Vitamin B12 Deficiency

Also known as: Vitamin B 12 Deficiency / Vitamin B-12 Deficiency / B12 Deficiency Vitamin / Cobalamin Deficiency / Hypocobalaminaemia / Hypocobalaminemia / Biotin deficiency / Cobalamin deficiency (disorder) / Deficiency of vitamin B>12< (disorder)

DrugDrug NameDrug Description
DB11191CobamamideAn ingredient found in a variety of supplements and vitamins.
DB01987CocarboxylaseThe coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex.
DB00115CyanocobalaminA vitamin available in many formulations to correct vitamin B12 deficiency.
DB08966FursultiamineCompound used for therapy of thiamine deficiency. It has also been suggested for several non-deficiency disorders but has not yet proven useful. Fursultiamine is a vitamin B1 derivative.
DB00200HydroxocobalaminA synthetic form of vitamin B12 used to treat vitamin B12 associated disorders and cyanide poisoning.
DB03614MecobalaminNot Available
DB00170MenadioneThe primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification.
DB00157NADHA nutrient used in some supplement products.
DB00230PregabalinAn anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants.
DB00165PyridoxineA vitamin used to correct vitamin B6 deficiency and to treat nausea during pregnancy.
DrugDrug NameTargetType
DB01987CocarboxylaseAcetolactate synthase, catabolictarget
DB01987CocarboxylasePyruvate dehydrogenase E1 componenttarget
DB01987CocarboxylasePyruvate-flavodoxin oxidoreductasetarget
DB01987CocarboxylaseIndole-3-pyruvate decarboxylasetarget
DB01987CocarboxylaseCarboxyethylarginine synthasetarget
DB01987CocarboxylaseTransketolase 1target
DB01987CocarboxylaseRNAtarget
DB01987CocarboxylaseBenzoylformate decarboxylaseenzyme
DB01987CocarboxylasePyruvate oxidaseenzyme
DB00115CyanocobalaminMethionine synthase reductasetarget
DB00115CyanocobalaminMethylmalonic aciduria type A protein, mitochondrialtarget
DB00115CyanocobalaminMethylmalonyl-CoA mutase, mitochondrialtarget
DB00115CyanocobalaminMethylmalonic aciduria and homocystinuria type C proteintarget
DB00115CyanocobalaminMethionine synthasetarget
DB00115CyanocobalaminMethylenetetrahydrofolate reductasetarget
DB00115CyanocobalaminProtein amnionlesstransporter
DB00115CyanocobalaminTranscobalamin-1transporter
DB00115CyanocobalaminTranscobalamin-2transporter
DB00115CyanocobalaminCob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrialenzyme
DB00115CyanocobalaminGastric intrinsic factortransporter
DB00115CyanocobalaminCubilintransporter
DB00115CyanocobalaminBifunctional adenosylcobalamin biosynthesis protein CobUenzyme
DB00115CyanocobalaminLow-density lipoprotein receptor-related protein 2transporter
DB00115CyanocobalaminMultidrug resistance-associated protein 1transporter
DB00115CyanocobalaminPancreatic proteasesenzyme
DB00200HydroxocobalaminMethylmalonic aciduria type A protein, mitochondrialtarget
DB00200HydroxocobalaminProtein amnionlesstarget
DB00200HydroxocobalaminTranscobalamin-1target
DB00200HydroxocobalaminMethylmalonyl-CoA mutase, mitochondrialtarget
DB00200HydroxocobalaminMethionine synthasetarget
DB00200HydroxocobalaminCubilintarget
DB00200HydroxocobalaminMethylmalonic aciduria and homocystinuria type C proteintarget
DB00200HydroxocobalaminTranscobalamin-2carrier
DB03614MecobalaminMethionine synthasetarget
DB00170MenadioneProthrombintarget
DB00170MenadioneVitamin K epoxide reductase complex subunit 1target
DB00170MenadioneCoagulation factor IXtarget
DB00170MenadioneVitamin K-dependent gamma-carboxylasetarget
DB00170MenadioneVitamin K-dependent protein Ctarget
DB00170MenadioneVitamin K-dependent protein Starget
DB00170MenadioneNAD(P)H dehydrogenase [quinone] 1target
DB00170MenadioneRibosyldihydronicotinamide dehydrogenase [quinone]target
DB00170MenadioneVitamin K epoxide reductase complex subunit 1-like protein 1target
DB00170MenadioneXanthine dehydrogenase/oxidaseenzyme
DB00170MenadioneAldehyde oxidaseenzyme
DB00170MenadioneMethylenetetrahydrofolate reductaseenzyme
DB00170MenadioneCytochrome P450 1A1enzyme
DB00170MenadioneOsteocalcintarget
DB00170MenadioneCytochrome P450 1A2enzyme
DB00170MenadioneCytochrome P450 2A6enzyme
DB00170MenadioneCytochrome P450 1B1enzyme
DB00170MenadioneCytochrome P450 2B6enzyme
DB00170MenadioneCytochrome P450 2C8enzyme
DB00170MenadioneCytochrome P450 2C9enzyme
DB00170MenadioneCytochrome P450 2C19enzyme
DB00170MenadioneCytochrome P450 2D6enzyme
DB00170MenadioneCytochrome P450 2E1enzyme
DB00170MenadioneCytochrome P450 3A4enzyme
DB00170MenadioneCytochrome P450 3A5enzyme
DB00170MenadioneCytochrome P450 3A7enzyme
DB00157NADHUDP-glucose 6-dehydrogenasetarget
DB00157NADHAlcohol dehydrogenase 1Atarget
DB00157NADHSorbitol dehydrogenasetarget
DB00157NADHAlcohol dehydrogenase 4target
DB00157NADHAlcohol dehydrogenase 1Ctarget
DB00157NADHAlcohol dehydrogenase 1Btarget
DB00157NADHAlcohol dehydrogenase class 4 mu/sigma chaintarget
DB00157NADHGlycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmictarget
DB00157NADHL-lactate dehydrogenase A-like 6Atarget
DB00157NADHAlcohol dehydrogenase class-3target
DB00157NADHAldose reductasetarget
DB00157NADH3-hydroxyacyl-CoA dehydrogenase type-2target
DB00157NADHMalate dehydrogenase, mitochondrialtarget
DB00157NADHL-lactate dehydrogenase A chaintarget
DB00157NADHNAD-dependent malic enzyme, mitochondrialtarget
DB00157NADHPeroxisomal multifunctional enzyme type 2target
DB00157NADHL-lactate dehydrogenase A-like 6Btarget
DB00157NADHL-lactate dehydrogenase C chaintarget
DB00157NADHL-lactate dehydrogenase B chaintarget
DB00157NADHPeroxisomal bifunctional enzymetarget
DB00157NADHHydroxyacyl-coenzyme A dehydrogenase, mitochondrialtarget
DB00157NADHNADP-dependent malic enzyme, mitochondrialtarget
DB00157NADHD-beta-hydroxybutyrate dehydrogenase, mitochondrialtarget
DB00157NADHMalate dehydrogenase, cytoplasmictarget
DB00157NADH3-hydroxyisobutyrate dehydrogenase, mitochondrialtarget
DB00157NADHTestosterone 17-beta-dehydrogenase 3target
DB00157NADH3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB00157NADHNADP-dependent malic enzymetarget
DB00157NADHD-3-phosphoglycerate dehydrogenasetarget
DB00157NADH3-keto-steroid reductasetarget
DB00157NADHIsocitrate dehydrogenase [NAD] subunit gamma, mitochondrialtarget
DB00157NADHIsocitrate dehydrogenase [NAD] subunit beta, mitochondrialtarget
DB00157NADHIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrialtarget
DB00157NADHEstradiol 17-beta-dehydrogenase 1target
DB00157NADHEstradiol 17-beta-dehydrogenase 2target
DB00157NADH11-cis retinol dehydrogenasetarget
DB00157NADHGDH/6PGL endoplasmic bifunctional proteintarget
DB00157NADHEstradiol 17-beta-dehydrogenase 8target
DB00157NADHAldo-keto reductase family 1 member C4target
DB00157NADHInosine-5'-monophosphate dehydrogenase 2target
DB00157NADHAldo-keto reductase family 1 member C3target
DB00157NADH15-hydroxyprostaglandin dehydrogenase [NAD(+)]target
DB00157NADHGDP-L-fucose synthasetarget
DB00157NADHAldo-keto reductase family 1 member C1target
DB00157NADHCorticosteroid 11-beta-dehydrogenase isozyme 1target
DB00157NADH3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2target
DB00157NADH3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB00157NADHInosine-5'-monophosphate dehydrogenase 1target
DB00157NADHTrifunctional enzyme subunit alpha, mitochondrialtarget
DB00157NADHAldehyde dehydrogenase, mitochondrialtarget
DB00157NADHCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB00157NADHAldo-keto reductase family 1 member C2target
DB00157NADHSterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylatingtarget
DB00157NADHAldehyde dehydrogenase family 3 member B2target
DB00157NADHMethylmalonate-semialdehyde dehydrogenase [acylating], mitochondrialtarget
DB00157NADHAldehyde dehydrogenase, dimeric NADP-preferringtarget
DB00157NADHRetinal dehydrogenase 1target
DB00157NADHGlyceraldehyde-3-phosphate dehydrogenase, testis-specifictarget
DB00157NADH4-trimethylaminobutyraldehyde dehydrogenasetarget
DB00157NADHAldehyde dehydrogenase family 1 member A3target
DB00157NADHAldehyde dehydrogenase X, mitochondrialtarget
DB00157NADHAldehyde dehydrogenase family 3 member B1target
DB00157NADHGlyceraldehyde-3-phosphate dehydrogenasetarget
DB00157NADHRetinal dehydrogenase 2target
DB00157NADHFatty aldehyde dehydrogenasetarget
DB00157NADHSuccinate-semialdehyde dehydrogenase, mitochondrialtarget
DB00157NADHAlpha-aminoadipic semialdehyde dehydrogenasetarget
DB00157NADHFlavin reductase (NADPH)target
DB00157NADHPyrroline-5-carboxylate reductase 2target
DB00157NADHPyrroline-5-carboxylate reductase 1, mitochondrialtarget
DB00157NADHGlutamate dehydrogenase 1, mitochondrialtarget
DB00157NADHPyruvate dehydrogenase E1 component subunit beta, mitochondrialtarget
DB00157NADHPyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrialtarget
DB00157NADHPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrialtarget
DB00157NADHBiliverdin reductase Atarget
DB00157NADHShort-chain specific acyl-CoA dehydrogenase, mitochondrialtarget
DB00157NADHDihydrofolate reductasetarget
DB00157NADH2-oxoglutarate dehydrogenase, mitochondrialtarget
DB00157NADHGlutamate dehydrogenase 2, mitochondrialtarget
DB00157NADH7-dehydrocholesterol reductasetarget
DB00157NADHRibosyldihydronicotinamide dehydrogenase [quinone]target
DB00157NADHNADH-ubiquinone oxidoreductase chain 2target
DB00157NADHAlpha-aminoadipic semialdehyde synthase, mitochondrialtarget
DB00157NADHNADH-ubiquinone oxidoreductase chain 3target
DB00157NADHNADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialtarget
DB00157NADHC-1-tetrahydrofolate synthase, cytoplasmictarget
DB00157NADHBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrialtarget
DB00157NADHDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrialtarget
DB00157NADHNADH-cytochrome b5 reductase 3target
DB00157NADHNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11target
DB00157NADHNADH-ubiquinone oxidoreductase chain 4target
DB00157NADHDihydropteridine reductasetarget
DB00157NADHNADH-ubiquinone oxidoreductase chain 1target
DB00157NADHNAD(P) transhydrogenase, mitochondrialtarget
DB00157NADHNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5target
DB00157NADHNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrialtarget
DB00157NADHNADH-ubiquinone oxidoreductase chain 4Ltarget
DB00157NADHNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialtarget
DB00157NADHNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7target
DB00157NADHNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1target
DB00157NADHNADH-ubiquinone oxidoreductase chain 6target
DB00157NADHNADH-ubiquinone oxidoreductase chain 5target
DB00157NADHNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4target
DB00157NADHNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6target
DB00157NADHAcyl carrier protein, mitochondrialtarget
DB00157NADHNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2target
DB00157NADHNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8target
DB00157NADHNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3target
DB00157NADHNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrialtarget
DB00157NADHNADH dehydrogenase [ubiquinone] 1 subunit C2target
DB00157NADHNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1target
DB00157NADHNADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialtarget
DB00157NADHNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10target
DB00157NADHNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4target
DB00157NADHNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3target
DB00157NADHNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrialtarget
DB00157NADHNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7target
DB00157NADHNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9target
DB00157NADHNADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialtarget
DB00157NADHNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialtarget
DB00157NADHNADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrialtarget
DB00157NADHNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6target
DB00157NADHNADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialtarget
DB00157NADHDihydrolipoyl dehydrogenase, mitochondrialtarget
DB00157NADHNADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialtarget
DB00157NADHGlutathione reductase, mitochondrialtarget
DB00157NADHNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12target
DB00157NADHNADH dehydrogenase [ubiquinone] iron-sulfur protein 5target
DB00157NADHNADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialtarget
DB00157NADHNADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialtarget
DB00157NADHNADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialtarget
DB00157NADHNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13target
DB00157NADHCysteine dioxygenase type 1target
DB00157NADHNADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrialtarget
DB00157NADHNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2target
DB00157NADHNADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialtarget
DB00157NADHCytochrome P450 4A11target
DB00157NADHDihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrialtarget
DB00157NADHAminomethyltransferase, mitochondrialtarget
DB00157NADHMethylsterol monooxygenase 1target
DB00157NADHHeme oxygenase 1target
DB00157NADHHeme oxygenase 2target
DB00157NADHSteroid 17-alpha-hydroxylase/17,20 lyasetarget
DB00157NADHTyrosinasetarget
DB00157NADHXanthine dehydrogenase/oxidaseenzyme
DB00157NADHAldehyde oxidaseenzyme
DB00157NADHAlcohol dehydrogenase 6enzyme
DB00157NADHAlcohol dehydrogenase [NADP(+)]enzyme
DB00157NADHAlcohol dehydrogenase 1Aenzyme
DB00157NADHAlcohol dehydrogenase 1Benzyme
DB00157NADHAlcohol dehydrogenase 4enzyme
DB00157NADHAlcohol dehydrogenase class-3enzyme
DB00157NADHAlcohol dehydrogenase class 4 mu/sigma chainenzyme
DB00230PregabalinExcitatory amino acid transporter 3transporter
DB00230PregabalinVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00230PregabalinLarge neutral amino acids transporter small subunit 1transporter
DB00165PyridoxinePyridoxal kinasetarget
DB00165PyridoxineCytochrome P450 1A1enzyme
DB00165PyridoxineSerum albumincarrier
DB00165PyridoxinePyridoxal kinaseenzyme
DB00165PyridoxinePyridoxal phosphate phosphataseenzyme
DB00165PyridoxineAlkaline phosphatase, tissue-nonspecific isozymetransporter
DB00165PyridoxineAlkaline phosphatase, tissue-nonspecific isozymeenzyme
DrugDrug NamePhaseStatusCount
DB00115Cyanocobalamin0Completed1
DB00115Cyanocobalamin1Active Not Recruiting1
DB14098Cobalamin2Completed1
DB09349Gastric intrinsic factor2Completed1
DB03614Mecobalamin2Completed1
DB00115Cyanocobalamin2 / 3Recruiting1
DB00115Cyanocobalamin4Completed2
DB00115Cyanocobalamin4Unknown Status1
DB00200Hydroxocobalamin4Completed1
DB14098CobalaminNot AvailableCompleted2
DB00115CyanocobalaminNot AvailableCompleted5
DB00200HydroxocobalaminNot AvailableCompleted1