Acute Coronary Syndrome (ACS)

Also known as: Acute Coronary Syndome / Actue Coronary Syndrome / Coronary Syndrome, Acute / ACS / Coronary Acute Syndrome / Acute Coronary Syndromes / Acute Coronary Syndrome / Acute coronary syndrome (disorder)

Drug	Drug Name	Drug Description
DB00945	Acetylsalicylic acid	A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events.
DB00758	Clopidogrel	An antiplatelet agent used to prevent blood clots in peripheral vascular disease, coronary artery disease, and cerebrovascular disease.
DB01225	Enoxaparin	A low molecular weight heparin used for the prophylaxis of deep vein thrombosis and ischemic complications of unstable angina and non-Q-wave myocardial infarction.
DB00063	Eptifibatide	A peptide-based antagonist for glycoprotein IIb/IIIa used in the medical management of myocardial infarction and as an adjunct to percutaneous coronary intervention.
DB08816	Ticagrelor	A P2Y12 platelet inhibitor used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death.

Drug	Drug Name	Target	Type
DB00945	Acetylsalicylic acid	Prostaglandin G/H synthase 1	target
DB00945	Acetylsalicylic acid	Prostaglandin G/H synthase 2	target
DB00945	Acetylsalicylic acid	Aldo-keto reductase family 1 member C1	target
DB00945	Acetylsalicylic acid	Solute carrier family 22 member 6	transporter
DB00945	Acetylsalicylic acid	P-glycoprotein 1	transporter
DB00945	Acetylsalicylic acid	Cytochrome P450 2C19	enzyme
DB00945	Acetylsalicylic acid	Cytochrome P450 2C9	enzyme
DB00945	Acetylsalicylic acid	5'-AMP-activated protein kinase	target
DB00945	Acetylsalicylic acid	Endothelin-1 receptor	target
DB00945	Acetylsalicylic acid	Cellular tumor antigen p53	target
DB00945	Acetylsalicylic acid	78 kDa glucose-regulated protein	target
DB00945	Acetylsalicylic acid	Ribosomal protein S6 kinase alpha-3	target
DB00945	Acetylsalicylic acid	NF-kappa-B inhibitor alpha	target
DB00945	Acetylsalicylic acid	Tumor necrosis factor-inducible gene 6 protein	target
DB00945	Acetylsalicylic acid	Caspase-1	target
DB00945	Acetylsalicylic acid	Caspase-3	target
DB00945	Acetylsalicylic acid	Inhibitor of nuclear factor kappa-B kinase subunit beta	target
DB00945	Acetylsalicylic acid	Extracellular signal-regulated kinase (ERK)	target
DB00945	Acetylsalicylic acid	G1/S-specific cyclin-D1	target
DB00945	Acetylsalicylic acid	Myc proto-oncogene protein	target
DB00945	Acetylsalicylic acid	Proliferating cell nuclear antigen	target
DB00945	Acetylsalicylic acid	Cyclin A	target
DB00945	Acetylsalicylic acid	UDP-glucuronosyltransferase 1-6	enzyme
DB00945	Acetylsalicylic acid	Arylamine N-acetyltransferase 2	enzyme
DB00945	Acetylsalicylic acid	Solute carrier family 22 member 8	transporter
DB00945	Acetylsalicylic acid	Sialidase-1	target
DB00758	Clopidogrel	P2Y purinoceptor 12	target
DB00758	Clopidogrel	Cytochrome P450 3A4	enzyme
DB00758	Clopidogrel	Cytochrome P450 2B6	enzyme
DB00758	Clopidogrel	Cytochrome P450 3A5	enzyme
DB00758	Clopidogrel	Cytochrome P450 2C19	enzyme
DB00758	Clopidogrel	Cytochrome P450 2C9	enzyme
DB00758	Clopidogrel	Cytochrome P450 1A2	enzyme
DB00758	Clopidogrel	Cytochrome P450 2C8	enzyme
DB00758	Clopidogrel	Liver carboxylesterase 1	enzyme
DB00758	Clopidogrel	P-glycoprotein 1	transporter
DB00758	Clopidogrel	Solute carrier family 22 member 1	transporter
DB00758	Clopidogrel	Solute carrier family 22 member 2	transporter
DB00758	Clopidogrel	Serum albumin	carrier
DB01225	Enoxaparin	Antithrombin-III	target
DB01225	Enoxaparin	Coagulation factor X	target
DB01225	Enoxaparin	Myeloperoxidase	enzyme
DB01225	Enoxaparin	Prothrombin	target
DB00063	Eptifibatide	Integrin beta-3	target
DB00063	Eptifibatide	Voltage-dependent N-type calcium channel	target
DB08816	Ticagrelor	Cytochrome P450 3A4	enzyme
DB08816	Ticagrelor	P2Y purinoceptor 12	target
DB08816	Ticagrelor	P-glycoprotein 1	transporter
DB08816	Ticagrelor	Cytochrome P450 2C9	enzyme
DB08816	Ticagrelor	Serum albumin	carrier
DB08816	Ticagrelor	Cytochrome P450 3A5	enzyme
DB08816	Ticagrelor	Cytochrome P450 2B6	enzyme

Drug	Drug Name	Phase	Status	Count
DB00907	Cocaine	0	Completed	1
DB00633	Dexmedetomidine	0	Completed	1
DB05227	APD791	1	Terminated	2
DB00945	Acetylsalicylic acid	1	Completed	3
DB00945	Acetylsalicylic acid	1	Terminated	2
DB06605	Apixaban	1	Completed	1
DB01076	Atorvastatin	1	Completed	2
DB15047	BMS-919373	1	Completed	1
DB00758	Clopidogrel	1	Completed	3
DB00758	Clopidogrel	1	Terminated	3
DB01225	Enoxaparin	1	Completed	2
DB12270	Losmapimod	1	Completed	2
DB00218	Moxifloxacin	1	Completed	1
DB00213	Pantoprazole	1	Completed	1
DB06209	Prasugrel	1	Terminated	1
DB01098	Rosuvastatin	1	Completed	2
DB01104	Sertraline	1	Terminated	1
DB00641	Simvastatin	1	Terminated	1
DB08816	Ticagrelor	1	Completed	3
DB10803	Typhoid Vi polysaccharide vaccine	1	Completed	1
DB16349	Vicagrel	1	Completed	2
DB05692	Vorapaxar	1	Completed	1
DB00404	Alprazolam	1 / 2	Recruiting	1
DB12000	Apabetalone	1 / 2	Completed	1
DB01156	Bupropion	1 / 2	Completed	1
DB00215	Citalopram	1 / 2	Completed	1
DB00215	Citalopram	1 / 2	Withdrawn	1
DB01590	Everolimus	1 / 2	Completed	1
DB01104	Sertraline	1 / 2	Completed	1
DB09499	Thiosulfuric acid	1 / 2	Completed	1
DB05810	99mTc-glucarate	2	Completed	1
DB05631	ALT-2074	2	Completed	1
DB00945	Acetylsalicylic acid	2	Completed	2
DB00945	Acetylsalicylic acid	2	Recruiting	2
DB00041	Aldesleukin	2	Recruiting	1
DB09302	Alirocumab	2	Completed	1
DB06605	Apixaban	2	Completed	1
DB06605	Apixaban	2	Terminated	1
DB12046	Atopaxar	2	Completed	2
DB01076	Atorvastatin	2	Completed	1
DB12758	Atreleuton	2	Completed	1
DB00612	Bisoprolol	2	Completed	2
DB18538	CER-001	2	Completed	2
DB06441	Cangrelor	2	Completed	1
DB00758	Clopidogrel	2	Completed	8
DB00758	Clopidogrel	2	Recruiting	2
DB01394	Colchicine	2	Recruiting	2
DB12289	Darexaban	2	Completed	1
DB00063	Eptifibatide	2	Completed	3
DB09303	Evolocumab	2	Active Not Recruiting	2
DB04945	Hemoglobin	2	Completed	1
DB01109	Heparin	2	Completed	1
DB05683	Iodofiltic acid I-123	2	Completed	1
DB11984	Letaxaban	2	Completed	1
DB00583	Levocarnitine	2	Completed	1
