Severe Atopic Dermatitis

DrugDrug NameDrug Description
DB14973AbrocitinibA kinase inhibitor used to treat moderate-to-severe atopic dermatitis in adults.
DB11817BaricitinibA Janus kinase inhibitor used to treat moderate to severe rheumatoid arthritis that has responded poorly to at least one TNF antagonist.
DB00443BetamethasoneA systemic corticosteroid used to relieve inflammation in various conditions, including but not limited to allergic states, dermatologic disorders, gastrointestinal diseases, and hematological disorders.
DB12159DupilumabA monoclonal antibody used to treat moderate to severe atopic dermatitis, asthma, and nasal polyps accompanied by chronic rhinosinusitis in adolescents and adults.
DB00864TacrolimusA calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis.
DB15091UpadacitinibAn oral Janus kinase (JAK)1-selective inhibitor used in the treatment of moderate to severe rheumatoid arthritis, active psoriatic arthritis, ankylosing spondylitis, and severe atopic dermatitis, including in patients who did not respond well to other therapies.
DrugDrug NameTargetType
DB14973AbrocitinibCytochrome P450 2C19enzyme
DB14973AbrocitinibCytochrome P450 2C9enzyme
DB14973AbrocitinibCytochrome P450 3A4enzyme
DB14973AbrocitinibCytochrome P450 2B6enzyme
DB14973AbrocitinibTyrosine-protein kinase JAK1target
DB14973AbrocitinibP-glycoprotein 1transporter
DB14973AbrocitinibSolute carrier family 22 member 1transporter
DB14973AbrocitinibTyrosine-protein kinase JAK2target
DB14973AbrocitinibTyrosine-protein kinase JAK3target
DB14973AbrocitinibNon-receptor tyrosine-protein kinase TYK2target
DB14973AbrocitinibSerum albumincarrier
DB14973AbrocitinibSolute carrier family 22 member 8transporter
DB11817BaricitinibSolute carrier family 22 member 8transporter
DB11817BaricitinibATP-binding cassette sub-family G member 2transporter
DB11817BaricitinibMultidrug and toxin extrusion protein 2transporter
DB11817BaricitinibCytochrome P450 3A4enzyme
DB11817BaricitinibTyrosine-protein kinase JAK1target
DB11817BaricitinibTyrosine-protein kinase JAK2target
DB11817BaricitinibSolute carrier family 22 member 6transporter
DB11817BaricitinibSolute carrier family 22 member 2transporter
DB11817BaricitinibSolute carrier organic anion transporter family member 1B3transporter
DB11817BaricitinibTyrosine-protein kinase JAK3target
DB11817BaricitinibP-glycoprotein 1transporter
DB11817BaricitinibNon-receptor tyrosine-protein kinase TYK2target
DB00443BetamethasoneGlucocorticoid receptortarget
DB00443BetamethasoneCytochrome P450 3A4enzyme
DB00443BetamethasoneP-glycoprotein 1transporter
DB00443BetamethasoneCytochrome P450 19A1enzyme
DB00443BetamethasoneCytochrome P450 3A5enzyme
DB00443BetamethasoneCytochrome P450 3A7enzyme
DB00443BetamethasoneCytochrome P450 2A6enzyme
DB00443BetamethasoneCytochrome P450 1B1enzyme
DB00443BetamethasoneCytochrome P450 2B6enzyme
DB00443BetamethasoneCytochrome P450 2C8enzyme
DB00443BetamethasoneCytochrome P450 2C9enzyme
DB00443BetamethasoneCytochrome P450 2C19enzyme
DB00443BetamethasoneSerum albumincarrier
DB00443BetamethasoneCorticosteroid-binding globulincarrier
DB12159DupilumabInterleukin-4 receptor subunit alphatarget
DB12159DupilumabInterleukin-13target
DB12159DupilumabInterleukin-4target
DB00864TacrolimusPeptidyl-prolyl cis-trans isomerase FKBP1Atarget
DB00864TacrolimusCytochrome P450 3A4enzyme
DB00864TacrolimusCytochrome P450 3A5enzyme
DB00864TacrolimusP-glycoprotein 1transporter
DB00864TacrolimusATP-binding cassette sub-family A member 5transporter
DB00864TacrolimusSerum albumincarrier
DB00864TacrolimusAlpha-1-acid glycoprotein 1carrier
DB00864TacrolimusSolute carrier organic anion transporter family member 1B1transporter
DB15091UpadacitinibTyrosine-protein kinase JAK1target
DB15091UpadacitinibCytochrome P450 3A4enzyme
DB15091UpadacitinibCytochrome P450 2D6enzyme
DB15091UpadacitinibP-glycoprotein 1transporter
DB15091UpadacitinibATP-binding cassette sub-family G member 2transporter
DB15091UpadacitinibSolute carrier organic anion transporter family member 1B1transporter
DrugDrug NamePhaseStatusCount
DB00091Cyclosporine3Completed2