Coronary Heart Disease (CHD)

Also known as: CHD - Coronary Heart Disease / Heart Disease, Coronary / Heart Diseases, Coronary / Coronary Diseases / Coronary Disease / Coronary Heart Diseases / Coronary Heart Disease / Coronary atherosclerosis (disorder) / Coronary arteriosclerosis (disorder) / Atherosclerotic cardiovascular disease / Coronary artery disease NOS / Disorder of coronary artery (disorder) / Coronary artery disease / Coronary artery disease (disorder) / Coronary (atherosclerosis or artery disease) or triple vessel disease of the heart / CAD / Coronary artery disorders / Disorder coronary artery / Coronary artery disorder / Coronary artery disorder (NOS) / Disease coronary artery

Drug	Drug Name	Drug Description
DB01095	Fluvastatin	An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
DB01241	Gemfibrozil	A lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia.
DB00227	Lovastatin	An HMG-CoA reductase inhibitor used to lower LDL cholesterol and reduce the risk of cardiovascular disease and associated conditions, including myocardial infarction and stroke.
DB00175	Pravastatin	An HMG-CoA reductase inhibitor used to lower lipid levels and to reduce the risk of cardiovascular events, including myocardial infarction and stroke.

Drug	Drug Name	Target	Type
DB01095	Fluvastatin	3-hydroxy-3-methylglutaryl-coenzyme A reductase	target
DB01095	Fluvastatin	Cytochrome P450 2C9	enzyme
DB01095	Fluvastatin	Cytochrome P450 3A4	enzyme
DB01095	Fluvastatin	Cytochrome P450 2C8	enzyme
DB01095	Fluvastatin	Cytochrome P450 2D6	enzyme
DB01095	Fluvastatin	Cytochrome P450 2C19	enzyme
DB01095	Fluvastatin	Cytochrome P450 1A1	enzyme
DB01095	Fluvastatin	Solute carrier organic anion transporter family member 1B1	transporter
DB01095	Fluvastatin	Solute carrier organic anion transporter family member 1B3	transporter
DB01095	Fluvastatin	Solute carrier organic anion transporter family member 2B1	transporter
DB01095	Fluvastatin	Solute carrier family 15 member 1	transporter
DB01095	Fluvastatin	Cytochrome P450 3A5	enzyme
DB01095	Fluvastatin	UDP-glucuronosyltransferase 1-1	enzyme
DB01095	Fluvastatin	UDP-glucuronosyltransferase 1-3	enzyme
DB01095	Fluvastatin	UDP-glucuronosyltransferase 2B7	enzyme
DB01095	Fluvastatin	Canalicular multispecific organic anion transporter 1	transporter
DB01095	Fluvastatin	Cytochrome P450 2B6	enzyme
DB01095	Fluvastatin	Histone deacetylase 2	target
DB01241	Gemfibrozil	Peroxisome proliferator-activated receptor alpha	target
DB01241	Gemfibrozil	Cytochrome P450 2C9	enzyme
DB01241	Gemfibrozil	Cytochrome P450 2C8	enzyme
DB01241	Gemfibrozil	Cytochrome P450 1A2	enzyme
DB01241	Gemfibrozil	Cytochrome P450 2C19	enzyme
DB01241	Gemfibrozil	UDP-glucuronosyltransferase 1-1	enzyme
DB01241	Gemfibrozil	Cytochrome P450 3A4	enzyme
DB01241	Gemfibrozil	UDP-glucuronosyltransferase 1-3	enzyme
DB01241	Gemfibrozil	Solute carrier organic anion transporter family member 1B1	target
DB01241	Gemfibrozil	UDP-glucuronosyltransferase 2B7	enzyme
