UGT1A6 substrate

Name

UGT1A6 substrate

Accession Number

DBCAT004045

Description

Not Available

Drugs

Drug	Drug Description
Acetaminophen	An analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent.
Propacetamol	Propacetamol is a paracetamol prodrug of intravenous administration used to control fever and pain of perioperative period in multimodal analgesia therapy.
Troglitazone	For the treatment of Type II diabetes mellitus. It is used alone or in combination with a sulfonylurea, metformin, or insulin as an adjunct to diet and exercise.
Mycophenolate mofetil	An inosine monophosphate dehydrogenase inhibitor used to prevent the rejection of kidney, heart, or liver transplants.
Propofol	A medication used in general anesthesia and for sedation.
Mycophenolic acid	An immunosuppressant used to prevent organ transplant rejections.
Deferiprone	An iron chelator used to treat patients with transfusional iron overload caused by thalassemia syndromes.
Valproic acid	An anticonvulsant used to control complex partial seizures and both simple and complex absence seizures.
Acetylsalicylic acid	A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events.
Naproxen	An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain.
Phenytoin	An anticonvulsant drug used in the prophylaxis and control of various types of seizures.
Ferric maltol	A complexed iron supplement used to treat iron deficiency in adults.
Edaravone	A free radical scavenger used to delay the progression of ALS.

Drugs & Drug Targets

Drug	Target	Type
Acetaminophen	Prostaglandin G/H synthase 1	target
Acetaminophen	Prostaglandin G/H synthase 2	target
Acetaminophen	Cytochrome P450 1A2	enzyme
Acetaminophen	Cytochrome P450 2E1	enzyme
Acetaminophen	P-glycoprotein 1	transporter
Acetaminophen	Cytochrome P450 2D6	enzyme
Acetaminophen	Cytochrome P450 2A6	enzyme
Acetaminophen	Cytochrome P450 3A4	enzyme
Acetaminophen	UDP-glucuronosyltransferase 1-1	enzyme
Acetaminophen	UDP-glucuronosyltransferase 1-6	enzyme
Acetaminophen	UDP-glucuronosyltransferase 1-9	enzyme
Acetaminophen	UDP-glucuronosyltransferase 2B15	enzyme
Acetaminophen	Sulfotransferase 1A1	enzyme
Acetaminophen	Sulfotransferase 1A3/1A4	enzyme
Acetaminophen	Arylamine N-acetyltransferase 2	enzyme
Acetaminophen	Prostaglandin E synthase 3	target
Acetaminophen	Transient receptor potential cation channel subfamily V member 1	target
Acetaminophen	Serum albumin	carrier
Acetaminophen	Fatty-acid amide hydrolase 1	enzyme
Acetaminophen	Glutathione S-transferase P	enzyme
Acetaminophen	Glutathione S-transferase Mu 1	enzyme
Propacetamol	Cholinesterase	enzyme
Propacetamol	Prostaglandin G/H synthase 1	target
Propacetamol	Prostaglandin G/H synthase 2	target
Propacetamol	Transient receptor potential cation channel subfamily V member 1	target
Propacetamol	Cannabinoid receptor 1	target
Propacetamol	Cytochrome P450 2E1	enzyme
Propacetamol	Cytochrome P450 1A2	enzyme
Propacetamol	Cytochrome P450 2D6	enzyme
Propacetamol	UDP-glucuronosyltransferase 1-1	enzyme
Propacetamol	UDP-glucuronosyltransferase 1-6	enzyme
Propacetamol	UDP-glucuronosyltransferase 1-9	enzyme
Propacetamol	UDP-glucuronosyltransferase 2B15	enzyme
Propacetamol	UDP-glucuronosyltransferase 1-10	enzyme
Propacetamol	Sulfotransferase 1A1	enzyme
Propacetamol	Sulfotransferase 1A3/1A4	enzyme
Propacetamol	Estrogen sulfotransferase	enzyme
Propacetamol	Bile salt sulfotransferase	enzyme
Propacetamol	Arylamine N-acetyltransferase 2	enzyme
Propacetamol	Cytochrome P450 2C9	enzyme
Propacetamol	Cytochrome P450 3A4	enzyme
Troglitazone	Peroxisome proliferator-activated receptor gamma	target
Troglitazone	Long-chain-fatty-acid--CoA ligase 4	target
Troglitazone	Plasminogen activator inhibitor 1	target
Troglitazone	Equilibrative nucleoside transporter 1	target
Troglitazone	Cytochrome P450 3A4	enzyme
Troglitazone	Cytochrome P450 2C19	enzyme
Troglitazone	UDP-glucuronosyltransferase 1-1	enzyme
Troglitazone	Cytochrome P450 2C8	enzyme
Troglitazone	Bile salt export pump	transporter
Troglitazone	Solute carrier organic anion transporter family member 1B1	transporter
Troglitazone	Estrogen-related receptor gamma	target
Troglitazone	Steroid hormone receptor ERR1	target
Troglitazone	Cytochrome P450 19A1	enzyme
Troglitazone	Cytochrome P450 1A1	enzyme
Troglitazone	Cytochrome P450 2B6	enzyme
Troglitazone	Cytochrome P450 2C9	enzyme
Troglitazone	Cytochrome P450 3A5	enzyme
Troglitazone	Cytochrome P450 3A7	enzyme
Troglitazone	UDP-glucuronosyltransferase 1-3	enzyme
Troglitazone	UDP-glucuronosyltransferase 1-4	enzyme
Troglitazone	UDP-glucuronosyltransferase 1-6	enzyme
Troglitazone	UDP-glucuronosyltransferase 1-7	enzyme
Troglitazone	UDP-glucuronosyltransferase 1-8	enzyme
Troglitazone	UDP-glucuronosyltransferase 1-9	enzyme
Troglitazone	UDP-glucuronosyltransferase 1-10	enzyme
Troglitazone	UDP-glucuronosyltransferase 2B7	enzyme
Troglitazone	UDP-glucuronosyltransferase 2B15	enzyme
Troglitazone	Peroxisome proliferator-activated receptor delta	target
Troglitazone	Peroxisome proliferator-activated receptor alpha	target
Troglitazone	Glutathione S-transferase P	target
Mycophenolate mofetil	Inosine-5'-monophosphate dehydrogenase 2	target
Mycophenolate mofetil	Inosine-5'-monophosphate dehydrogenase 1	target
Mycophenolate mofetil	UDP-glucuronosyltransferase 1-1	enzyme
Mycophenolate mofetil	UDP-glucuronosyltransferase 1-7	enzyme
Mycophenolate mofetil	UDP-glucuronosyltransferase 1-6	enzyme
Mycophenolate mofetil	UDP-glucuronosyltransferase 1-9	enzyme
Mycophenolate mofetil	UDP-glucuronosyltransferase 2B7	enzyme
Mycophenolate mofetil	UDP-glucuronosyltransferase 1-8	enzyme
Mycophenolate mofetil	UDP-glucuronosyltransferase 1-10	enzyme
Mycophenolate mofetil	Liver carboxylesterase 1	enzyme
Mycophenolate mofetil	Cytochrome P450 3A4	enzyme
Mycophenolate mofetil	Cytochrome P450 3A5	enzyme
Mycophenolate mofetil	Cytochrome P450 2C8	enzyme
Mycophenolate mofetil	Solute carrier organic anion transporter family member 1B1	transporter
Mycophenolate mofetil	Solute carrier organic anion transporter family member 1B3	transporter
Mycophenolate mofetil	ATP-binding cassette sub-family G member 2	transporter
Mycophenolate mofetil	P-glycoprotein 1	transporter
Mycophenolate mofetil	6-pyruvoyl tetrahydrobiopterin synthase	target
Mycophenolate mofetil	Carboxylic ester hydrolase	enzyme
Mycophenolate mofetil	Canalicular multispecific organic anion transporter 1	transporter
Propofol	Cytochrome P450 2B6	enzyme
Propofol	UDP-glucuronosyltransferase 1-1	enzyme
Propofol	UDP-glucuronosyltransferase 1-9	enzyme
Propofol	Gamma-aminobutyric acid receptor subunit beta-2	target
Propofol	Gamma-aminobutyric acid receptor subunit beta-3	target
Propofol	Serum albumin	carrier
Propofol	Sodium channel protein type 4 subunit alpha	target
Propofol	Sodium channel protein type 2 subunit alpha	target
Propofol	Fatty-acid amide hydrolase 1	enzyme
Propofol	Cytochrome P450 2C9	enzyme
Propofol	UDP-glucuronosyltransferase 1-8	enzyme
Propofol	Cytochrome P450 2E1	enzyme
Propofol	Cytochrome P450 1B1	enzyme
Propofol	Cytochrome P450 1A1	enzyme
Propofol	Cytochrome P450 1A2	enzyme
Propofol	Cytochrome P450 2C18	enzyme
Propofol	Cytochrome P450 2C19	enzyme
Propofol	Cytochrome P450 2C8	enzyme
Propofol	UDP-glucuronosyltransferase 1-6	enzyme
Propofol	GABA(A) Receptor	target
Propofol	P-glycoprotein 1	transporter
Mycophenolic acid	Inosine-5'-monophosphate dehydrogenase 2	target
Mycophenolic acid	Inosine-5'-monophosphate dehydrogenase 1	target
Mycophenolic acid	UDP-glucuronosyltransferase 1-1	enzyme
Mycophenolic acid	UDP-glucuronosyltransferase 1-9	enzyme
Mycophenolic acid	UDP-glucuronosyltransferase 2B7	enzyme
Mycophenolic acid	UDP-glucuronosyltransferase 1-7	enzyme
Mycophenolic acid	UDP-glucuronosyltransferase 1-6	enzyme
Mycophenolic acid	Serum albumin	carrier
Mycophenolic acid	UDP-glucuronosyltransferase 1-8	enzyme
Mycophenolic acid	UDP-glucuronosyltransferase 1-10	enzyme
Mycophenolic acid	Cytochrome P450 3A4	enzyme
Mycophenolic acid	Cytochrome P450 3A5	enzyme
Mycophenolic acid	Cytochrome P450 2C8	enzyme
Deferiprone	UDP-glucuronosyltransferase 1-6	enzyme
Deferiprone	Iron	target
Valproic acid	Histone deacetylase 9	target
Valproic acid	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	target
Valproic acid	Cytochrome P450 2A6	enzyme
Valproic acid	Cytochrome P450 2B6	enzyme
Valproic acid	Cytochrome P450 2C9	enzyme
Valproic acid	Solute carrier family 22 member 5	transporter
Valproic acid	Solute carrier family 22 member 6	transporter
Valproic acid	Solute carrier family 22 member 8	transporter
Valproic acid	Monocarboxylate transporter 1	transporter
Valproic acid	Solute carrier family 22 member 7	transporter
Valproic acid	Cytochrome P450 3A5	enzyme
Valproic acid	UDP-glucuronosyltransferase 1-9	enzyme
Valproic acid	Prostaglandin G/H synthase 1	enzyme
Valproic acid	Cytochrome P450 1A2	enzyme
Valproic acid	Cytochrome P450 2C19	enzyme
Valproic acid	Cytochrome P450 3A4	enzyme
Valproic acid	UDP-glucuronosyltransferase 1-4	enzyme
Valproic acid	UDP-glucuronosyltransferase 1-8	enzyme
Valproic acid	UDP-glucuronosyltransferase 1-10	enzyme
Valproic acid	UDP-glucuronosyltransferase 1-6	enzyme
Valproic acid	UDP-glucuronosyltransferase 1-3	enzyme
Valproic acid	UDP-glucuronosyltransferase 2B7	enzyme
Valproic acid	UDP-glucuronosyltransferase 2B15	enzyme
Valproic acid	2-oxoglutarate dehydrogenase, mitochondrial	target
Valproic acid	Succinate-semialdehyde dehydrogenase, mitochondrial	target
Valproic acid	Sodium channel protein	target
Valproic acid	Histone deacetylase 2	target
Valproic acid	Peroxisome proliferator-activated receptor alpha	target
Valproic acid	Peroxisome proliferator-activated receptor delta	target
Valproic acid	Peroxisome proliferator-activated receptor gamma	target
Valproic acid	Serum albumin	carrier
Valproic acid	UDP-glucuronosyltransferase 1-1	enzyme
Valproic acid	Solute carrier organic anion transporter family member 2B1	transporter
Valproic acid	Histone deacetylase	target
Valproic acid	Cyclin-dependent kinase inhibitor 1	target
Valproic acid	Hepatocyte growth factor	target
Valproic acid	Ornithine decarboxylase	target
Valproic acid	Programmed cell death 1 ligand 1	target
Acetylsalicylic acid	Prostaglandin G/H synthase 1	target
Acetylsalicylic acid	Prostaglandin G/H synthase 2	target
Acetylsalicylic acid	Aldo-keto reductase family 1 member C1	target
Acetylsalicylic acid	Solute carrier family 22 member 6	transporter
Acetylsalicylic acid	P-glycoprotein 1	transporter
Acetylsalicylic acid	Cytochrome P450 2C19	enzyme
Acetylsalicylic acid	Cytochrome P450 2C9	enzyme
Acetylsalicylic acid	5'-AMP-activated protein kinase	target
Acetylsalicylic acid	Endothelin-1 receptor	target
Acetylsalicylic acid	Cellular tumor antigen p53	target
Acetylsalicylic acid	78 kDa glucose-regulated protein	target
Acetylsalicylic acid	Ribosomal protein S6 kinase alpha-3	target
Acetylsalicylic acid	NF-kappa-B inhibitor alpha	target
Acetylsalicylic acid	Tumor necrosis factor-inducible gene 6 protein	target
Acetylsalicylic acid	Caspase-1	target
Acetylsalicylic acid	Caspase-3	target
Acetylsalicylic acid	Inhibitor of nuclear factor kappa-B kinase subunit beta	target
Acetylsalicylic acid	Extracellular signal-regulated kinase (ERK)	target
Acetylsalicylic acid	G1/S-specific cyclin-D1	target
Acetylsalicylic acid	Myc proto-oncogene protein	target
Acetylsalicylic acid	Proliferating cell nuclear antigen	target
Acetylsalicylic acid	Cyclin A	target
Acetylsalicylic acid	UDP-glucuronosyltransferase 1-6	enzyme
Acetylsalicylic acid	Arylamine N-acetyltransferase 2	enzyme
Acetylsalicylic acid	Solute carrier family 22 member 8	transporter
Acetylsalicylic acid	Sialidase-1	target
Naproxen	Prostaglandin G/H synthase 1	target
