Metastatic Castration Sensitive Prostate Cancer

Also known as: Metastatic Castration Sensitive Prostate Cancer (mCSPC) / Metastatic Castration-sensitive Prostate Cancer / Metastatic Castrate Sensitive Prostate Cancer / Metastatic Castrate-sensitive Prostate Cancer

DrugDrug NameDrug Description
DB05812AbirateroneAn antiandrogen used in the treatment of metastatic castration-resistant prostate cancer and metastatic high-risk castration-sensitive prostate cancer.
DB11901ApalutamideAn androgen receptor inhibitor used to treat non-metastatic castration-resistant and metastatic castration-sensitive prostate cancer.
DB08899EnzalutamideA second-generation androgen receptor inhibitor used to treat castration-resistant prostate cancer and metastatic castration-sensitive prostate cancer.
DrugDrug NameTargetType
DB05812AbirateroneSteroid 17-alpha-hydroxylase/17,20 lyasetarget
DB05812AbirateroneSerum albumincarrier
DB05812AbirateroneAlpha-1-acid glycoprotein 1carrier
DB05812AbirateroneCytochrome P450 3A4enzyme
DB05812AbirateroneBile salt sulfotransferaseenzyme
DB05812AbirateroneMultidrug resistance-associated protein 1transporter
DB05812AbirateroneCytochrome P450 2D6enzyme
DB05812AbirateroneCytochrome P450 2C8enzyme
DB05812AbirateroneCytochrome P450 1A2enzyme
DB05812AbirateroneCytochrome P450 2C19enzyme
DB05812AbirateroneCytochrome P450 2C9enzyme
DB05812AbirateroneCytochrome P450 3A5enzyme
DB05812AbirateroneSolute carrier organic anion transporter family member 1B1transporter
DB11901ApalutamideAndrogen receptortarget
DB11901ApalutamideCytochrome P450 3A4enzyme
DB11901ApalutamideCytochrome P450 2C8enzyme
DB11901ApalutamideCytochrome P450 2C19enzyme
DB11901ApalutamideCytochrome P450 2C9enzyme
DB11901ApalutamideP-glycoprotein 1transporter
DB11901ApalutamideATP-binding cassette sub-family G member 2transporter
DB11901ApalutamideSolute carrier organic anion transporter family member 1B1transporter
DB11901ApalutamideSolute carrier family 22 member 2transporter
DB11901ApalutamideSolute carrier family 22 member 8transporter
DB11901ApalutamideMultidrug and toxin extrusion protein 2transporter
DB11901ApalutamideGABA(A) Receptortarget
DB11901ApalutamideMultidrug and toxin extrusion protein 1transporter
DB11901ApalutamideSerum albumincarrier
DB08899EnzalutamideSerum albumincarrier
DB08899EnzalutamideCytochrome P450 2C8enzyme
DB08899EnzalutamideCytochrome P450 3A4enzyme
DB08899EnzalutamideAndrogen receptortarget
DB08899EnzalutamideCytochrome P450 2C9enzyme
DB08899EnzalutamideCytochrome P450 2C19enzyme
DB08899EnzalutamideCytochrome P450 2B6enzyme
DB08899EnzalutamideCytochrome P450 3A5enzyme
DB08899EnzalutamideP-glycoprotein 1transporter
DrugDrug NamePhaseStatusCount
DB05812Abiraterone1Recruiting1
DB11901Apalutamide1Recruiting1
DB01248Docetaxel1Recruiting1
DB00959Methylprednisolone1Recruiting1
DB00635Prednisone1Recruiting1
DB11853Relugolix1Recruiting1
DB06699Degarelix2Active Not Recruiting1
DB06186Ipilimumab2Active Not Recruiting1
DB05812Abiraterone3Active Not Recruiting1
DB05812Abiraterone3Completed1
DB05812Abiraterone3Recruiting1
DB11901Apalutamide3Recruiting1
DB12941Darolutamide3Recruiting1
DB08899Enzalutamide3Recruiting1
DB11793Niraparib3Active Not Recruiting1
DB00635Prednisone3Active Not Recruiting1
DB00635Prednisone3Completed1
DB11901Apalutamide4Recruiting1
DB05812AbirateroneNot AvailableCompleted1
DB11901ApalutamideNot AvailableCompleted1
DB06772CabazitaxelNot AvailableCompleted1
DB06699DegarelixNot AvailableCompleted1
DB01248DocetaxelNot AvailableCompleted1
DB08899EnzalutamideNot AvailableCompleted1
DB00014GoserelinNot AvailableCompleted1
DB00007LeuprolideNot AvailableCompleted1
DB13982Lutetium Lu-177Not AvailableCompleted1
DB12813Radium Ra-223Not AvailableCompleted1
DB06825TriptorelinNot AvailableCompleted1