Agents Causing Muscle Toxicity
- Name
- Agents Causing Muscle Toxicity
- Accession Number
- DBCAT003935
- Description
Agents that cause muscle disorders including significant elevations of serum creatine kinase (CK), myopathy, myalgia, myositis, and rhabdomyolysis.
- Drugs
Drug Drug Description Fluvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Pitavastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Simvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular events including myocardial infarction and stroke. Atorvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Lovastatin An HMG-CoA reductase inhibitor used to lower LDL cholesterol and reduce the risk of cardiovascular disease and associated conditions, including myocardial infarction and stroke. Cerivastatin A statin (or HMG CoA reductase inhibitor) used with dietary changes to decrease lipid levels and reduce the risk of cardiovascular events. Mevastatin Not used therapeutically due to its many side effects. Rosuvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Trabectedin An alkylating agent approved for the treatment of unresectable or metastatic soft tissue sarcoma (liposarcoma or leiomyosarcoma). Leflunomide A pyrimidine synthesis inhibitor indicated to treat rheumatoid arthritis. Daptomycin A cyclic lipopeptide antibiotic used to treat complicated skin and skin structure infections by susceptible Gram-positive bacteria and bacteremia due to Staphylococcus aureus. Propofol A medication used in general anesthesia and for sedation. Ciprofloxacin A second generation fluoroquinolone used to treat various susceptible bacterial infections. Norfloxacin A broad-spectrum fluoroquinolone antibiotic with variable activity against gram-positive and gram-negative bacteria. Typically reserved for the treatment of UTIs due to accumulation in the urine. Ofloxacin An antibacterial agent used for the treatment of bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract. Trimethoprim An antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. Sulfamethoxazole An oral sulfonamide antibiotic, given in combination with trimethoprim, used to treat a variety of infections of the urinary tract, respiratory system, and gastrointestinal tract. Isoniazid An antibiotic used to treat mycobacterial infections; most commonly use in combination with other antimycobacterial agents for the treatment of active or latent tuberculosis. Minocycline A tetracycline analog used to treat a wide variety of infections in the body. Cladribine A purine antimetabolite used for the management of relapsing forms of Multiple Sclerosis (MS), used in patients who have not responded to or who were unable to tolerate alternative MS drugs. Cytarabine A pyrimidine nucleoside analogue used to treat acute non-lymphocytic leukemia, lymphocytic leukemia, and the blast phase of chronic myelocytic leukemia. Methotrexate An antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis. Docetaxel A taxoid antineoplastic agent used in the treatment of various cancers, such as locally advanced or metastatic breast cancer, metastatic prostate cancer, gastric adenocarcinoma, and head and neck cancer. Paclitaxel A taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer. Letrozole An aromatase inhibitor used to treat breast cancer in postmenopausal women. Leuprolide A peptide-based GnRH receptor superagonist used for the palliative treatment of prostate cancer, uterine leiomyomata, endometriosis, and central precocious puberty. Procarbazine An antineoplastic agent indicated for the treatment of stage III and stage IV Hodgkin's disease in combination with other chemotherapeutic agents. Vincristine A vinca alkaloid used to treat acute leukemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. Cimetidine A histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion. Ranitidine A histamine H2 antagonist used to treat duodenal ulcers, Zollinger-Ellison syndrome, gastric ulcers, GERD, and erosive esophagitis. Nizatidine An H2 receptor antagonist used to treat GERD and a variety of ulcers. Indinavir A protease inhibitor used to treat HIV infection. Lamivudine A reverse transcriptase inhibitor used to treat HIV and hepatitis B infections. Ritonavir An HIV protease inhibitor used in combination with other antivirals in the treatment of HIV infection. Saquinavir An HIV protease inhibitor used in combination with other antiretroviral agents for the treatment of HIV-1 with advanced immunodeficiency. Stavudine A dideoxynucleoside used in the treatment of HIV infection. Zidovudine A dideoxynucleoside used in the treatment of HIV infection. Ganciclovir A DNA polymerase inhibitor used to treat cytomegalovirus and herpetic keratitis of the eye. Betamethasone A systemic corticosteroid used to relieve inflammation in various conditions, including but not limited to allergic states, dermatologic disorders, gastrointestinal diseases, and hematological disorders. Triamcinolone A glucocorticoid used to treat a wide variety of inflammatory conditions of organ systems and tissues. Alendronic acid A bisphosphonate drug that prevents osteoclastic bone resorption which is used for the prevention and treatment of osteoporosis. Ibandronate A bisphosphonate used to treat osteoporosis in postmenopausal women. Pamidronic acid A bisphosphonate used to treat Paget's disease, to treat hypercalcemia of malignancy, and to treat osteolytic bone lesions. Risedronic acid A bisphosphonate used to treat osteoporosis and Paget's disease. Fenofibrate A peroxisome proliferator receptor alpha activator used to lower LDL-C, total-C, triglycerides, and