Acebutolol hydrochlorideProduct ingredient for Acebutolol
- Name
- Acebutolol hydrochloride
- Drug Entry
- Acebutolol
A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action.
- Accession Number
- DBSALT000192
- Structure
Structure for Acebutolol hydrochloride (DBSALT000192)
- Synonyms
- Acebutolol HCl
- UNII
- B025Y34C54
- CAS Number
- 34381-68-5
- Weight
- Average: 372.887
Monoisotopic: 372.181585133 - Chemical Formula
- C18H29ClN2O4
- InChI Key
- KTUFKADDDORSSI-UHFFFAOYSA-N
- InChI
- InChI=1S/C18H28N2O4.ClH/c1-5-6-18(23)20-14-7-8-17(16(9-14)13(4)21)24-11-15(22)10-19-12(2)3;/h7-9,12,15,19,22H,5-6,10-11H2,1-4H3,(H,20,23);1H
- IUPAC Name
- N-(3-acetyl-4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)butanamide hydrochloride
- SMILES
- Cl.CCCC(=O)NC1=CC=C(OCC(O)CNC(C)C)C(=C1)C(C)=O
- External Links
- KEGG Drug
- D00597
- KEGG Compound
- C07677
- PubChem Compound
- 36816
- ChemSpider
- 33788
- ChEBI
- 2380
- ChEMBL
- CHEMBL1200813
- Wikipedia
- Acebutolol
- Predicted Properties
Property Value Source Water Solubility 0.172 mg/mL ALOGPS logP 1.43 ALOGPS logP 1.53 Chemaxon logS -3.3 ALOGPS pKa (Strongest Acidic) 13.91 Chemaxon pKa (Strongest Basic) 9.65 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 87.66 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 94.87 m3·mol-1 Chemaxon Polarizability 38.4 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon