Tenofovir disoproxil fumarateProduct ingredient for Tenofovir disoproxil
- Name
- Tenofovir disoproxil fumarate
- Drug Entry
- Tenofovir disoproxil
Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name Viread, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (nRTIs). This drug is prescribed in combination with other drugs for the management of HIV infection as well as for Hepatitis B therapy. Tenofovir disoproxil was initially approved in 2001 Label.
- Accession Number
- DBSALT000172
- Structure
Structure for Tenofovir disoproxil fumarate (DBSALT000172)
- Synonyms
- Not Available
- UNII
- OTT9J7900I
- CAS Number
- 202138-50-9
- Weight
- Average: 635.5149
Monoisotopic: 635.183987333 - Chemical Formula
- C23H34N5O14P
- InChI Key
- VCMJCVGFSROFHV-WZGZYPNHSA-N
- InChI
- InChI=1S/C19H30N5O10P.C4H4O4/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;5-3(6)1-2-4(7)8/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);1-2H,(H,5,6)(H,7,8)/b;2-1+/t14-;/m1./s1
- IUPAC Name
- (2E)-but-2-enedioic acid; bis({[(propan-2-yloxy)carbonyl]oxy}methyl) {[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methanephosphonate
- SMILES
- [H]\C(=C(\[H])C(O)=O)C(O)=O.[H][C@@](C)(CN1C=NC2=C(N)N=CN=C12)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C
- External Links
- KEGG Drug
- D01982
- PubChem Compound
- 6398764
- ChemSpider
- 4911265
- ChEBI
- 63718
- ChEMBL
- CHEMBL1486
- Wikipedia
- Tenofovir_disoproxil
- Predicted Properties
Property Value Source Water Solubility 0.712 mg/mL ALOGPS logP -0.02 ALOGPS logP 2.65 Chemaxon logS -2.9 ALOGPS pKa (Strongest Acidic) 18.55 Chemaxon pKa (Strongest Basic) 3.74 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 10 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 185.44 Å2 Chemaxon Rotatable Bond Count 19 Chemaxon Refractivity 118.59 m3·mol-1 Chemaxon Polarizability 48.94 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon