Acetazolamide sodiumProduct ingredient for Acetazolamide
- Name
- Acetazolamide sodium
- Drug Entry
- Acetazolamide
One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
- Accession Number
- DBSALT000539
- Structure
Structure for Acetazolamide sodium (DBSALT000539)
- Synonyms
- Not Available
- UNII
- 429ZT169UH
- CAS Number
- 1424-27-7
- Weight
- Average: 244.227
Monoisotopic: 243.970076101 - Chemical Formula
- C4H5N4NaO3S2
- InChI Key
- MRSXAJAOWWFZJJ-UHFFFAOYSA-M
- InChI
- InChI=1S/C4H6N4O3S2.Na/c1-2(9)6-3-7-8-4(12-3)13(5,10)11;/h1H3,(H3,5,6,7,9,10,11);/q;+1/p-1
- IUPAC Name
- sodium N-acetyl-5-sulfamoyl-1,3,4-thiadiazol-2-aminide
- SMILES
- [Na+].CC(=O)[N-]C1=NN=C(S1)S(N)(=O)=O
- External Links
- PubChem Compound
- 13290219
- ChemSpider
- 14297
- ChEBI
- 31163
- ChEMBL
- CHEMBL1200814
- Wikipedia
- Acetazolamide
- Predicted Properties
Property Value Source Water Solubility 6.47 mg/mL ALOGPS logP -0.65 ALOGPS logP -1 Chemaxon logS -1.6 ALOGPS pKa (Strongest Acidic) 6.55 Chemaxon pKa (Strongest Basic) -3.3 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 112.24 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 44.78 m3·mol-1 Chemaxon Polarizability 18.72 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon