Serotonin 5-HT2C Receptor Antagonists

Accession Number

DBCAT005169

Description

Entities that are capable of exerting an antagonistic effect on 5-HT2C receptors.

Drugs

Drug	Drug Description
Ziprasidone	An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia.
Olanzapine	An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders.
Mirtazapine	A tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite.
Promazine	A phenothiazine used to manage schizophrenia.
Propiomazine	Propiomazine is largely used for its antihistamininc sleep inducing effects in treating insomnia.
Minaprine	For the treatment of depression
Tramadol	A centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults.
Clozapine	An atypical or second-generation antipsychotic drug used in treatment-resistant schizophrenia and to decrease suicide risk in schizophrenic patients.
Methysergide	An ergot alkaloid used for the prophylaxis of migraine and cluster headaches.
Sertindole	An atypical antipsychotic indicated in the treatment of schizophrenia.
Mianserin	A tetracyclic antidepressant with therapeutic activity similar to amitriptyline used to treat depression and anxiety.
Asenapine	An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia.
Agomelatine	Agomelatine is indicated to treat major depressive episodes in adults.
Paliperidone	An atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders.
Aripiprazole	An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome.
Methotrimeprazine	A phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder.
Loxapine	A antipsychotic used for the treatment of schizophrenia.
Cyproheptadine	A combined serotonin and histamine antagonist used in the treatment of allergic symptoms, for appetite stimulation, and off-label in the treatment of serotonin syndrome.
Yohimbine	An alpha-2-adrenergic blocker and sympatholytic found in supplements used to.
Clomipramine	A tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Tourette’s disorder.
Doxepin	A psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia.
Tegaserod	A serotonin-4 (5-HT4) receptor agonist indicated for the treatment of constipation predominant irritable bowel syndrome (IBS-C) specifically in women under the age of 65. There is currently no safety or efficacy data for use of tegaserol in men.
Nefazodone	An antidepressant used in the treatment of depression.
Imipramine	A tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis.
Amoxapine	A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression.
Nortriptyline	A tricyclic antidepressant used in the treatment of depression.
Trimipramine	A tricyclic antidepressant used to treat depression.
Amitriptyline	A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety.
Captodiame	Captodiame is indicated for the treatment of anxiety.
Fluoxetine	A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I.
Lorpiprazole	In 2016, lorpiprazole was classified in the "Chemical structure-related drug-like criteria of global approved drugs" as an antipsychotic and anxiolytic. An antipsychotic is a medication used to treat a state...
Pizotifen	A serotonin and tryptamine antagonist indicated for migraine prophylaxis.
Risperidone	A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression.
Cyclobenzaprine	A skeletal muscle relaxant that works on the brainstem to treat muscle spasms of local origin.
Flupentixol	A thioxanthene neuroleptic used to treat schizophrenia and depression.
Cariprazine	An atypical antipsychotic used to treat schizophrenia and acute manic or mixed episodes due to bipolar I disorder.

Drugs & Drug Targets

Drug	Target	Type
Ziprasidone	Alpha-1A adrenergic receptor	target
Ziprasidone	Dopamine D2 receptor	target
Ziprasidone	5-hydroxytryptamine receptor 2C	target
Ziprasidone	Dopamine D3 receptor	target
Ziprasidone	5-hydroxytryptamine receptor 1A	target
Ziprasidone	5-hydroxytryptamine receptor 1D	target
Ziprasidone	Histamine H1 receptor	target
Ziprasidone	5-hydroxytryptamine receptor 2A	target
Ziprasidone	Dopamine D4 receptor	target
Ziprasidone	5-hydroxytryptamine receptor 7	target
Ziprasidone	Cytochrome P450 3A4	enzyme
Ziprasidone	Alpha-2A adrenergic receptor	target
Ziprasidone	Alpha-1B adrenergic receptor	target
Ziprasidone	Alpha-2B adrenergic receptor	target
Ziprasidone	Alpha-2C adrenergic receptor	target
Ziprasidone	Dopamine D1 receptor	target
Ziprasidone	Dopamine D5 receptor	target
Ziprasidone	Muscarinic acetylcholine receptor M1	target
Ziprasidone	Muscarinic acetylcholine receptor M2	target
Ziprasidone	Muscarinic acetylcholine receptor M3	target
Ziprasidone	Muscarinic acetylcholine receptor M4	target
Ziprasidone	Muscarinic acetylcholine receptor M5	target
Ziprasidone	5-hydroxytryptamine receptor 1B	target
Ziprasidone	5-hydroxytryptamine receptor 1E	target
Ziprasidone	5-hydroxytryptamine receptor 6	target
Ziprasidone	Aldehyde oxidase	enzyme
Ziprasidone	Serum albumin	carrier
Ziprasidone	P-glycoprotein 1	transporter
Ziprasidone	Alpha-1-acid glycoprotein 1	carrier
Ziprasidone	5-hydroxytryptamine 3 receptor	target
Ziprasidone	5-hydroxytryptamine receptor 5A	target
Olanzapine	Dopamine D1 receptor	target
Olanzapine	Muscarinic acetylcholine receptor M1	target
Olanzapine	Muscarinic acetylcholine receptor M3	target
Olanzapine	5-hydroxytryptamine receptor 2A	target
Olanzapine	Dopamine D4 receptor	target
Olanzapine	Histamine H1 receptor	target
Olanzapine	Muscarinic acetylcholine receptor M4	target
Olanzapine	Muscarinic acetylcholine receptor M2	target
Olanzapine	Dopamine D2 receptor	target
Olanzapine	5-hydroxytryptamine receptor 2C	target
Olanzapine	Dopamine D3 receptor	target
Olanzapine	Alpha-1B adrenergic receptor	target
Olanzapine	Cytochrome P450 1A2	enzyme
Olanzapine	5-hydroxytryptamine receptor 3A	target
Olanzapine	5-hydroxytryptamine receptor 6	target
Olanzapine	Alpha-1A adrenergic receptor	target
Olanzapine	Dopamine D5 receptor	target
Olanzapine	Serum albumin	carrier
Olanzapine	Alpha-1-acid glycoprotein 1	carrier
Olanzapine	Dimethylaniline monooxygenase [N-oxide-forming] 3	enzyme
Olanzapine	Cytochrome P450 2D6	enzyme
Olanzapine	P-glycoprotein 1	transporter
Olanzapine	Cytochrome P450 2C19	enzyme
Olanzapine	D(1) dopamine receptor	target
Olanzapine	Beta adrenergic receptor	target
Olanzapine	5-hydroxytryptamine receptor 1	target
Olanzapine	GABA(A) Receptor Benzodiazepine Binding Site	target
Olanzapine	Cytochrome P450 2C9	enzyme
Olanzapine	UDP-glucuronosyltransferase 1-4	enzyme
Olanzapine	Cytochrome P450 3A4	enzyme
Olanzapine	Cytochrome P450 3A Subfamily	enzyme
Mirtazapine	5-hydroxytryptamine receptor 2A	target
Mirtazapine	5HT3 serotonin receptor	target
Mirtazapine	Alpha-2A adrenergic receptor	target
Mirtazapine	5-hydroxytryptamine receptor 2C	target
Mirtazapine	Kappa-type opioid receptor	target
Mirtazapine	Histamine H1 receptor	target
Mirtazapine	Cytochrome P450 1A2	enzyme
Mirtazapine	Cytochrome P450 3A4	enzyme
Mirtazapine	Cytochrome P450 2D6	enzyme
Mirtazapine	Alpha-1 adrenergic receptors	target
Mirtazapine	Sodium-dependent serotonin transporter	transporter
Promazine	Dopamine D2 receptor	target
Promazine	5-hydroxytryptamine receptor 2A	target
Promazine	5-hydroxytryptamine receptor 2C	target
Promazine	Alpha-1A adrenergic receptor	target
Promazine	Muscarinic acetylcholine receptor M1	target
Promazine	Histamine H1 receptor	target
Promazine	Cytochrome P450 2C19	enzyme
Promazine	Cytochrome P450 1A2	enzyme
Promazine	Cytochrome P450 3A4	enzyme
Promazine	Cytochrome P450 2C9	enzyme
Promazine	Cytochrome P450 2D6	enzyme
Propiomazine	5-hydroxytryptamine receptor 2A	target
Propiomazine	Dopamine D2 receptor	target
Propiomazine	Histamine H1 receptor	target
Propiomazine	5-hydroxytryptamine receptor 2C	target
Propiomazine	Alpha-1A adrenergic receptor	target
Propiomazine	Muscarinic acetylcholine receptor	target
Minaprine	Dopamine D1 receptor	target
Minaprine	Dopamine D2 receptor	target
Minaprine	5-hydroxytryptamine receptor 2A	target
Minaprine	5-hydroxytryptamine receptor 2B	target
Minaprine	5-hydroxytryptamine receptor 2C	target
Minaprine	Sodium-dependent serotonin transporter	target
Minaprine	Cytochrome P450 2D6	enzyme
Minaprine	Muscarinic acetylcholine receptor M1	target
Minaprine	Acetylcholinesterase	target
Minaprine	Amine oxidase [flavin-containing] A	target
Tramadol	Mu-type opioid receptor	target
Tramadol	Sodium-dependent noradrenaline transporter	target
Tramadol	5-hydroxytryptamine receptor 2C	target
Tramadol	Kappa-type opioid receptor	target
Tramadol	Sodium-dependent serotonin transporter	target
Tramadol	Cytochrome P450 2D6	enzyme
Tramadol	Delta-type opioid receptor	target
Tramadol	Cytochrome P450 3A4	enzyme
Tramadol	Cytochrome P450 2B6	enzyme
Tramadol	Alpha-7 nicotinic cholinergic receptor subunit	target
Tramadol	Muscarinic acetylcholine receptor M3	target
Tramadol	Muscarinic acetylcholine receptor M1	target
Tramadol	UDP-glucuronosyltransferase 1-1	enzyme
Tramadol	Neurokinin 1 receptor	target
Tramadol	Sodium channel protein type 2 subunit alpha	target
Tramadol	Transient receptor potential cation channel subfamily V member 1	target
Tramadol	NMDA receptor	target
Tramadol	Adenosine receptor A1	target
Tramadol	Alpha-2 adrenergic receptors	target
Clozapine	Dopamine D4 receptor	target
Clozapine	Histamine H1 receptor	target
Clozapine	Dopamine D2 receptor	target
Clozapine	Neuron-specific vesicular protein calcyon	target
Clozapine	Histamine H4 receptor	target
Clozapine	5-hydroxytryptamine receptor 2A	target
Clozapine	5-hydroxytryptamine receptor 1A	target
Clozapine	5-hydroxytryptamine receptor 2C	target
Clozapine	Dopamine D1 receptor	target
Clozapine	Cytochrome P450 1A2	enzyme
Clozapine	Cytochrome P450 2D6	enzyme
Clozapine	Dopamine D3 receptor	target
Clozapine	Muscarinic acetylcholine receptor M1	target
Clozapine	Muscarinic acetylcholine receptor M2	target
Clozapine	Muscarinic acetylcholine receptor M3	target
Clozapine	Muscarinic acetylcholine receptor M4	target
Clozapine	Muscarinic acetylcholine receptor M5	target
Clozapine	5-hydroxytryptamine receptor 1B	target
Clozapine	5-hydroxytryptamine receptor 1D	target
Clozapine	5-hydroxytryptamine receptor 1E	target
Clozapine	5-hydroxytryptamine receptor 3A	target
Clozapine	5-hydroxytryptamine receptor 6	target
Clozapine	5-hydroxytryptamine receptor 7	target
Clozapine	Alpha-1A adrenergic receptor	target
Clozapine	Alpha-1B adrenergic receptor	target
Clozapine	Alpha-2A adrenergic receptor	target
Clozapine	Alpha-2B adrenergic receptor	target
Clozapine	Alpha-2C adrenergic receptor	target
Clozapine	Cytochrome P450 2C9	enzyme
Clozapine	P-glycoprotein 1	transporter
Clozapine	Cytochrome P450 3A4	enzyme
Clozapine	Cytochrome P450 2C19	enzyme
Clozapine	Dimethylaniline monooxygenase [N-oxide-forming] 3	enzyme
Clozapine	UDP-glucuronosyltransferase 1-4	enzyme
Clozapine	Cytochrome P450 1A1	enzyme
Clozapine	Cytochrome P450 2A6	enzyme
Clozapine	Cytochrome P450 2C8	enzyme
Clozapine	Glutathione S-transferase P	target
Clozapine	Alpha-1-acid glycoprotein 1	carrier
Clozapine	Serum albumin	carrier
Clozapine	Dopamine D5 receptor	target
Clozapine	Gamma-aminobutyric acid type B receptor subunit 1	target
Clozapine	Gamma-aminobutyric acid type B receptor subunit 2	target
Clozapine	Solute carrier family 22 member 1	transporter
Clozapine	Solute carrier family 22 member 2	transporter
Clozapine	Solute carrier family 22 member 3	transporter
Clozapine	Gamma-aminobutyric acid receptor subunit alpha-1	target
Clozapine	Gamma-aminobutyric acid receptor subunit beta-1	target
Clozapine	Gamma-aminobutyric acid receptor subunit gamma-1	target
Methysergide	5-hydroxytryptamine receptor 2A	target
Methysergide	5-hydroxytryptamine receptor 1A	target
Methysergide	5-hydroxytryptamine receptor 7	target
Methysergide	5-hydroxytryptamine receptor 2C	target
Methysergide	5-hydroxytryptamine receptor 2B	target
Methysergide	5-hydroxytryptamine receptor 1B	target
Methysergide	5-hydroxytryptamine receptor 1F	target
Methysergide	5-hydroxytryptamine receptor 1E	target
Methysergide	Cytochrome P450 3A4	enzyme
Sertindole	5-hydroxytryptamine receptor 2A	target
Sertindole	5-hydroxytryptamine receptor 2C	target
Sertindole	Dopamine D2 receptor	target
Sertindole	Alpha-1A adrenergic receptor	target
Sertindole	Alpha-1B adrenergic receptor	target
Sertindole	Alpha-1D adrenergic receptor	target
Sertindole	Potassium voltage-gated channel subfamily H member 2	target
Sertindole	5-hydroxytryptamine receptor 6	target
Sertindole	Cytochrome P450 2D6	enzyme
Sertindole	Cytochrome P450 3A4	enzyme
Mianserin	Histamine H1 receptor	target
Mianserin	Alpha-2A adrenergic receptor	target
Mianserin	5-hydroxytryptamine receptor 2A	target
Mianserin	5-hydroxytryptamine receptor 2C	target
Mianserin	Cytochrome P450 2D6	enzyme
Mianserin	Sodium-dependent serotonin transporter	target
Mianserin	Cytochrome P450 3A4	enzyme
Mianserin	Cytochrome P450 1A2	enzyme
Mianserin	Cytochrome P450 2B6	enzyme
Mianserin	Sodium-dependent noradrenaline transporter	target
Mianserin	Histamine H4 receptor	target
Mianserin	5-hydroxytryptamine receptor 1A	target
Mianserin	Alpha-2C adrenergic receptor	target
Mianserin	5-hydroxytryptamine receptor 2B	target
Mianserin	5-hydroxytryptamine receptor 1F	target
Mianserin	Alpha-2B adrenergic receptor	target
Mianserin	Dopamine D3 receptor	target
Mianserin	Kappa-type opioid receptor	target
Mianserin	Sodium-dependent dopamine transporter	target
Mianserin	5-hydroxytryptamine receptor 7	target
Mianserin	Dopamine D2 receptor	target
Mianserin	5-hydroxytryptamine receptor 6	target
Mianserin	Alpha-1 adrenergic receptors	target
Mianserin	D(1) dopamine receptor	target
Asenapine	5-hydroxytryptamine receptor 1A	target
Asenapine	5-hydroxytryptamine receptor 1B	target
Asenapine	5-hydroxytryptamine receptor 2A	target
Asenapine	5-hydroxytryptamine receptor 2B	target
Asenapine	5-hydroxytryptamine receptor 2C	target
Asenapine	5-hydroxytryptamine receptor 6	target
Asenapine	5-hydroxytryptamine receptor 7	target
Asenapine	Alpha-2A adrenergic receptor	target
Asenapine	Alpha-2B adrenergic receptor	target
Asenapine	Alpha-2C adrenergic receptor	target
Asenapine	Alpha-1A adrenergic receptor	target
Asenapine	Dopamine D1 receptor	target
Asenapine	Dopamine D2 receptor	target
Asenapine	Dopamine D3 receptor	target
Asenapine	Dopamine D4 receptor	target
Asenapine	Histamine H1 receptor	target
Asenapine	Histamine H2 receptor	target
Asenapine	Cytochrome P450 1A2	enzyme
Asenapine	Cytochrome P450 2D6	enzyme
Asenapine	5-hydroxytryptamine receptor 5A	target
Asenapine	UDP-glucuronosyltransferase 1-4	enzyme
Asenapine	Cytochrome P450 3A4	enzyme
Asenapine	Beta-1 adrenergic receptor	target
Asenapine	Beta-2 adrenergic receptor	target
Asenapine	Serum albumin	carrier
Asenapine	alpha1-acid glycoprotein	carrier
Agomelatine	5-hydroxytryptamine receptor 2C	target
Agomelatine	Melatonin receptor type 1B	target
Agomelatine	Melatonin receptor type 1A	target
Agomelatine	Cytochrome P450 2C9	enzyme
Agomelatine	Cytochrome P450 1A2	enzyme
Paliperidone	Dopamine D2 receptor	target
Paliperidone	5-hydroxytryptamine receptor 2A	target
Paliperidone	Histamine H1 receptor	target
Paliperidone	Alpha-1A adrenergic receptor	target
Paliperidone	Alpha-1B adrenergic receptor	target
Paliperidone	Dopamine D3 receptor	target
Paliperidone	Dopamine D4 receptor	target
Paliperidone	Dopamine D1 receptor	target
Paliperidone	Alpha-2A adrenergic receptor	target
Paliperidone	Alpha-2B adrenergic receptor	target
Paliperidone	Alpha-2C adrenergic receptor	target
Paliperidone	5-hydroxytryptamine receptor 1A	target
Paliperidone	5-hydroxytryptamine receptor 1D	target
Paliperidone	5-hydroxytryptamine receptor 2C	target
Paliperidone	5-hydroxytryptamine receptor 7	target
Paliperidone	Cytochrome P450 3A4	enzyme
Paliperidone	Cytochrome P450 2D6	enzyme
Paliperidone	Cytochrome P450 3A5	enzyme
Paliperidone	P-glycoprotein 1	transporter
Aripiprazole	Dopamine D2 receptor	target
Aripiprazole	5-hydroxytryptamine receptor 1A	target
Aripiprazole	5-hydroxytryptamine receptor 2A	target
Aripiprazole	Cytochrome P450 3A4	enzyme
Aripiprazole	Cytochrome P450 2D6	enzyme
Aripiprazole	5-hydroxytryptamine receptor 1B	target
Aripiprazole	5-hydroxytryptamine receptor 1D	target
Aripiprazole	5-hydroxytryptamine receptor 1E	target
Aripiprazole	Dopamine D1 receptor	target
Aripiprazole	Dopamine D5 receptor	target
Aripiprazole	Dopamine D3 receptor	target
Aripiprazole	Dopamine D4 receptor	target
Aripiprazole	5-hydroxytryptamine receptor 2C	target
Aripiprazole	5-hydroxytryptamine receptor 3A	target
Aripiprazole	5-hydroxytryptamine receptor 6	target
Aripiprazole	5-hydroxytryptamine receptor 7	target
Aripiprazole	Histamine H1 receptor	target
Aripiprazole	Alpha-1A adrenergic receptor	target
Aripiprazole	Alpha-1B adrenergic receptor	target
Aripiprazole	Alpha-2A adrenergic receptor	target
Aripiprazole	Alpha-2B adrenergic receptor	target
Aripiprazole	Alpha-2C adrenergic receptor	target
Aripiprazole	Cytochrome P450 3A5	enzyme
Aripiprazole	Cytochrome P450 3A7	enzyme
Aripiprazole	Serum albumin	carrier
Aripiprazole	5-hydroxytryptamine receptor 2B	target
Aripiprazole	5-hydroxytryptamine receptor 5A	target
Aripiprazole	Beta-1 adrenergic receptor	target
Aripiprazole	Beta-2 adrenergic receptor	target
Aripiprazole	Histamine H2 receptor	target
Aripiprazole	Histamine H3 receptor	target
Aripiprazole	Histamine H4 receptor	target
Aripiprazole	Muscarinic acetylcholine receptor M1	target
Aripiprazole	Muscarinic acetylcholine receptor M2	target
Aripiprazole	Muscarinic acetylcholine receptor M3	target
Aripiprazole	Muscarinic acetylcholine receptor M4	target
Aripiprazole	Muscarinic acetylcholine receptor M5	target
Aripiprazole	Kappa-type opioid receptor	target
Aripiprazole	Mu-type opioid receptor	target
Aripiprazole	Delta-type opioid receptor	target
Aripiprazole	Glutamate (NMDA) receptor	target
Aripiprazole	Sodium-dependent dopamine transporter	target
Aripiprazole	Sodium-dependent serotonin transporter	target
Aripiprazole	P-glycoprotein 1	transporter
Aripiprazole	ATP-binding cassette sub-family G member 2	transporter
Methotrimeprazine	Dopamine D3 receptor	target
Methotrimeprazine	Histamine H1 receptor	target
Methotrimeprazine	Muscarinic acetylcholine receptor M1	target
Methotrimeprazine	Muscarinic acetylcholine receptor M2	target
Methotrimeprazine	Muscarinic acetylcholine receptor M3	target
Methotrimeprazine	Muscarinic acetylcholine receptor M4	target
Methotrimeprazine	Muscarinic acetylcholine receptor M5	target
Methotrimeprazine	Alpha-1A adrenergic receptor	target
Methotrimeprazine	Alpha-1B adrenergic receptor	target
Methotrimeprazine	Alpha-1D adrenergic receptor	target
Methotrimeprazine	Cytochrome P450 2D6	enzyme
Methotrimeprazine	Dopamine D2 receptor	target
Methotrimeprazine	Dopamine D1 receptor	target
Methotrimeprazine	Dopamine D5 receptor	target
Methotrimeprazine	Dopamine D4 receptor	target
Methotrimeprazine	Alpha-2A adrenergic receptor	target
Methotrimeprazine	Alpha-2B adrenergic receptor	target
Methotrimeprazine	Alpha-2C adrenergic receptor	target
Methotrimeprazine	5-hydroxytryptamine receptor 2A	target
Methotrimeprazine	5-hydroxytryptamine receptor 2C	target
Methotrimeprazine	Cytochrome P450 2E1	enzyme
Loxapine	Dopamine D1 receptor	target
Loxapine	Dopamine D2 receptor	target
Loxapine	5-hydroxytryptamine receptor 2A	target
Loxapine	5-hydroxytryptamine receptor 2C	target
Loxapine	5-hydroxytryptamine receptor 1A	target
Loxapine	5-hydroxytryptamine receptor 1B	target
Loxapine	5-hydroxytryptamine receptor 1D	target
Loxapine	5-hydroxytryptamine receptor 1E	target
Loxapine	5-hydroxytryptamine receptor 3A	target
Loxapine	5-hydroxytryptamine receptor 5A	target
Loxapine	5-hydroxytryptamine receptor 6	target
Loxapine	5-hydroxytryptamine receptor 7	target
Loxapine	Alpha-1A adrenergic receptor	target
Loxapine	Alpha-1B adrenergic receptor	target
Loxapine	Alpha-2A adrenergic receptor	target
Loxapine	Alpha-2B adrenergic receptor	target
Loxapine	Alpha-2C adrenergic receptor	target
Loxapine	Beta-1 adrenergic receptor	target
Loxapine	Muscarinic acetylcholine receptor M1	target
Loxapine	Muscarinic acetylcholine receptor M2	target
Loxapine	Muscarinic acetylcholine receptor M3	target
Loxapine	Muscarinic acetylcholine receptor M4	target
Loxapine	Muscarinic acetylcholine receptor M5	target
Loxapine	D(1) dopamine receptor	target
Loxapine	Dopamine D3 receptor	target
Loxapine	Dopamine D4 receptor	target
Loxapine	Dopamine D5 receptor	target
Loxapine	Histamine H1 receptor	target
Loxapine	Histamine H2 receptor	target
Loxapine	Histamine H4 receptor	target
Loxapine	Sodium-dependent serotonin transporter	target
Loxapine	Sodium-dependent noradrenaline transporter	target
Loxapine	Sodium-dependent dopamine transporter	target
Cyproheptadine	5-hydroxytryptamine receptor 2A	target
Cyproheptadine	Histamine H1 receptor	target
Cyproheptadine	Muscarinic acetylcholine receptor M1	target
Cyproheptadine	Muscarinic acetylcholine receptor M2	target
Cyproheptadine	Muscarinic acetylcholine receptor M3	target
Cyproheptadine	5-hydroxytryptamine receptor 2C	target
Cyproheptadine	UDP-glucuronosyltransferase 1-3	enzyme
Cyproheptadine	5-hydroxytryptamine receptor 7	target
Cyproheptadine	UDP-glucuronosyltransferase 2B10	enzyme
Cyproheptadine	UDP-glucuronosyltransferase 1-4	enzyme
Cyproheptadine	5-hydroxytryptamine receptor 2B	target
Cyproheptadine	Histamine H2 receptor	target
Cyproheptadine	Solute carrier family 22 member 1	transporter
Cyproheptadine	Serum albumin	carrier
Yohimbine	Alpha-2A adrenergic receptor	target
Yohimbine	Alpha-2B adrenergic receptor	target
Yohimbine	Alpha-2C adrenergic receptor	target
Yohimbine	5-hydroxytryptamine receptor 1A	target
Yohimbine	5-hydroxytryptamine receptor 1B	target
Yohimbine	5-hydroxytryptamine receptor 1D	target
Yohimbine	Dopamine D2 receptor	target
Yohimbine	Dopamine D3 receptor	target
Yohimbine	5-hydroxytryptamine receptor 2A	target
Yohimbine	5-hydroxytryptamine receptor 2C	target
Yohimbine	Cytochrome P450 2D6	enzyme
Yohimbine	Cytochrome P450 3A4	enzyme
Yohimbine	ATP-sensitive potassium channel	target
Yohimbine	5-hydroxytryptamine receptor 2B	target
Clomipramine	Sodium-dependent serotonin transporter	target
Clomipramine	Sodium-dependent noradrenaline transporter	target
Clomipramine	Glutathione S-transferase P	target
Clomipramine	5-hydroxytryptamine receptor 2A	target
Clomipramine	Cytochrome P450 1A2	enzyme
Clomipramine	Cytochrome P450 2D6	enzyme
Clomipramine	Cytochrome P450 2C19	enzyme
Clomipramine	P-glycoprotein 1	transporter
Clomipramine	Cytochrome P450 3A4	enzyme
Clomipramine	5-hydroxytryptamine receptor 2B	target
Clomipramine	5-hydroxytryptamine receptor 2C	target
Clomipramine	Serum albumin	carrier
Doxepin	Sodium-dependent serotonin transporter	target
Doxepin	Sodium-dependent noradrenaline transporter	target
Doxepin	Histamine H1 receptor	target
Doxepin	Histamine H2 receptor	target
Doxepin	Cytochrome P450 2D6	enzyme
Doxepin	Muscarinic acetylcholine receptor M1	target
Doxepin	Muscarinic acetylcholine receptor M2	target
Doxepin	Muscarinic acetylcholine receptor M3	target
Doxepin	Muscarinic acetylcholine receptor M4	target
Doxepin	Muscarinic acetylcholine receptor M5	target
Doxepin	Alpha-1A adrenergic receptor	target
Doxepin	5-hydroxytryptamine receptor 1A	target
Doxepin	5-hydroxytryptamine receptor 2A	target
Doxepin	Cytochrome P450 2C19	enzyme
Doxepin	Cytochrome P450 2C9	enzyme
Doxepin	Cytochrome P450 1A2	enzyme
Doxepin	P-glycoprotein 1	transporter
Doxepin	5-hydroxytryptamine receptor 2B	target
Doxepin	5-hydroxytryptamine receptor 2C	target
Doxepin	Alpha-1B adrenergic receptor	target
Doxepin	Alpha-1D adrenergic receptor	target
Doxepin	Cytochrome P450 3A4	enzyme
Doxepin	5-hydroxytryptamine receptor 6	target
Doxepin	Histamine H4 receptor	target
Doxepin	Potassium voltage-gated channel subfamily H member 2	target
Doxepin	Serum albumin	carrier
Doxepin	Alpha-1-acid glycoprotein 1	carrier
Tegaserod	5-hydroxytryptamine receptor 4	target
Tegaserod	5-hydroxytryptamine receptor 2B	target
Tegaserod	5-hydroxytryptamine receptor 2C	target
Tegaserod	5-hydroxytryptamine receptor 2A	target
Tegaserod	Sodium-dependent serotonin transporter	transporter
Tegaserod	Cytochrome P450 1A2	enzyme
Tegaserod	Cytochrome P450 2C8	enzyme
Tegaserod	Cytochrome P450 2D6	enzyme
Tegaserod	Cytochrome P450 2E1	enzyme
Tegaserod	ATP-binding cassette sub-family G member 2	transporter
Tegaserod	P-glycoprotein 1	transporter
Nefazodone	5-hydroxytryptamine receptor 2A	target
Nefazodone	Sodium-dependent serotonin transporter	target
Nefazodone	Sodium-dependent noradrenaline transporter	target
Nefazodone	Alpha-1A adrenergic receptor	target
Nefazodone	Alpha-1B adrenergic receptor	target
Nefazodone	Cytochrome P450 3A4	enzyme
Nefazodone	Cytochrome P450 2D6	enzyme
Nefazodone	Sodium-dependent dopamine transporter	target
Nefazodone	Alpha-2A adrenergic receptor	target
Nefazodone	5-hydroxytryptamine receptor 1A	target
Nefazodone	CYP2B protein	enzyme
Nefazodone	P-glycoprotein 1	transporter
Nefazodone	5-hydroxytryptamine receptor 2C	target
Nefazodone	Potassium voltage-gated channel subfamily H member 2	target
Nefazodone	Cytochrome P450 3A Subfamily	enzyme
Nefazodone	Solute carrier organic anion transporter family member 1B3	transporter
Nefazodone	Solute carrier organic anion transporter family member 2B1	transporter
Nefazodone	Bile salt export pump	transporter
Imipramine	Sodium-dependent noradrenaline transporter	target
Imipramine	Sodium-dependent serotonin transporter	target
Imipramine	Cytochrome P450 1A2	enzyme
Imipramine	Cytochrome P450 2C19	enzyme
Imipramine	Cytochrome P450 2D6	enzyme
Imipramine	Histamine H1 receptor	target
Imipramine	Alpha-1A adrenergic receptor	target
Imipramine	5-hydroxytryptamine receptor 2A	target
Imipramine	Muscarinic acetylcholine receptor M1	target
Imipramine	Muscarinic acetylcholine receptor M2	target
Imipramine	Muscarinic acetylcholine receptor M3	target
Imipramine	Muscarinic acetylcholine receptor M4	target
Imipramine	Muscarinic acetylcholine receptor M5	target
Imipramine	Potassium voltage-gated channel subfamily D member 2	target
Imipramine	Potassium voltage-gated channel subfamily D member 3	target
Imipramine	Alpha-1D adrenergic receptor	target
Imipramine	Alpha-1-acid glycoprotein 1	carrier
Imipramine	Solute carrier family 22 member 2	transporter
Imipramine	Solute carrier family 22 member 3	transporter
Imipramine	P-glycoprotein 1	transporter
Imipramine	Solute carrier family 22 member 4	transporter
Imipramine	Cytochrome P450 3A4	enzyme
Imipramine	Cytochrome P450 2B6	enzyme
Imipramine	Cytochrome P450 2C18	enzyme
Imipramine	Cytochrome P450 2E1	enzyme
Imipramine	Cytochrome P450 3A7	enzyme
Imipramine	5-hydroxytryptamine receptor 2C	target
Imipramine	Alpha-1B adrenergic receptor	target
Imipramine	5-hydroxytryptamine receptor 7	target
Imipramine	D(1) dopamine receptor	target
Imipramine	Dopamine D2 receptor	target
Imipramine	Potassium voltage-gated channel subfamily H member 2	target
Imipramine	Sodium-dependent dopamine transporter	target
Imipramine	5-hydroxytryptamine receptor 1A	target
Imipramine	5-hydroxytryptamine receptor 6	target
Imipramine	Potassium voltage-gated channel subfamily H member 1	target
Imipramine	Serum albumin	carrier
Imipramine	Alpha-1-acid glycoprotein 2	target
Amoxapine	Sodium-dependent serotonin transporter	target
Amoxapine	Sodium-dependent noradrenaline transporter	target
Amoxapine	Alpha-2A adrenergic receptor	target
Amoxapine	Dopamine D2 receptor	target
Amoxapine	Alpha-1A adrenergic receptor	target
Amoxapine	Dopamine D1 receptor	target
Amoxapine	Muscarinic acetylcholine receptor M1	target
Amoxapine	Gamma-aminobutyric acid receptor subunit alpha-1	target
Amoxapine	Alpha-1-acid glycoprotein 1	carrier
Amoxapine	Cytochrome P450 2D6	enzyme
Amoxapine	5-hydroxytryptamine receptor 2A	target
Amoxapine	5-hydroxytryptamine receptor 2C	target
Amoxapine	5-hydroxytryptamine receptor 6	target
Amoxapine	5-hydroxytryptamine receptor 7	target
Amoxapine	Dopamine D3 receptor	target
Amoxapine	Dopamine D4 receptor	target
Amoxapine	Histamine H1 receptor	target
Amoxapine	Alpha-1 adrenergic receptors	target
Amoxapine	Muscarinic acetylcholine receptor	target
Amoxapine	5-hydroxytryptamine receptor 2B	target
Amoxapine	5-hydroxytryptamine receptor 3A	target
Amoxapine	5-hydroxytryptamine receptor 1A	target
Amoxapine	5-hydroxytryptamine receptor 1B	target
Amoxapine	Alpha-2 adrenergic receptors	target
Amoxapine	Histamine H4 receptor	target
Amoxapine	GABA(A) Receptor	target
Amoxapine	Sodium-dependent dopamine transporter	target
Nortriptyline	Sodium-dependent serotonin transporter	target
Nortriptyline	Sodium-dependent noradrenaline transporter	target
Nortriptyline	Cytochrome P450 1A2	enzyme
Nortriptyline	Cytochrome P450 2D6	enzyme
Nortriptyline	Serum albumin	carrier
Nortriptyline	Alpha-1-acid glycoprotein 1	carrier
Nortriptyline	Histamine H1 receptor	target
Nortriptyline	5-hydroxytryptamine receptor 2A	target
Nortriptyline	Alpha-1A adrenergic receptor	target
Nortriptyline	5-hydroxytryptamine receptor 1A	target
Nortriptyline	Cytochrome P450 3A4	enzyme
Nortriptyline	Cytochrome P450 3A5	enzyme
Nortriptyline	Alpha-1D adrenergic receptor	target
Nortriptyline	Cytochrome P450 2C19	enzyme
Nortriptyline	Cytochrome P450 2E1	enzyme
Nortriptyline	5-hydroxytryptamine receptor 2C	target
Nortriptyline	Alpha-1B adrenergic receptor	target
Nortriptyline	Alpha-2 adrenergic receptors	target
Nortriptyline	Beta adrenergic receptor	target
Nortriptyline	Dopamine D2 receptor	target
Nortriptyline	Sigma receptor	target
Nortriptyline	5-hydroxytryptamine receptor 1C	target
Nortriptyline	Sodium-dependent noradrenaline transporter	transporter
Nortriptyline	Muscarinic acetylcholine receptor	target
Nortriptyline	P-glycoprotein 1	transporter
Trimipramine	Sodium-dependent serotonin transporter	target
Trimipramine	Sodium-dependent noradrenaline transporter	target
Trimipramine	Cytochrome P450 2D6	enzyme
Trimipramine	Sodium-dependent dopamine transporter	target
Trimipramine	5-hydroxytryptamine receptor 2A	target
Trimipramine	5-hydroxytryptamine receptor 1A	target
Trimipramine	Alpha-1A adrenergic receptor	target
Trimipramine	Alpha-1B adrenergic receptor	target
Trimipramine	Dopamine D2 receptor	target
Trimipramine	Alpha-2B adrenergic receptor	target
Trimipramine	Histamine H1 receptor	target
Trimipramine	Cytochrome P450 2C19	enzyme
Trimipramine	P-glycoprotein 1	transporter
Trimipramine	Cytochrome P450 2C9	enzyme
Trimipramine	5-hydroxytryptamine receptor 2C	target
Trimipramine	5-hydroxytryptamine receptor 3A	target
Trimipramine	5-hydroxytryptamine receptor 1D	target
Trimipramine	Alpha-2A adrenergic receptor	target
Trimipramine	D(1) dopamine receptor	target
Trimipramine	Beta adrenergic receptor	target
Trimipramine	Muscarinic acetylcholine receptor	target
Trimipramine	5-hydroxytryptamine receptor 1C	target
Amitriptyline	Sodium-dependent serotonin transporter	target
Amitriptyline	Sodium-dependent noradrenaline transporter	target
Amitriptyline	Potassium voltage-gated channel subfamily KQT member 2	target
Amitriptyline	Alpha-2A adrenergic receptor	target
Amitriptyline	Cytochrome P450 1A2	enzyme
Amitriptyline	Cytochrome P450 2C19	enzyme
Amitriptyline	Cytochrome P450 2D6	enzyme
Amitriptyline	Serum albumin	carrier
Amitriptyline	Alpha-1-acid glycoprotein 1	carrier
Amitriptyline	Histamine H1 receptor	target
Amitriptyline	5-hydroxytryptamine receptor 2A	target
Amitriptyline	5-hydroxytryptamine receptor 1A	target
Amitriptyline	Alpha-1A adrenergic receptor	target
Amitriptyline	Cytochrome P450 3A4	enzyme
Amitriptyline	Cytochrome P450 3A5	enzyme
Amitriptyline	Potassium voltage-gated channel subfamily A member 1	target
Amitriptyline	Alpha-1D adrenergic receptor	target
Amitriptyline	Delta-type opioid receptor	target
Amitriptyline	Kappa-type opioid receptor	target
Amitriptyline	High affinity nerve growth factor receptor	target
Amitriptyline	BDNF/NT-3 growth factors receptor	target
Amitriptyline	Cytochrome P450 2C9	enzyme
Amitriptyline	Cytochrome P450 2B6	enzyme
Amitriptyline	Cytochrome P450 2C8	enzyme
Amitriptyline	Histamine H2 receptor	target
Amitriptyline	Histamine H4 receptor	target
Amitriptyline	Sigma non-opioid intracellular receptor 1	target
Amitriptyline	5-hydroxytryptamine receptor 2C	target
Amitriptyline	Alpha-1B adrenergic receptor	target
Amitriptyline	5-hydroxytryptamine receptor 7	target
Amitriptyline	5-hydroxytryptamine receptor 1D	target
Amitriptyline	Mu-type opioid receptor	target
Amitriptyline	5-hydroxytryptamine receptor 1B	target
Amitriptyline	5-hydroxytryptamine receptor 6	target
Amitriptyline	Potassium voltage-gated channel subfamily KQT member 3	target
Amitriptyline	UDP-glucuronosyltransferase 2B10	enzyme
Amitriptyline	5-hydroxytryptamine receptor 1C	target
Amitriptyline	Muscarinic acetylcholine receptor	target
Amitriptyline	HERG human cardiac K+ channel	target
Amitriptyline	P-glycoprotein 1	transporter
Amitriptyline	UDP-glucuronosyltransferase 1-4	enzyme
Amitriptyline	Glutathione S-transferases (Cytosolic)	enzyme
Captodiame	5-hydroxytryptamine receptor 2C	target
Captodiame	Sigma non-opioid intracellular receptor 1	target
Captodiame	Dopamine D3 receptor	target
Fluoxetine	Sodium-dependent serotonin transporter	target
Fluoxetine	Cytochrome P450 2C9	enzyme
