Cardiovascular Risk

Also known as: Cardiovascular Risk Markers / Cardiovascular Risks Markers / Cardiovasculars Risk Factors / Cardiovascular Disease Risk / Cardiovascular Disease (CVD) Risk Factors / Cardiovascular Risks / Cardiovascular Diseases Risk / Risk Factor, Cardiovascular / Cardiovascular Disease Risk Factors / Cardiovascular (CV) Risk / Cardiovascular Factor Risk / Cardiovascular Disease Risk Factor / Risk Factors Cardiovascular Disease / Cardiovascular Risk Factor / Cardiovascular Risk Factors / CVD Risk Factors / Disease risk factor

DrugDrug NameDrug Description
DB00945Acetylsalicylic acidA salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events.
DB01076AtorvastatinAn HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
DB06292DapagliflozinA sodium-glucose cotransporter 2 inhibitor used in the management of type 2 diabetes mellitus.
DB09045DulaglutideA GLP-1 agonist used to manage type 2 diabetes mellitus.
DB08887Icosapent ethylAn ethyl ester of eicosapentaenoic acid (EPA) that reduces synthesis and enhances clearance of triglycerides that is used to treat patients with severe hypertriglyceridemia.
DB00331MetforminA biguanide antihyperglycemic used in conjunction with diet and exercise for glycemic control in type 2 diabetes mellitus. It is also used off-label for insulin resistance in polycystic ovary syndrome (PCOS).
DB12713SotagliflozinAn orally administered dual SGLT1/2 inhibitor used alongside insulin to improve glycemic control in patients with type 1 diabetes mellitus.
DrugDrug NameTargetType
DB00945Acetylsalicylic acidProstaglandin G/H synthase 1target
DB00945Acetylsalicylic acidProstaglandin G/H synthase 2target
DB00945Acetylsalicylic acidAldo-keto reductase family 1 member C1target
DB00945Acetylsalicylic acidSolute carrier family 22 member 6transporter
DB00945Acetylsalicylic acidP-glycoprotein 1transporter
DB00945Acetylsalicylic acidCytochrome P450 2C19enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acid5'-AMP-activated protein kinasetarget
DB00945Acetylsalicylic acidEndothelin-1 receptortarget
DB00945Acetylsalicylic acidCellular tumor antigen p53target
DB00945Acetylsalicylic acid78 kDa glucose-regulated proteintarget
DB00945Acetylsalicylic acidRibosomal protein S6 kinase alpha-3target
DB00945Acetylsalicylic acidNF-kappa-B inhibitor alphatarget
DB00945Acetylsalicylic acidTumor necrosis factor-inducible gene 6 proteintarget
DB00945Acetylsalicylic acidCaspase-1target
DB00945Acetylsalicylic acidCaspase-3target
DB00945Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00945Acetylsalicylic acidExtracellular signal-regulated kinase (ERK)target
DB00945Acetylsalicylic acidG1/S-specific cyclin-D1target
DB00945Acetylsalicylic acidMyc proto-oncogene proteintarget
DB00945Acetylsalicylic acidProliferating cell nuclear antigentarget
DB00945Acetylsalicylic acidCyclin Atarget
DB00945Acetylsalicylic acidUDP-glucuronosyltransferase 1-6enzyme
DB00945Acetylsalicylic acidArylamine N-acetyltransferase 2enzyme
DB00945Acetylsalicylic acidSolute carrier family 22 member 8transporter
DB00945Acetylsalicylic acidSialidase-1target
DB01076Atorvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB01076AtorvastatinCytochrome P450 3A4enzyme
DB01076AtorvastatinDipeptidyl peptidase 4target
DB01076AtorvastatinCytochrome P450 2D6enzyme
DB01076AtorvastatinCytochrome P450 2C9enzyme
DB01076AtorvastatinCytochrome P450 2C19enzyme
DB01076AtorvastatinCytochrome P450 3A5enzyme
DB01076AtorvastatinCytochrome P450 3A7enzyme
DB01076AtorvastatinP-glycoprotein 1transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1A2transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1B1transporter
DB01076AtorvastatinMultidrug resistance-associated protein 4transporter
DB01076AtorvastatinMultidrug resistance-associated protein 5transporter
DB01076AtorvastatinMultidrug resistance-associated protein 1transporter
DB01076AtorvastatinCytochrome P450 2B6enzyme
DB01076AtorvastatinCytochrome P450 2C8enzyme
DB01076AtorvastatinAryl hydrocarbon receptortarget
DB01076AtorvastatinSolute carrier organic anion transporter family member 2B1transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1B3transporter
DB01076AtorvastatinUDP-glucuronosyltransferase 1-1enzyme
DB01076AtorvastatinUDP-glucuronosyltransferase 1-3enzyme
DB01076AtorvastatinCanalicular multispecific organic anion transporter 1transporter
DB01076AtorvastatinBile salt export pumptransporter
DB01076AtorvastatinSerum albumincarrier
DB01076AtorvastatinHistone deacetylase 2target
DB01076AtorvastatinNuclear receptor subfamily 1 group I member 3target
DB06292DapagliflozinSodium/glucose cotransporter 2target
DB06292DapagliflozinCytochrome P450 1A1enzyme
DB06292DapagliflozinCytochrome P450 1A2enzyme
DB06292DapagliflozinCytochrome P450 2A6enzyme
DB06292DapagliflozinCytochrome P450 2C9enzyme
DB06292DapagliflozinCytochrome P450 2D6enzyme
DB06292DapagliflozinCytochrome P450 3A4enzyme
DB06292DapagliflozinUDP-glucuronosyltransferase 1-9enzyme
DB06292DapagliflozinUDP-glucuronosyltransferase 2B4enzyme
DB06292DapagliflozinUDP-glucuronosyltransferase 2B7enzyme
DB06292DapagliflozinP-glycoprotein 1transporter
DB09045DulaglutideGlucagon-like peptide 1 receptortarget
DB00331Metformin5'-AMP-activated protein kinase subunit beta-1target
DB00331MetforminSolute carrier family 22 member 2transporter
DB00331MetforminSolute carrier family 22 member 1transporter
DB00331MetforminMultidrug and toxin extrusion protein 1transporter
DB00331MetforminEquilibrative nucleoside transporter 4transporter
DB00331MetforminSolute carrier family 22 member 3transporter
DB00331MetforminMultidrug and toxin extrusion protein 2transporter
DB00331MetforminElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialtarget
DB00331MetforminGlycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmictarget
DB12713SotagliflozinUDP-glucuronosyltransferase 1-9enzyme
DB12713SotagliflozinUDP-glucuronosyltransferase 1-1enzyme
DB12713SotagliflozinUDP-glucuronosyltransferase 2B7enzyme
DB12713SotagliflozinCytochrome P450 3A4enzyme
DB12713SotagliflozinSodium/glucose cotransporter 2target
DB12713SotagliflozinSodium/glucose cotransporter 1target
DB12713SotagliflozinCytochrome P450 2D6enzyme
DB12713SotagliflozinP-glycoprotein 1transporter
DB12713SotagliflozinATP-binding cassette sub-family G member 2transporter
DB12713SotagliflozinSolute carrier organic anion transporter family member 1B1transporter
DB12713SotagliflozinSolute carrier organic anion transporter family member 1B3transporter
DB12713SotagliflozinCanalicular multispecific organic anion transporter 1transporter
DrugDrug NamePhaseStatusCount
DB12301Doravirine0Not Yet Recruiting1
DB00470Dronabinol0Active Not Recruiting1
DB00879Emtricitabine0Not Yet Recruiting1
DB14009Medical Cannabis0Active Not Recruiting1
DB09299Tenofovir alafenamide0Not Yet Recruiting1
DB00437Allopurinol1Completed3
DB12618Apocynin1Completed3
DB00125Arginine1Recruiting1
DB00126Ascorbic acid1Recruiting1
DB12054BQ-1231Recruiting1
DB17984BQ-7881Recruiting1
DB01164Calcium chloride1Recruiting1
DB01136Carvedilol1Active Not Recruiting1
DB14547Chloride ion1Completed1
DB04398Lactic acid1Recruiting1
DB12750N-omega-nitro-L-arginine methyl ester1Completed1
DB12750N-omega-nitro-L-arginine methyl ester1Recruiting2
DB00325Nitroprusside1Completed1
DB00325Nitroprusside1Recruiting1
DB00368Norepinephrine1Recruiting1
DB00388Phenylephrine1Completed1
DB00761Potassium chloride1Recruiting1
DB00360Sapropterin1Completed1
DB09153Sodium chloride1Recruiting1
DB12449Tempol1Completed2
DB00945Acetylsalicylic acid2Recruiting1
DB01076Atorvastatin2Recruiting1
DB06292Dapagliflozin2Recruiting1
DB15935Lumasiran2Not Yet Recruiting1
DB11228Methylcellulose2Recruiting1
DB00435Nitric Oxide2Recruiting1
DB12290Puerarin2Completed1
DB04115Berberine2 / 3Completed1
DB09061Cannabidiol2 / 3Terminated1
DB01076Atorvastatin3Unknown Status1
DB14901Inclisiran3Completed1
DB00583Levocarnitine3Unknown Status1
DB00922Levosimendan3Recruiting1
DB00284Acarbose4Completed1
DB00945Acetylsalicylic acid4Completed1
DB00381Amlodipine4Recruiting1
DB11672Curcumin4Unknown Status1
DB09038Empagliflozin4Completed1
DB00977Ethinylestradiol4Completed1
DB00222Glimepiride4Completed1
DB08887Icosapent ethyl4Active Not Recruiting1
DB04835Maraviroc4Completed1
DB00563Methotrexate4Recruiting1
DB00957Norgestimate4Completed1
DB00715Paroxetine4Completed1
DB08860Pitavastatin4Completed1
DB01098Rosuvastatin4Active Not Recruiting1
DB01098Rosuvastatin4Completed1
DB01098Rosuvastatin4Withdrawn1
DB00641Simvastatin4Withdrawn1
DB11325Soy sterol4Completed1
DB00795Sulfasalazine4Recruiting1
DB00758ClopidogrelNot AvailableCompleted1
DB00973EzetimibeNot AvailableCompleted1
DB01592IronNot AvailableRecruiting1
DB00722LisinoprilNot AvailableCompleted1
DB01024Mycophenolic acidNot AvailableNot Yet Recruiting1
DB00184NicotineNot AvailableUnknown Status1
DB12930OpipramolNot AvailableEnrolling by Invitation1
DB06209PrasugrelNot AvailableCompleted1
DB00175PravastatinNot AvailableCompleted1
DB00641SimvastatinNot AvailableCompleted1
DB02772SucroseNot AvailableRecruiting1
DB00864TacrolimusNot AvailableNot Yet Recruiting1
DB08816TicagrelorNot AvailableCompleted1