DB00722	Lisinopril	2	Unknown Status	1
DB12270	Losmapimod	2	Completed	1
DB00264	Metoprolol	2	Unknown Status	1
DB11839	PZ-128	2	Completed	1
DB00761	Potassium chloride	2	Completed	1
DB11090	Potassium nitrate	2	Completed	1
DB06209	Prasugrel	2	Completed	3
DB00243	Ranolazine	2	Terminated	1
DB06228	Rivaroxaban	2	Completed	2
DB06228	Rivaroxaban	2	Recruiting	1
DB08816	Ticagrelor	2	Completed	5
DB00775	Tirofiban	2	Completed	1
DB12310	Trehalose	2	Unknown Status	1
DB05737	Varespladib methyl	2	Completed	1
DB12164	Varespladib methyl	2	Completed	1
DB00758	Clopidogrel	2 / 3	Completed	1
DB01394	Colchicine	2 / 3	Completed	1
DB01065	Melatonin	2 / 3	Completed	1
DB00806	Pentoxifylline	2 / 3	Completed	1
DB06209	Prasugrel	2 / 3	Completed	1
DB08816	Ticagrelor	2 / 3	Completed	1
DB00945	Acetylsalicylic acid	3	Completed	3
DB00945	Acetylsalicylic acid	3	Not Yet Recruiting	1
DB00945	Acetylsalicylic acid	3	Terminated	2
DB06203	Alogliptin	3	Completed	1
DB06605	Apixaban	3	Terminated	1
DB01076	Atorvastatin	3	Completed	3
DB01076	Atorvastatin	3	Terminated	1
DB00006	Bivalirudin	3	Completed	2
DB01156	Bupropion	3	Completed	1
DB06441	Cangrelor	3	Completed	1
DB06441	Cangrelor	3	Terminated	2
DB04540	Cholesterol	3	Recruiting	1
DB00758	Clopidogrel	3	Completed	15
DB00758	Clopidogrel	3	Recruiting	1
DB00758	Clopidogrel	3	Terminated	3
DB00758	Clopidogrel	3	Unknown Status	1
DB01394	Colchicine	3	Completed	1
DB00151	Cysteine	3	Unknown Status	1
DB12181	Dalcetrapib	3	Completed	1
DB12181	Dalcetrapib	3	Recruiting	1
DB06311	Darapladib	3	Completed	1
DB00063	Eptifibatide	3	Completed	2
DB09303	Evolocumab	3	Completed	1
DB11728	Fondaparinux	3	Completed	1
DB01109	Heparin	3	Completed	4
DB14901	Inclisiran	3	Recruiting	1
DB00030	Insulin human	3	Completed	1
DB09265	Lixisenatide	3	Completed	1
DB12270	Losmapimod	3	Completed	1
DB00331	Metformin	3	Recruiting	1
DB16233	Milvexian	3	Recruiting	1
DB00184	Nicotine	3	Recruiting	1
DB00338	Omeprazole	3	Terminated	1
DB06635	Otamixaban	3	Completed	1
DB09140	Oxygen	3	Completed	2
DB06209	Prasugrel	3	Completed	12
DB06228	Rivaroxaban	3	Active Not Recruiting	1
DB06228	Rivaroxaban	3	Completed	1
DB01098	Rosuvastatin	3	Completed	2
DB00641	Simvastatin	3	Completed	1
DB08816	Ticagrelor	3	Active Not Recruiting	1
DB04902	Ticagrelor	3	Completed	2
DB08816	Ticagrelor	3	Completed	7
DB08816	Ticagrelor	3	Not Yet Recruiting	1
DB08816	Ticagrelor	3	Recruiting	1
DB08816	Ticagrelor	3	Terminated	1
DB08816	Ticagrelor	3	Unknown Status	2
DB00775	Tirofiban	3	Completed	1
DB00775	Tirofiban	3	Withdrawn	1
DB01273	Varenicline	3	Completed	1
DB01273	Varenicline	3	Recruiting	1
DB05737	Varespladib methyl	3	Terminated	1
DB16346	Veliflapon	3	Suspended	1
DB00163	Vitamin E	3	Unknown Status	1
DB00054	Abciximab	4	Completed	1
DB00284	Acarbose	4	Completed	1
DB00316	Acetaminophen	4	Completed	1
DB00945	Acetylsalicylic acid	4	Active Not Recruiting	2
DB00945	Acetylsalicylic acid	4	Completed	15
DB00945	Acetylsalicylic acid	4	Not Yet Recruiting	1
DB00945	Acetylsalicylic acid	4	Recruiting	7
DB00945	Acetylsalicylic acid	4	Terminated	1