DB01241	Gemfibrozil	UDP-glucuronosyltransferase 1-9	enzyme
DB01241	Gemfibrozil	UDP-glucuronosyltransferase 2B4	enzyme
DB01241	Gemfibrozil	UDP-glucuronosyltransferase 2B17	enzyme
DB01241	Gemfibrozil	Serum albumin	carrier
DB01241	Gemfibrozil	Solute carrier family 22 member 8	target
DB01241	Gemfibrozil	Solute carrier organic anion transporter family member 2B1	target
DB01241	Gemfibrozil	Solute carrier organic anion transporter family member 1B3	target
DB00227	Lovastatin	3-hydroxy-3-methylglutaryl-coenzyme A reductase	target
DB00227	Lovastatin	Cytochrome P450 3A4	enzyme
DB00227	Lovastatin	Cytochrome P450 2C8	enzyme
DB00227	Lovastatin	Integrin alpha-L	target
DB00227	Lovastatin	Histone deacetylase 2	target
DB00227	Lovastatin	Serum paraoxonase/lactonase 3	enzyme
DB00227	Lovastatin	P-glycoprotein 1	transporter
DB00227	Lovastatin	Solute carrier organic anion transporter family member 1A2	transporter
DB00227	Lovastatin	Solute carrier organic anion transporter family member 1B1	transporter
DB00227	Lovastatin	UDP-glucuronosyltransferase 1-1	enzyme
DB00227	Lovastatin	UDP-glucuronosyltransferase 1-3	enzyme
DB00227	Lovastatin	UDP-glucuronosyltransferase 2B7	enzyme
DB00227	Lovastatin	Canalicular multispecific organic anion transporter 1	transporter
DB00227	Lovastatin	Bile salt export pump	transporter
DB00227	Lovastatin	Serum albumin	carrier
DB00227	Lovastatin	Cytochrome P450 2C19	enzyme
DB00227	Lovastatin	Solute carrier organic anion transporter family member 2B1	transporter
DB00227	Lovastatin	Solute carrier organic anion transporter family member 1B3	transporter
DB00175	Pravastatin	3-hydroxy-3-methylglutaryl-coenzyme A reductase	target
DB00175	Pravastatin	Solute carrier organic anion transporter family member 2B1	transporter
DB00175	Pravastatin	P-glycoprotein 1	transporter
DB00175	Pravastatin	Solute carrier organic anion transporter family member 1A2	transporter
DB00175	Pravastatin	Solute carrier family 22 member 6	transporter
DB00175	Pravastatin	Solute carrier family 22 member 8	transporter
DB00175	Pravastatin	Canalicular multispecific organic anion transporter 1	transporter
DB00175	Pravastatin	Solute carrier family 22 member 11	transporter
DB00175	Pravastatin	ATP-binding cassette sub-family G member 2	transporter
DB00175	Pravastatin	Solute carrier family 22 member 7	transporter
DB00175	Pravastatin	Solute carrier organic anion transporter family member 1B1	transporter
DB00175	Pravastatin	Monocarboxylate transporter 1	transporter
DB00175	Pravastatin	Bile salt export pump	transporter
DB00175	Pravastatin	Solute carrier organic anion transporter family member 1B3	transporter
DB00175	Pravastatin	Histone deacetylase 2	target

Drug	Drug Name	Phase	Status	Count
DB00155	Citrulline	0	Unknown Status	1
DB00973	Ezetimibe	0	Completed	1
DB09302	Alirocumab	1	Completed	1
DB15094	Anfibatide	1	Completed	1
DB01076	Atorvastatin	1	Completed	1
DB01394	Colchicine	1	Recruiting	1
DB00973	Ezetimibe	1	Completed	1
DB11576	Ferric oxide	1	Completed	1
DB05760	Telcagepant	1	Completed	1
DB12228	Telcagepant	1	Completed	1
DB00160	Alanine	2	Completed	1
DB11876	Alanyl glutamine	2	Completed	1
DB06552	Anpocogin	2	Completed	1
DB00126	Ascorbic acid	2	Completed	1
DB00207	Azithromycin	2	Terminated	1
DB06755	Beta carotene	2	Completed	1
DB09020	Bisacodyl	2	Completed	1
DB00006	Bivalirudin	2	Unknown Status	1
DB01164	Calcium chloride	2	Completed	2
DB01432	Cholestyramine	2	Completed	1
DB00115	Cyanocobalamin	2	Completed	1
DB06695	Dabigatran etexilate	2	Completed	1
DB12181	Dalcetrapib	2	Completed	4
DB12140	Dilmapimod	2	Completed	1
DB00254	Doxycycline	2	Terminated	1
DB00063	Eptifibatide	2	Completed	1
DB01175	Escitalopram	2	Unknown Status	1
DB05869	Ethyl pyruvate	2	Terminated	1
DB05599	Fibroblast growth factor-1	2	Not Yet Recruiting	1
DB00158	Folic acid	2	Completed	1
DB00569	Fondaparinux	2	Withdrawn	1
DB01241	Gemfibrozil	2	Completed	1
DB01645	Genistein	2	Completed	1
DB01109	Heparin	2	Completed	1
DB01109	Heparin	2	Withdrawn	1
DB00117	Histidine	2	Completed	1
DB09106	Hydroxyethyl Starch	2	Completed	1
DB00130	L-Glutamine	2	Completed	1
DB00922	Levosimendan	2	Completed	1
DB06655	Liraglutide	2	Completed	1
DB00227	Lovastatin	2	Completed	1
DB16452	MAS825	2	Not Yet Recruiting	1
DB14513	Magnesium	2	Completed	1
DB04899	Nesiritide	2	Completed	1
DB00627	Niacin	2	Completed	1
DB00435	Nitric Oxide	2	Completed	1
DB00727	Nitroglycerin	2	Unknown Status	1
DB11133	Omega-3 fatty acids	2	Completed	1
DB06635	Otamixaban	2	Completed	1
DB11839	PZ-128	2	Completed	1
DB12971	Pactimibe	2	Completed	1
DB00761	Potassium chloride	2	Completed	2
DB00175	Pravastatin	2	Completed	2
DB00165	Pyridoxine	2	Completed	1
DB00178	Ramipril	2	Completed	1
DB05553	Regrelor	2	Terminated	1
DB00615	Rifabutin	2	Terminated	1
DB01098	Rosuvastatin	2	Completed	1
DB09153	Sodium chloride	2	Completed	3
DB13946	Testosterone undecanoate	2	Completed	1
DB06273	Tocilizumab	2	Completed	1
DB00150	Tryptophan	2	Completed	1
DB00163	Vitamin E	2	Completed	1
DB05692	Vorapaxar	2	Completed	1
DB09030	Vorapaxar	2	Completed	1
DB00945	Acetylsalicylic acid	2 / 3	Completed	1
DB00594	Amiloride	2 / 3	Completed	1
DB00758	Clopidogrel	2 / 3	Completed	1
DB00286	Conjugated estrogens	2 / 3	Completed	1
DB00584	Enalapril	2 / 3	Completed	1
DB00158	Folic acid	2 / 3	Completed	1
DB00603	Medroxyprogesterone acetate	2 / 3	Completed	1
DB14049	Nitrate	2 / 3	Completed	1
DB00284	Acarbose	3	Completed	1
DB00945	Acetylsalicylic acid	3	Completed	5
DB00945	Acetylsalicylic acid	3	Unknown Status	1
DB00009	Alteplase	3	Completed	3
DB00381	Amlodipine	3	Completed	2
DB06630	Anacetrapib	3	Completed	1
DB11842	Angiotensin II	3	Completed	2
DB00126	Ascorbic acid	3	Completed	1
DB00335	Atenolol	3	Completed	1
DB01076	Atorvastatin	3	Completed	7
DB01076	Atorvastatin	3	Terminated	1
DB00207	Azithromycin	3	Completed	1
DB00542	Benazepril	3	Completed	1
DB00201	Caffeine	3	Completed	1
DB01373	Calcium	3	Completed	2
DB00796	Candesartan cilexetil	3	Completed	1
DB01136	Carvedilol	3	Completed	1
DB00310	Chlorthalidone	3	Completed	2
DB01432	Cholestyramine	3	Completed	3
DB00636	Clofibrate	3	Completed	1
DB00758	Clopidogrel	3	Withdrawn	1
DB00375	Colestipol	3	Completed	2
DB00286	Conjugated estrogens	3	Completed	3
DB12181	Dalcetrapib	3	Completed	2
DB00509	Dextrothyroxine	3	Completed	1
DB00343	Diltiazem	3	Completed	2
DB00975	Dipyridamole	3	Completed	2
DB00841	Dobutamine	3	Completed	1
DB00590	Doxazosin	3	Completed	1
DB00584	Enalapril	3	Completed	1
DB01228	Encainide	3	Completed	1
DB00783	Estradiol	3	Completed	7
DB09303	Evolocumab	3	Active Not Recruiting	1
DB00973	Ezetimibe	3	Completed	11
DB01023	Felodipine	3	Completed	1
DB01039	Fenofibrate	3	Completed	1
DB13873	Fenofibric acid	3	Completed	6
DB01195	Flecainide	3	Completed	1
DB00695	Furosemide	3	Completed	1
DB01241	Gemfibrozil	3	Completed	1
DB00222	Glimepiride	3	Completed	1
DB01109	Heparin	3	Completed	1
DB14740	Hyaluronidase	3	Completed	1
DB01275	Hydralazine	3	Completed	1
DB00999	Hydrochlorothiazide	3	Completed	1
DB01306	Insulin aspart	3	Completed	1
DB01307	Insulin detemir	3	Completed	1
DB00047	Insulin glargine	3	Completed	1
DB00030	Insulin human	3	Completed	3
DB00883	Isosorbide dinitrate	3	Completed	1
DB09083	Ivabradine	3	Completed	1
DB11629	Laropiprant	3	Completed	1
DB00722	Lisinopril	3	Completed	2
DB00227	Lovastatin	3	Completed	2
DB14513	Magnesium	3	Completed	1
DB00603	Medroxyprogesterone acetate	3	Completed	4
DB00331	Metformin	3	Completed	1
DB00264	Metoprolol	3	Completed	1
DB05528	Mipomersen	3	Completed	2
DB00680	Moricizine	3	Completed	1
DB04899	Nesiritide	3	Withdrawn	1
DB00627	Niacin	3	Completed	5
DB00627	Niacin	3	Terminated	1
DB01115	Nifedipine	3	Completed	1
DB00727	Nitroglycerin	3	Completed	1
DB11133	Omega-3 fatty acids	3	Completed	1
DB09539	Omega-3-acid ethyl esters	3	Completed	1
DB01132	Pioglitazone	3	Completed	1
DB08860	Pitavastatin	3	Completed	1
DB14500	Potassium	3	Completed	1
DB00175	Pravastatin	3	Completed	1
DB00396	Progesterone	3	Completed	3
DB00571	Propranolol	3	Completed	2
DB00178	Ramipril	3	Completed	1
DB00912	Repaglinide	3	Completed	1
DB00206	Reserpine	3	Completed	1
DB00412	Rosiglitazone	3	Completed	1
DB01098	Rosuvastatin	3	Completed	5
DB01098	Rosuvastatin	3	Unknown Status	1
DB01236	Sevoflurane	3	Completed	1
DB00641	Simvastatin	3	Completed	9
DB00641	Simvastatin	3	Terminated	1
DB00086	Streptokinase	3	Completed	2
DB00675	Tamoxifen	3	Completed	1
DB01162	Terazosin	3	Completed	1
DB08816	Ticagrelor	3	Withdrawn	1
DB06281	Torcetrapib	3	Completed	1
DB06281	Torcetrapib	3	Terminated	1
DB00384	Triamterene	3	Completed	1
DB00177	Valsartan	3	Completed	1
DB11094	Vitamin D	3	Completed	1
DB00163	Vitamin E	3	Completed	3
DB00682	Warfarin	3	Completed	1
DB13453	Xenon	3	Completed	1
DB00054	Abciximab	4	Completed	3
DB00054	Abciximab	4	Terminated	1
DB00284	Acarbose	4	Completed	1
DB00945	Acetylsalicylic acid	4	Active Not Recruiting	1
DB00945	Acetylsalicylic acid	4	Completed	11
DB00945	Acetylsalicylic acid	4	Not Yet Recruiting	2
DB00945	Acetylsalicylic acid	4	Recruiting	1
DB12417	Anagliptin	4	Completed	1
DB00335	Atenolol	4	Completed	1
DB01076	Atorvastatin	4	Completed	8
DB01076	Atorvastatin	4	Not Yet Recruiting	1
DB01076	Atorvastatin	4	Terminated	1
DB01076	Atorvastatin	4	Unknown Status	2
DB12768	BCG vaccine	4	Completed	1
DB00006	Bivalirudin	4	Completed	2
DB00006	Bivalirudin	4	Unknown Status	1
DB01136	Carvedilol	4	Unknown Status	1
DB00758	Clopidogrel	4	Active Not Recruiting	1
DB00758	Clopidogrel	4	Completed	10
DB00758	Clopidogrel	4	Not Yet Recruiting	2
DB00758	Clopidogrel	4	Recruiting	1
DB00758	Clopidogrel	4	Unknown Status	4
DB00758	Clopidogrel	4	Withdrawn	1
DB14726	Dabigatran	4	Completed	1
DB14726	Dabigatran	4	Terminated	1
DB14726	Dabigatran	4	Withdrawn	1
DB01189	Desflurane	4	Recruiting	1
DB00975	Dipyridamole	4	Completed	1
DB09038	Empagliflozin	4	Completed	1
DB09038	Empagliflozin	4	Recruiting	1
DB01225	Enoxaparin	4	Completed	1
DB01175	Escitalopram	4	Completed	1
DB00973	Ezetimibe	4	Completed	5
DB00973	Ezetimibe	4	Unknown Status	1
DB00927	Famotidine	4	Completed	1
DB01039	Fenofibrate	4	Completed	1
DB01095	Fluvastatin	4	Completed	2
DB01095	Fluvastatin	4	Unknown Status	1
DB01109	Heparin	4	Completed	2
DB01109	Heparin	4	Unknown Status	1
DB09106	Hydroxyethyl Starch	4	Completed	1
DB14901	Inclisiran	4	Recruiting	1
DB00753	Isoflurane	4	Recruiting	1
DB00883	Isosorbide dinitrate	4	Completed	1
DB01020	Isosorbide mononitrate	4	Not Yet Recruiting	1
DB09083	Ivabradine	4	Unknown Status	1
DB04398	Lactic acid	4	Completed	1
DB11629	Laropiprant	4	Completed	1
DB00722	Lisinopril	4	Completed	1
DB00264	Metoprolol	4	Completed	1
DB00264	Metoprolol	4	Not Yet Recruiting	1
DB00627	Niacin	4	Completed	3
DB09220	Nicorandil	4	Completed	1
DB09220	Nicorandil	4	Not Yet Recruiting	1
DB09220	Nicorandil	4	Unknown Status	1
DB00184	Nicotine	4	Completed	1
DB00727	Nitroglycerin	4	Not Yet Recruiting	1
DB00727	Nitroglycerin	4	Unknown Status	2
DB00338	Omeprazole	4	Completed	1
DB00213	Pantoprazole	4	Completed	1
DB00946	Phenprocoumon	4	Terminated	1
DB00946	Phenprocoumon	4	Withdrawn	1
DB09528	Phylloquinone	4	Withdrawn	1
DB01132	Pioglitazone	4	Completed	1
DB01132	Pioglitazone	4	Unknown Status	1
DB08860	Pitavastatin	4	Completed	2
DB06209	Prasugrel	4	Completed	1
DB06209	Prasugrel	4	Unknown Status	1
DB00175	Pravastatin	4	Completed	1
DB00175	Pravastatin	4	Unknown Status	1
DB00818	Propofol	4	Recruiting	1
DB00571	Propranolol	4	Completed	1
DB00178	Ramipril	4	Unknown Status	1
DB06213	Regadenoson	4	Completed	1
DB06228	Rivaroxaban	4	Withdrawn	1
DB01098	Rosuvastatin	4	Completed	2
DB01098	Rosuvastatin	4	Unknown Status	3
DB01236	Sevoflurane	4	Recruiting	1
DB00641	Simvastatin	4	Completed	5
DB00877	Sirolimus	4	Completed	1
DB01261	Sitagliptin	4	Completed	2
DB00966	Telmisartan	4	Unknown Status	1
DB08816	Ticagrelor	4	Completed	1
DB08816	Ticagrelor	4	Not Yet Recruiting	1
DB08816	Ticagrelor	4	Unknown Status	3
DB00775	Tirofiban	4	Terminated	1
DB09069	Trimetazidine	4	Not Yet Recruiting	1
DB09069	Trimetazidine	4	Unknown Status	1
DB01273	Varenicline	4	Completed	1
