Phenylephrine hydrochlorideProduct ingredient for Phenylephrine
- Name
- Phenylephrine hydrochloride
- Drug Entry
- Phenylephrine
Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,6,8 dilate the pupil,7 and induce local vasoconstriction.1 The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s.2
Phenylephrine was granted FDA approval in 1939.7
- Accession Number
- DBSALT000858
- Structure
Structure for Phenylephrine hydrochloride (DBSALT000858)
- Synonyms
- Phenylephrine HCl
- UNII
- 04JA59TNSJ
- CAS Number
- 61-76-7
- Weight
- Average: 203.67
Monoisotopic: 203.0713064 - Chemical Formula
- C9H14ClNO2
- InChI Key
- OCYSGIYOVXAGKQ-FVGYRXGTSA-N
- InChI
- InChI=1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1
- IUPAC Name
- hydrogen 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol chloride
- SMILES
- [H+].[Cl-].CNC[C@H](O)C1=CC(O)=CC=C1
- External Links
- KEGG Drug
- D00511
- PubChem Compound
- 441279
- ChemSpider
- 390042
- ChEBI
- 8094
- ChEMBL
- CHEMBL1200339
- Wikipedia
- Phenylephrine
- Predicted Properties
Property Value Source Water Solubility 22.0 mg/mL ALOGPS logP -0.69 ALOGPS logP -0.07 Chemaxon logS -0.88 ALOGPS pKa (Strongest Acidic) 9.07 Chemaxon pKa (Strongest Basic) 9.69 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 52.49 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 47.25 m3·mol-1 Chemaxon Polarizability 17.97 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon