Chronic Heart Failure (CHF)

Also known as: Chronic Heart Failure / Cardiac failure chronic

Drug	Drug Name	Drug Description
DB01396	Digitoxin	A cardiac glycoside used in the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure.
DB09083	Ivabradine	A HCN channel blocker used to reduce the risk of hospitalization for worsening heart failure in adult patients and for treatment of stable symptomatic heart failure as a result of dilated cardiomyopathy in pediatric patients.
DB00922	Levosimendan	A calcium sensitizer indicated to treat acutely decompensated severe chronic heart failure.
DB13401	Metildigoxin	A digitalis glycoside indicated in the treatment of acute and chronic heart failure.

Drug	Drug Name	Target	Type
DB01396	Digitoxin	Sodium/potassium-transporting ATPase subunit alpha-1	target
DB01396	Digitoxin	Serum albumin	carrier
DB01396	Digitoxin	Cholesterol side-chain cleavage enzyme, mitochondrial	enzyme
DB01396	Digitoxin	Cytochrome P450 3A4	enzyme
DB01396	Digitoxin	Solute carrier organic anion transporter family member 1A2	transporter
DB01396	Digitoxin	Solute carrier organic anion transporter family member 4C1	transporter
DB01396	Digitoxin	P-glycoprotein 1	transporter
DB09083	Ivabradine	Cytochrome P450 3A4	enzyme
DB09083	Ivabradine	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	target
DB00922	Levosimendan	Troponin C, slow skeletal and cardiac muscles	target
DB00922	Levosimendan	ATP-sensitive inward rectifier potassium channel 11	target
DB00922	Levosimendan	ATP-sensitive inward rectifier potassium channel 8	target
DB00922	Levosimendan	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	target

Drug	Drug Name	Phase	Status	Count
DB00171	ATP	1	Completed	1
DB11777	Cenderitide	1	Completed	1
DB15288	Etamicastat	1	Completed	3
DB08917	Ferric carboxymaltose	1	Completed	1
DB09069	Trimetazidine	1	Unknown Status	1
DB09146	Iron sucrose	1 / 2	Unknown Status	1
DB12497	Alagebrium	2	Terminated	1
DB00381	Amlodipine	2	Terminated	1
DB11842	Angiotensin II	2	Suspended	1
DB16593	Chinese cinnamon	2	Completed	1
DB00169	Cholecalciferol	2	Completed	1
DB00872	Conivaptan	2	Completed	1
DB11981	Elamipretide	2	Completed	1
DB09038	Empagliflozin	2	Completed	1
DB13961	Fish oil	2	Completed	1
DB15726	Human Umbilical Cord Mesenchymal Stem Cells	2	Completed	1
DB00922	Levosimendan	2	Completed	1
DB11816	Omecamtiv Mecarbil	2	Completed	1
DB01074	Perhexiline	2	Completed	1
DB11333	Poloxamer 188	2	Terminated	1
DB09292	Sacubitril	2	Completed	1
DB05794	Serelaxin	2	Completed	1
DB05794	Serelaxin	2	Terminated	1
DB00052	Somatotropin	2	Completed	1
DB00052	Somatotropin	2	Suspended	1
DB00177	Valsartan	2	Completed	2
DB00067	Vasopressin	2	Completed	1
DB11094	Vitamin D	2	Completed	1
DB00331	Metformin	2 / 3	Completed	1
DB01104	Sertraline	2 / 3	Completed	1
DB09026	Aliskiren	3	Completed	1
DB00126	Ascorbic acid	3	Completed	1
DB00612	Bisoprolol	3	Completed	1
DB08907	Canagliflozin	3	Recruiting	1
DB01136	Carvedilol	3	Completed	1
DB00169	Cholecalciferol	3	Terminated	1
DB09038	Empagliflozin	3	Recruiting	1
DB00584	Enalapril	3	Completed	1
DB08917	Ferric carboxymaltose	3	Completed	2
DB08917	Ferric carboxymaltose	3	Terminated	1
DB14491	Ferrous fumarate	3	Completed	1
DB15839	Hawthorn leaf with flower	3	Completed	1
DB01592	Iron	3	Withdrawn	1
DB15763	Iron polymaltose	3	Completed	1
DB09083	Ivabradine	3	Completed	1
DB16956	L-Acetylleucine	3	Completed	1
DB00275	Olmesartan	3	Completed	1
DB17606	Rexlemestrocel-L	3	Completed	1
DB09292	Sacubitril	3	Completed	1
DB06417	Somatotropin	3	Completed	1
DB00152	Thiamine	3	Completed	1
DB00177	Valsartan	3	Completed	1
DB00163	Vitamin E	3	Completed	1
DB00819	Acetazolamide	4	Active Not Recruiting	1
DB00819	Acetazolamide	4	Completed	1
DB00819	Acetazolamide	4	Recruiting	1
DB00437	Allopurinol	4	Completed	2
DB01118	Amiodarone	4	Completed	1
DB00612	Bisoprolol	4	Completed	2
DB01136	Carvedilol	4	Completed	1
DB00390	Digoxin	4	Completed	1
DB08917	Ferric carboxymaltose	4	Completed	1
DB08917	Ferric carboxymaltose	4	Recruiting	1
DB15617	Ferric derisomaltose	4	Completed	1
DB00695	Furosemide	4	Active Not Recruiting	1
DB00695	Furosemide	4	Completed	1
DB00695	Furosemide	4	Recruiting	1
DB00999	Hydrochlorothiazide	4	Recruiting	1
DB14522	Hydroxide ion	4	Completed	1
DB10791	Influenza A virus A/California/7/2009 X-179A (H1N1) antigen (formaldehyde inactivated)	4	Completed	1
DB14445	Influenza A virus A/Victoria/210/2009 X-187 (H3N2) antigen (formaldehyde inactivated)	4	Completed	1
DB10794	Influenza B virus B/Brisbane/60/2008 antigen (formaldehyde inactivated)	4	Completed	1
DB01029	Irbesartan	4	Completed	1
DB01592	Iron	4	Completed	1
DB01592	Iron	4	Unknown Status	1
DB12208	Iron isomaltoside 1000	4	Completed	1
DB15763	Iron polymaltose	4	Completed	2
DB15763	Iron polymaltose	4	Recruiting	1
DB11209	Iron protein succinylate	4	Unknown Status	1
DB09146	Iron sucrose	4	Completed	1
DB11110	Magnesium citrate	4	Active Not Recruiting	1
DB00331	Metformin	4	Completed	1
DB00524	Metolazone	4	Active Not Recruiting	1
DB04861	Nebivolol	4	Completed	1
DB04899	Nesiritide	4	Completed	1
DB14556	Peracetic acid	4	Completed	1
DB08860	Pitavastatin	4	Completed	1
DB00175	Pravastatin	4	Completed	1
DB09292	Sacubitril	4	Completed	1
DB13946	Testosterone undecanoate	4	Completed	1
DB00214	Torasemide	4	Unknown Status	1
DB00177	Valsartan	4	Completed	1
DB11094	Vitamin D	4	Completed	1
DB04630	Aldosterone	Not Available	Completed	1
DB00612	Bisoprolol	Not Available	Completed	1
DB00612	Bisoprolol	Not Available	Unknown Status	1
DB01197	Captopril	Not Available	Completed	1
DB01136	Carvedilol	Not Available	Completed	1
DB01136	Carvedilol	Not Available	Not Yet Recruiting	1
DB01136	Carvedilol	Not Available	Unknown Status	1
DB00584	Enalapril	Not Available	Completed	1
DB00700	Eplerenone	Not Available	Completed	1
DB00222	Glimepiride	Not Available	Completed	1
DB09146	Iron sucrose	Not Available	Completed	1
DB09083	Ivabradine	Not Available	Completed	2
DB09083	Ivabradine	Not Available	Unknown Status	1
DB06655	Liraglutide	Not Available	Completed	1
DB00722	Lisinopril	Not Available	Completed	1
DB00264	Metoprolol	Not Available	Completed	1
DB00264	Metoprolol	Not Available	Not Yet Recruiting	1
DB00790	Perindopril	Not Available	Completed	1
DB00178	Ramipril	Not Available	Completed	1
DB09292	Sacubitril	Not Available	Completed	2
DB09292	Sacubitril	Not Available	Unknown Status	1
DB00421	Spironolactone	Not Available	Completed	1
DB00177	Valsartan	Not Available	Completed	2
DB00177	Valsartan	Not Available	Unknown Status	1
DB15456	Vericiguat	Not Available	Recruiting	1