Thrombin Inhibitors
- Name
- Thrombin Inhibitors
- Accession Number
- DBCAT004228
- Description
Not Available
- Drugs
Drug Drug Description Argatroban A synthetic direct thrombin inhibitor used for the prevention and treatment of thrombosis related to heparin use. Bivalirudin A direct thrombin inhibitor used to treat heparin-induced thrombocytopenia and to prevent thrombosis during percutaneous coronary intervention. Desirudin Indicated as prophylaxis of deep vein thrombosis for patients undergoing hip replacement surgery. Lepirudin A protein-based direct thrombin inhibitor used as an anticoagulant in patients with heparin-induced thrombocytopenia. Antithrombin Alfa A recombinant antithrombin used to treat peri-operative and peripartum thromboembolic events in hereditary antithrombin deficiency. Dabigatran Dabigatran is the active form of the orally bioavailable prodrug dabigatran etexilate. - Drugs & Drug Targets
Drug Target Type Argatroban Prothrombin target Argatroban Cytochrome P450 3A4 enzyme Argatroban Cytochrome P450 3A5 enzyme Argatroban Serum albumin carrier Argatroban alpha1-acid glycoprotein carrier Bivalirudin Prothrombin target Bivalirudin Myeloperoxidase enzyme Desirudin Carboxypeptidase A1 enzyme Lepirudin Prothrombin target Antithrombin Alfa Prothrombin target Antithrombin Alfa Coagulation factor X target