DB00945	Acetylsalicylic acid	Not Available	Completed	4
DB00945	Acetylsalicylic acid	Not Available	Withdrawn	1
DB00062	Albumin human	Not Available	Active Not Recruiting	1
DB00381	Amlodipine	Not Available	Completed	1
DB00381	Amlodipine	Not Available	Withdrawn	1
DB09326	Ammonia N-13	Not Available	Recruiting	1
DB11842	Angiotensin II	Not Available	Completed	1
DB11842	Angiotensin II	Not Available	Recruiting	1
DB00335	Atenolol	Not Available	Withdrawn	1
DB12054	BQ-123	Not Available	Completed	1
DB17984	BQ-788	Not Available	Completed	1
DB00612	Bisoprolol	Not Available	Completed	1
DB00006	Bivalirudin	Not Available	Completed	1
DB00006	Bivalirudin	Not Available	Withdrawn	1
DB01136	Carvedilol	Not Available	Completed	1
DB00310	Chlorthalidone	Not Available	Completed	1
DB01166	Cilostazol	Not Available	Completed	1
DB00636	Clofibrate	Not Available	Completed	1
DB00758	Clopidogrel	Not Available	Completed	5
DB06311	Darapladib	Not Available	Completed	1
DB00633	Dexmedetomidine	Not Available	Completed	1
DB00509	Dextrothyroxine	Not Available	Completed	1
DB00590	Doxazosin	Not Available	Completed	1
DB00584	Enalapril	Not Available	Withdrawn	1
DB12652	Endothelin-1	Not Available	Completed	1
DB01225	Enoxaparin	Not Available	Completed	1
DB00783	Estradiol	Not Available	Completed	2
DB00783	Estradiol	Not Available	Terminated	1
DB00977	Ethinylestradiol	Not Available	Completed	1
DB09303	Evolocumab	Not Available	Completed	1
DB01276	Exenatide	Not Available	Active Not Recruiting	1
DB00973	Ezetimibe	Not Available	Completed	2
DB00973	Ezetimibe	Not Available	Unknown Status	1
DB00222	Glimepiride	Not Available	Completed	1
DB00999	Hydrochlorothiazide	Not Available	Completed	1
DB00030	Insulin human	Not Available	Completed	3
DB00753	Isoflurane	Not Available	Completed	1
DB01064	Isoprenaline	Not Available	Completed	1
DB01020	Isosorbide mononitrate	Not Available	Withdrawn	1
DB00007	Leuprolide	Not Available	Completed	1
DB00367	Levonorgestrel	Not Available	Completed	1
DB00722	Lisinopril	Not Available	Completed	1
DB00331	Metformin	Not Available	Completed	1
DB00264	Metoprolol	Not Available	Completed	1
DB00471	Montelukast	Not Available	Completed	1
DB00627	Niacin	Not Available	Completed	2
DB00727	Nitroglycerin	Not Available	Withdrawn	1
DB09140	Oxygen	Not Available	Active Not Recruiting	1
DB00790	Perindopril	Not Available	Completed	1
DB14500	Potassium	Not Available	Completed	1
DB00396	Progesterone	Not Available	Completed	1
DB00818	Propofol	Not Available	Completed	1
DB06213	Regadenoson	Not Available	Completed	1
DB06233	Ridaforolimus	Not Available	Completed	1
DB01098	Rosuvastatin	Not Available	Completed	1
DB01236	Sevoflurane	Not Available	Completed	1
DB00641	Simvastatin	Not Available	Completed	1
DB00641	Simvastatin	Not Available	Unknown Status	1
DB00421	Spironolactone	Not Available	Completed	1
DB11300	Thrombin	Not Available	Withdrawn	1
DB08816	Ticagrelor	Not Available	Completed	2
DB00661	Verapamil	Not Available	Completed	1
DB04878	Voglibose	Not Available	Unknown Status	1