Acute Pain

Also known as: Pain, Acute / Pain Acute / Pain NOS / Pain finding / Acute pain NOS / Pain

DrugDrug NameDrug Description
DB15465BenzhydrocodoneBenzyhydrocodone is indicated, in combination with acetaminophen, for the short-term management of acute pain requiring opioid therapy.
DB00201CaffeineA stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth.
DB00395CarisoprodolA centrally acting muscle relaxant used to relieve the discomfort associated with various musculoskeletal conditions.
DB00482CelecoxibAn NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis.
DB00749EtodolacAn NSAID used to treat osteoarthritis and rheumatoid arthritis, as well as acute pain.
DB00956HydrocodoneAn opioid agonist used as an analgesic and antitussive agent.
DB01050IbuprofenAn NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation.
DB04743NimesulideA cyclooxygenase 2 inhibitor used to treat acute pain and primary dysmenorrhea.
DB00296RopivacaineAn amide-type local anesthetic used for local or regional anesthesia during surgery and for short-term management of acute pain.
DB00708SufentanilAn opioid used to induce and maintain anesthesia, to act as an analgesic in labor and delivery, and to treat severe, acute pain.
DB00193TramadolA centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults.
DrugDrug NameTargetType
DB00201CaffeineAdenosine receptor A1target
DB00201CaffeinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB00201CaffeineAdenosine receptor A2atarget
DB00201CaffeineCytochrome P450 1A2enzyme
DB00201CaffeineRyanodine receptor 1target
DB00201CaffeineCytochrome P450 3A4enzyme
DB00201CaffeineCytochrome P450 2E1enzyme
DB00201CaffeineCytochrome P450 2C8enzyme
DB00201CaffeineCytochrome P450 2C9enzyme
DB00201CaffeineCytochrome P450 1A1enzyme
DB00201CaffeineCytochrome P450 1B1enzyme
DB00201CaffeineCytochrome P450 2D6enzyme
DB00201CaffeineCyclic nucleotide phosphodiesterasetarget
DB00201CaffeineDNA-dependent protein kinase catalytic subunittarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformtarget
DB00201CaffeineInositol 1,4,5-trisphosphate receptortarget
DB00201CaffeineSerine-protein kinase ATMtarget
DB00201CaffeineATP-binding cassette sub-family G member 2transporter
DB00201CaffeineAdenosine receptor A2btarget
DB00201CaffeineAdenosine receptor A3target
DB00201CaffeinePhosphodiesterase enzymestarget
DB00395CarisoprodolCytochrome P450 2C19enzyme
DB00395CarisoprodolGamma-aminobutyric acid receptor subunit alpha-1target
DB00395CarisoprodolGamma-aminobutyric acid receptor subunit beta-2target
DB00395CarisoprodolGamma-aminobutyric acid receptor subunit gamma-2target
DB00395CarisoprodolGamma-aminobutyric acid receptor subunit alpha-5target
DB00395CarisoprodolGamma-aminobutyric acid receptor subunit alpha-3target
DB00482CelecoxibProstaglandin G/H synthase 2target
DB00482Celecoxib3-phosphoinositide-dependent protein kinase 1target
DB00482CelecoxibCytochrome P450 2C9enzyme
DB00482CelecoxibCytochrome P450 2D6enzyme
DB00482CelecoxibMultidrug resistance-associated protein 4transporter
DB00482CelecoxibCytochrome P450 3A4enzyme
