Pulmonary Hypertension (PH)

Also known as: Pulmonary; Hypertension / Hypertension Pulmonary / Hypertension, Pulmonary / Pulmonary hypertensions / Pulmonary Hypertension / Other secondary pulmonary hypertension / Pulmonary hypertension NOS

DrugDrug NameDrug Description
DB00343DiltiazemA calcium channel blocker used to treat hypertension and to manage chronic stable angina.
DB01115NifedipineA dihydropyridine calcium channel blocker indicated for the management of several subtypes of angina pectoris, and hypertension.
DB00435Nitric OxideA vasodilating agent used in the treatment of hypoxic respiratory failure in premature neonates.
DB09140OxygenAn essential element for human survival used in clinical conditions in which there is a lack of oxygen, such as, but not limited to, anoxia, hypoxia or dyspnea.
DB00374TreprostinilA prostacyclin vasodilator for the treatment of pulmonary arterial hypertension to relieve exercise associated symptoms and to prevent clinical deterioration after stopping epoprostenol.
DrugDrug NameTargetType
DB00343DiltiazemVoltage-dependent calcium channel gamma-1 subunittarget
DB00343DiltiazemCytochrome P450 3A4enzyme
DB00343DiltiazemCytochrome P450 2C19enzyme
DB00343DiltiazemCytochrome P450 2D6enzyme
DB00343DiltiazemCytochrome P450 3A5enzyme
DB00343DiltiazemCytochrome P450 3A7enzyme
DB00343DiltiazemP-glycoprotein 1transporter
DB00343DiltiazemCytochrome P450 2C8enzyme
DB00343DiltiazemSerum albumincarrier
DB00343DiltiazemAlpha-1-acid glycoprotein 1carrier
DB00343DiltiazemVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB01115NifedipineCytochrome P450 3A4enzyme
DB01115NifedipineCytochrome P450 2E1enzyme
DB01115NifedipineCytochrome P450 2D6enzyme
DB01115NifedipineCalmodulintarget
DB01115NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB01115NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB01115NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB01115NifedipineVoltage-dependent L-type calcium channel subunit beta-2target
DB01115NifedipinePotassium voltage-gated channel subfamily D member 3target
DB01115NifedipineVoltage-dependent T-type calcium channeltarget
DB01115NifedipineCytochrome P450 1A2enzyme
DB01115NifedipineCytochrome P450 2A6enzyme
DB01115NifedipineCytochrome P450 2C8enzyme
DB01115NifedipineCanalicular multispecific organic anion transporter 2transporter
DB01115NifedipineP-glycoprotein 1transporter
DB01115NifedipineCanalicular multispecific organic anion transporter 1transporter
DB01115NifedipineCytochrome P450 1A1enzyme
DB01115NifedipineCytochrome P450 2B6enzyme
DB01115NifedipineNuclear receptor subfamily 1 group I member 2target
DB01115NifedipineSolute carrier organic anion transporter family member 1B1transporter
DB01115NifedipineBile salt export pumptransporter
DB01115NifedipineCytochrome P450 2C9enzyme
DB01115NifedipineSerum albumincarrier
DB01115Nifedipinealpha1-acid glycoproteincarrier
DB01115NifedipineCytochrome P450 3A5enzyme
DB00435Nitric OxideGuanylate cyclase soluble subunit alpha-2target
DB00435Nitric OxideAldehyde dehydrogenase, mitochondrialenzyme
DB00435Nitric OxideCytochrome P450 1A2enzyme
DB00435Nitric OxideCytochrome P450 2B6enzyme
DB00435Nitric OxideCytochrome P450 3A4enzyme
DB00435Nitric OxideMetallothionein-1Atarget
DB00435Nitric OxideIndoleamine 2,3-dioxygenase 1target
DB00435Nitric OxideNitric oxide synthase, endothelialtarget
DB09140OxygenNADPH oxidase 1target
DB09140OxygenCytochrome c oxidase subunit 1target
DB09140OxygenHemoglobin subunit betacarrier
DB09140OxygenHemoglobin subunit alphacarrier
DB00374TreprostinilP2Y purinoceptor 12target
DB00374TreprostinilPeroxisome proliferator-activated receptor deltatarget
DB00374TreprostinilProstacyclin receptortarget
DB00374TreprostinilCytochrome P450 2C9enzyme
DB00374TreprostinilProstaglandin E2 receptor EP2 subtypetarget
DB00374TreprostinilProstaglandin D2 receptortarget
DB00374TreprostinilCytochrome P450 2C8enzyme
DrugDrug NamePhaseStatusCount
DB00155Citrulline0Terminated1
DB09155Helium0Recruiting1
DB01005Hydroxyurea0Withdrawn1
DB00435Nitric Oxide0Not Yet Recruiting1
DB00435Nitric Oxide0Terminated1
DB00556Perflutren0Recruiting1
DB11104Sulfur hexafluoride0Recruiting1
DB13453Xenon0Recruiting1
DB00062Albumin human1Completed1
DB06403Ambrisentan1Completed1
DB00559Bosentan1Completed1
DB01197Captopril1Completed1
DB01136Carvedilol1Completed1
DB01136Carvedilol1Terminated1
DB01136Carvedilol1Withdrawn1
DB00878Chlorhexidine1Withdrawn1
DB08908Dimethyl fumarate1Terminated1
DB01240Epoprostenol1Unknown Status1
DB00016Erythropoietin1Completed1
DB00736Esomeprazole1Completed1
DB16106GSK22560981Completed1
DB01005Hydroxyurea1Completed1
DB01088Iloprost1Completed1
DB00619Imatinib1Withdrawn1
DB14049Nitrate1Completed1
DB14049Nitrate1Withdrawn1
DB00435Nitric Oxide1Completed3
DB00727Nitroglycerin1Unknown Status1
DB09112Nitrous acid1Completed1
DB08931Riociguat1Completed2
DB00203Sildenafil1Completed1
DB00641Simvastatin1Unknown Status1
DB00877Sirolimus1Completed1
DB15952Sodium nitrate1Completed1
DB15952Sodium nitrate1Withdrawn1
DB00421Spironolactone1Completed1
DB00820Tadalafil1Completed1
DB00374Treprostinil1Completed3
DB09145Water1Withdrawn1
DB13453Xenon1Recruiting1
DB00026Anakinra1 / 2Terminated1
DB11588Carbon monoxide1 / 2Withdrawn1
DB15107Fludeoxyglucose1 / 2Completed1
DB01005Hydroxyurea1 / 2Terminated1
DB01088Iloprost1 / 2Withdrawn1
DB00235Milrinone1 / 2Completed1
DB00435Nitric Oxide1 / 2Recruiting1
DB13928Semaglutide1 / 2Recruiting1
DB00203Sildenafil1 / 2Completed1
DB00641Simvastatin1 / 2Completed1
DB00819Acetazolamide2Completed1
DB15111Acetic acid C-112Completed1
DB00945Acetylsalicylic acid2Completed1
DB00945Acetylsalicylic acid2Terminated1
DB00087Alemtuzumab2Recruiting1
DB00770Alprostadil2Terminated1
DB00770Alprostadil2Withdrawn1
DB15736Alunacedase alfa2Completed1
DB06403Ambrisentan2Completed6
DB06403Ambrisentan2Terminated1
DB00098Antithymocyte immunoglobulin (rabbit)2Recruiting1
DB01076Atorvastatin2Completed1
DB12054BQ-1232Completed1
DB05983Bardoxolone methyl2Completed1
DB00559Bosentan2Terminated3
DB06774Capsaicin2Completed2
DB00758Clopidogrel2Completed1
DB09110Coenzyme M2Recruiting1
DB00531Cyclophosphamide2Recruiting1
DB01240Epoprostenol2Completed1
DB01240Epoprostenol2Terminated1
DB00099Filgrastim2Recruiting1
DB09150Fludeoxyglucose (18F)2Completed1
DB00028Human immunoglobulin G2Recruiting1
DB07118Hymecromone2Completed1
DB01088Iloprost2Completed3
DB01088Iloprost2Terminated2
DB01088Iloprost2Withdrawn1
DB00619Imatinib2Terminated1
DB01592Iron2Withdrawn1
DB09146Iron sucrose2Withdrawn1
DB00130L-Glutamine2Completed1
DB08932Macitentan2Completed2
DB08932Macitentan2Terminated1
DB00331Metformin2Recruiting1
DB00235Milrinone2Completed2
DB08893Mirabegron2Unknown Status1
DB00435Nitric Oxide2Active Not Recruiting1
DB00435Nitric Oxide2Completed2
DB00435Nitric Oxide2Terminated1
DB00435Nitric Oxide2Unknown Status1
DB00435Nitric Oxide2Withdrawn1
DB12529Nitrite2Completed2
DB09112Nitrous acid2Completed1
DB11736PF-004897912Terminated1
DB05607PRX-080662Completed1
DB05607PRX-080662Terminated1
DB01132Pioglitazone2Terminated1
DB01708Prasterone2Completed1
DB08931Riociguat2Active Not Recruiting2
DB08931Riociguat2Completed3
DB08931Riociguat2Recruiting1
DB08931Riociguat2Terminated2
DB00073Rituximab2Recruiting1
DB01001Salbutamol2Completed1
DB11362Selexipag2Unknown Status1
DB00203Sildenafil2Completed5
DB00203Sildenafil2Recruiting1
DB00203Sildenafil2Terminated3
DB00641Simvastatin2Terminated1
DB12118Sotatercept2Recruiting1
DB11104Sulfur hexafluoride2Completed1
DB00820Tadalafil2Completed2
DB00820Tadalafil2Not Yet Recruiting1
DB12204Terbogrel2Completed1
DB12204Terbogrel2Terminated1
DB04572Thiotepa2Recruiting1
DB00374Treprostinil2Completed1
DB00374Treprostinil2Terminated1
DB00374Treprostinil2Withdrawn2
DB00067Vasopressin2Terminated1
DB00682Warfarin2Terminated1
DB00819Acetazolamide2 / 3Completed2
DB06403Ambrisentan2 / 3Completed2
DB00559Bosentan2 / 3Completed1
DB00633Dexmedetomidine2 / 3Terminated1
DB01088Iloprost2 / 3Completed1
DB01088Iloprost2 / 3Unknown Status1
DB08932Macitentan2 / 3Unknown Status1
DB00235Milrinone2 / 3Active Not Recruiting1
DB00203Sildenafil2 / 3Completed2
DB00203Sildenafil2 / 3Terminated1
DB00203Sildenafil2 / 3Unknown Status2
DB06268Sitaxentan2 / 3Unknown Status1
DB00820Tadalafil2 / 3Completed1
DB00374Treprostinil2 / 3Completed1
DB00374Treprostinil2 / 3Terminated1
DB00945Acetylsalicylic acid3Completed1
DB06403Ambrisentan3Completed5
DB06403Ambrisentan3Terminated1
DB05983Bardoxolone methyl3Terminated1
DB00559Bosentan3Completed3
DB00559Bosentan3Terminated4
DB00559Bosentan3Unknown Status1
DB00155Citrulline3Completed1
DB01175Escitalopram3Completed1
DB15598Ferric maltol3Terminated1
DB01088Iloprost3Completed4
DB01088Iloprost3Terminated1
DB00678Losartan3Completed1
DB08932Macitentan3Recruiting1
DB00235Milrinone3Completed1
DB01115Nifedipine3Completed1
DB00435Nitric Oxide3Completed1
DB00435Nitric Oxide3Terminated4
DB09140Oxygen3Terminated1
DB01708Prasterone3Unknown Status1
DB12462Ralinepag3Enrolling by Invitation1
DB12462Ralinepag3Recruiting1
DB12462Ralinepag3Terminated1
DB08931Riociguat3Active Not Recruiting1
DB08931Riociguat3Completed5
DB09292Sacubitril3Completed1
DB11362Selexipag3Active Not Recruiting2
DB11362Selexipag3Recruiting1
DB00203Sildenafil3Completed6
DB00203Sildenafil3Terminated3
DB00203Sildenafil3Unknown Status5
DB00203Sildenafil3Withdrawn2
DB06268Sitaxentan3Completed1
DB06268Sitaxentan3Terminated5
DB00820Tadalafil3Completed4
DB00820Tadalafil3Not Yet Recruiting1
DB00820Tadalafil3Recruiting1
DB00820Tadalafil3Terminated1
DB00820Tadalafil3Withdrawn1
DB06558Tezosentan3Terminated1
DB00374Treprostinil3Completed6
DB00374Treprostinil3Terminated3
DB00374Treprostinil3Withdrawn1
DB06267Udenafil3Completed1
DB00177Valsartan3Completed1
DB00862Vardenafil3Completed1
DB00819Acetazolamide4Completed1
DB00009Alteplase4Completed1
DB06403Ambrisentan4Completed2
DB06403Ambrisentan4Terminated1
DB06403Ambrisentan4Unknown Status1
DB06403Ambrisentan4Withdrawn1
DB00559Bosentan4Completed2
DB00559Bosentan4Terminated1
DB00559Bosentan4Unknown Status1
DB04920Clevidipine4Completed1
DB09341Dextrose, unspecified form4Completed1
DB01240Epoprostenol4Completed3
DB01240Epoprostenol4Recruiting1
DB01240Epoprostenol4Terminated1
DB14148Human albumin microspheres4Completed1
DB01088Iloprost4Terminated3
DB00753Isoflurane4Completed1
DB00703Methazolamide4Completed1
DB04861Nebivolol4Terminated1
DB04899Nesiritide4Completed1
DB04899Nesiritide4Terminated1
DB00435Nitric Oxide4Recruiting1
DB00435Nitric Oxide4Terminated1
DB00556Perflutren4Completed1
DB00818Propofol4Completed1
DB00243Ranolazine4Completed3
DB08931Riociguat4Completed2
DB08931Riociguat4Recruiting1
DB08931Riociguat4Unknown Status1
DB00203Sildenafil4Completed5
DB00203Sildenafil4Terminated1
DB00203Sildenafil4Withdrawn2
DB00421Spironolactone4Unknown Status1
DB00820Tadalafil4Completed2
DB00820Tadalafil4Withdrawn1
DB00374Treprostinil4Completed3
DB00374Treprostinil4Recruiting1
DB00374Treprostinil4Terminated2
DB04630AldosteroneNot AvailableCompleted1
DB00770AlprostadilNot AvailableCompleted1
DB06403AmbrisentanNot AvailableCompleted2
DB06403AmbrisentanNot AvailableWithdrawn1
DB00125ArginineNot AvailableCompleted1
DB00559BosentanNot AvailableCompleted1
DB00559BosentanNot AvailableWithdrawn1
DB01136CarvedilolNot AvailableCompleted1
DB00872ConivaptanNot AvailableWithdrawn1
DB01262DecitabineNot AvailableCompleted1
DB08826DeferiproneNot AvailableCompleted1
DB00746DeferoxamineNot AvailableCompleted1
DB00390DigoxinNot AvailableCompleted1
DB01240EpoprostenolNot AvailableCompleted1
DB00292EtomidateNot AvailableRecruiting1
DB09502Fludeoxyglucose (18F)Not AvailableRecruiting1
DB01088IloprostNot AvailableCompleted11
DB09146Iron sucroseNot AvailableCompleted1
DB01221KetamineNot AvailableRecruiting1
DB00922LevosimendanNot AvailableCompleted1
DB00922LevosimendanNot AvailableRecruiting1
DB00235MilrinoneNot AvailableRecruiting1
DB14049NitrateNot AvailableCompleted1
DB06213RegadenosonNot AvailableTerminated1
DB08931RiociguatNot AvailableCompleted4
DB08931RiociguatNot AvailableNo Longer Available1
DB00203SildenafilNot AvailableCompleted5
DB00203SildenafilNot AvailableNot Yet Recruiting1
DB00203SildenafilNot AvailableUnknown Status1
DB06268SitaxentanNot AvailableWithdrawn1
DB00421SpironolactoneNot AvailableWithdrawn1
DB00374TreprostinilNot AvailableAvailable1
DB00374TreprostinilNot AvailableCompleted1
DB18634Vasoactive intestinal peptideNot AvailableCompleted1