Tardive Dyskinesia (TD)

Also known as: Dyskinesia tardive / Tardive Dyskinesia / Dyskinesia: [tardive] or [oro-facial] / Tardive dyskinesia -RETIRED- / Drug induced blepharospasm / Neuroleptic-induced tardive dyskinesia (disorder) / Dyskinesia: [orofacial] or [tardive]

Drug	Drug Name	Drug Description
DB01068	Clonazepam	A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, and seizures.
DB12161	Deutetrabenazine	A vesicular monoamine transporter 2 inhibitor used for the symptomatic treatment of tardive dyskinesia and chorea associated with Huntington's disease.
DB04844	Tetrabenazine	A vesicular monoamine transporter 2 (VMAT) inhibitor used for the management of chorea associated with Huntington's Disease.
DB11915	Valbenazine	A vesicular monoamine transporter 2 inhibitor used to treat tardive dyskinesia and chorea associated with Huntington's disease.

Drug	Drug Name	Target	Type
DB01068	Clonazepam	Cytochrome P450 3A4	enzyme
DB01068	Clonazepam	Serum albumin	carrier
DB01068	Clonazepam	Cytochrome P450 2E1	enzyme
DB01068	Clonazepam	Arylamine N-acetyltransferase 2	enzyme
DB01068	Clonazepam	GABA(A) Receptor	target
DB01068	Clonazepam	Nuclear receptor subfamily 1 group I member 2	target
DB01068	Clonazepam	GABA(A) Receptor Benzodiazepine Binding Site	target
DB12161	Deutetrabenazine	Synaptic vesicular amine transporter	target
DB12161	Deutetrabenazine	Carbonyl reductase [NADPH] 1	enzyme
DB12161	Deutetrabenazine	Carbonyl reductase [NADPH] 3	enzyme
DB12161	Deutetrabenazine	Cytochrome P450 2D6	enzyme
DB12161	Deutetrabenazine	Cytochrome P450 1A2	enzyme
DB12161	Deutetrabenazine	Cytochrome P450 3A5	enzyme
DB12161	Deutetrabenazine	Cytochrome P450 3A4	enzyme
DB04844	Tetrabenazine	Synaptic vesicular amine transporter	target
DB04844	Tetrabenazine	Cytochrome P450 2D6	enzyme
DB04844	Tetrabenazine	Dopamine D2 receptor	target
DB04844	Tetrabenazine	Carbonyl reductase [NADPH] 1	enzyme
DB11915	Valbenazine	Synaptic vesicular amine transporter	target
DB11915	Valbenazine	Cytochrome P450 2D6	enzyme
DB11915	Valbenazine	Cytochrome P450 3A4	enzyme
DB11915	Valbenazine	Cytochrome P450 3A5	enzyme

Drug	Drug Name	Phase	Status	Count
DB05316	Pimavanserin	0	Completed	1
DB11915	Valbenazine	1	Not Yet Recruiting	1
DB01404	Ginseng	1 / 2	Completed	1
DB00114	Pyridoxal phosphate	2	Terminated	1
DB11915	Valbenazine	2	Completed	4
DB12161	Deutetrabenazine	2 / 3	Completed	1
DB00571	Propranolol	2 / 3	Withdrawn	1
DB11915	Valbenazine	2 / 3	Completed	1
DB12161	Deutetrabenazine	3	Completed	2
DB01381	Ginkgo biloba	3	Completed	1
DB01202	Levetiracetam	3	Completed	1
DB09210	Piracetam	3	Completed	1
DB00165	Pyridoxine	3	Withdrawn	1
DB04844	Tetrabenazine	3	Completed	1
DB11915	Valbenazine	3	Completed	3
DB06288	Amisulpride	4	Completed	1
DB00674	Galantamine	4	Completed	1
DB00334	Olanzapine	4	Completed	1
DB11915	Valbenazine	4	Completed	2
DB11915	Valbenazine	4	Not Yet Recruiting	1
DB11915	Valbenazine	4	Recruiting	1
DB01273	Varenicline	4	Unknown Status	1
DB01065	Melatonin	Not Available	Completed	1