Metformin hydrochlorideProduct ingredient for Metformin
- Name
- Metformin hydrochloride
- Drug Entry
- Metformin
Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.23,14
Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "insulin sensitizer", leading to a decrease in insulin resistance and a clinically significant reduction of plasma fasting insulin levels.14 Another well-known benefit of this drug is modest weight loss, making it an effective choice for obese patients type II diabetes.12
Metformin was first approved in Canada in 1972,8 and received subsequent FDA approval in the US in 1995.23
- Accession Number
- DBSALT000114
- Structure
Structure for Metformin hydrochloride (DBSALT000114)
- Synonyms
- Metformin HCl
- UNII
- 786Z46389E
- CAS Number
- 1115-70-4
- Weight
- Average: 165.625
Monoisotopic: 165.078123116 - Chemical Formula
- C4H12ClN5
- InChI Key
- OETHQSJEHLVLGH-UHFFFAOYSA-N
- InChI
- InChI=1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
- IUPAC Name
- 1-carbamimidamido-N,N-dimethylmethanimidamide hydrochloride
- SMILES
- Cl.CN(C)C(=N)NC(N)=N
- External Links
- PubChem Compound
- 14219
- ChemSpider
- 13583
- ChEBI
- 6802
- ChEMBL
- CHEMBL1703
- Wikipedia
- Metformin
- Predicted Properties
Property Value Source Water Solubility 1.38 mg/mL ALOGPS logP -1.8 ALOGPS logP -0.92 Chemaxon logS -2 ALOGPS pKa (Strongest Basic) 12.33 Chemaxon Physiological Charge 2 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 88.99 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 56.64 m3·mol-1 Chemaxon Polarizability 13.43 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon