibSerum albumincarrier
Abemaciclibalpha1-acid glycoproteincarrier
AbemaciclibCytochrome P450 3A4enzyme
AbemaciclibP-glycoprotein 1transporter
AbemaciclibATP-binding cassette sub-family G member 2transporter
AbemaciclibSolute carrier family 22 member 2transporter
AbemaciclibCytochrome P450 1A2enzyme
AbemaciclibCytochrome P450 2B6enzyme
AbemaciclibCytochrome P450 2C8enzyme
AbemaciclibCytochrome P450 2C9enzyme
AbemaciclibCytochrome P450 2D6enzyme
BrigatinibALK tyrosine kinase receptortarget
BrigatinibEpidermal growth factor receptortarget
BrigatinibTyrosine-protein kinase ABL1target
BrigatinibInsulin-like growth factor 1 receptortarget
BrigatinibReceptor-type tyrosine-protein kinase FLT3target
BrigatinibCytochrome P450 2C8enzyme
BrigatinibCytochrome P450 3A4enzyme
BrigatinibInsulin receptortarget
BrigatinibHepatocyte growth factor receptortarget
BrigatinibReceptor tyrosine-protein kinase erbB-4target
BrigatinibReceptor tyrosine-protein kinase erbB-2target
BrigatinibATP-binding cassette sub-family B member 5transporter
BrigatinibATP-binding cassette sub-family G member 2transporter
BrigatinibSolute carrier family 22 member 1transporter
BrigatinibMultidrug and toxin extrusion protein 1transporter
BrigatinibMultidrug and toxin extrusion protein 2transporter
BrigatinibCytochrome P450 3A Subfamilyenzyme
CopanlisibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
CopanlisibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
CopanlisibCytochrome P450 3A4enzyme
CopanlisibCytochrome P450 3A5enzyme
CopanlisibCytochrome P450 3A7enzyme
CopanlisibP-glycoprotein 1transporter
CopanlisibATP-binding cassette sub-family G member 2transporter
CopanlisibMultidrug and toxin extrusion protein 2transporter
CopanlisibSerum albumincarrier
CopanlisibCytochrome P450 1A1enzyme
CopanlisibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformtarget
CopanlisibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformtarget
LorlatinibALK tyrosine kinase receptortarget
LorlatinibCytochrome P450 3A Subfamilyenzyme
LorlatinibCytochrome P450 3A5enzyme
LorlatinibCytochrome P450 2B6enzyme
LorlatinibCytochrome P450 2C8enzyme
LorlatinibCytochrome P450 2C19enzyme
LorlatinibUDP-glucuronosyltransferase 1-3enzyme
LorlatinibCytochrome P450 3A4enzyme
PemigatinibCytochrome P450 3A4enzyme
PemigatinibFibroblast growth factor receptor 1target
PemigatinibFibroblast growth factor receptor 2target
PemigatinibFibroblast growth factor receptor 3target
PemigatinibFibroblast growth factor receptor 4target
PemigatinibP-glycoprotein 1transporter
PemigatinibATP-binding cassette sub-family G member 2transporter
PemigatinibSolute carrier family 22 member 2transporter
PemigatinibMultidrug and toxin extrusion protein 1transporter
TirbanibulinProto-oncogene tyrosine-protein kinase Srctarget
TirbanibulinTubulin beta chaintarget
TirbanibulinCytochrome P450 3A4enzyme
TirbanibulinCytochrome P450 2C8enzyme
TirbanibulinCytochrome P450 1A2enzyme
TirbanibulinCytochrome P450 2B6enzyme
TirbanibulinCytochrome P450 2C9enzyme
TirbanibulinCytochrome P450 2C19enzyme
TirbanibulinCytochrome P450 2D6enzyme
TirbanibulinMultidrug and toxin extrusion protein 1transporter
TirbanibulinMultidrug and toxin extrusion protein 2transporter
TirbanibulinSolute carrier organic anion transporter family member 1B1transporter
TirbanibulinSolute carrier organic anion transporter family member 1B3transporter
TirbanibulinSolute carrier family 22 member 1transporter
TirbanibulinSolute carrier family 22 member 2transporter
InfigratinibCytochrome P450 3A4enzyme
InfigratinibMultidrug and toxin extrusion protein 1transporter
InfigratinibATP-binding cassette sub-family G member 2transporter
InfigratinibBile salt export pumptransporter
InfigratinibSolute carrier family 22 member 1transporter
InfigratinibSolute carrier family 22 member 2transporter
InfigratinibMultidrug and toxin extrusion protein 2transporter
InfigratinibP-glycoprotein 1transporter
InfigratinibSolute carrier organic anion transporter family member 1B1transporter
InfigratinibSolute carrier organic anion transporter family member 1B3transporter
InfigratinibApolipoproteinscarrier
InfigratinibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
InfigratinibFibroblast growth factor receptor 1target
InfigratinibFibroblast growth factor receptor 2target
InfigratinibFibroblast growth factor receptor 3target
InfigratinibFibroblast growth factor receptor 4target
LarotrectinibCytochrome P450 3A4enzyme
LarotrectinibHigh affinity nerve growth factor receptortarget
LarotrectinibBDNF/NT-3 growth factors receptortarget
LarotrectinibNT-3 growth factor receptortarget
LarotrectinibP-glycoprotein 1transporter
LarotrectinibATP-binding cassette sub-family G member 2transporter
TivozanibCytochrome P450 3A4enzyme
TivozanibSerum albumincarrier
TivozanibVascular endothelial growth factor receptor 1target
TivozanibVascular endothelial growth factor receptor 2target
TivozanibVascular endothelial growth factor receptor 3target
TivozanibMast/stem cell growth factor receptor Kittarget
TivozanibPlatelet-derived growth factor receptor betatarget
TivozanibP-glycoprotein 1transporter
TivozanibATP-binding cassette sub-family G member 2transporter
TivozanibReceptor-type tyrosine-protein kinase FLT3target
TivozanibPlatelet-derived growth factor receptor alphatarget
TivozanibProtein-tyrosine kinase 6target
TivozanibAngiopoietin-1 receptortarget
TivozanibFibroblast growth factor receptor 1target
TivozanibHepatocyte growth factor receptortarget
UmbralisibP-glycoprotein 1transporter
UmbralisibCytochrome P450 2C9enzyme
UmbralisibCytochrome P450 1A2enzyme
UmbralisibCytochrome P450 3A4enzyme
UmbralisibCasein kinase I isoform epsilontarget
UmbralisibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
UmbralisibTyrosine-protein kinase ABL1enzyme
UmbralisibTyrosine-protein kinase ABL1target
TucatinibReceptor tyrosine-protein kinase erbB-2target
TucatinibATP-binding cassette sub-family G member 2transporter
TucatinibP-glycoprotein 1transporter
TucatinibSolute carrier family 22 member 2transporter
TucatinibMultidrug and toxin extrusion protein 1transporter
TucatinibMultidrug and toxin extrusion protein 2transporter
TucatinibCytochrome P450 2C8enzyme
TucatinibCytochrome P450 3A Subfamilyenzyme
TucatinibReceptor tyrosine-protein kinase erbB-2enzyme
TucatinibReceptor tyrosine-protein kinase erbB-3target
RipretinibMast/stem cell growth factor receptor Kittarget
RipretinibPlatelet-derived growth factor receptor betatarget
RipretinibAngiopoietin-1 receptortarget
RipretinibVascular endothelial growth factor receptor 2target
RipretinibSerine/threonine-protein kinase B-raftarget
RipretinibPlatelet-derived growth factor receptor alphatarget
RipretinibCytochrome P450 2C8enzyme
RipretinibPlatelet-derived growth factor receptor alphaenzyme
RipretinibSerum albumincarrier
Ripretinibalpha1-acid glycoproteincarrier
RipretinibP-glycoprotein 1transporter
RipretinibATP-binding cassette sub-family G member 2transporter
RipretinibMultidrug and toxin extrusion protein 1transporter
RipretinibCytochrome P450 3A4enzyme
RipretinibCytochrome P450 2D6enzyme
RipretinibCytochrome P450 2E1enzyme
TepotinibP-glycoprotein 1transporter
TepotinibCytochrome P450 3A4enzyme
TepotinibCytochrome P450 2C8enzyme
TepotinibATP-binding cassette sub-family G member 2transporter
TepotinibHepatocyte growth factor receptortarget
TepotinibNischarintarget
TepotinibMelatonin receptor type 1Btarget
TepotinibSerum albumincarrier
TepotinibAlpha-1-acid glycoprotein 1carrier
TepotinibSolute carrier family 22 member 1transporter
TepotinibSolute carrier family 22 member 2transporter
TepotinibMultidrug and toxin extrusion protein 1transporter
TepotinibMultidrug and toxin extrusion protein 2transporter
TepotinibBile salt export pumptransporter
TepotinibCytochrome P450 2C9enzyme
AvapritinibPlatelet derived growth factor receptor alphatarget
AvapritinibMast/stem cell growth factor receptor Kittarget
AvapritinibP-glycoprotein 1transporter
AvapritinibATP-binding cassette sub-family G member 2transporter
AvapritinibCytochrome P450 3A4enzyme
AvapritinibCytochrome P450 2C9enzyme
AvapritinibBile salt export pumptransporter
AvapritinibMultidrug and toxin extrusion protein 1transporter
AvapritinibMultidrug and toxin extrusion protein 2transporter
TrilaciclibSolute carrier family 22 member 2transporter
TrilaciclibMultidrug and toxin extrusion protein 1transporter
TrilaciclibMultidrug and toxin extrusion protein 2transporter
TrilaciclibCytochrome P450 1A2enzyme
TrilaciclibATP-binding cassette sub-family G member 2transporter
TrilaciclibP-glycoprotein 1transporter
TrilaciclibCyclin-dependent kinase 4target
TrilaciclibCyclin-dependent kinase 6target
TrilaciclibCyclin-dependent kinase 9target
TrilaciclibCyclin-dependent kinase 2target
TrilaciclibCyclin-dependent kinase 5target
TrilaciclibCyclin-dependent kinase 7target
CapmatinibCytochrome P450 3A4enzyme
CapmatinibAldehyde oxidaseenzyme
CapmatinibHepatocyte growth factor receptortarget
CapmatinibP-glycoprotein 1transporter
CapmatinibMultidrug and toxin extrusion protein 1transporter
CapmatinibMultidrug and toxin extrusion protein 2transporter
CapmatinibCytochrome P450 1A2enzyme
CapmatinibATP-binding cassette sub-family G member 2transporter
SelpercatinibProto-oncogene tyrosine-protein kinase receptor Rettarget
SelpercatinibVascular endothelial growth factor receptor 1target
SelpercatinibVascular endothelial growth factor receptor 3target
SelpercatinibFibroblast growth factor receptor 1target
SelpercatinibFibroblast growth factor receptor 2target
SelpercatinibFibroblast growth factor receptor 3target
SelpercatinibCytochrome P450 3A4enzyme
SelpercatinibCytochrome P450 2C8enzyme
SelpercatinibCytochrome P450 3A Subfamilyenzyme
SelpercatinibP-glycoprotein 1transporter
SelpercatinibATP-binding cassette sub-family G member 2transporter
SelpercatinibMultidrug and toxin extrusion protein 1transporter
PralsetinibProto-oncogene tyrosine-protein kinase receptor Rettarget
PralsetinibEpithelial discoidin domain-containing receptor 1target
PralsetinibNT-3 growth factor receptortarget
PralsetinibReceptor-type tyrosine-protein kinase FLT3target
PralsetinibTyrosine-protein kinase JAK1target
PralsetinibTyrosine-protein kinase JAK2target
PralsetinibHigh affinity nerve growth factor receptortarget
PralsetinibVascular endothelial growth factor receptor 2target
PralsetinibPlatelet-derived growth factor receptor betatarget
PralsetinibFibroblast growth factor receptor 1target
PralsetinibFibroblast growth factor receptor 2target
PralsetinibCytochrome P450 3A4enzyme
PralsetinibCytochrome P450 3A5enzyme
PralsetinibCytochrome P450 2D6enzyme
PralsetinibCytochrome P450 1A2enzyme
PralsetinibCytochrome P450 2C8enzyme
PralsetinibCytochrome P450 2C9enzyme
PralsetinibP-glycoprotein 1transporter
PralsetinibATP-binding cassette sub-family G member 2transporter
PralsetinibSolute carrier organic anion transporter family member 1B1transporter
PralsetinibSolute carrier organic anion transporter family member 1B3transporter
PralsetinibSolute carrier family 22 member 6transporter
PralsetinibMultidrug and toxin extrusion protein 1transporter
PralsetinibMultidrug and toxin extrusion protein 2transporter
PralsetinibBile salt export pumptransporter
SelumetinibDual specificity mitogen-activated protein kinase kinase 1target
SelumetinibDual specificity mitogen-activated protein kinase kinase 2target
SelumetinibSerum albumincarrier
Selumetinibalpha1-acid glycoproteincarrier
SelumetinibP-glycoprotein 1transporter
SelumetinibATP-binding cassette sub-family G member 2transporter
SelumetinibCytochrome P450 2C19enzyme
SelumetinibUDP-glucuronosyltransferase 1-1enzyme
SelumetinibCytochrome P450 2C9enzyme
SelumetinibCytochrome P450 3A4enzyme
SelumetinibCytochrome P450 1A2enzyme
SelumetinibCytochrome P450 2C8enzyme
SelumetinibUDP-glucuronosyltransferase 1-3enzyme
SelumetinibCytochrome P450 2E1enzyme
SelumetinibCytochrome P450 3A5enzyme
ZanubrutinibCytochrome P450 3A4enzyme
ZanubrutinibP-glycoprotein 1transporter
ZanubrutinibCytochrome P450 2B6enzyme
ZanubrutinibTyrosine-protein kinase BTKtarget
ZanubrutinibEpidermal growth factor receptortarget
ZanubrutinibReceptor tyrosine-protein kinase erbB-2target
ZanubrutinibReceptor tyrosine-protein kinase erbB-4target
ZanubrutinibTyrosine-protein kinase ITK/TSKtarget
ZanubrutinibCytoplasmic tyrosine-protein kinase BMXtarget
ZanubrutinibTyrosine-protein kinase JAK2target
ZanubrutinibTyrosine-protein kinase Tectarget
ZanubrutinibTyrosine-protein kinase Blktarget
ZanubrutinibTyrosine-protein kinase JAK3target
ZanubrutinibProtein-tyrosine kinase 6target
ZanubrutinibTyrosine-protein kinase Fgrtarget
ZanubrutinibTyrosine-protein kinase FRKtarget
ZanubrutinibTyrosine-protein kinase Lcktarget
ZanubrutinibTyrosine-protein kinase TXKtarget
ZanubrutinibCytochrome P450 3A Subfamilyenzyme
Dimethyl sulfoxideTransthyretincarrier
Dimethyl sulfoxideCytochrome P450 2C19enzyme
Dimethyl sulfoxideCytochrome P450 2D6enzyme
Dimethyl sulfoxideCytochrome P450 3A4enzyme
Dimethyl sulfoxideInterleukin-5 receptor subunit alphatarget
Dimethyl sulfoxideMucin-16target
Dimethyl sulfoxideMyc proto-oncogene proteintarget
EncorafenibCytochrome P450 3A4enzyme
EncorafenibCytochrome P450 2C19enzyme
EncorafenibCytochrome P450 2D6enzyme
EncorafenibSerine/threonine-protein kinase B-raftarget
EncorafenibG1/S-specific cyclin-D1target
EncorafenibUDP-glucuronosyltransferase 1-1enzyme
EncorafenibSerum albumincarrier
EncorafenibCytochrome P450 1A2enzyme
EncorafenibCytochrome P450 2B6enzyme
EncorafenibCytochrome P450 2C8enzyme
EncorafenibCytochrome P450 2C9enzyme
EncorafenibCytochrome P450 3A5enzyme
EncorafenibCytochrome P450 3A7enzyme
EncorafenibP-glycoprotein 1transporter
EncorafenibSolute carrier family 22 member 2transporter
EncorafenibATP-binding cassette sub-family G member 2transporter
EncorafenibSolute carrier family 22 member 6transporter
EncorafenibSolute carrier family 22 member 8transporter
EncorafenibSolute carrier organic anion transporter family member 1B1transporter
EncorafenibSolute carrier organic anion transporter family member 1B3transporter
EncorafenibRAF proto-oncogene serine/threonine-protein kinasetarget
EncorafenibMitogen-activated protein kinase 8target
EncorafenibMitogen-activated protein kinase 9target
EncorafenibMitogen-activated protein kinase 10target
EncorafenibLIM domain kinase 1target
EncorafenibLIM domain kinase 2target
EncorafenibDual specificity mitogen-activated protein kinase kinase 4target
EncorafenibSerine/threonine-protein kinase 36target
DuvelisibCytochrome P450 3A4enzyme
DuvelisibP-glycoprotein 1transporter
DuvelisibATP-binding cassette sub-family G member 2transporter
DuvelisibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformtarget
DuvelisibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
DacomitinibCytochrome P450 2D6enzyme
DacomitinibSerum albumincarrier
DacomitinibCytochrome P450 3A4enzyme
DacomitinibCytochrome P450 2C9enzyme
DacomitinibUDP-glucuronosyltransferase 1-1enzyme
DacomitinibP-glycoprotein 1transporter
DacomitinibATP-binding cassette sub-family G member 2transporter
DacomitinibSolute carrier family 22 member 1transporter
DacomitinibEpidermal growth factor receptortarget
BinimetinibUDP-glucuronosyltransferase 1-1enzyme
BinimetinibCytochrome P450 1A2enzyme
BinimetinibCytochrome P450 2C19enzyme
BinimetinibDual specificity mitogen-activated protein kinase kinase 2target
BinimetinibSerum albumincarrier
BinimetinibDual specificity mitogen-activated protein kinase kinase 1target
BinimetinibATP-binding cassette sub-family G member 2transporter
BinimetinibP-glycoprotein 1transporter
EntrectinibCytochrome P450 3A4enzyme
EntrectinibP-glycoprotein 1transporter
EntrectinibHigh affinity nerve growth factor receptortarget
EntrectinibBDNF/NT-3 growth factors receptortarget
EntrectinibNT-3 growth factor receptortarget
EntrectinibProto-oncogene tyrosine-protein kinase ROStarget
EntrectinibTyrosine-protein kinase JAK2target
EntrectinibActivated CDC42 kinase 1target
FostamatinibAdenosine receptor A3target
Fostamatinibvesicular monoamine transporter 2 (VMAT2)target
FostamatinibFatty-acid amide hydrolase 1target
FostamatinibEquilibrative nucleoside transporter 1target
FostamatinibUDP-glucuronosyltransferase 1-1target
FostamatinibcGMP-specific 3',5'-cyclic phosphodiesterasetarget
FostamatinibArachidonate 5-lipoxygenasetarget
FostamatinibCathepsin Starget
FostamatinibCathepsin L1target
FostamatinibTyrosine-protein kinase ABL1target
FostamatinibCalcium-dependent protein kinase 1target
FostamatinibSerine/threonine-protein kinase PknBtarget
FostamatinibRibosomal protein S6 kinase alpha-6target
FostamatinibNon-receptor tyrosine-protein kinase TYK2target
FostamatinibAtypical kinase COQ8A, mitochondrialtarget
FostamatinibTyrosine-protein kinase JAK1target
FostamatinibHepatocyte growth factor receptortarget
FostamatinibSerine/threonine-protein kinase NIM1target
FostamatinibSerine/threonine-protein kinase MST4target
FostamatinibcAMP-dependent protein kinase catalytic subunit alphatarget
FostamatinibSerine/threonine-protein kinase 24target
FostamatinibSerine/threonine-protein kinase 3target
FostamatinibTyrosine-protein kinase Tectarget
FostamatinibTyrosine-protein kinase SYKtarget
FostamatinibSerine/threonine-protein kinase 33target
FostamatinibSerine/threonine-protein kinase 35target
FostamatinibSerine/threonine-protein kinase 36target
FostamatinibSerine/threonine-protein kinase 38target
FostamatinibSerine/threonine-protein kinase 38-liketarget
FostamatinibSTE20/SPS1-related proline-alanine-rich protein kinasetarget
FostamatinibSerine/threonine-protein kinase TAO1target
FostamatinibSerine/threonine-protein kinase TAO2target
FostamatinibSerine/threonine-protein kinase TAO3target
FostamatinibSerine/threonine-protein kinase TBK1target
FostamatinibAngiopoietin-1 receptortarget
FostamatinibDual specificity testis-specific protein kinase 1target
FostamatinibTGF-beta receptor type-1target
FostamatinibTGF-beta receptor type-2target
FostamatinibTyrosine-protein kinase receptor Tie-1target
FostamatinibSerine/threonine-protein kinase tousled-like 1target
FostamatinibSerine/threonine-protein kinase tousled-like 2target
FostamatinibTRAF2 and NCK-interacting protein kinasetarget
FostamatinibNon-receptor tyrosine-protein kinase TNK1target
FostamatinibActivated CDC42 kinase 1target
FostamatinibSerine/threonine-protein kinase TNNI3Ktarget
FostamatinibTestis-specific serine/threonine-protein kinase 1target
FostamatinibDual specificity protein kinase TTKtarget
FostamatinibTyrosine-protein kinase TXKtarget
FostamatinibTyrosine-protein kinase receptor TYRO3target
FostamatinibSerine/threonine-protein kinase ULK1target
FostamatinibSerine/threonine-protein kinase ULK2target
FostamatinibSerine/threonine-protein kinase ULK3target
FostamatinibWee1-like protein kinasetarget
FostamatinibTyrosine-protein kinase Yestarget
FostamatinibMitogen-activated protein kinase kinase kinase 19target
FostamatinibMitogen-activated protein kinase kinase kinase MLTtarget
FostamatinibTyrosine-protein kinase ZAP-70target
FostamatinibAP2-associated protein kinase 1target
FostamatinibTyrosine-protein kinase ABL2target
FostamatinibActivin receptor type-1target
FostamatinibActivin receptor type-1Btarget
FostamatinibAtypical kinase COQ8B, mitochondrialtarget
FostamatinibALK tyrosine kinase receptortarget
FostamatinibAnkyrin repeat and protein kinase domain-containing protein 1target
FostamatinibAurora kinase Atarget
FostamatinibAurora kinase Btarget
FostamatinibAurora kinase Ctarget
FostamatinibTyrosine-protein kinase receptor UFOtarget
FostamatinibTyrosine-protein kinase Blktarget
FostamatinibBMP-2-inducible protein kinasetarget
FostamatinibBone morphogenetic protein receptor type-1Btarget
FostamatinibBone morphogenetic protein receptor type-2target
FostamatinibCytoplasmic tyrosine-protein kinase BMXtarget
FostamatinibSerine/threonine-protein kinase B-raftarget
FostamatinibTyrosine-protein kinase BTKtarget
FostamatinibCalcium/calmodulin-dependent protein kinase type 1target
FostamatinibCalcium/calmodulin-dependent protein kinase type 1Dtarget
FostamatinibCalcium/calmodulin-dependent protein kinase type 1Gtarget
FostamatinibCalcium/calmodulin-dependent protein kinase type II subunit alphatarget
FostamatinibCalcium/calmodulin-dependent protein kinase type II subunit betatarget
FostamatinibCalcium/calmodulin-dependent protein kinase type II subunit deltatarget
FostamatinibCalcium/calmodulin-dependent protein kinase type II subunit gammatarget
FostamatinibCalcium/calmodulin-dependent protein kinase kinase 1target
FostamatinibCalcium/calmodulin-dependent protein kinase kinase 2target
FostamatinibPeripheral plasma membrane protein CASKtarget
FostamatinibKappa-caseintarget
FostamatinibCyclin-dependent kinase 1target
FostamatinibSerine/threonine-protein kinase MRCK gammatarget
FostamatinibCyclin-dependent kinase 4target
FostamatinibCyclin-dependent kinase-like 1target
FostamatinibCyclin-dependent kinase-like 2target
FostamatinibSerine/threonine-protein kinase Chk1target
FostamatinibSerine/threonine-protein kinase Chk2target
FostamatinibCitron Rho-interacting kinasetarget
FostamatinibDual specificity protein kinase CLK1target
FostamatinibDual specificity protein kinase CLK2target
FostamatinibDual specificity protein kinase CLK3target
FostamatinibDual specificity protein kinase CLK4target
FostamatinibMacrophage colony-stimulating factor 1 receptortarget
FostamatinibTyrosine-protein kinase CSKtarget
FostamatinibCasein kinase I isoform alphatarget
FostamatinibCasein kinase II subunit alphatarget
FostamatinibCasein kinase II subunit alpha'target
FostamatinibDeath-associated protein kinase 1target
FostamatinibDeath-associated protein kinase 2target
FostamatinibDeath-associated protein kinase 3target
FostamatinibSerine/threonine-protein kinase DCLK1target
FostamatinibSerine/threonine-protein kinase DCLK2target
FostamatinibSerine/threonine-protein kinase DCLK3target
FostamatinibEpithelial discoidin domain-containing receptor 1target
FostamatinibDiscoidin domain-containing receptor 2target
FostamatinibDual specificity tyrosine-phosphorylation-regulated kinase 1Atarget
FostamatinibDual specificity tyrosine-phosphorylation-regulated kinase 1Btarget
FostamatinibEpidermal growth factor receptortarget
FostamatinibEukaryotic translation initiation factor 2-alpha kinase 1target
FostamatinibInterferon-induced, double-stranded RNA-activated protein kinasetarget
FostamatinibeIF-2-alpha kinase GCN2target
FostamatinibEphrin type-A receptor 1target
FostamatinibEphrin type-A receptor 2target
FostamatinibEphrin type-A receptor 3target
FostamatinibEphrin type-A receptor 4target
FostamatinibEphrin type-A receptor 5target
FostamatinibEphrin type-A receptor 6target
FostamatinibEphrin type-A receptor 7target
FostamatinibEphrin type-A receptor 8target
FostamatinibEphrin type-B receptor 1target
FostamatinibEphrin type-B receptor 2target
FostamatinibEphrin type-B receptor 4target
FostamatinibEphrin type-B receptor 6target
FostamatinibReceptor tyrosine-protein kinase erbB-2target
FostamatinibReceptor tyrosine-protein kinase erbB-4target
FostamatinibSerine/threonine-protein kinase/endoribonuclease IRE1target
FostamatinibTyrosine-protein kinase Fertarget
FostamatinibTyrosine-protein kinase Fes/Fpstarget
FostamatinibFibroblast growth factor receptor 1target
FostamatinibFibroblast growth factor receptor 2target
FostamatinibFibroblast growth factor receptor 3target
FostamatinibTyrosine-protein kinase Fgrtarget
FostamatinibVascular endothelial growth factor receptor 1target
FostamatinibReceptor-type tyrosine-protein kinase FLT3target
FostamatinibVascular endothelial growth factor receptor 3target
FostamatinibSerine/threonine-protein kinase mTORtarget
FostamatinibTyrosine-protein kinase FRKtarget
FostamatinibTyrosine-protein kinase Fyntarget
FostamatinibCyclin-G-associated kinasetarget
FostamatinibGlycogen synthase kinase-3 alphatarget
FostamatinibGlycogen synthase kinase-3 betatarget
FostamatinibTyrosine-protein kinase HCKtarget
FostamatinibHomeodomain-interacting protein kinase 2target
FostamatinibHomeodomain-interacting protein kinase 3target
FostamatinibSerine/threonine-protein kinase ICKtarget
FostamatinibInhibitor of nuclear factor kappa-B kinase subunit betatarget
FostamatinibInhibitor of nuclear factor kappa-B kinase subunit epsilontarget
FostamatinibInsulin receptortarget
FostamatinibInsulin receptor-related proteintarget
FostamatinibInterleukin-1 receptor-associated kinase 1target
FostamatinibInterleukin-1 receptor-associated kinase 3target
FostamatinibInterleukin-1 receptor-associated kinase 4target
FostamatinibTyrosine-protein kinase ITK/TSKtarget
FostamatinibTyrosine-protein kinase JAK2target
FostamatinibTyrosine-protein kinase JAK3target
FostamatinibVascular endothelial growth factor receptor 2target
FostamatinibSerine/threonine-protein kinase SIK3target
FostamatinibMast/stem cell growth factor receptor Kittarget
FostamatinibSerine/threonine-protein kinase LATS1target
FostamatinibTyrosine-protein kinase Lcktarget
FostamatinibLIM domain kinase 1target
FostamatinibLIM domain kinase 2target
FostamatinibLeucine-rich repeat serine/threonine-protein kinase 2target
FostamatinibLeukocyte tyrosine kinase receptortarget
FostamatinibTyrosine-protein kinase Lyntarget
FostamatinibDual specificity mitogen-activated protein kinase kinase 2target
FostamatinibDual specificity mitogen-activated protein kinase kinase 3target
FostamatinibDual specificity mitogen-activated protein kinase kinase 5target
FostamatinibDual specificity mitogen-activated protein kinase kinase 6target
FostamatinibMitogen-activated protein kinase kinase kinase 1target
FostamatinibMitogen-activated protein kinase kinase kinase 10target
FostamatinibMitogen-activated protein kinase kinase kinase 11target
FostamatinibMitogen-activated protein kinase kinase kinase 12target
FostamatinibMitogen-activated protein kinase kinase kinase 13target
FostamatinibMitogen-activated protein kinase kinase kinase 15target
FostamatinibMitogen-activated protein kinase kinase kinase 2target
FostamatinibMitogen-activated protein kinase kinase kinase 3target
FostamatinibMitogen-activated protein kinase kinase kinase 4target
FostamatinibMitogen-activated protein kinase kinase kinase 6target
FostamatinibMitogen-activated protein kinase kinase kinase 9target
FostamatinibMitogen-activated protein kinase kinase kinase kinase 1target
FostamatinibMitogen-activated protein kinase kinase kinase kinase 2target
FostamatinibMitogen-activated protein kinase kinase kinase kinase 3target
FostamatinibMitogen-activated protein kinase kinase kinase kinase 4target
FostamatinibMitogen-activated protein kinase kinase kinase kinase 5target
FostamatinibMitogen-activated protein kinase 10target
FostamatinibMitogen-activated protein kinase 13target
FostamatinibMitogen-activated protein kinase 14target
FostamatinibMitogen-activated protein kinase 15target
FostamatinibMitogen-activated protein kinase 4target
FostamatinibMitogen-activated protein kinase 7target
FostamatinibMitogen-activated protein kinase 9target
FostamatinibMAP kinase-activated protein kinase 5target
FostamatinibSerine/threonine-protein kinase MARK1target
FostamatinibSerine/threonine-protein kinase MARK2target
FostamatinibMAP/microtubule affinity-regulating kinase 3target
FostamatinibMAP/microtubule affinity-regulating kinase 4target
FostamatinibCLIP-associating protein 1target
FostamatinibMicrotubule-associated serine/threonine-protein kinase 1target
FostamatinibMegakaryocyte-associated tyrosine-protein kinasetarget
FostamatinibMaternal embryonic leucine zipper kinasetarget
FostamatinibTyrosine-protein kinase Mertarget
FostamatinibMisshapen-like kinase 1target
FostamatinibMAP kinase-interacting serine/threonine-protein kinase 1target
FostamatinibMAP kinase-interacting serine/threonine-protein kinase 2target
FostamatinibMacrophage-stimulating protein receptortarget
FostamatinibMuscle, skeletal receptor tyrosine-protein kinasetarget
FostamatinibMyosin light chain kinase, smooth muscletarget
FostamatinibMyosin light chain kinase 2, skeletal/cardiac muscletarget
FostamatinibMyosin light chain kinase 3target
FostamatinibMyosin light chain kinase family member 4target
FostamatinibMyosin-IIIatarget
FostamatinibSerine/threonine-protein kinase Nek1target
FostamatinibSerine/threonine-protein kinase Nek11target
FostamatinibSerine/threonine-protein kinase Nek2target
FostamatinibSerine/threonine-protein kinase Nek3target
FostamatinibSerine/threonine-protein kinase Nek4target
FostamatinibSerine/threonine-protein kinase Nek5target
FostamatinibSerine/threonine-protein kinase Nek9target
FostamatinibHigh affinity nerve growth factor receptortarget
FostamatinibBDNF/NT-3 growth factors receptortarget
FostamatinibNT-3 growth factor receptortarget
FostamatinibNUAK family SNF1-like kinase 1target
FostamatinibNUAK family SNF1-like kinase 2target
FostamatinibSerine/threonine-protein kinase OSR1target
FostamatinibSerine/threonine-protein kinase PAK 1target
FostamatinibSerine/threonine-protein kinase PAK 2target
FostamatinibSerine/threonine-protein kinase PAK 3target
FostamatinibSerine/threonine-protein kinase PAK 4target
FostamatinibSerine/threonine-protein kinase PAK 6target
FostamatinibSerine/threonine-protein kinase PAK 5target
FostamatinibCyclin-dependent kinase 16target
FostamatinibCyclin-dependent kinase 17target
FostamatinibPlatelet-derived growth factor receptor alphatarget
FostamatinibPlatelet-derived growth factor receptor betatarget
Fostamatinib3-phosphoinositide-dependent protein kinase 1target
FostamatinibCyclin-dependent kinase 15target
FostamatinibPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoformtarget
FostamatinibPhosphatidylinositol 4-kinase betatarget
FostamatinibPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit betatarget
FostamatinibPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gammatarget
FostamatinibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
FostamatinibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformtarget
FostamatinibSerine/threonine-protein kinase pim-1target
FostamatinibSerine/threonine-protein kinase pim-3target
FostamatinibPhosphatidylinositol 5-phosphate 4-kinase type-2 betatarget
FostamatinibPhosphatidylinositol 5-phosphate 4-kinase type-2 gammatarget
FostamatinibMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinasetarget
FostamatinibSerine/threonine-protein kinase N1target
FostamatinibSerine/threonine-protein kinase N2target
FostamatinibSerine/threonine-protein kinase PLK1target
FostamatinibSerine/threonine-protein kinase PLK2target
FostamatinibSerine/threonine-protein kinase PLK3target
FostamatinibSerine/threonine-protein kinase PLK4target
Fostamatinib5'-AMP-activated protein kinase catalytic subunit alpha-1target
Fostamatinib5'-AMP-activated protein kinasetarget
FostamatinibcAMP-dependent protein kinase catalytic subunit betatarget
FostamatinibProtein kinase C delta typetarget
FostamatinibProtein kinase C epsilon typetarget
FostamatinibProtein kinase C gamma type (PRKCG)target
FostamatinibProtein kinase C iota typetarget
FostamatinibProtein kinase C theta typetarget
FostamatinibSerine/threonine-protein kinase D1target
FostamatinibcGMP-dependent protein kinase 2target
FostamatinibSerine/threonine-protein kinase PRP4 homologtarget
FostamatinibFocal adhesion kinase 1target
FostamatinibProtein-tyrosine kinase 2-betatarget
FostamatinibProtein-tyrosine kinase 6target
FostamatinibRAF proto-oncogene serine/threonine-protein kinasetarget
FostamatinibProto-oncogene tyrosine-protein kinase receptor Rettarget
FostamatinibSerine/threonine-protein kinase RIO1target
FostamatinibSerine/threonine-protein kinase RIO2target
FostamatinibSerine/threonine-protein kinase RIO3target
FostamatinibReceptor-interacting serine/threonine-protein kinase 1target
FostamatinibReceptor-interacting serine/threonine-protein kinase 2target
FostamatinibReceptor-interacting serine/threonine-protein kinase 4target
FostamatinibRho-associated protein kinase 2target
FostamatinibProto-oncogene tyrosine-protein kinase ROStarget
FostamatinibRibosomal protein S6 kinase alpha-1target
FostamatinibRibosomal protein S6 kinase alpha-3target
FostamatinibSerine/threonine-protein kinase SBK1target
FostamatinibUncharacterized serine/threonine-protein kinase SBK3target
FostamatinibSerine/threonine-protein kinase Sgk3target
FostamatinibSerine/threonine-protein kinase SIK1target
FostamatinibSerine/threonine-protein kinase SIK2target
FostamatinibSTE20-like serine/threonine-protein kinasetarget
FostamatinibSNF-related serine/threonine-protein kinasetarget
FostamatinibProto-oncogene tyrosine-protein kinase Srctarget
FostamatinibTyrosine-protein kinase Srmstarget
FostamatinibSerine/threonine-protein kinase 10target
FostamatinibSerine/threonine-protein kinase 16target
FostamatinibSerine/threonine-protein kinase 17Atarget
FostamatinibSerine/threonine-protein kinase 17Btarget
FostamatinibSerine/threonine-protein kinase 32Atarget
FostamatinibCytochrome P450 3A4enzyme
FostamatinibATP-binding cassette sub-family G member 2transporter
FostamatinibATP-binding cassette sub-family B member 5transporter
FostamatinibUDP-glucuronosyltransferase 1-9enzyme
AlpelisibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
AlpelisibCytochrome P450 3A4enzyme
AlpelisibCytochrome P450 2C9enzyme
AlpelisibCytochrome P450 2C8enzyme
AlpelisibCytochrome P450 2C19enzyme
AlpelisibATP-binding cassette sub-family G member 2transporter
AlpelisibP-glycoprotein 1transporter
GilteritinibSerum albumincarrier
GilteritinibCytochrome P450 3A4enzyme
GilteritinibReceptor-type tyrosine-protein kinase FLT3target
GilteritinibSerotonin Receptorstarget
GilteritinibP-glycoprotein 1transporter
GilteritinibMultidrug and toxin extrusion protein 1transporter
GilteritinibATP-binding cassette sub-family G member 2transporter
GilteritinibSolute carrier family 22 member 1transporter
GilteritinibTyrosine-protein kinase receptor UFOtarget
GilteritinibALK tyrosine kinase receptortarget
ErdafitinibCytochrome P450 2C9enzyme
ErdafitinibCytochrome P450 3A4enzyme
ErdafitinibFibroblast growth factor receptor 1target
ErdafitinibFibroblast growth factor receptor 2target
ErdafitinibFibroblast growth factor receptor 3target
ErdafitinibFibroblast growth factor receptor 4target
ErdafitinibP-glycoprotein 1transporter
ErdafitinibSolute carrier family 22 member 2transporter
ErdafitinibRET proto-oncogenetarget
ErdafitinibMacrophage colony-stimulating factor 1 receptortarget
ErdafitinibPlatelet-derived growth factor receptor alphatarget
ErdafitinibPlatelet-derived growth factor receptor betatarget
ErdafitinibMast/stem cell growth factor receptor Kittarget
ErdafitinibVascular endothelial growth factor receptor 2target
Erdafitinibalpha1-acid glycoproteincarrier
FedratinibP-glycoprotein 1transporter
FedratinibATP-binding cassette sub-family G member 2transporter
FedratinibSolute carrier organic anion transporter family member 1B1transporter
FedratinibSolute carrier organic anion transporter family member 1B3transporter
FedratinibPOU domain, class 2, transcription factor 2transporter
FedratinibMultidrug and toxin extrusion protein 1transporter
FedratinibMultidrug and toxin extrusion protein 2transporter
FedratinibCytochrome P450 3A4enzyme
FedratinibCytochrome P450 2C19enzyme
FedratinibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
FedratinibTyrosine-protein kinase JAK2target
FedratinibReceptor-type tyrosine-protein kinase FLT3target
FedratinibTyrosine-protein kinase JAK1target
FedratinibCytochrome P450 2D6enzyme
PexidartinibCytochrome P450 3A4enzyme
PexidartinibUDP-glucuronosyltransferase 1-4enzyme
PexidartinibMacrophage colony-stimulating factor 1 receptortarget
PexidartinibCytochrome P450 2B6enzyme
PexidartinibCytochrome P450 2C9enzyme
PexidartinibUDP-glucuronosyltransferase 1-1enzyme
PexidartinibMultidrug and toxin extrusion protein 1transporter
PexidartinibMultidrug and toxin extrusion protein 2transporter
PexidartinibSolute carrier organic anion transporter family member 1B1transporter
PexidartinibSolute carrier organic anion transporter family member 1B3transporter
PexidartinibSolute carrier organic anion transporter family member 2B1transporter
PexidartinibSerum albumincarrier
PexidartinibAlpha-1-acid glycoprotein 1carrier
PexidartinibMast/stem cell growth factor receptor Kittarget
PexidartinibReceptor-type tyrosine-protein kinase FLT3target
PexidartinibPlatelet-derived growth factor receptor betatarget
MobocertinibEpidermal growth factor receptortarget
MobocertinibCytochrome P450 3A4enzyme
MobocertinibCytochrome P450 3A5enzyme
MobocertinibCytochrome P450 3A7enzyme
MobocertinibP-glycoprotein 1transporter
MobocertinibATP-binding cassette sub-family G member 2transporter
PacritinibCytochrome P450 3A4enzyme
PacritinibCytochrome P450 1A2enzyme
PacritinibTyrosine-protein kinase JAK2target
PacritinibReceptor-type tyrosine-protein kinase FLT3target
PacritinibP-glycoprotein 1transporter
PacritinibATP-binding cassette sub-family G member 2transporter
PacritinibSolute carrier family 22 member 1transporter
PacritinibCytochrome P450 2C19enzyme
PacritinibSolute carrier family 22 member 2transporter
PirtobrutinibCytochrome P450 3A4enzyme
PirtobrutinibUDP-glucuronosyltransferase 1-8enzyme
PirtobrutinibUDP-glucuronosyltransferase 1-9enzyme
PirtobrutinibCytochrome P450 2C8enzyme
PirtobrutinibCytochrome P450 2C9enzyme
PirtobrutinibCytochrome P450 1A2enzyme
PirtobrutinibCytochrome P450 2B6enzyme
PirtobrutinibCytochrome P450 2C19enzyme
PirtobrutinibCytochrome P450 2D6enzyme
PirtobrutinibCytochrome P450 3A5enzyme
PirtobrutinibTyrosine-protein kinase BTKtarget
PirtobrutinibP-glycoprotein 1transporter
PirtobrutinibATP-binding cassette sub-family G member 2transporter
LeniolisibCytochrome P450 1A2enzyme
LeniolisibATP-binding cassette sub-family G member 2transporter
LeniolisibSolute carrier organic anion transporter family member 1B1transporter
LeniolisibSolute carrier organic anion transporter family member 1B3transporter
LeniolisibP-glycoprotein 1transporter
LeniolisibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
LeniolisibCytochrome P450 3A4enzyme
LeniolisibCytochrome P450 3A5enzyme
LeniolisibCytochrome P450 2D6enzyme
LeniolisibCytochrome P450 1A1enzyme
FutibatinibCytochrome P450 3A4enzyme
FutibatinibP-glycoprotein 1transporter
FutibatinibATP-binding cassette sub-family G member 2transporter
FutibatinibSerum albumincarrier
FutibatinibAlpha-1-acid glycoprotein 1carrier
FutibatinibCytochrome P450 2C9enzyme
FutibatinibCytochrome P450 2D6enzyme
FutibatinibFibroblast growth factor receptor 1target
FutibatinibFibroblast growth factor receptor 2target
FutibatinibFibroblast growth factor receptor 3target
FutibatinibFibroblast growth factor receptor 4target