Naproxen	Prostaglandin G/H synthase 2	target
Naproxen	Serum albumin	carrier
Naproxen	Cytochrome P450 2C9	enzyme
Naproxen	Cytochrome P450 1A2	enzyme
Naproxen	Solute carrier organic anion transporter family member 1A2	transporter
Naproxen	Solute carrier family 22 member 6	transporter
Naproxen	Cytochrome P450 2C8	enzyme
Naproxen	UDP-glucuronosyltransferase 2B7	enzyme
Naproxen	Peptostreptococcal albumin-binding protein	target
Naproxen	Bile salt export pump	transporter
Naproxen	P-glycoprotein 1	transporter
Naproxen	UDP-glucuronosyltransferase 1-3	enzyme
Naproxen	UDP-glucuronosyltransferase 1-6	enzyme
Naproxen	UDP-glucuronosyltransferase 1-7	enzyme
Naproxen	UDP-glucuronosyltransferase 1-8	enzyme
Naproxen	UDP-glucuronosyltransferase 1-9	enzyme
Naproxen	UDP-glucuronosyltransferase 1-10	enzyme
Naproxen	Solute carrier family 22 member 8	transporter
Phenytoin	Sodium channel protein type 5 subunit alpha	target
Phenytoin	Sodium channel protein type 1 subunit alpha	target
Phenytoin	Cytochrome P450 2C8	enzyme
Phenytoin	Cytochrome P450 2C19	enzyme
Phenytoin	Cytochrome P450 2C9	enzyme
Phenytoin	Cytochrome P450 2B6	enzyme
Phenytoin	Cytochrome P450 3A5	enzyme
Phenytoin	Serum albumin	carrier
Phenytoin	Cytochrome P450 3A4	enzyme
Phenytoin	Solute carrier organic anion transporter family member 1C1	transporter
Phenytoin	P-glycoprotein 1	transporter
Phenytoin	Canalicular multispecific organic anion transporter 1	transporter
Phenytoin	Cytochrome P450 11B1, mitochondrial	enzyme
Phenytoin	Cytochrome P450 3A7	enzyme
Phenytoin	Nuclear receptor subfamily 1 group I member 2	target
Phenytoin	Sodium channel subunit beta-1	target
Phenytoin	Sodium channel protein type 3 subunit alpha	target
Phenytoin	UDP-glucuronosyltransferase 1-1	enzyme
Phenytoin	UDP-glucuronosyltransferase 1-6	enzyme
Phenytoin	UDP-glucuronosyltransferase 1-9	enzyme
Phenytoin	Thyroxine-binding globulin	carrier
Phenytoin	Potassium voltage-gated channel subfamily H member 2	target
Phenytoin	Voltage-dependent L-type calcium channel	target
Phenytoin	Sodium channel protein type 2 subunit alpha	target
Phenytoin	Sodium channel protein type 8 subunit alpha	target
Phenytoin	GABA(A) Receptor	target
Phenytoin	Cytochrome P450 1A2	enzyme
Phenytoin	Cytochrome P450 2A6	enzyme
Phenytoin	Cytochrome P450 2D6	enzyme
Phenytoin	Cytochrome P450 2E1	enzyme
Phenytoin	Epoxide hydrolase 1	enzyme
Phenytoin	UDP-glucuronosyltransferase 1-4	enzyme
Phenytoin	Catechol O-methyltransferase	enzyme
Phenytoin	NAD(P)H dehydrogenase [quinone] 1	enzyme
Phenytoin	Cytochrome P450 2C18	enzyme
Ferric maltol	UDP-glucuronosyltransferase 1-6	enzyme
Ferric maltol	Integrin beta-3	target
Ferric maltol	Natural resistance-associated macrophage protein 2	target
Ferric maltol	Natural resistance-associated macrophage protein 2	transporter
Ferric maltol	Integrin beta-3	transporter
Edaravone	Solute carrier family 22 member 6	transporter
Edaravone	Solute carrier family 22 member 8	transporter
Edaravone	UDP-glucuronosyltransferase 1-1	enzyme
Edaravone	UDP-glucuronosyltransferase 1-6	enzyme
Edaravone	UDP-glucuronosyltransferase 1-7	enzyme
Edaravone	UDP-glucuronosyltransferase 1-8	enzyme
Edaravone	UDP-glucuronosyltransferase 1-9	enzyme
Edaravone	UDP-glucuronosyltransferase 1-10	enzyme
Edaravone	UDP-glucuronosyltransferase 2B7	enzyme
Edaravone	UDP-glucuronosyltransferase 2B17	enzyme
Edaravone	Sulfotransferase	enzyme
Edaravone	Serum albumin	carrier