DB00945	Acetylsalicylic acid	4	Unknown Status	2
DB00640	Adenosine	4	Completed	1
DB09302	Alirocumab	4	Completed	1
DB00437	Allopurinol	4	Completed	1
DB01060	Amoxicillin	4	Not Yet Recruiting	1
DB11598	Antithrombin III human	4	Unknown Status	1
DB06605	Apixaban	4	Completed	1
DB01076	Atorvastatin	4	Completed	8
DB01076	Atorvastatin	4	Unknown Status	1
DB01393	Bezafibrate	4	Completed	1
DB00006	Bivalirudin	4	Completed	2
DB00006	Bivalirudin	4	Unknown Status	2
DB01373	Calcium	4	Unknown Status	1
DB06441	Cangrelor	4	Completed	3
DB06441	Cangrelor	4	Unknown Status	2
DB01136	Carvedilol	4	Completed	1
DB01166	Cilostazol	4	Completed	3
DB00215	Citalopram	4	Terminated	1
DB00758	Clopidogrel	4	Completed	21
DB00758	Clopidogrel	4	Not Yet Recruiting	1
DB00758	Clopidogrel	4	Recruiting	6
DB00758	Clopidogrel	4	Terminated	3
DB00758	Clopidogrel	4	Unknown Status	11
DB00758	Clopidogrel	4	Withdrawn	2
DB01394	Colchicine	4	Completed	2
DB01394	Colchicine	4	Recruiting	1
DB01394	Colchicine	4	Unknown Status	1
DB14726	Dabigatran	4	Completed	1
DB14726	Dabigatran	4	Recruiting	1
DB14726	Dabigatran	4	Terminated	1
DB00343	Diltiazem	4	Completed	1
DB00841	Dobutamine	4	Completed	1
DB01225	Enoxaparin	4	Completed	5
DB00668	Epinephrine	4	Completed	1
DB01175	Escitalopram	4	Completed	1
DB00187	Esmolol	4	Unknown Status	1
DB00736	Esomeprazole	4	Completed	2
DB00402	Eszopiclone	4	Completed	1
DB09303	Evolocumab	4	Recruiting	2
DB01276	Exenatide	4	Completed	1
DB00973	Ezetimibe	4	Completed	3
DB00927	Famotidine	4	Completed	2
DB01039	Fenofibrate	4	Completed	1
DB01039	Fenofibrate	4	Unknown Status	1
DB00569	Fondaparinux	4	Completed	1
DB01109	Heparin	4	Completed	2
DB01109	Heparin	4	Unknown Status	1
DB01611	Hydroxychloroquine	4	Completed	1
DB00030	Insulin human	4	Completed	1
DB00030	Insulin human	4	Suspended	1
DB09083	Ivabradine	4	Completed	1
DB06725	Lornoxicam	4	Completed	1
DB00331	Metformin	4	Unknown Status	1
DB00264	Metoprolol	4	Completed	2
DB00235	Milrinone	4	Completed	1
DB00471	Montelukast	4	Terminated	1
DB00295	Morphine	4	Completed	2
DB00622	Nicardipine	4	Unknown Status	1
DB06690	Nitrous oxide	4	Completed	1
DB00338	Omeprazole	4	Unknown Status	1
DB09140	Oxygen	4	Completed	1
DB00213	Pantoprazole	4	Not Yet Recruiting	1
DB00213	Pantoprazole	4	Unknown Status	1
DB00946	Phenprocoumon	4	Completed	1
DB00946	Phenprocoumon	4	Terminated	1
DB01022	Phylloquinone	4	Completed	1
DB14500	Potassium	4	Completed	1
DB06209	Prasugrel	4	Completed	16
DB06209	Prasugrel	4	Recruiting	4
DB06209	Prasugrel	4	Terminated	3
DB06209	Prasugrel	4	Unknown Status	5
DB00175	Pravastatin	4	Completed	3
DB00178	Ramipril	4	Unknown Status	1
DB06228	Rivaroxaban	4	Completed	2
DB06228	Rivaroxaban	4	Not Yet Recruiting	1
DB06228	Rivaroxaban	4	Recruiting	2
DB06228	Rivaroxaban	4	Unknown Status	2
DB01098	Rosuvastatin	4	Completed	5
DB01098	Rosuvastatin	4	Unknown Status	3
DB00641	Simvastatin	4	Completed	1
DB00641	Simvastatin	4	Unknown Status	1
DB01261	Sitagliptin	4	Unknown Status	1
DB00086	Streptokinase	4	Completed	1
DB00966	Telmisartan	4	Unknown Status	1
DB00031	Tenecteplase	4	Unknown Status	1
DB08816	Ticagrelor	4	Completed	24
DB08816	Ticagrelor	4	Recruiting	10
DB08816	Ticagrelor	4	Terminated	1
DB08816	Ticagrelor	4	Unknown Status	13
DB08816	Ticagrelor	4	Withdrawn	3
DB00775	Tirofiban	4	Completed	1
DB00775	Tirofiban	4	Unknown Status	1
DB01273	Varenicline	4	Unknown Status	1
DB11094	Vitamin D	4	Unknown Status	1
DB11739	Vonoprazan	4	Not Yet Recruiting	1
DB00682	Warfarin	4	Recruiting	1
DB00425	Zolpidem	4	Unknown Status	1
DB00945	Acetylsalicylic acid	Not Available	Active Not Recruiting	1
DB00945	Acetylsalicylic acid	Not Available	Completed	1
DB00945	Acetylsalicylic acid	Not Available	Recruiting	1
DB00945	Acetylsalicylic acid	Not Available	Terminated	1
DB00945	Acetylsalicylic acid	Not Available	Withdrawn	1
DB09302	Alirocumab	Not Available	Not Yet Recruiting	1
DB09302	Alirocumab	Not Available	Recruiting	1
DB09302	Alirocumab	Not Available	Unknown Status	1
DB00009	Alteplase	Not Available	Withdrawn	1
DB01076	Atorvastatin	Not Available	Unknown Status	2
DB00612	Bisoprolol	Not Available	Completed	1
DB01156	Bupropion	Not Available	Completed	1
DB00796	Candesartan cilexetil	Not Available	Terminated	1
DB04540	Cholesterol	Not Available	Not Yet Recruiting	1
DB00758	Clopidogrel	Not Available	Completed	7
DB00758	Clopidogrel	Not Available	Unknown Status	3
DB00758	Clopidogrel	Not Available	Withdrawn	1
DB01394	Colchicine	Not Available	Not Yet Recruiting	1
DB06779	Dalteparin	Not Available	Completed	1
DB01225	Enoxaparin	Not Available	Withdrawn	1
DB09303	Evolocumab	Not Available	Not Yet Recruiting	1
DB09303	Evolocumab	Not Available	Recruiting	1
DB09303	Evolocumab	Not Available	Unknown Status	1
DB00973	Ezetimibe	Not Available	Recruiting	1
DB00973	Ezetimibe	Not Available	Unknown Status	1
DB11728	Fondaparinux	Not Available	Completed	1
DB01109	Heparin	Not Available	Completed	1
DB00883	Isosorbide dinitrate	Not Available	Completed	1
DB00264	Metoprolol	Not Available	Unknown Status	1
DB00184	Nicotine	Not Available	Completed	2
DB16284	Pelacarsen	Not Available	Withdrawn	1
DB06209	Prasugrel	Not Available	Completed	2
DB06209	Prasugrel	Not Available	Unknown Status	1
DB00178	Ramipril	Not Available	Completed	1
DB06228	Rivaroxaban	Not Available	Completed	4
DB06228	Rivaroxaban	Not Available	Recruiting	1
DB01098	Rosuvastatin	Not Available	Completed	1
DB01098	Rosuvastatin	Not Available	Unknown Status	2
DB01104	Sertraline	Not Available	Completed	1
DB00641	Simvastatin	Not Available	Unknown Status	1
DB01323	St. John's Wort	Not Available	Withdrawn	1
DB00086	Streptokinase	Not Available	Withdrawn	1
DB16336	Tafolecimab	Not Available	Not Yet Recruiting	1
DB00966	Telmisartan	Not Available	Terminated	1
DB08816	Ticagrelor	Not Available	Active Not Recruiting	1
DB08816	Ticagrelor	Not Available	Completed	12
DB08816	Ticagrelor	Not Available	Recruiting	1
DB08816	Ticagrelor	Not Available	Unknown Status	4
DB00775	Tirofiban	Not Available	Terminated	1
DB01273	Varenicline	Not Available	Unknown Status	1
DB00682	Warfarin	Not Available	Completed	1