Apo B, while increasing HDL-C in hypercholesterolemia, dyslipidemia, and hypertriglyceridemia. Gemfibrozil A lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia. Niacin A B vitamin used to treat hypertriglyceridemia and pellagra. Amphotericin B An antifungal used to treat fungal infections in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis. Terbinafine An allylamine antifungal used to treat dermatophyte infections of toenails and fingernails as well as other fungal skin infections. Carbimazole A drug used for the reduction of thyroid function. Propylthiouracil A thiourea antithyroid agent used to treat hyperthyroidism. Cyclosporine A steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis. Mycophenolate mofetil An inosine monophosphate dehydrogenase inhibitor used to prevent the rejection of kidney, heart, or liver transplants. Tacrolimus A calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis. Amiodarone A class III antiarrhythmic indicated for the treatment of recurrent hemodynamically unstable ventricular tachycardia and recurrent ventricular fibrillation. Bumetanide A sulfamyl diuretic used to treat edema in congestive heart failure, hepatic and renal disease, and nephrotic syndrome. Captopril An ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy. Enalapril A prodrug of an ACE inhibitor used to treat hypertension and congestive heart failure. Eprosartan An ARB used to treat hypertension, diabetic nephropathy, and congestive heart failure. Lercanidipine A calcium channel blocker for the management of hypertension. Methyldopa A centrally-acting alpha-2 adrenergic agonist used to manage hypertension alone or in combination with hydrochlorothiazide, and to treat hypertensive crises. Baclofen A GABA-ergic agonist used to manage severe spasticity of cerebral or spinal origin in adult and pediatric patients. Chloroquine An antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis. Ethanol For therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (tic douloureux), in patients for whom neurosurgical... Iloprost A synthetic prostacyclin analog indicated to treat pulmonary arterial hypertension (PAH). Isotretinoin A retinoid used to treat severe recalcitrant acne. Ivermectin An anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis. Infliximab A monoclonal anti tumor necrosis factor alpha antibody used in the treatment of a wide variety of inflammatory conditions such as rheumatoid arthritis, Crohn's disease, and ankylosing spondylitis. Mebeverine An antispasmodic used for the symptomatic treatment of stomach pain and spasms associated with irritable bowel syndrome and other gastrointestinal illnesses. Mefloquine An antimalarial agent used in the prophylaxis and treatment of malaria caused by Plasmodium falciparum and Plasmodium vivax. Metoclopramide An antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying. Montelukast A leukotriene receptor antagonist used as part of an asthma therapy regimen, to prevent exercise induced bronchoconstriction, and to treat seasonal allergic rhinitis. Nafarelin A gonadotropin releasing hormone agonist used to treat central precocious puberty. Naltrexone A narcotic antagonist used in opioid overdose. Penicillamine A chelator used to treat Wilson's disease, cystinuria, and rheumatoid arthritis. Phenytoin An anticonvulsant drug used in the prophylaxis and control of various types of seizures. Salmeterol A long-acting beta-2 adrenergic receptor agonist used to treat asthma and COPD. Sildenafil A phosphodiesterase inhibitor used for the treatment of erectile dysfunction. Somatotropin A recombinant human growth hormone used as replacement therapy in various conditions of growth failure, growth hormone deficiency, and weakness in children and adults. Tacrine An anticholinesterase drug used for the management of Alzheimer's disease symptoms. Tianeptine An atypical tricyclic antidepressant with antidepressant and anxiolytic effects primarily used to treat major depressive disorder. Triazolam A benzodiazepine used for short term treatment of insomnia. Pravastatin An HMG-CoA reductase inhibitor used to lower lipid levels and to reduce the risk of cardiovascular events, including myocardial infarction and stroke. Dexamethasone A glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders. Clofibrate A fibric acid derivative used to treat hypertriglyceridemia and high cholesterol. Bezafibrate A lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder. Etofibrate Etofibrate is a fibrate produced by the combination of clofibrate ester linked to niacin. These components separate in the body slowly allowing for pharmacokinetics similar to controlled-release formulations. Simfibrate Not Annotated Clofibride Not Annotated Fenofibric acid A fibrate used to treat severe hypertriglyceridemia, primary hypercholesterolemia, or mixed dyslipidemia. Ciprofibrate Not Annotated Ronifibrate Not Annotated Colchicine An alkaloid used to treat gout and Familial Mediterranean Fever as well as prevent major cardiovascular events. Emetine Not Annotated Ipecac An emetic agent used to induce vomiting in poisoning. Procainamide A medication used to treat life threatening ventricular arrhythmias. Acipimox A niacin derivative used in Fredrickson type IIb and type IV hyperlipoproteinemia. Raltegravir An antiretroviral agent used for the treatment of HIV infections in conjunction with other antiretrovirals. Ubidecarenone A cofactor found in various dietary supplements. Fusidic acid A topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria. Aluminium clofibrate Not Annotated - Drugs & Drug Targets