Fluoxetine	Cytochrome P450 2D6	enzyme
Fluoxetine	CYP2B protein	enzyme
Fluoxetine	Cytochrome P450 1A2	enzyme
Fluoxetine	Cytochrome P450 3A4	enzyme
Fluoxetine	Cytochrome P450 2C19	enzyme
Fluoxetine	P-glycoprotein 1	transporter
Fluoxetine	Cytochrome P450 2B6	enzyme
Fluoxetine	Cytochrome P450 3A5	enzyme
Fluoxetine	Serum albumin	carrier
Fluoxetine	Alpha-1-acid glycoprotein 1	carrier
Fluoxetine	Potassium voltage-gated channel subfamily H member 2	target
Fluoxetine	5-hydroxytryptamine receptor 2C	target
Fluoxetine	Cyclin-dependent kinases regulatory subunit 1	target
Fluoxetine	Neuronal acetylcholine receptor subunit alpha-2	target
Fluoxetine	Neuronal acetylcholine receptor subunit alpha-3	target
Fluoxetine	Neuronal acetylcholine receptor subunit beta-4	target
Lorpiprazole	5-hydroxytryptamine receptor 2A	target
Lorpiprazole	5-hydroxytryptamine receptor 2C	target
Lorpiprazole	Alpha-1 adrenergic receptors	target
Lorpiprazole	Alpha-2 adrenergic receptors	target
Lorpiprazole	Histamine H1 receptor	target
Lorpiprazole	Sodium-dependent serotonin transporter	target
Lorpiprazole	Cytochrome P450 2D6	enzyme
Lorpiprazole	Cytochrome P450 3A4	enzyme
Lorpiprazole	Serum albumin	carrier
Pizotifen	Muscarinic acetylcholine receptor M2	target
Pizotifen	Muscarinic acetylcholine receptor M1	target
Pizotifen	Muscarinic acetylcholine receptor M3	target
Pizotifen	5-hydroxytryptamine receptor 2A	target
Pizotifen	5-hydroxytryptamine receptor 2B	target
Pizotifen	5-hydroxytryptamine receptor 2C	target
Pizotifen	Histamine H1 receptor	target
Pizotifen	5-hydroxytryptamine receptor 1A	target
Pizotifen	5-hydroxytryptamine receptor 1B	target
Pizotifen	Alpha-1A adrenergic receptor	target
Pizotifen	Alpha-1B adrenergic receptor	target
Pizotifen	Alpha-1D adrenergic receptor	target
Pizotifen	Alpha-2A adrenergic receptor	target
Pizotifen	Alpha-2B adrenergic receptor	target
Pizotifen	Alpha-2C adrenergic receptor	target
Pizotifen	UDP-glucuronosyltransferase 2B10	enzyme
Risperidone	Cytochrome P450 2D6	enzyme
Risperidone	Cytochrome P450 3A4	enzyme
Risperidone	P-glycoprotein 1	transporter
Risperidone	Serum albumin	carrier
Risperidone	Alpha-1-acid glycoprotein 1	carrier
Risperidone	5-hydroxytryptamine receptor 2A	target
Risperidone	Dopamine D2 receptor	target
Risperidone	Alpha-1B adrenergic receptor	target
Risperidone	Alpha-2B adrenergic receptor	target
Risperidone	Alpha-1A adrenergic receptor	target
Risperidone	Alpha-2C adrenergic receptor	target
Risperidone	Histamine H1 receptor	target
Risperidone	5-hydroxytryptamine receptor 2C	target
Risperidone	5-hydroxytryptamine receptor 1D	target
Risperidone	5-hydroxytryptamine receptor 1A	target
Risperidone	5-hydroxytryptamine receptor 7	target
Risperidone	D(2L) dopamine receptor	target
Risperidone	Dopamine D1 receptor	target
Cyclobenzaprine	5-hydroxytryptamine receptor 2A	target
Cyclobenzaprine	Cytochrome P450 1A2	enzyme
Cyclobenzaprine	Cytochrome P450 3A4	enzyme
Cyclobenzaprine	Cytochrome P450 2D6	enzyme
Cyclobenzaprine	Serum albumin	carrier
Cyclobenzaprine	UDP-glucuronosyltransferase 1-4	enzyme
Cyclobenzaprine	UDP-glucuronosyltransferase 2B10	enzyme
Cyclobenzaprine	5-hydroxytryptamine receptor 2B	target
Cyclobenzaprine	5-hydroxytryptamine receptor 2C	target
Cyclobenzaprine	5-hydroxytryptamine receptor 7	target
Cyclobenzaprine	5-hydroxytryptamine receptor 6	target
Cyclobenzaprine	Sodium-dependent serotonin transporter	target
Cyclobenzaprine	Sodium-dependent noradrenaline transporter	target
Cyclobenzaprine	Toll-like receptor 4	target
Cyclobenzaprine	Aldehyde oxidase	target
Flupentixol	Alpha-1A adrenergic receptor	target
Flupentixol	Dopamine D2 receptor	target
Flupentixol	Dopamine D1 receptor	target
Flupentixol	Aromatic-L-amino-acid decarboxylase	enzyme
Flupentixol	5-hydroxytryptamine receptor 2A	target
Flupentixol	P-glycoprotein 1	transporter
Flupentixol	Muscarinic acetylcholine receptor M1	target
Flupentixol	Liver carboxylesterase 1	enzyme
Flupentixol	Dopamine D3 receptor	target
Flupentixol	Dopamine D4 receptor	target
Flupentixol	5-hydroxytryptamine receptor 2C	target
Cariprazine	Cytochrome P450 3A4	enzyme
Cariprazine	Cytochrome P450 2D6	enzyme
Cariprazine	P-glycoprotein 1	transporter
Cariprazine	Cytochrome P450 3A5	enzyme
Cariprazine	Dopamine D3 receptor	target
Cariprazine	Dopamine D2 receptor	target
Cariprazine	5-hydroxytryptamine receptor 1A	target
Cariprazine	5-hydroxytryptamine receptor 2B	target
Cariprazine	5-hydroxytryptamine receptor 2A	target
Cariprazine	Histamine H1 receptor	target
Cariprazine	5-hydroxytryptamine receptor 2C	target
Cariprazine	Alpha-1A adrenergic receptor	target
Cariprazine	Cytochrome P450 1A2	enzyme
Cariprazine	Cytochrome P450 2C9	enzyme
Cariprazine	Cytochrome P450 2C19	enzyme
Cariprazine	Cytochrome P450 2E1	enzyme