DB00482CelecoxibCytochrome P450 2C8enzyme
DB00482CelecoxibCarbonic anhydrase 2target
DB00482CelecoxibCarbonic anhydrase 3target
DB00482CelecoxibBile salt export pumptransporter
DB00482CelecoxibCadherin-11target
DB00482CelecoxibP-glycoprotein 1transporter
DB00482CelecoxibATP-binding cassette sub-family G member 2transporter
DB00482CelecoxibProstaglandin G/H synthase 2enzyme
DB00482CelecoxibSialidase-1target
DB00749EtodolacProstaglandin G/H synthase 1target
DB00749EtodolacProstaglandin G/H synthase 2target
DB00749EtodolacCytochrome P450 2C9enzyme
DB00749EtodolacUDP-glucuronosyltransferase 1-9enzyme
DB00749EtodolacRetinoic acid receptor RXR-alphatarget
DB00749EtodolacSerum albumincarrier
DB00749EtodolacSolute carrier family 22 member 6transporter
DB00749EtodolacUDP-glucuronosyltransferase 1-3enzyme
DB00749EtodolacUDP-glucuronosyltransferase 1-10enzyme
DB00749EtodolacUDP-glucuronosyltransferase 2B7enzyme
DB00956HydrocodoneMu-type opioid receptortarget
DB00956HydrocodoneDelta-type opioid receptortarget
DB00956HydrocodoneCytochrome P450 3A4enzyme
DB00956HydrocodoneCytochrome P450 2D6enzyme
DB00956HydrocodoneCytochrome P450 2B6enzyme
DB00956HydrocodoneCytochrome P450 2C19enzyme
DB00956HydrocodoneSigma non-opioid intracellular receptor 1target
DB01050IbuprofenProstaglandin G/H synthase 1target
DB01050IbuprofenProstaglandin G/H synthase 2target
DB01050IbuprofenCytochrome P450 2C9enzyme
DB01050IbuprofenSerum albumincarrier
DB01050IbuprofenMultidrug resistance-associated protein 4transporter
DB01050IbuprofenMultidrug resistance-associated protein 1transporter
DB01050IbuprofenSolute carrier organic anion transporter family member 1A2transporter
DB01050IbuprofenSolute carrier family 22 member 6transporter
DB01050IbuprofenSolute carrier family 22 member 8transporter
DB01050IbuprofenSolute carrier family 22 member 11transporter
DB01050IbuprofenSolute carrier organic anion transporter family member 2B1transporter
DB01050IbuprofenP-glycoprotein 1transporter
DB01050IbuprofenUDP-glucuronosyltransferase 1-3enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 1-9enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 2B4enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 2B7enzyme
DB01050IbuprofenCytochrome P450 2C8enzyme
DB01050IbuprofenCytochrome P450 2C19enzyme
DB01050IbuprofenApoptosis regulator Bcl-2target
DB01050IbuprofenThrombomodulintarget
DB01050IbuprofenFatty acid-binding protein, intestinaltarget
DB01050IbuprofenPeroxisome proliferator-activated receptor gammatarget
DB01050IbuprofenCystic fibrosis transmembrane conductance regulatortarget
DB01050IbuprofenPeroxisome proliferator-activated receptor alphatarget
DB01050IbuprofenPlatelet glycoprotein Ib alpha chaintarget
DB01050IbuprofenProtein S100-A7target
DB01050IbuprofenAlpha-methylacyl-CoA racemaseenzyme
DB01050IbuprofenCytochrome P450 3A4enzyme
DB04743NimesulideProstaglandin G/H synthase 2target
DB04743NimesulideGroup IIE secretory phospholipase A2target
DB04743NimesulideLactotransferrintarget
DB04743NimesulideCytochrome P450 3A4enzyme
DB00296RopivacaineSodium channel protein type 10 subunit alphatarget
DB00296RopivacaineCytochrome P450 1A2enzyme
DB00296RopivacaineCytochrome P450 2B6enzyme
DB00296RopivacaineCytochrome P450 3A4enzyme
DB00296RopivacaineAlpha-1-acid glycoprotein 1carrier
DB00708SufentanilMu-type opioid receptortarget
DB00708SufentanilDelta-type opioid receptortarget
DB00708SufentanilKappa-type opioid receptortarget
DB00708SufentanilCytochrome P450 3A4enzyme
DB00193TramadolMu-type opioid receptortarget
DB00193TramadolSodium-dependent noradrenaline transportertarget
DB00193Tramadol5-hydroxytryptamine receptor 2Ctarget
DB00193TramadolKappa-type opioid receptortarget
DB00193TramadolSodium-dependent serotonin transportertarget
DB00193TramadolCytochrome P450 2D6enzyme
DB00193TramadolDelta-type opioid receptortarget
DB00193TramadolCytochrome P450 3A4enzyme
DB00193TramadolCytochrome P450 2B6enzyme
DB00193TramadolNeuronal acetylcholine receptor subunit alpha-7target
DB00193TramadolMuscarinic acetylcholine receptor M3target
DB00193TramadolMuscarinic acetylcholine receptor M1target
DB00193TramadolUDP-glucuronosyltransferase 1-1enzyme
DB00193TramadolNeurokinin 1 receptortarget
DB00193TramadolSodium channel protein type 2 subunit alphatarget
DB00193TramadolTransient receptor potential cation channel subfamily V member 1target
DB00193TramadolNMDA receptortarget
DB00193TramadolAdenosine receptor A1target
DB00193TramadolAlpha-2 adrenergic receptorstarget
DrugDrug NamePhaseStatusCount
DB00297Bupivacaine0Completed1
DB00996Gabapentin0Completed1
DB01221Ketamine0Recruiting1
DB00281Lidocaine0Recruiting1
DB14009Medical Cannabis0Recruiting1
DB00333Methadone0Completed1
DB00295Morphine0Completed1
DB06690Nitrous oxide0Recruiting1
DB00296Ropivacaine0Completed1
DB00296Ropivacaine0Recruiting1
DB00624Testosterone0Completed1
DB00316Acetaminophen1Completed2
DB00316Acetaminophen1Withdrawn2
DB00297Bupivacaine1Completed1
DB09214Dexketoprofen1Completed1
DB00898Ethanol1Completed1
DB08818Hyaluronic acid1Completed1
DB00956Hydrocodone1Recruiting1
DB00956Hydrocodone1Withdrawn2
DB00327Hydromorphone1Completed1
DB00327Hydromorphone1Terminated1
DB01050Ibuprofen1Completed2
DB01221Ketamine1Terminated1
DB00961Mepivacaine1Recruiting1
DB00295Morphine1Completed1
DB00788Naproxen1Completed1
DB14881Oliceridine1Completed1
DB00497Oxycodone1Completed3
DB12012PF-044578451Completed1
DB00230Pregabalin1Completed1
DB00750Prilocaine1Recruiting1
DB00852Pseudoephedrine1Completed1
DB00899Remifentanil1Completed1
DB09153Sodium chloride1Recruiting1
DB00575Clonidine1 / 2Completed1
DB00633Dexmedetomidine1 / 2Unknown Status1
DB00813Fentanyl1 / 2Completed1
DB01221Ketamine1 / 2Completed1
DB00295Morphine1 / 2Completed2
DB00295Morphine1 / 2Unknown Status1
DB00388Phenylephrine1 / 2Completed1
DB00899Remifentanil1 / 2Completed1
DB01638Sorbitol1 / 2Completed1
DB00067Vasopressin1 / 2Terminated1
DB05050ADL58592Completed1
DB00316Acetaminophen2Completed3
DB00297Bupivacaine2Completed2
DB11131Capsicum oleoresin2Withdrawn1
DB00190Carbidopa2Recruiting1
DB00190Carbidopa2Withdrawn1
DB00482Celecoxib2Completed3
DB09214Dexketoprofen2Completed1
DB11938Difelikefalin2Completed2
DB00470Dronabinol2Withdrawn1
DB01628Etoricoxib2Completed1
DB00813Fentanyl2Withdrawn1
DB00956Hydrocodone2Completed1
DB00327Hydromorphone2Completed3
DB01050Ibuprofen2Completed2
DB01221Ketamine2Completed2
DB01221Ketamine2Withdrawn1
DB00465Ketorolac2Withdrawn1
DB01002Levobupivacaine2Completed1
DB01235Levodopa2Recruiting1
DB01235Levodopa2Withdrawn1
DB00825Levomenthol2Terminated1
DB00281Lidocaine2Not Yet Recruiting1
DB00186Lorazepam2Terminated1
DB14009Medical Cannabis2Terminated1
DB00784Mefenamic acid2Withdrawn1
DB14123Menthol2Withdrawn1
DB04817Metamizole2Withdrawn2
DB09543Methyl salicylate2Withdrawn1
DB01017Minocycline2Completed1
DB00295Morphine2Completed3
DB00295Morphine2Recruiting1
DB00295Morphine2Withdrawn2
DB01183Naloxone2Recruiting1
DB00788Naproxen2Completed1
DB00788Naproxen2Recruiting1
DB00788Naproxen2Withdrawn1
DB14881Oliceridine2Completed1
DB00497Oxycodone2Completed1
DB00107Oxytocin2Recruiting1
DB00899Remifentanil2Unknown Status1
DB00296Ropivacaine2Completed1
DB00747Scopolamine2Withdrawn1
DB00708Sufentanil2Completed1
DB06204Tapentadol2Completed1
DB06264Tolperisone2Completed1
DB00193Tramadol2Completed3
DB00193Tramadol2Withdrawn1
DB00577Valaciclovir2Recruiting1
DB14343Arnica montana flower2 / 3Recruiting1
DB00181Baclofen2 / 3Active Not Recruiting1
DB00297Bupivacaine2 / 3Completed2
DB00297Bupivacaine2 / 3Recruiting1
DB00633Dexmedetomidine2 / 3Completed1
DB00586Diclofenac2 / 3Completed1
DB11823Esketamine2 / 3Completed1
DB00327Hydromorphone2 / 3Completed1
DB01221Ketamine2 / 3Completed3
DB01221Ketamine2 / 3Recruiting1
DB01221Ketamine2 / 3Withdrawn1
DB00465Ketorolac2 / 3Completed1
DB00281Lidocaine2 / 3Completed2
DB09337Medical air2 / 3Terminated1
DB00683Midazolam2 / 3Withdrawn1
DB00295Morphine2 / 3Completed1
DB06690Nitrous oxide2 / 3Terminated1
DB09140Oxygen2 / 3Terminated1
DB00554Piroxicam2 / 3Completed1
DB00296Ropivacaine2 / 3Recruiting1
DB03754Tromethamine2 / 3Completed1
DB00316Acetaminophen3Completed7
DB00297Bupivacaine3Completed1
DB00297Bupivacaine3Not Yet Recruiting1
DB09061Cannabidiol3Completed1
DB06774Capsaicin3Completed1
DB00482Celecoxib3Completed2
DB00924Cyclobenzaprine3Terminated1
DB01234Dexamethasone3Recruiting1
DB09214Dexketoprofen3Completed2
DB00633Dexmedetomidine3Not Yet Recruiting1
DB00586Diclofenac3Completed5
DB00898Ethanol3Recruiting1
DB00749Etodolac3Terminated1
DB00813Fentanyl3Completed2
DB00813Fentanyl3Terminated1
DB00327Hydromorphone3Completed4
DB00327Hydromorphone3Terminated1
DB01050Ibuprofen3Completed1
DB01050Ibuprofen3Not Yet Recruiting1
DB01050Ibuprofen3Unknown Status1
DB01221Ketamine3Completed1
DB01221Ketamine3Terminated1
DB01221Ketamine3Unknown Status1
DB01009Ketoprofen3Completed1
DB00465Ketorolac3Not Yet Recruiting1
DB00465Ketorolac3Recruiting1
DB00281Lidocaine3Completed1
DB00281Lidocaine3Unknown Status1
DB00333Methadone3Recruiting2
DB01028Methoxyflurane3Completed1
DB01028Methoxyflurane3Recruiting1
DB00295Morphine3Completed5
DB00295Morphine3Not Yet Recruiting1
DB00295Morphine3Recruiting1
DB00295Morphine3Terminated1
DB00295Morphine3Unknown Status1
DB12293Nefopam3Completed1
DB14881Oliceridine3Completed3
DB16271Opiranserin3Completed1
DB01192Oxymorphone3Completed1
DB01192Oxymorphone3Terminated1
DB00230Pregabalin3Completed1
DB00296Ropivacaine3Recruiting1
DB02772Sucrose3Unknown Status1
DB00708Sufentanil3Completed1
DB06204Tapentadol3Completed2
DB06264Tolperisone3Completed1
DB00193Tramadol3Completed5
DB00193Tramadol3Recruiting2
DB00316Acetaminophen4Completed10
DB00316Acetaminophen4Recruiting1
DB00316Acetaminophen4Terminated1
DB00316Acetaminophen4Unknown Status1
DB00316Acetaminophen4Withdrawn1
DB06274Alvimopan4Withdrawn1
DB00963Bromfenac4Completed1
DB00297Bupivacaine4Completed14
DB00297Bupivacaine4Recruiting2
DB00297Bupivacaine4Terminated1
DB00297Bupivacaine4Unknown Status1
DB00297Bupivacaine4Withdrawn2
DB00921Buprenorphine4Completed1
DB00921Buprenorphine4Unknown Status1
DB00575Clonidine4Recruiting1
DB01234Dexamethasone4Completed5
DB01234Dexamethasone4Recruiting1
DB01234Dexamethasone4Terminated1
DB01234Dexamethasone4Unknown Status1
DB09214Dexketoprofen4Completed2
DB09214Dexketoprofen4Recruiting1
DB00633Dexmedetomidine4Active Not Recruiting2
DB00633Dexmedetomidine4Completed1
DB00633Dexmedetomidine4Withdrawn1
DB09341Dextrose, unspecified form4Completed1
DB15341Dinalbuphine sebacate4Not Yet Recruiting1
DB00476Duloxetine4Completed1
DB00668Epinephrine4Completed2
DB00668Epinephrine4Terminated1
DB13259Ethyl chloride4Completed1
DB00749Etodolac4Completed1
DB01628Etoricoxib4Unknown Status1
DB12728Fenpropidin4Unknown Status1
DB00813Fentanyl4Active Not Recruiting1
DB00813Fentanyl4Completed3
DB00813Fentanyl4Terminated2
DB00996Gabapentin4Completed1
DB00996Gabapentin4Withdrawn1
DB08872Gabapentin enacarbil4Withdrawn1
DB00327Hydromorphone4Completed3
DB00327Hydromorphone4Withdrawn1
DB01050Ibuprofen4Completed3
DB01050Ibuprofen4Recruiting2
DB01050Ibuprofen4Unknown Status1
DB01221Ketamine4Active Not Recruiting1
DB01221Ketamine4Completed8
DB01221Ketamine4Not Yet Recruiting2
DB01221Ketamine4Recruiting1
DB01221Ketamine4Terminated4
DB01221Ketamine4Withdrawn2
DB00465Ketorolac4Active Not Recruiting1
DB00465Ketorolac4Completed1
DB00465Ketorolac4Recruiting1
DB01002Levobupivacaine4Completed1
DB01002Levobupivacaine4Unknown Status1
DB00281Lidocaine4Completed4
DB00281Lidocaine4Recruiting1
DB00281Lidocaine4Unknown Status1
DB00281Lidocaine4Withdrawn2
DB06725Lornoxicam4Completed1
DB00653Magnesium sulfate4Active Not Recruiting1
DB00653Magnesium sulfate4Recruiting1
DB09337Medical air4Completed1
DB01028Methoxyflurane4Completed5
DB01028Methoxyflurane4Unknown Status1
DB00959Methylprednisolone4Recruiting1
DB00295Morphine4Completed5
DB00295Morphine4Recruiting1
DB00295Morphine4Unknown Status3
DB00295Morphine4Withdrawn1
DB01183Naloxone4Unknown Status1
DB00788Naproxen4Completed1
DB06690Nitrous oxide4Completed1
DB14881Oliceridine4Completed1
DB00497Oxycodone4Completed3
DB00497Oxycodone4Terminated1
DB09140Oxygen4Completed1
DB08439Parecoxib4Recruiting1
DB00230Pregabalin4Completed1
DB00750Prilocaine4Completed1
DB00818Propofol4Active Not Recruiting1
DB00818Propofol4Completed1
DB00899Remifentanil4Completed1
DB00533Rofecoxib4Terminated1
DB00296Ropivacaine4Completed2
DB00296Ropivacaine4Recruiting1
DB00296Ropivacaine4Terminated1
DB00296Ropivacaine4Withdrawn3
DB01236Sevoflurane4Completed1
DB00708Sufentanil4Completed2
DB00708Sufentanil4Recruiting1
DB00708Sufentanil4Terminated1
DB00708Sufentanil4Unknown Status1
DB06204Tapentadol4Completed1
DB00193Tramadol4Completed4
DB00193Tramadol4Recruiting1
DB00580Valdecoxib4Terminated1
DB00285Venlafaxine4Recruiting1
DB00316AcetaminophenNot AvailableCompleted3
DB00945Acetylsalicylic acidNot AvailableCompleted1
DB00126Ascorbic acidNot AvailableCompleted1
DB00297BupivacaineNot AvailableCompleted4
DB00297BupivacaineNot AvailableRecruiting2
DB00297BupivacaineNot AvailableUnknown Status1
DB09300ButylscopolamineNot AvailableCompleted1
DB00318CodeineNot AvailableTerminated1
DB01234DexamethasoneNot AvailableCompleted3
DB01234DexamethasoneNot AvailableRecruiting1
DB09214DexketoprofenNot AvailableCompleted1
DB00633DexmedetomidineNot AvailableCompleted1
DB00633DexmedetomidineNot AvailableNot Yet Recruiting1
DB00633DexmedetomidineNot AvailableRecruiting4
DB00476DuloxetineNot AvailableCompleted2
DB00476DuloxetineNot AvailableUnknown Status1
DB00668EpinephrineNot AvailableCompleted1
DB11823EsketamineNot AvailableRecruiting1
DB00187EsmololNot AvailableRecruiting1
DB01628EtoricoxibNot AvailableRecruiting1
DB00813FentanylNot AvailableCompleted2
DB00813FentanylNot AvailableRecruiting2
DB00813FentanylNot AvailableWithdrawn1
DB00327HydromorphoneNot AvailableRecruiting1
DB00327HydromorphoneNot AvailableTerminated1
DB01050IbuprofenNot AvailableUnknown Status1
DB01221KetamineNot AvailableActive Not Recruiting1
DB01221KetamineNot AvailableCompleted5
DB01221KetamineNot AvailableRecruiting6
DB01221KetamineNot AvailableTerminated2
DB01221KetamineNot AvailableUnknown Status1
DB00825LevomentholNot AvailableCompleted1
DB00281LidocaineNot AvailableCompleted2
DB00281LidocaineNot AvailableRecruiting6
DB00281LidocaineNot AvailableUnknown Status1
DB14513MagnesiumNot AvailableCompleted1
DB14513MagnesiumNot AvailableRecruiting1
DB14123MentholNot AvailableCompleted1
DB00333MethadoneNot AvailableNot Yet Recruiting1
DB00959MethylprednisoloneNot AvailableRecruiting1
DB00683MidazolamNot AvailableCompleted2
DB00683MidazolamNot AvailableWithdrawn1
DB00295MorphineNot AvailableActive Not Recruiting1
DB00295MorphineNot AvailableCompleted4
DB00295MorphineNot AvailableNot Yet Recruiting1
DB00295MorphineNot AvailableTerminated3
DB00295MorphineNot AvailableUnknown Status1
DB00844NalbuphineNot AvailableCompleted1
DB00497OxycodoneNot AvailableTerminated1
DB00497OxycodoneNot AvailableUnknown Status1
DB01113PapaverineNot AvailableRecruiting1
DB00818PropofolNot AvailableCompleted1
DB00899RemifentanilNot AvailableRecruiting3
DB00296RopivacaineNot AvailableActive Not Recruiting1
DB00296RopivacaineNot AvailableCompleted2
DB00296RopivacaineNot AvailableNot Yet Recruiting1
DB00296RopivacaineNot AvailableRecruiting2
DB00296RopivacaineNot AvailableUnknown Status1
DB06204TapentadolNot AvailableRecruiting1
DB00193TramadolNot AvailableCompleted2
DB00193TramadolNot AvailableRecruiting1
DB14003alpha-Tocopherol acetateNot AvailableCompleted1