Castration Resistant Prostate Cancer

Also known as: Castrate-Resistant Prostate Cancer / Castration Resistant Prostate Cancer (CRPC) / Castrate Resistant Prostate Cancer (CRPC) / Castrate Resistance Prostate Cancer / Castrate Resistent Prostate Cancer / Castrate Resistant Prostate Cancer / Castration-Resistant Prostate Cancer (CRPC) / Castration resistant / Castration-Resistant Prostate Cancer / Castration-Resistant / Castrate-resistant Prostate Cancer (CRPC) / Castration Resistant Prostate Cancer, CRPC / Prostate Cancer (CRPC) / Prostate Cancer Castration-resistant Prostate Cancer / Prostatic Cancer, Castration-Resistant / Castration Resistant Prostatic Cancer / Castration-Resistant Prostatic Cancer / Hormone-refractory prostate cancer / Hormone refractory prostate cancer (disorder)

Drug	Drug Name	Drug Description
DB08899	Enzalutamide	A second-generation androgen receptor inhibitor used to treat castration-resistant prostate cancer and metastatic castration-sensitive prostate cancer.

Drug	Drug Name	Target	Type
DB08899	Enzalutamide	Serum albumin	carrier
DB08899	Enzalutamide	Cytochrome P450 2C8	enzyme
DB08899	Enzalutamide	Cytochrome P450 3A4	enzyme
DB08899	Enzalutamide	Androgen receptor	target
DB08899	Enzalutamide	Cytochrome P450 2C9	enzyme
DB08899	Enzalutamide	Cytochrome P450 2C19	enzyme
DB08899	Enzalutamide	Cytochrome P450 2B6	enzyme
DB08899	Enzalutamide	Cytochrome P450 3A5	enzyme
DB08899	Enzalutamide	P-glycoprotein 1	transporter

Drug	Drug Name	Phase	Status	Count
DB00035	Desmopressin	0	Unknown Status	1
DB08899	Enzalutamide	0	Active Not Recruiting	1
DB08884	Gadoxetic acid	0	Unknown Status	1
DB00624	Testosterone	0	Active Not Recruiting	1
DB05812	Abiraterone	1	Active Not Recruiting	3
DB05812	Abiraterone	1	Completed	2
DB05812	Abiraterone	1	Withdrawn	1
DB11901	Apalutamide	1	Completed	1
DB11595	Atezolizumab	1	Completed	1
DB11595	Atezolizumab	1	Terminated	1
DB15189	Birabresib	1	Completed	1
DB15189	Birabresib	1	Terminated	1
DB11666	Buparlisib	1	Completed	1
DB12740	CC-115	1	Completed	1
DB17269	Cirtuvivint	1	Active Not Recruiting	1
DB08865	Crizotinib	1	Completed	1
DB11651	Dactolisib	1	Completed	1
DB17208	Disitamab vedotin	1	Not Yet Recruiting	1
DB01248	Docetaxel	1	Active Not Recruiting	1
DB01248	Docetaxel	1	Completed	2
DB01248	Docetaxel	1	Terminated	1
DB05094	Enzalutamide	1	Completed	3
DB08899	Enzalutamide	1	Completed	5
DB17506	Etrumadenant	1	Completed	1
DB00544	Fluorouracil	1	Active Not Recruiting	1
DB15637	Fluzoparib	1	Active Not Recruiting	1
DB00441	Gemcitabine	1	Terminated	1
DB11918	Guadecitabine	1	Active Not Recruiting	1
DB11743	Ipatasertib	1	Terminated	1
DB06186	Ipilimumab	1	Completed	1
DB00762	Irinotecan	1	Active Not Recruiting	1
DB00650	Leucovorin	1	Active Not Recruiting	1
DB00683	Midazolam	1	Completed	1
DB00338	Omeprazole	1	Completed	1
DB14799	PF-06821497	1	Recruiting	1
DB01229	Paclitaxel	1	Terminated	1
DB01269	Panitumumab	1	Active Not Recruiting	1
DB06663	Pasireotide	1	Completed	1
DB09037	Pembrolizumab	1	Active Not Recruiting	1
DB09037	Pembrolizumab	1	Recruiting	1
DB09037	Pembrolizumab	1	Terminated	1
DB01132	Pioglitazone	1	Completed	1
DB00635	Prednisone	1	Active Not Recruiting	1
DB00635	Prednisone	1	Withdrawn	1
DB08913	Radium Ra 223 dichloride	1	Completed	1
DB15766	Retifanlimab	1	Active Not Recruiting	1
DB04974	Rimiducid	1	Completed	2
DB11127	Selenious acid	1	Withdrawn	1
DB06688	Sipuleucel-T	1	Completed	1
DB00682	Warfarin	1	Completed	1
DB17505	Zimberelimab	1	Completed	1
DB05812	Abiraterone	1 / 2	Recruiting	1
DB05812	Abiraterone	1 / 2	Terminated	1
DB11595	Atezolizumab	1 / 2	Active Not Recruiting	1
DB01128	Bicalutamide	1 / 2	Terminated	1
DB05153	Cabozantinib	1 / 2	Active Not Recruiting	1
DB08875	Cabozantinib	1 / 2	Active Not Recruiting	1
DB00958	Carboplatin	1 / 2	Unknown Status	1
DB01992	Coenzyme A	1 / 2	Recruiting	1
DB00531	Cyclophosphamide	1 / 2	Terminated	1
DB11651	Dactolisib	1 / 2	Terminated	1
DB12941	Darolutamide	1 / 2	Terminated	1
DB01248	Docetaxel	1 / 2	Active Not Recruiting	1
DB01248	Docetaxel	1 / 2	Completed	2
DB08899	Enzalutamide	1 / 2	Active Not Recruiting	1
DB05094	Enzalutamide	1 / 2	Completed	1
DB08899	Enzalutamide	1 / 2	Recruiting	1
DB08899	Enzalutamide	1 / 2	Withdrawn	1
DB17506	Etrumadenant	1 / 2	Active Not Recruiting	1
DB11743	Ipatasertib	1 / 2	Terminated	1
DB01167	Itraconazole	1 / 2	Withdrawn	1
DB13982	Lutetium Lu-177	1 / 2	Recruiting	1
DB01204	Mitoxantrone	1 / 2	Completed	1
DB15483	Modified vaccinia ankara	1 / 2	Unknown Status	1
DB09035	Nivolumab	1 / 2	Unknown Status	1
DB17274	ONCOS-102	1 / 2	Terminated	1
DB09074	Olaparib	1 / 2	Recruiting	1
DB12066	Orteronel	1 / 2	Withdrawn	1
DB01229	Paclitaxel	1 / 2	Unknown Status	1
DB09221	Polaprezinc	1 / 2	Completed	1
DB00635	Prednisone	1 / 2	Completed	2
DB00635	Prednisone	1 / 2	Terminated	1
DB08913	Radium Ra 223 dichloride	1 / 2	Completed	1
DB09566	Radium Ra 223 dichloride	1 / 2	Completed	1
DB11972	Rilotumumab	1 / 2	Completed	1
DB18691	Rovaleucel	1 / 2	Recruiting	1
DB12893	Sacituzumab govitecan	1 / 2	Active Not Recruiting	1
DB12275	Seviteronel	1 / 2	Completed	1
DB11760	Talazoparib	1 / 2	Recruiting	1
DB00853	Temozolomide	1 / 2	Recruiting	1
DB06287	Temsirolimus	1 / 2	Terminated	1
DB16732	Tisotumab vedotin	1 / 2	Completed	2
DB17505	Zimberelimab	1 / 2	Active Not Recruiting	1
DB05812	Abiraterone	2	Active Not Recruiting	1
DB05812	Abiraterone	2	Completed	4
DB05812	Abiraterone	2	Terminated	1
DB05812	Abiraterone	2	Unknown Status	1
DB00945	Acetylsalicylic acid	2	Recruiting	1
DB16412	Adebrelimab	2	Recruiting	1
DB11901	Apalutamide	2	Recruiting	1
DB06094	Apatorsen	2	Completed	1
DB00126	Ascorbic acid	2	Recruiting	1
DB15387	Bintrafusp alfa	2	Not Yet Recruiting	1
DB06772	Cabazitaxel	2	Completed	1
DB06772	Cabazitaxel	2	Unknown Status	1
DB05153	Cabozantinib	2	Completed	1
DB08875	Cabozantinib	2	Completed	1
DB08875	Cabozantinib	2	Recruiting	1
DB05153	Cabozantinib	2	Terminated	1
DB08875	Cabozantinib	2	Terminated	2
DB00136	Calcitriol	2	Terminated	1
DB00958	Carboplatin	2	Recruiting	1
DB00958	Carboplatin	2	Terminated	1
DB06322	Carotuximab	2	Recruiting	1
DB00169	Cholecalciferol	2	Terminated	1
DB12941	Darolutamide	2	Recruiting	3
DB12941	Darolutamide	2	Terminated	1
DB06643	Denosumab	2	Terminated	1
DB01248	Docetaxel	2	Active Not Recruiting	1
DB01248	Docetaxel	2	Completed	2
DB01248	Docetaxel	2	Recruiting	1
DB01248	Docetaxel	2	Unknown Status	1
DB08899	Enzalutamide	2	Active Not Recruiting	3
DB05094	Enzalutamide	2	Completed	2
DB08899	Enzalutamide	2	Completed	5
DB08899	Enzalutamide	2	Recruiting	2
DB08899	Enzalutamide	2	Terminated	2
DB01590	Everolimus	2	Terminated	1
DB00499	Flutamide	2	Completed	1
DB15637	Fluzoparib	2	Unknown Status	1
DB00741	Hydrocortisone	2	Terminated	1
DB16479	Inbakicept	2	Not Yet Recruiting	1
DB06186	Ipilimumab	2	Recruiting	1
DB01167	Itraconazole	2	Terminated	1
DB01026	Ketoconazole	2	Terminated	1
DB13982	Lutetium Lu-177	2	Recruiting	1
DB16778	Lutetium Lu-177 vipivotide tetraxetan	2	Recruiting	1
DB17480	Nanrilkefusp alfa	2	Recruiting	1
DB11711	Navarixin	2	Completed	1
DB11828	Neratinib	2	Withdrawn	1
DB09035	Nivolumab	2	Completed	1
DB09035	Nivolumab	2	Recruiting	2
DB09074	Olaparib	2	Recruiting	1
DB00338	Omeprazole	2	Recruiting	1
DB06663	Pasireotide	2	Terminated	1
DB09037	Pembrolizumab	2	Completed	2
DB09037	Pembrolizumab	2	Recruiting	4
DB01174	Phenobarbital	2	Recruiting	1
DB00635	Prednisone	2	Completed	3
DB00635	Prednisone	2	Terminated	1
DB00635	Prednisone	2	Unknown Status	1
DB08913	Radium Ra 223 dichloride	2	Completed	1
DB09566	Radium Ra 223 dichloride	2	Completed	1
DB12813	Radium Ra-223	2	Recruiting	1
DB08896	Regorafenib	2	Withdrawn	1
DB12275	Seviteronel	2	Completed	1
DB06688	Sipuleucel-T	2	Completed	1
DB00624	Testosterone	2	Completed	1
DB13944	Testosterone enanthate	2	Recruiting	1
DB13946	Testosterone undecanoate	2	Recruiting	1
DB14922	Tislelizumab	2	Withdrawn	1
DB15219	Tomivosertib	2	Completed	1
DB11806	VTP-194204	2	Completed	1
DB01248	Docetaxel	2 / 3	Recruiting	1
DB08899	Enzalutamide	2 / 3	Recruiting	1
DB13144	Lenograstim	2 / 3	Terminated	1
DB01042	Melphalan	2 / 3	Terminated	1
DB05812	Abiraterone	3	Active Not Recruiting	1
DB06772	Cabazitaxel	3	Terminated	1
DB05153	Cabozantinib	3	Completed	1
DB08875	Cabozantinib	3	Completed	1
DB08875	Cabozantinib	3	Terminated	1
DB05487	Custirsen	3	Terminated	1
DB12941	Darolutamide	3	Completed	1
DB06643	Denosumab	3	Completed	2
DB01248	Docetaxel	3	Terminated	1
DB08899	Enzalutamide	3	Active Not Recruiting	1
DB08899	Enzalutamide	3	Completed	1
DB01204	Mitoxantrone	3	Terminated	1
DB11793	Niraparib	3	Active Not Recruiting	1
DB00635	Prednisone	3	Active Not Recruiting	1
DB00635	Prednisone	3	Completed	1
DB00635	Prednisone	3	Terminated	2
DB09153	Sodium chloride	3	Terminated	1
DB05812	Abiraterone	4	Recruiting	1
DB06643	Denosumab	4	Recruiting	1
DB08899	Enzalutamide	4	Recruiting	1
DB00644	Gonadorelin	4	Recruiting	1
DB00282	Pamidronic acid	4	Recruiting	1
DB14805	Piflufolastat F 18	4	Not Yet Recruiting	1
DB00635	Prednisone	4	Recruiting	1
DB00399	Zoledronic acid	4	Recruiting	1
DB05812	Abiraterone	Not Available	Recruiting	1
DB06772	Cabazitaxel	Not Available	Completed	1
DB01248	Docetaxel	Not Available	Completed	1
DB08899	Enzalutamide	Not Available	Completed	1
DB13982	Lutetium Lu-177	Not Available	Available	1
DB00635	Prednisone	Not Available	Recruiting	1
DB08913	Radium Ra 223 dichloride	Not Available	Active Not Recruiting	1
DB08913	Radium Ra 223 dichloride	Not Available	Completed	3
DB09566	Radium Ra 223 dichloride	Not Available	Completed	1
DB08913	Radium Ra 223 dichloride	Not Available	Unknown Status	1
DB12813	Radium Ra-223	Not Available	Completed	1
DB12813	Radium Ra-223	Not Available	Unknown Status	1